Tissue-specificity of arsenic carcinogenesis - Production mechanism of reactive oxygen species in target organs of arsenic carcinogenesis -

• Project/Area Number: 12672178
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental pharmacy
• Research Institution: Nihon University
• Principal Investigator: YAMANAKA Kenzo Nihon University, College of Pharmacy, Associate Professor, 薬学部, 助教授 (50182572)
• Project Period (FY): 2000 – 2001
• Project Status: Completed (Fiscal Year 2001)
• Budget Amount: ¥2,700,000 (Direct Cost: ¥2,700,000); Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 8-oxodG / oxidative stress / dimethylarsinic acid / arsenic / carcinogenesis / arsenic / 無機砒素 / ジメチル砒素 / 8-OHdG / ジメチル砒素過酸化ラジカル

Research Abstract

Recent studies have indicated that oral administration of dimethylarsinic acid (DMA) to rats led to a higher incidence of 8-oxo-2'-deoxyguanosine (8-oxodG) formation in liver and kidney. Therefore, we focused our attention on the induction of oxidative damage in skin, lung, liver and urinary b adder the target organs in arsenic carcinogenesis. The present study is to establish a mouse animal model to understand the mechanism of human arsenic carcinogenesis through the production of oxidative damage. The present findings that the formation of 8-oxodG was observed in skin, lung, liver and urinary bladder in our animal model would be useful for the understanding the arsenic carcinogenesis mechanism in relation to the formation of free radical species.

Research Products

• [Publications] Kenzo Yamanaka 他5名: "Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis"Biochemical and Biophysical Research Communications. 287. 66-70 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kenzo Yamanaka et al.: "Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-oxo-2'-deoxyguanpsine level specifically in the target organs for arsenic carcinogenesis"Biochemical and Biophysical Research Communications. 287. 66-70 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] 山中 健三 ら 他5名: "Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis"Biochemical and Biophysical Research Communications. 287. 66-70 (2001)