| Project/Area Number |
12672062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoritsu College of Pharmacy |
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Principal Investigator |
TAKEDA Tadahiro Kyoritsu College of Pharmacy, Department of Natural Medicines, Professor, 教授 (90106253)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Anti-ulcer pectic polysaccharide / Bupleurum falcatum / Chemical synthesis / Glycosphingolipid / Parasite / Amphoteric glycosphingolipid / Pheretima hilgendorfi / β-mannnosidic linkage / Anti-ulcer-pectic polysaccharide / Chemical synthesis / Parasite / Amphoteric glycosphingolipid / Pheretime hilgendorfi / Acidic tetrasaccharide / Echinococcus multilocularis / Host-parasite interaction |
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| Research Abstract |
Recent research from a variety of fields has revealed numerous biological roles for glycoconjugate. In order to investigate the functions of such molecules, extensive efforts have been directed toward the synthesis of natural and modified structures, we have pursued three materials as target glycoconjugates.
1) Syntheses of model compounds related to an antigenic epitope in pectic polysaccharides from Bupleurum falcatum L. Stereocontrolled syntheses of model compounds related to a category of the major antigenic epitope against anti-bupleurum 2IIc/PG-1-IgG. Glycosylation of the glucuronic acid donors gave the desired di- and trisaccharide derivatives. Furthermore the products were transformed into the oligo-valent clustering saccharides.
2) Synthesis of amphoteric glycolipid analogues containing a phosphocholine residue from the earthworm Pheretima hilgendorfi. We have synthesized for the first time the oligosaccharides including phosphocholine using 2-chloro-2-oxo-1,3,2-dioxaphospholane in good yield and a phosphocholine group seemed to act as an inhibitor to a histamine release.
3) Synthesis of amphoteric analogues from the porcine nematode, Ascaris suum. The key reaction of this synthetic procedure is the formation of a intramolecular aglycon delivery approachf or β-selective mannnosylation.
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