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Age related functional and morphological alterations in rat diaphragm and phrenic motoneuron

Research Project

Project/Area Number 12680035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionYamaguchi University

Principal Investigator

MIYATA Hirofumi  Professor, Biological Sciences, Yamaguchi Univ., 農学部, 教授 (90190793)

Co-Investigator(Kenkyū-buntansha) WADA Naomi  Professor, Veterinary Medicine, Yamaguchi Univ., 農学部, 教授 (20210982)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsRat / Phrenic motoneuron / Diaphragm / Muscle fiber / Rheobase / Input resistance / Specific force / Contraction speed
Research Abstract

No significant differences were found in all parameters in recruited phrenic motoneuron, while the rheobase of the non-recruited motoneurons was significantly lower in the 2-year group than the other two groups. The mean interval of action potentials of the recruited motoneurons was longer in the 1- and 2-year groups than the 10-week group, and the firing pattern in 2-year group was considerably irregular. Although there were no significant differences in the twitch tension among the groups, tetanus tensions by high frequency stimulation (20-100Hz) were significantly lower in the older group. The time to peak tension and half relaxation time were significantly longer in aged diaphragm muscles. The histochemical profiles of aged diaphragm muscle showed a smaller area of FG fibers and higher percentage of SO fibers.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Miyata H., Wada N.: "Denervation causes changes in electrophysiological properties in rat phrenic motoneurons"Neurosci. Lett.. 310. 149-152 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyata H., Wada N.: "Electrophysiological and metabolical properties of compensatory activated phrenic motoneurons in rats"Med. & Sci in Sports & Exer.. 31(5). S216 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyata H., Kawai Y.: "Alteration of recruitment and rate cording of compensatory activated phrenic motoneuron in rats"Adv. Exerc. Sports Physiol.. 8(4). 165 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyata H, Yamano S, Shyono E: "Age-related functional changes in the rat diaphragm and phrenic motoneuron"Med. & Sci in Sports & Exer.. 32(5)(In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyatja H., Wada N.: "Nervation causes changes in electr ophysiological properties in rat phrenic motoneurons"Neurosci. Lett.. 310. 149-152 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyatja H., Wada N.: "Electrophysiological and metabolical properties of compensatory activated phrenic motoneuron in rats."Med. & Sci. in Sports & Exer.. 31(5). s216 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyatja H., Kawai Y.: "Alteration of recruitment and rate cording of compensatory activated phrenic motoneuron in rats"Adv. Exerc. Sports Physiol.. 8(4). 165 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyata H., Yamano S., Shyono E.: "Age-related functional changes in the rat diaphragm and phrenic motoneuron"Med. & Sci. in Sports & Exer.. 32(5)in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyata H., Wada N.: "Denervation causes changes in electiophysiological properties in rat phrenic motoneurons"Neurosci. Lett.. 310. 149-152 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miyata H., Wada N.: "Electrophysiological and metabolical properties of compensatory activated phrenic motoneurons in rats"Med. & Sci in Sports & Exer.. 31(5). S216 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miyata H., Kawai Y.: "Alteration of recruitment and rate cording of compensatory activated phrenic motoneuron in rats"Adv. Exerc. Sports Physiol.. 8(4). 165 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miyata H, Yamano S. Shyono E.: "Age-related functional changes in the rat diaphragm and phrenic motoneuron"Med. & Sci in Sports & Exer.. 32(5)(In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirofumi Miyata, Naomi Wada: "Denervation causes changes in electrophysiological properties in rat phrenic motoneurons"Neuroscience letters. 310. 149-152 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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