Study on environmental pollution with mutagens in high mortality areas by lung cancer
| Project/Area Number |
12680555
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
環境影響評価(含放射線生物学)
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
WATANABE Tetsushi Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, assistant professor, 薬学部, 助教授 (90182930)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAYAMA Teruhisa Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, full professor, 薬学部, 教授 (10121568)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Keywords | mutagen / soil / 1,3-dinitropyrene / 1,6-dinitropyrene / 1,8-dinitropyrene / 3-nitrobenzoanthrone / airborne particle / 変異原性物質 / ジニトロピレン |
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| Research Abstract |
1,3-Dinitropyrene (DNP), 1,6-DNP and 1,8-DNP in 30 surface soil samples were quantified by high performance liquid chromatography equipped with a platinum/rhodium catalyst column and a fluorescence detector. DNP isomers were detected in all soil samples examined, and their concentration in soil samples ranged from a few pg/g of soil. 3-Nitrobenzanthrone (NBA) was detected as a major mutagen in a soil sample that showed strong mutagenicity. To clarify the distribution of 3-NBA in the environment, we developed an analytical method of 3-NBA in airborne particles and surface soil. 3-NBA was partially purify by HPLC and quantified by HPLC with a fluorescence detector. Concentrations of 3-NBA in ambient air in the Kinki area were a few pg/m3, and those in soil samples from the Kinki, Tokai and Kanto areas ranged from a few ng to a few hundred ng/g of soil.
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Report
(3 results)
Research Products
(6 results)
