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Establishment of education system based on the regional health promotion activity to prevent life style-related diseases in children

Research Project

Project/Area Number 12672268
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 基礎・地域看護学
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

OHZEKI Takehiko (2001-2002)  Hamamatsu University, Faculty of Medicine, Professor, 医学部, 教授 (20152126)

松本 友子 (2000)  浜松医科大学, 医学部, 教授 (40157376)

Co-Investigator(Kenkyū-buntansha) 安梅 勅江  浜松医科大学, 医学部, 教授 (20201907)
ARAKIDA Mikako  Hamamatsu University, Faculty of Medicine, Professor, 医学部, 教授 (50303558)
KANAMORI Masao  Hamamatsu University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (90127019)
竹内 宏一  浜松医科大学, 医学部, 教授 (90021394)
大関 武彦  浜松医科大学, 医学部, 教授 (20152126)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsLife style-related disorder / Life style / Regional health promotion / Health education / Health education system / Elementary school pupil / Junior high school pupil / Leptin
Research Abstract

The purpose of the study was to establish a school-based system for health promotion in childrdn. Boys and girls in elementary schools (1177) and junior high schools (1064) joined the study. The following items were assessed: (1) body height and weight, and body composition, (2) biochemical and hormonal markers, (3) life style-related factors such as foods and exercise, etc. For assessment of obesity, percentage of overweight for the standard was shown more reliable than BMI (body mass index) especially in childhood. There were significant regional differences in serum lipid levels, suggesting that in addition to genetic causes intervention and education seemed effective to improve dyslipidemia in children. Fat-derived hormone, leptin, was significantly related with body weight and the degree of overweight. Leptin was demonstrated as one of the indicators for fatness even in children. There were gender differences in eating behavior and favorite foods already in childhood. Follow-up study demonstrated efficacy of the health promotion activity in the study. The school-based system for prevention of life style-related diseases is suggested effective for boys and girls in the elementary schoolas well as junior high school.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Liu YJ, Nakagawa Y, Toya K, Wang Y, Saegusa H, Nakanishi T, Ohzeki T: "Effects of spironolactone on systolic blood pressure in experimental diabetic rats"Kidney International. 57. 2064-2071 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakanishi T, Li R, Liu Z, Yi M, Nakagawa Y, Ohzeki T: "Sexual dimorphism in relationship of serum leptin and relative weight for the standard in normal-weight, but not in overweight children as well as adolescents"European Journal of Clinical Nutrition. 55. 989-993 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Endoh A, Inoue N, Katoh T, Nakamura T, Sugimura H, Ohzeki: "A case of glycogen storage disease IA with multiple hepatic tumors managed by transcatheter arterial embolization and acarbose diet"Journal of Pediatric Gastroenterology and Nutrition. 33. 333-336 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Liu Y, Nakagawa Y, Wang Y, Li R, Li X, Ohzeki T, Friedman T: "Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice"Diabetes. 52. 1409-1416 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujisawa Y, Miyamoto K, Furuhashi K, Sano S, Nakagawa Y, Ohzeki T: "A novel mutation in the renal V_2-gene in a boy with 21-trisomy"Pediatric Nephrology. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Li R, Nakagawa Y, Nakanishi T, Fujisawa Y, Ohzeki T: "Different responsiveness in body weight to 11β-hydroxysteroid dehydrogenase inhibition by glycyrphetic acid treatment in obese and lean zudien rats"Metabolism. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 大関 武彦: "小児科学新生児学テキスト:栄養(肥満),代謝疾患"診断と治療社. 991 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Liu Y-J, Nakagawa Y, Toya K, Wang Y, Saegusa H, Nakanishi T, Ohzeki T: "Effects of spironolactone on systolic blood pressure in experimental diabetic rats."Kidney International. 57. 2064-2071 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kanamori M, Nakanishi T, Arakida M, Matsumoto T, Ohzeki T, Helfenstein U, Gasser T: "Birth weight, obesity and hemoglobin Alc in Japanese school children : Results from the cross-sectional study based on the Hamamatsu Study."Hormone Research. 53(suppl 2). 177 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa Y, Liu Y-J, Nakanishi T, Saegusa H, Toya K, Ohzeki T: "Analysis of 11β-hydroxysteroid dehydrogenase type 2 in the kidney of streptozotocin-induced diabetes rats"Pediatric Research. 49(6). 120A (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakanishi T, Yi M, Li R, Saegusa H, Nakagawa Y, Ohzeki T: "Effects of treatment with 11β-hydroxysteroid dehydrogenase inhibitor during infancy on body weight and glucose tolerance in adult rats."Pediatric Research. 49(6). 120A (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Endoh A, Inoue N, Katoh T, Nakamura T, Sugimura H, Ohzeki T: "A case of glycogen storage disease IA with multiple hepatic tumors managed by transcatheter arterial embolization and acarbose diet."Journal of Pediatric Gastroenterology and Nutrition. 33. 333-336 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakanishi T, Li R, Liu Z, Yi M, Nakagawa Y, Ohzeki T: "Sexual dimorphism in relationship of serum leptin and relative weight for the standard in normal-weight, but not in overweight, children as well as adolescents."European Journal of Clinical Nutrition. 55. 989-993 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujisawa Y, Furuhashi K, Miyamoto T, Sano S, Nakagawa Y, Ohzeki T: "High-dose DDAVP partially relieved polyuria in a familial case of nephrogenic diabetes insipidus due to a novel mutation of V2 receptor gene."Hormone Research. 58. 90 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Endoh A, Nakanishi T, Ohzeki T, Kobashi G, Ishimaru Y, Kanamori M: "Serum leptin and soluble leptin receptor in normal subjects."The Endocrine Society's 84^<th> Annual Meeting, San Francisco. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Renshan L, Nakanishi T, Fujisawa Y, Endoh A, Nakagawa Y, Ohzeki T: "Different responsiveness in body weight to 11β-hydroxysteroid dehydrogenase 1 gene."International Congress on Hormones and Cancer. Fukuoka. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakanishi T, Li R, Liu Z, Yi M, Nakagawa Y, Ohzeki T: "Sexual dimorphism in relation of serum leptin and relative weight for the standard in normal-weight, but not in overweight children as well as adolescents"European Journal of Clinical Nutrition. 55. 989-993 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Endoh A, Inoue N, Katoh T, Nakamura T, Sugimura H, Ohzeki T: "A case of glycogen storage disease IA with multiple hepatic tumors managed by transcatheter embolization and an acarbose diet"Journal of Pediatric Gastroenterology and Nutrition. 33. 333-336 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大関 武彦: "小児期の肥満・過体重の判定"肥満研究. 7. 21-26 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大関武彦, 中川祐一, 中西俊樹, 稲葉泰子: "小児肥満の特徴とその管理"日本臨床. 59. 597-602 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakanishi T, Li R, Liu Z, Yi M, Nakagawa Y, Ohzeki T: "Sexual dimorphism in relation of serum leptin and relative weight for the standard in normal-weight, but not in overweight, children as well as adolescents"European Journal of Clinical Nutrition. 55. 989-993 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Endoh A, Inoue N, Katoh T, Nakamura T, Sugimura H, Ohzeki T: "A case of glycogen storage disease IA with multiple hepatic tumors managed by transcatheter embolization and an acarbose diet"Journal of Pediatric Gastroenterology and Nutrition. 33. 333-336 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Watanabe C, Yajima S, Taguchi T, Toya K, Fujii Y, Hongo T, Ohzeki T: "Successful unrelated bone marrow transplantation for a patient with chronic granulomatous disease associated with resistant pneumonitis and Aspergillus osteomyelitis"Bone Marrow Transplantation. 28. 83-87 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 稲葉泰子, 中西俊樹, 中川祐一, 大関武彦: "小児肥満の分子栄養学(肥満遺伝子)"小児科診療. 64. 680-685 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 大関武彦, 中川祐一, 中西俊樹, 稲葉泰子: "小児の肥満の特徴とその管理"日本臨床. 59. 597-602 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中西俊樹,大関武彦: "肥満とその分子メカニズム"小児科. 42:155. 155-163 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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