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Structures and Biological Activities of Terpenoids

Research Project

Project/Area Number 12672077
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionSetsunan University

Principal Investigator

INADA Akira  Setsunan University, Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (70095305)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Tsutomu  Setsunan University, Pharmaceutical Sciences, Professor, 薬学部, 教授 (10028855)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Keywordstriterpene / steroid / sesquiterpene / diamide / meliaceous plant / antitumor activity / アカテツ科植物 / 抗発ガン活性 / トリテルペノイド / セスキテルペノイド / アグライア属植物 / 抗発癌プロモーター活性
Research Abstract

In the course of our study on the structural and biological chemistry of terpenoids and other constituents from natural plants, we have obtained following results during 2000-2002.
1) Chemical examination of the leaves of Aglaia grandis (Meliaceae) led to the isolation of three new putrescine-type diamides, three new pregnane-steroids, one known aromadendrane-sesquiterpene, and five known cycloartane-triterpenes.
2) In order to establish the (24 R) or (24 S) absolute structure of some 24-hydroxycycloartane-triterpenes, X-ray structural analysis was carried out for 24, 25-dihydroxycycloartan-3-one and determined its (24R) structure unequivocally.
3) Chemical examination of the leaves of Aglaia elliptica led to the isolation of two new diamides, two known diamides, and three known cycloartane-triterpenes.
4) Aminopyrrolidine-diamides, odorine and odorinol, obtained from Aglaia odoraia, exhibited remarkable inhibitory effect on two-stage mouse skin carcinogenesis tests.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Akira INADA: "Three putrescine bisamides from the leaves Aglaia"Phytochemistry. 53. 1091-1095 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinkini Bhattacharyya: "(24R)-24,25-Dihydroxycycloartan-3-one"Acta Crystallographica Sect.C. C56. 979-980 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira INADA: "Diamide Derivatives and Cycloartanes from the leaves of Aglaia elliprica"Chemical Pharmaceutical Bulletin. 49・9. 1226-1228 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira INADA: "Cancer Chemopreventive Activity of Odorine and Odorinol from Aglaia odorata"Biological Pharmaceutical Bulletin. 24・11. 1282-1285 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira INADA: "Cancer Chemopreventive Activity of Odorine and, Odorinol from Aglaia odorata,"BioL Pharm Bull. 24(11). 1282-1285 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira lNADA: "Diamide Derivatives and Cycloartanes from the leaves of Aglaia elliptica,"Chem. Pharm Bull.. 49(9). 1226-1228 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinkini BHATTACHARYYA: "(24R)-24, 25-Dihydroxy-cycloartan-3-one"Acta Cryst. C56. 979-980 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira lNADA: "Three putrescine bisamides from the leaves of Aglaia grandis,"Phytochemistry. 53. 1091-1095 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira INADA: "Diamide Derivatires and Cycloartanes from the Leaves of Agloia elliptica"Chemical Pharmaceatical Bulletin. 49・9. 1226-1228 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akira INADA: "Cancer Chemopreventive Activity of Odorine and Odoninol from Aglaid odorata"Biologgical Pharmacerutical. 24・11. 1282-1285 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akira Inada: "Three putrescine bisamides from theleaves of Aglaia grandis"Phytochemistry. 53. 1091-1095 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kinkini Bhattacharyya: "(24R)-24,25-Dihydroxycycloartane-3-one"Acta crystallographica Sect.C. C56. 979-980 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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