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多変量自己回帰モデルによるヒト神経性循環調節のシステム同定に関する研究

Research Project

Project/Area Number 12680851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionAichi Medical University

Principal Investigator

SUGIYAMA Yoshiki  Aichi Medical University School of Medicine, Department of Health and Psychosocial Medicine, Associate Professor, 医学部, 助教授 (50240809)

Co-Investigator(Kenkyū-buntansha) OKADA Akiyoshi  Aichi University of Education, Health Care Center Lecturer, 保健管理センター, 講師 (20319320)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsneural control of systemic circulation / multivariate autoregressive model / baroreflex / muscle sympathetic nerve activity / impulse response / system identification / lower body negative pressure / neck chamber method / 筋交感神経活動 / 圧受容器反射機能 / 下半身陰圧負荷 / マイクロニューログラフィ
Research Abstract

Closed loop analysis using a multivariate auto-regressive model was applied to time series data for the RR interval (RRI), mean blood pressure (BP), vasomotor sympathetic nerve activity recorded as muscle sympathetic nerve activity (MSNA) and respiration with subjects, to determine integratively the neural control of human systemic circulation at supine rest, during head-up tilt and in elderly subjects. The auto-power spectral density curves showed the existence of Mayor's and respiratory rhythms, in which the coherence indicated a linear linkage among these variables. A noise contribution analysis revealed that Mayer's waves in BP are derived from the combination of both BP and MSNA. At supine rest, impulse responses, when assuming 1 mmHg elevation in BP, showed that MSNA is transiently suppressed (BP-to-MSNA response) and RRI is elongated by 4 ms in the following second (BP-to-RRI response). On the other hand, the MSNA-to-BP response revealed that MSNA discharge induces a prolonged (up to 30 s) elevation in BP, while RRI-to-BP response elicited a transient decrease in BP. During head-up tilt, impulse response analysis showed that MSNA-to-BP response was accentuated and prolonged, and that BP-to-RRI response was suppressed, compared with those in a supine position. RRI-to-BP and BP-to-MSNA were unchanged. In elderly subjects, BP-to-RRI response was diminished, whereas BP-to-MSNA response was unchanged. MSNA-to-BP response was markedly reduced, while RRI-to-BP response was unchanged. These results suggest that closed loop analysis using a multivariate auto-regressive model can describe qualitatively and quantitatively the neural control of human systemic circulation. However, further investigation is necessary to confirm the validity of the method.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report

Research Products

(14 results)

All Other

All Publications (14 results)

  • [Publications] 須藤千恵, 杉山由樹, 間野忠明, 小林章雄: "多変量自己回帰モデルによる神経性循環調節機能の解析"宇宙航空環境医学. 35・4. 161 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 杉山由樹, 須藤千恵, 間野忠明, 小林章雄: "起立時の神経性循環調節機能-多変量自己回帰モデルによる解析"宇宙航空環境医学. 35・4. 161 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 杉山由樹, 古賀一男: "下半身陰圧負荷時のNeck Chamber法による頸動脈圧受容器-心拍数反射機能の評価"宇宙航空環境医学. 37・4. 86 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fu Q., Sugiyama Y., Kamiya A., Mano T.: "A comparison of autonomic responses in humans induced by two simulation models of weightlessness : lower body positive pressure and 6 head-down tilt"Journal of the Autonomic Nervous System. 80. 101-107 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugiyama Y., Kobayashi F., Sudoh C., Mano T.: "Head-up tilt時のヒト心血管機能の神経性調節"Japanese Journal of Physiology. 49S. S183 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fu Q., Sugiyama Y., Kamiya A., Mano T.: "A comparison of autonomic responses in humans induced by two simulation models of weightlessness: lower body positive pressure and 6 head-down tilt"Journal of the Autonomic Nervous System. 80. 101-107 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugiyama Y., Kobayashi F., Sudoh C., Mano T.: "Neural control of cardiovascular function during head-up tilt in humans"Japanese Journal of Physiology. 49S. S183 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 須藤千恵, 杉山由樹, 間野忠明, 小林章雄: "多変量自己回帰モデルによる神経性循環調節機能の解析"宇宙航空環境医学. 35・4. 161 (1998)

    • Related Report
      2001 Annual Research Report
  • [Publications] 杉山由樹, 須藤千恵, 間野忠明, 小林章雄: "起立時の神経性循環調節機能-多変量自己回帰モデルによる解析"宇宙航空環境医学. 35・4. 161 (1998)

    • Related Report
      2001 Annual Research Report
  • [Publications] 杉山由樹, 古賀一男: "下半身陰圧負荷時のNeck Chamber法による頸動脈圧受容器-心拍数反射機能の評価"宇宙航空環境医学. 37・4. 86 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Fu Q., Sugiyama Y., Kamiya A., Mano T.: "A comparison of autonomic responses in humans induced by two simulation models of weightlessness : lower body positive pressure and 6 head-down tilt"Journal of the Autonomic Nervous System. 80. 101-107 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sugiyama Y., Kobayashi F., Sudoh C., Mano T.: "Head-up tilt時のヒト心血管機能の神経性調節"Japanese Journal of Physiology. 49S. S183 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 杉山由樹,古賀一男: "下半身陰圧負荷時のNeck Chamber法による頸動脈圧受容器-心拍数反射機能の評価"宇宙航空環境医学. 37・4. 86 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fu Q.,Sugiyama Y.,Kamiya A.,Mano T.: "A comparison of autonomic responses in humans induced by two simulation models of weightlessness : lower body positive pressure and 6 head-down tilt"Journal of the Autonomic Nervous System. 80. 101-107 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-03-31   Modified: 2016-04-21  

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