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Trials for the evaluation of hepatic insulin resistance with novel simplified method using platelet

Research Project

Project/Area Number 12672244
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionThe University of Tokushima

Principal Investigator

MIZUNO Akira  The University of Tokushima, Medical School Hospital, Instructor, 医学部・附属病院, 助手 (80219641)

Co-Investigator(Kenkyū-buntansha) NOMA Yoshihiko  The University of Tokushima, Medical School Hospital, Assistant Professor, 医学部・附属病院, 講師 (10218349)
KUWAJIMA Masamichi  The University of Tokushima, School of Medicine, Associate Professor, 医学部, 助教授 (00205262)
村上 尚  徳島大学, 医学部, 助手 (40210009)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsInsulin resistance / diabetes mellitus / liver cirrhosis / portal glucosensor / platelet / レプチン
Research Abstract

We examined insulin sensitivity in 60 patients with chronic liver disease using hyperinsulinemic euglycemic clamp method and our simplified method by platelet aggregation, because we noticed that insulin sensitivity in cirrhotic patients evaluated by simplified method using platelet was tend to be in normal in the other study. So we concluded that simplified method using platelet could reflect insulin resistance only in the peripheral tissues but not in the liver tissue. We found that the C-peptide (CPR) response to oral glucose load during hyperinsulinemic euglycemic clamp (clamp-OGL-CPR method) could evaluate the function of portal glucosensor (PGS). We measured CPR response in 30 diabetics, 10 obese subjects with IGT and 10 obese subjects with normal glucose tolerance and 10 normal subjects as control. The CPR response in the diabetics with or without obesity and obese subjects with IGT was remarkably reduced or completely absent nevertheless that in obese subjects without glucose intolerance (simple obesity) was good. CPR response in the patients with liver cirrhosis during clamp-OGL-CPR method was remarkably reduced like diabetic patient. We supposed that the disorders in PGS might be related to postprandial hyperglycemia not only in diabetics but also in the patients with liver cirrhosis, and could not relate to insulin resistance. Now we have been examining the relation between the function of PGS and the glucose intolerance in the animal model of type 2 diabetes. In other study, we made clear that leptin could increase insulin-stimulated glucose uptake in the peripheral tissues but not in liver tissue.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Ogino T: "Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF"Genomics. 70. 19-25 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhu M: "Deffective morhogenesis and functional maturation in fetal islet-like cell clusters from the OLETF rat, a model of type 2 diabetes"Int J Experimental Diabet Res. 1-10 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuno A: "Effect of leptin on insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat"Reg Pept. 99. 41-44 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogino T: "Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF"Genomics. 70. 19-25 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhu M.: "Deffective morhogenesis and functional maturation in fetalislet-like cell clusters from the OLETF rat, a model of type 2 diabetes"Int J Experomental Diabet Res. 1-10 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuno A.: "Effect of leptin on insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat"Reg Pept. 99. 41-44 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuno A: "Effect of leptin on insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat"Reg Pept. 99. 41-44 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中村多希: "肝硬変患者の耐糖能障害に関するアセスメント"栄養・評価と治療. 18(4). 31-34 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akira Mizuno: "Effect leptin on insulin sensitivity in the Otsuka Long Evans Tokushima fatty rat"Regulatory Peptides. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 武田英二: "臨床医(肝硬変を合併した糖尿病の治療指針)"中外医学社. 157 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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