| Project/Area Number |
12680831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tottori University |
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Principal Investigator |
SHIGEMASA Yoshihiro Faculty of Engineering, Tottori University, Professor, 工学部, 教授 (00032029)
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| Co-Investigator(Kenkyū-buntansha) |
MORIMOTO Minoru Faculty of Engineering, Tottori University, Research Associate, 工学部, 助手 (10273880)
SAIMOTO Hiroyuki Faculty of Engineering, Tottori University, Associate Professor, 工学部, 助教授 (20186977)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Chitosan / Biolactivity / Self organization / Chitosan derivative / Glycolchitosan / Micelle / Phenolic compound / Mannich reaction / 会合体 / コレステロール / デヒドロアビエチル / 両親媒性多糖 / 乳化安定化 / Mannich reaction / 構造制御 / 疎水性置換基 / ミセル形成 / 蛍光プローブ |
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| Research Abstract |
Chitosan is a polysaccharide having various biological activities. The hydrophobized chitosan derivatives are expected to form self aggregates in aqueous solution. Such an aggregation of bioactive polymers are useful for biomaterials. In this study, we have synthesized new hydrophobized chitosan derivatives branched cholesterol or dehydroabietylamine moieties as a side chain to the amino group of chitosan. The self aggregation of he chitosan derivatives were studied by the fluorescence probe method. The results suggested the cholesterol-chitosan derivative formed micelle-like aggregation, while the dehydroabietylamine-chitosan derivative aggregated randomly. Furthermore, we have developed the one-pot introduction of N-benzyl side chains to chitosan using by a Mannich reaction.
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