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Study on environmental pollution with mutagens in high mortality areas by lung cancer

Research Project

Project/Area Number 12680555
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 環境影響評価(含放射線生物学)
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

WATANABE Tetsushi  Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, assistant professor, 薬学部, 助教授 (90182930)

Co-Investigator(Kenkyū-buntansha) HIRAYAMA Teruhisa  Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, full professor, 薬学部, 教授 (10121568)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥3,200,000 (Direct Cost: ¥3,200,000)
Keywordsmutagen / soil / 1,3-dinitropyrene / 1,6-dinitropyrene / 1,8-dinitropyrene / 3-nitrobenzoanthrone / airborne particle / 変異原性物質 / ジニトロピレン
Research Abstract

1,3-Dinitropyrene (DNP), 1,6-DNP and 1,8-DNP in 30 surface soil samples were quantified by high performance liquid chromatography equipped with a platinum/rhodium catalyst column and a fluorescence detector. DNP isomers were detected in all soil samples examined, and their concentration in soil samples ranged from a few pg/g of soil. 3-Nitrobenzanthrone (NBA) was detected as a major mutagen in a soil sample that showed strong mutagenicity. To clarify the distribution of 3-NBA in the environment, we developed an analytical method of 3-NBA in airborne particles and surface soil. 3-NBA was partially purify by HPLC and quantified by HPLC with a fluorescence detector. Concentrations of 3-NBA in ambient air in the Kinki area were a few pg/m3, and those in soil samples from the Kinki, Tokai and Kanto areas ranged from a few ng to a few hundred ng/g of soil.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Tetsushi Watanabe: "Mutagenic activity of Surface soil and quantification of 1,3-,1,6-and 1,8-dinitropyrene isomers in soil in Japan"Chemical Research in Toxicology. 13. 281-286 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetsushi Watanabe: "Genotoxicity of Soil"J.Health Science. 47. 433-438 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetsushi Watanabe: "Mutagenic activity of surface soil and quantification of 1,3-, 1,6- and 1,8-dinitropyrene isomers in soil in Japan"Chemical Research in Toxicology. 13. 281-286 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetsushi Watanabe: "Genotoxicity of soil"J. Health Science. 47. 433-438 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetsushi Watanabe: "Gentoxicity of soil"J. Health Science. 47. 433-438 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tetsushi Watanabe et al.: "Mutagenic activity of surface soil and quantification of 1,3-,1,6-and 1,8-dinitropyrene isomers in soil in Japan"Chemical Research Toxicology. 13. 281-286 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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