| Project/Area Number |
12672075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
YOSHIKAWA Masayuki Kyoto Pharmaceutical University, Professor, 薬学部, 教授 (90116129)
|
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| Co-Investigator(Kenkyū-buntansha) |
MORIKAWA Toshio Kyoto Pharmaceutical University, Assistant, 薬学部, 助手 (10340449)
MURAKAMI Toshiyuki Kyoto Pharmaceutical University, Assistant, 薬学部, 助手 (40278445)
MATSUDA Hisashi Kyoto Pharmaceutical University, Associate Professor, 薬学部, 助教授 (40288593)
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| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥2,500,000 (Direct Cost: ¥2,500,000)
|
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| Keywords | Aesculus hippocastanum / Trigonella foenum-graceum / Euptelea polyandra / Camellia sinensis var. assamica / Pisum sativum / Momordica charantia / triterpene saponin / digestive tract / サポニン / 神経伝達物質 / エンドウ / 田七人参 / 血糖値上昇抑制 |
|---|
| Research Abstract |
Oleanolic acid (ex. momordine Ic) and acylated polyhydroxyolean-12-ene 3-monodesmosides (ex. escins) were found to have neither insulin-like nor insulin-releasing activity, but they inhibited gastric emptying and glucose-uptake in the small intestine. Investigation of the mode of action revealed that the inhibition of gastric emptying was mediated by capsaicin-sensitive sensory nerves and the stimulating the release and/or production of dopamine to act through dopamine, receptors, which in turn causes of prostaglandins.
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