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Search for neuronal mechanisms related to thinking using flexible representation of various information on the nervous system

Research Project

Project/Area Number 12680793
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 神経・脳内生理学
Research InstitutionKYOTO UNIVERSTTY

Principal Investigator

FUNAHASHI Shintaro  Kyoto University, Integrated Human Studies, Professor, 総合人間学部, 教授 (00145830)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsprefrontal cortex / working memory / population vector / delayed response / monkey / information processing / single neuron activity / 神経回路 / 情報表現 / 一時貯蔵機構 / 相互作用
Research Abstract

We collected single-neuron activities from the prefrontal cortex while monkeys performed two spatial working memory tasks (ODR and R-ODR tasks) and constructed population vectors using all collected single-neuron activities. Population vectors constructed from cue- and response-period activity showed similar directions to the directions of the visual cues and the saccades in both tasks, indicating that these population vectors represent information regarding the direction of the visual cue and the direction of the saccade. Based on these results, we obtained population vectors during the 250 ms time window shifting every 50 ms during the delay period. In the ODR task, all population vectors were directed similar to the direction of the visual cue. However, in the R-ODR task, population vector rotated gradually during the delay period from the cue direction to the saccade direction. To understand neuronal mechanisms essential for the rotation of population vectors in the R-ODR task, we examined temporal patterns of two kinds of delay-period activity ; one encoding the cue location and the other encoding the saccade direction. We observed the rapid increase of delay-period activity encoding the saccade direction over the activity encoding the cue location, and found that the time course of this increase coincided with the initiation of rotation in population vectors in the R-ODR task. These results indicate that the information processed during spatial working memory tasks can be depicted as the temporal change of the direction in population vectors. These results also indicate that information processing during thinking corresponds to the gradual transition from a population of neuronal activities representing one kind of information to a population of neuronal activities representing other kind of information.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Funahashi, S.: "Neuronal mechanisms of executive control by the prefrontal cortex"Neuroscience Research. 39. 147-165 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 船橋新太郎: "前頭連合野とワーキングメモリ"神経研究の進歩. 45. 223-234 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeda, K., Funahashi, S.: "Prefrontal task-related activity representing visual cue location on saccade direction in spatial working memory tasks"Journal of Neurophysiology. 87. 567-588 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Funahashi, S., Takeda, K.: "Population-vector analysis by primate prefrontal neuron activities"Journal of Biological Physics. 28. 1-11 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Funahashi, S., Inoue, M.: "Neuronal interactions related to working memory processes in the primate prefrontal cortex revealed by crosscorrelation analysis"Cerebral Cortex. 10. 535-551 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Funahashi, S.: "Neuronal mechanisms of executive control by the prefrontal cortex"Neuroscience Research. 39. 147-165 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Funahashi and M. Inoue: "Neuronal interactions related to working memory processes in the primate prefrontal cortex revealed by cross-correlation analysis"Cerebral Cortex. 10. 535-551 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Funahashi: "Neuronal mechanisms of executive control by the prefrontal cortex"Neuroscience Research. 39. 147-165 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Takeda and S. Funahashi: "Prefrontal task-related activity representing visual cue location or saccade direction in spatial working memory tasks"Journal of Neurophysiology. 87. 567-588 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Funahashi and K. Takeda: "Population-vector analysis by primate prefrontal neuron activities"Journal of Biological Physics. 28. 1-11 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Funahashi, S.: "Neuronal mechanisms of executive control by the prefrontal cortex"Neuroscience Research. 39. 147-165 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 船橋新太郎: "前頭連合野とワーキングメモリ"神経研究の進歩. 45. 223-234 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeda, K., Funahashi, S.: "Prefrontal task-related activity representing visual cue location or saccade direction in spatial working memory tasks"Journal of Neurophysiology. 87. 567-588 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Funahashi, S., Takeda, K.: "Population-vector analysis by primate prefrontal neuron activities"Journal of Biological Physics. 28. 1-11 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.Funahashi: "Neuronal mechanisms of executive control by the prefrontal cortex"Neuroscience Research. 39. 147-165 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Funahahi,M.Inoue: "Neuronal interactions related to working memory processes in the prefrontal cortex revealed by cross-correlation analysis"Cerebral Cortex. 10. 535-551 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 渡辺由美子,船橋新太郎: "視床の機能的役割 記憶"Clinical Neuroscience. 18. 903-905 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 船橋新太郎: "ワーキングメモリの神経機構と前頭連合野の役割"苧阪直行 編 『脳とワーキングメモリ』 京都大学学術出版会. 21-49 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 船橋新太郎: "作業記憶"甘利,外山 編 『脳科学大事典』 朝倉書店. 175-179 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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