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HCV高感染地区における口腔粘膜疾患の発生状況-口腔癌並びに前癌病変の発生に関する前向き研究

Research Project

Project/Area Number 12771260
Research Category

Grant-in-Aid for Encouragement of Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKurume University

Principal Investigator

長尾 由実子  久留米大学, 医学部, 助手 (90227992)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsC型肝炎ウイルス(HCV) / 口腔扁平苔癬 / 肝外病変 / HCVキャリア / 自己抗体 / 口腔癌
Research Abstract

HCV高感染地区のHCVキャリアを対象とした肝外病変の疫学調査-とくに口腔扁平苔癬
【目的と背景】我々は,以前にHCV高感染地区(福岡県H町)の住民検診を行ない,HCV感染者には非感染者よりも有意に口腔前癌病変が多いことや(Hepatol Res 1997),肝外病変の有病率が高いことを報告した(Gastroenterology 2000)。今回は他県でのHCV高感染地区(広島県O町)において口腔扁平苔癬(OLP)を初めとする肝外病変の疫学調査を行なった。【対象】O町のHCVキャリア59名(平均年齢70.7歳,M/F;21/38)。【方法】(1)口腔粘膜病変の診査(2)HCV抗体,HCV RNA, HCV genotype,抗核抗体(ANA),リウマチ因子(RF),抗SS-A, B抗体の測定(3)肝外病変の有無についての問診を行ない,検診結果については各住民に文書で報告。【結果】全員がHCV抗体陽性で,HCV RNA陽性者は57人,HCV genotypeは1b;45人(78.9%),2a;6人(10.5%),2b;5人(8.8%),1b+2b;1人(1.8%)。
OLP有病率は8.5%(5/59)(2人がびらん型,3人が網状型)で,白板症は1.7%(1/59)に認められた。口腔乾燥症状を有する者は25.4%,自己抗体が少なくとも1つ以上陽性であった者は42.4%(25/59),肝外病変を認めた住民は66%(39/59)であった。【結論】今回の結果は,我々の研究結果が特定の地域(H町)に限られた現象ではないということを実証した(Hepatol Res 2002,広島医学12,2000)。

Report

(2 results)
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Yumiko Nagao: "High prevalence of anticardiolipin antibodies in patients with HCV-ssociated oral lichen planus"Int J Mol Med. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yumiko Nagao: "High incidence of extrahepatic manifestations in an HCV hyperendemic area"Hepatol Res. 22. 27-36 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Michio Sata: "Hepatitis virus and Extrahepatic manifestations-skin, mucosa, muscle, and hematopoietic organs-"Int Med. 40. 185-189 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 長尾由実子: "扁平苔癬とHCV"口腔粘膜学会誌. 7. 1-19 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 長尾由実子: "特集/日常診療における肝炎・肝癌の診かた考え方-A型肝炎の現状と今後"診断と治療. 89. 1776-1779 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 長尾由実子: "特集C型肝炎のすべて,C型肝炎と肝外病変"肝胆膵. 43. 847-861 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 佐田通夫: "A型肝炎の最近の動向と合併症"肝臓. 42. 575-580 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 長尾由実子: "扁平苔癬とC型肝炎ウイルス"歯界展望. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 長尾由実子: "Annual Review 消化器 2001"中外医学社. 340 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 長尾由実子: "今日の消化器疾患治療指針第2版"医学書院(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yumiko Nagao: "Histopathological and immunohistochemical study of oral lichen planus-associated HCV infection"Eur J Int Med. 11. 277-282 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yumiko Nagao: "High incidence of oral lichen planus in an HCV hyperendemic area"Gastroenterology. 119. 882-883 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yumiko Nagao: "Detection of hepatitis C virus RNA in oral lichen planus and oral cancer tissues"J Oral Pathol Med. 29. 259-266 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yumiko Nagao: "Detection of hepatitis C virus in saliva before and after scaling of dental calculus"Kansenshogaku Zasshi. 74. 961-965 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐田通夫: "C型肝炎ウイルスの肝外病変-口腔病変を中心に-"肝臓病学の進歩. 26. 29-37 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐田通夫: "肝炎ウイルスの臨床-肝炎ウイルスによる皮膚,粘膜,筋,造血器病変-"日本内科学会雑誌. 89. 1860-1866 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yumiko Nagao: "High incidence of extrahepatic manifestations in an HCV hyperendemic area"Hepatol Res. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Michio Sata: "Hepatitis virus and extrahepatic manifestations-skin, mucosa, muscle, and hematopoietic organs-"Int Med. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 吉澤浩司: "HCV検診で発見されたHCVキャリアを対象とした腹部超音波検診および口腔粘膜疾患検診"広島医学. 53. 1201-1204 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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