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Development of frontier life science research for prevention and therapy of endemic diseases in Asia and the Pacific Rim Region

Research Project

Project/Area Number 12800004
Research Category

Grant-in-Aid for Special Purposes

Allocation TypeSingle-year Grants
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

KOIKE Katsuro  Japanese Foundation for Cancer Research, Cancer Institute, Department Chief, 癌研究所・遺伝子研究施設部, 部長 (30085625)

Co-Investigator(Kenkyū-buntansha) ASASHIMA Makoto  Graduate School of Arts and Sciences, The University of Tokyo, Professor, 大学院・総合文化研究科, 教授 (00090564)
MIYAJIMA Atsushi  Institute of Molecular and Cellular Biosciences, The University of Tokyo, Professor, 分子細胞生物学研究所, 教授 (50135232)
ARAI Ken-ichi  Institute of Medical Science, The University of Tokyo, Professor, 医科学研究所, 教授 (00012782)
SUGINO Akio  Research Institute for Microbial Deseases, Osaka University, Professor, 微生物病研究所, 教授 (90231737)
ITO Yoshiaki  Institute for Virus Research, Kyoto University, Professor, ウイルス研究所, 教授 (80004612)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥19,200,000 (Direct Cost: ¥19,200,000)
Fiscal Year 2001: ¥19,200,000 (Direct Cost: ¥19,200,000)
KeywordsFrontier Life Sciences / Asia and Pacific Rim region / Asia-Pacific Molecular Biology Network / Genomics / Proteomics / International collabolation / ゲノム情報 / プロテオーム
Research Abstract

This project performs support surveillance study and joint research on subjects of priority needs, in order to advance R&D in the field of frontier life science, targeting to prevent development and to conduct medical treatment of endemic diseases in Asia and the Pacific Rim region. For this realization, frequent information exchange and collaboration are encouraged among researchers of the Asia-Pacific International Molecular Biology Network (A-IMBN), by which, in turn, Japanese scientists will contribute in Asia and the Pacific Rim region. Mutual exchange of researchers and research collaboration are intended to facilitate investigation of the project priorities and to build the cooperative research system with the foreign researchers.
Based on the results from wide surveillance study on the essential research projects, in the Heisei 12 fiscal year, study was also conducted in the Heisei 13 fiscal year, focusing on the priority research projects. The following projects were selected.
1 … More . Genomics in infectious diseases and immunology. 2. Genomics and proteomics of cancer. 3. Human genome polymorphism. 4. Biotechnology of pharmacogenomics and cell therapy.
Under this 2-years project, the following international activities were supported for information and researcher exchanges and the research collaboration.
1. In September, 2000, the A-IMBN conference was held in Brisbane, Australia.
2. In March, 2001, the international symposium of life science was held in Tokyo.
3. In July, 2001, the A-IMBN symposium was supported in the International Congress of Developmental Biology, in Kyoto.
4. In November, 2001, the A-IMBN conference was held in Taipei.
5. The Singapore/Japan symposium was held in March, 2002 in Singapore.
6. Infrastructure of the international information network was advanced.
7. In March, 2001, the mutual exchange of the researcher between Singapore and Japan was discussed. A member of this project will move to the Institute of Molecular and Cell Biology of Singapore, in April, 2002. Less

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (199 results)

All Other

All Publications (199 results)

  • [Publications] Chong Feng Gao: "Caspase-dependent cytosolic release of cytochrome c and membrane translocation of Bax in p53-induced apoptosis"Exp. Cell Res.. 264. 145-151 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masai H: "Cdc7 kinase complex : a key regulator in the initiation of DNA replication"J Cell Physiol. 190. 287-296 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeda M: "Cell cycle-dependent interaction of Mad2 with conserved Box1/2 region of human granulocyte-macrophage colony-stimulating factor receptor common betac"J Biol Chem.. 276. 41803-41809 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchiyama M: "Sna41goa1, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polalpha"Mol Genet Genomics. 265. 1039-1049 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Liu J: "Inhibition of NFATx activation by an oligopeptide : disrupting the interaction of NFATx with calcineurin"J Immunol. 167. 2677-2687 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takenaka Y: "Transformation of Paramecium caudatum with a novel expression vector harboring codon-optimized GFP gene"Gene. 284. 233-240 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanaka Y: "Anti-CD44 Monoclonal Antibody (IM7) Induces Murine Systemic Shock Mediated by Platelet Activating Factor"J Autoimmun. 18. 9-15 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuura T: "Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes"J Inorg Biochem. 88. 183-191 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takano S: "Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/peptide-binding protein 74 (PBP74) and GRP94"Biochem J. 357. 393-398 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takano S: "p53-independent upregulation of p21 WAF1 in NIH 3T3 cells malignantly transformed by mot-2"Cell Res. 11. 55-60 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsui T: "K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development"EMBO J. 21. 1021-1030 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeuchi M: "Cultivation of aorta-gonad-mesonephros-derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances engraftment to the bone marrow"Blood. 99. 1190-1196 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murakami R: "Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity"J Antibiot. 54. 710-713 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinoshita T: "Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment"Exp Hematol. 29. 1091-1097 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagayama H: "Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim"Bone Marrow Transplant. 29. 197-204 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomonari A: "Severe autoimmune thrombocytopenia after allogeneic bone marrow transplantation for aplastic anemia"Int J Hematol. 74. 228-232 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ooi J: "Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia"Br J Haematol. 114. 834-836 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okada M: "Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc"EMBO J. 21. 675-684 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shinagawa T: "Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice"Oncogene. 20. 8100-8108 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takagi T: "Murine Schnurri-2 is required for positive selection of thymocytes"Nat Immunol. 2. 1048-1053 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Harbers M: "Intracellular localization of the Ret finger protein depends on a functional nuclear export signal and protein kinase C activation"J Biol Chem. 276. 48596-48607 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Khan MM: "PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb"J Biol Chem. 276. 43491-43494 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanikawa J: "Regulation of c-Myb activity by tumor suppressor p53"Blood Cells Mol Dis. 27. 479-482 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kokura K: "The Ski protein family is required for MeCP2-mediated transcriptional repression"J Biol Chem. 276. 34115-34121 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Wada M: "The Second Largest Subunit of Mouse DNA Polymerase epsilon, DPE2, Interacts with SAP18 and Recruits the Sin3 Co-Repressor Protein to DNA"J Biochem (Tokyo). 131. 307-311 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kakeda M: "Role of the thrombopoietin (TPO)/Mpl system : c-Mpl-like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis"Dev Growth Differ. 44. 63-75 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayata T: "Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies"Mech Dev. 112. 37-51 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Onuma Y: "Stroma-dependent maintenance of cytokine responsive hematopoietic progenitor cells derived from long-term bone marrow culture"Proc Natl Acad Sci USA. 99. 2020-2025 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Onuma Y: "Multiple nodal-related genes act coordinately in Xenopus embryogenesis"Dev Biol. 241. 94-105 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Igarashi T: "Cloning and characterization of the Xenopus laevis p8 gene"Dev Growth Differ. 43. 693-698 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishinakamura R: "Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development"Development. 128. 3105-3115 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ariizumi T: "In vitro induction systems for analyses of amphibian organogenesis and body patterning"Int J Dev Biol. 45. 273-279 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ichigi J: "Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity"In Vitro Cell Dev Biol Anim. 37. 31-44 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kawasaki Y: "Yeast replicative DNA polymerases and their role at the replication fork"Mol Cells. 12. 277-285 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Waga S: "DNA polymerase varepsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts"Proc Natl Acad Sci USA. 98. 4978-4983 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Osato M: "Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias"Int J Hematol. 74. 245-251 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ishimoto O: "Possible oncogenic potential of DeltaNp73 : a newly identified isoform of human p73"Cancer Res. 62. 636-641 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetsuka K: "Acidic amino acid transport characteristics of a newly developed conditionally immortalized rat type 2 astrocyte cell line (TR-AST)"Cell Struct Funct. 26. 197-203 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi K: "Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage"J Immunol. 167. 4957-4965 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Obinata M: "Possible applications of conditionally immortalized tissue cell lines with differentiation functions"Biochem Biophys Res Commun. 286. 667-672 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato AK: "Stromal cells provide signals different from cytokines for STAT5 activation in hematopoietic cells"Cell Struct Funct. 26. 95-101 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kitaoka E: "Establishment and characterization of chondrocyte cell lines from the costal cartilage of SV40 large T antigen transgenic mice"J Cell Biochem. 81. 571-582 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchiyama M: "Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast"J Biol Chem. 276. 26189-26196 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chong Feng Gao: "Caspase-dependent cytosolic release of cytochrome c and membrane translocation of Bax in p53-mduced apoptosis"Exp. Cell Res.. 264. 145-151 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masai H: "Cdc7 kinase complex : a key regulator in the initiation of DNA replication"J Cell Physiol.. 190. 287-296 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeda M: "Cell cycle-dependent interaction of Mad2 with conserved Box1/2 region of human granulocyte-macrophage colony-stimulating factor receptor common betac"J Biol Chem.. 276. 41803-41841 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchiyama M: "Sna41goal, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polalpha"Mol Genet Genomics. 265. 1039-1049 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Liu J: "Inhibition of NFATx activation by an oligopeptide : disrupting the interaction of NFATx with calcineurin"J Immunol.. 167. 2677-2687 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takenaka Y: "Transformation of Paramecium caudatum with a novel expression vector harboring codon-optimized GFP gene"Gene. 284. 233-240 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanaka Y: "Anti-CD44 Monoclonal Antibody (IM7) Induces Murine Systemic Shock Mediated by Platelet Activating Factor"J Autoimmun. 18. 9-15 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuura T: "Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes"J lnorg Biochem. 88. 183-191 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takano S: "Identification and characterization of molecular interactions between glucose-regulated protein (GRPs) mortalin/GRP75 /peptide-binding protein 74 (PBP74) and GRP94"Biochem J.. 357. 393-398 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takano S: "p53-independent upregulation of p21 WAF1in NIH 3T3 cells malignantly transformed by mot-2"Cell Res.. 11. 55-60 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsui T: "K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development"EMBO J. 21. 1021-1030 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeuchi M: "Cultivation of aorta-gonad-mesonephros- derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances engraftment to the bone marrow"Blood. 99. 1190-1196 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murakami R: "Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp.1. Production, isolation and biological activity"J Antibiot.. 54. 710-713 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinoshita T: "Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment"Exp Hematol.. 29. 1091-1097 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Onuma Y: "Multiple nodal-related genes act coordinately in Xenopus embryogenesis"Dev Biol.. 241. 94-105 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Igarashi T: "Cloning and characterization of the Xenopus laevis p8 gene"Dev Growth Differ. 43. 693-698 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishinakamura R: "Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development"Development. 128. 3105-3115 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ariizumi T: "In vitro induction systems for analyses of amphibian organogenesis and body patterning"Int J Dev Biol.. 45. 273-279 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ichigi J: "Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity"In Vitro Cell Dev Biol Anim.. 37. 31-44 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kawasaki Y: "Yeast replicative DNA polymerases and their role at the replication fork"Mol Cells. 12. 277-285 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Waga S: "DNA polymerase varepsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts"Proc Natl Acad Sci USA. 98. 4978-4983 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Osato M: "Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias"Int J Hematol.. 74. 245-251 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ishimoto O: "Possible oncogenic potential of DeltaNo73 : a newly identified isoform of human p73"Cancer Res.. 62. 636-641 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetsuka K: "Acidic amino acid transport characteristics of a newly developed conditionally immortalized rat type 2 astrocyte cell line (TR-AST)"Cell Struct Funct. 26. 197-203 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayashi K: "Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage"J Immunol.. 167. 4957-4965 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Obinata M: "Possible applications of conditionally immortalized tissue cell lines with differentiation functions"Biochem Biophys Res Commun.. 286. 667-672 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato AK: "Stromal cells provide signals different from cytokines for STAT5 activation in hematopoietic cells"Cell Struct Funct.. 26. 95-101 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kitaoka E: "Establishment and characterization of chondrocyte cell lines from the costal cartilage of SV40 large T antigen transgenic mice"J Cell Biochem.. 81. 571-582 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagayama H: "Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim"Bone Marrow Transplant. 29. 197-204 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomonari A: "Severe autoimmune thrombocytopenia after allogeneic bone marrow transplantation for aplastic anemia"Int J Hematol.. 74. 228-232 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ooi J: "Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia"Br J Haematol.. 114. 834-836 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okada M: "Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc"EMBO J. 21. 675-684 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shinagawa T: "Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice"Oncogene. 2. 8100-8108 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takagi T: "Murine Schnurri-2 is required for positive selection of thymocytes."Nat Immunol.. 2. 1048-1053 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Harbers M: "Intracellular localization of the Ret finger protein depends on a functional nuclear export signal and protein kinase C activation"J Biol Chem.. 276. 48596-48648 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Khan MM: "PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb"J Biol Chem.. 276. 43491-43543 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanikawa J: "Regulation of c-Myb activity by tumor suppressor p53"Blood Cells Mol Dis.. 27. 479-482 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kokura K: "The Ski protein family is required for MeCP2-mediated transcriptional repression"J Biol Chem.. 276. 34115-34234 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Wada M: "The Second Largest Subunit of Mouse DNA Polymerase epsilon, DPE2, Interacts with SAP18 and Recruits the Sin3 Co-Repressor Protein to DNA"J Biochem. (Tokyo). 131. 307-311 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kakeda M: "Role of the thrombopoietin (TPO)/Mpl system : c-Mpl-like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis"Dev Growth Differ.. 44. 63-75 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hayata T: "Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies"Mech Dev.. 112. 37-51 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Onuma Y: "Stroma-dependent maintenance of cytokine responsive hematopoietic progenitor cells derived from long-term bone marrow culture"Proc Natl Acad Sci USA. 99. 2020-2025 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchiyama M: "Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast"J Biol Chem.. 276. 26189-26226 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chong Feng Gao: "Caspase-dependent cytosolic release of cytochrome c and membrane translocation of Bax in p53-induced apoptosis"Exp.Cell Res.. 264. 145-151 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masai H: "Cdc7 kinase complex : a key regulator in the initiation of DNA replication"J Cell Physiol. 190. 287-296 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeda M: "Cell cycle-dependent interaction of Mad2 with conserved Box1/2 region of human granulocyte-macrophage colony-stimulating factor receptor common betac"J Biol Chem.. 276. 41803-41809 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uchiyama M: "Sna41goa1, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polalpha"Mol Genet Genomics. 265. 1039-1049 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Liu J: "Inhibition of NFATx activation by an oligopeptide : disrupting the interaction of NFATx with calcineurin"J Immunol. 167. 2677-2687 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takenaka Y: "Transformation of Paramecium caudatum with a novel expression vector harboring codon-optimized GFP gene"Gene. 284. 233-240 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tanaka Y: "Anti-CD44 Monoclonal Antibody(IM7) Induces Murine Systemic Shock Mediated by Platelet Activating Factor"J Autoimmun. 18. 9-15 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsuura T: "Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes"J Inorg Biochem. 88. 183-191 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takano S: "Identification and characterization of molecular interactions between glucose-regulated proteins(GRPs) mortalin/GRP75 /peptide-binding protein 74(PBP74) and GRP94"Biochem J. 357. 393-398 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takano S: "p53-independent upregulation of p21WAF1 in NIH 3T3 cells malignantly transformed by mot-2"Cell Res. 11. 55-60 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsui T: "K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development"EMBO J. 21. 1021-1030 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeuchi M: "Cultivation of aorta-gonad-mesonephros-derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances engraftment to the bone marrow"Blood. 99. 1190-1196 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Murakami R: "Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. l. Production, isolation and biological activity"J Antibiot. 54. 710-713 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kinoshita T: "Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment"Exp Hematol. 29. 1091-1097 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagayama H: "Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim"Bone Marrow Transplant. 29. 197-204 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tomonari A: "Severe autoimmune thrombocytopenia after allogeneic bone marrow transplantation for aplastic anemia"Int J Hematol. 74. 228-232 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ooi J: "Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia"Br J Haematol. 114. 834-836 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okada M: "Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc"EMBO J. 21. 675-684 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shinagawa T: "Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice"Oncogene. 20. 8100-8108 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takagi T: "Murine Schnurri-2 is required for positive selection of thymocytes"Nat lmmunol. 2. 1048-1053 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Harbers M: "Intracellular localization of the Ret finger protein depends on a functional nuclear export signal and protein kinase C activation"J Biol Chem. 276. 48596-48607 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Khan MM: "PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb"J Biol Chem. 276. 43491-43494 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tanikawa J: "Regulation of c-Myb activity by tumor suppressor p53"Blood Cells Mol Dis. 27. 479-482 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kokura K: "The Ski protein family is required for MeCP2-mediated transcriptional repression"J Biol Chem. 276. 34115-34121 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Wada M: "The Second Largest Subunit of Mouse DNA Polymerase epsilon, DPE2, Interacts with SAP18 and Recruits the Sin3 Co-Repressor Protein to DNA"J Biochem(Tokyo). 131. 307-311 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kakeda M: "Role of the thrombopoietin (TPO)/Mpl system : c-Mpl-like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis"Dev Growth Differ. 44. 63-75 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hayata T: "Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies"Mech Dev. 112. 37-51 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Onuma Y: "Stroma-dependent maintenance of cytokine responsive hematopoietic progenitor cells derived from long-term bone marrow culture"Proc Natl Acad Sci USA. 99. 2020-2025 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Onuma Y: "Multiple nodal-related genes act coordinately in Xenopus embryogenesis"Dev Biol. 241. 94-105 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Igarashi T: "Cloning and characterization of the Xenopus laevis p8 gene"Dev Growth Differ. 43. 693-698 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nishinakamura R: "Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development"Development. 128. 3105-3115 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ariizumi T: "In vitro induction systems for analyses of amphibian organogenesis and body patterning"Int J Dev Biol. 45. 273-279 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ichigi J: "Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity"In Vitro Cell Dev Biol Anim. 37. 31-44 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawasaki Y: "Yeast replicative DNA polymerases and their role at the replication fork"Mol Cells. 12. 277-285 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Waga S: "DNA polymerase varepsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts"Proc Natl Acad Sci U S A. 98. 4978-4983 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Osato M: "Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias"Int J Hematol. 74. 245-251 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ishimoto O: "Possible oncogenic potential of DeltaNp73 : a newly identified isoform of human p73"Cancer Res. 62. 636-641 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tetsuka K: "Acidic amino acid transport characteristics of a newly developed conditionally immortalized rat type 2 astrocyte cell line (TR-AST)"Cell Struct Funct. 26. 197-203 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hayashi K: "Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage"J Immunol. 167. 4957-4965 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Obinata M: "Possible applications of conditionally immortalized tissue cell lines with differentiation functions"Biochem Biophys Res Commun. 286. 667-672 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato AK: "Stromal cells provide signals different from cytokines for STAT5 activation in hematopoietic cells"Cell Struct Funct. 26. 95-101 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kitaoka E: "Establishment and characterization of chondrocyte cell lines from the costal cartilage of SV40 large T antigen transgenic mice"J Cell Biochem. 81. 571-582 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uchiyama M: "Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast"J Biol Chem. 276. 26189-26196 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] A.Honda: "HCV-core protein accelerates recovery from the insensitivity of liver cells to Fas-mediated apoptosis induced by an injection of anti-Fas antibody in mice"J.Hepatology. 33. 440-447 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Hayashi: "The Binding Site of Transcription Factor YY1 Is Required for The Intra-molecular Recombination between Terminally Repeated Sequences of Linear Replicative Hepatitis B Virus DNA"J.Virol.. 74. 9741-9478 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hara T.: "Form of human p53 protein during nuclear transport in Xenopus laevis embryos."Exp.Cell Res.. 258. 152-161 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Nakanishi-Matsui: "Integrated hepatitis B virus DNA preserves the binding sequence of transcription factor Yin and Yang 1 at the virus-cell junction."J.Virol.. 74. 5562-5568 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kosugi N: "The preferential expression of CD7 and CD34 in myeloid blast crisis in chronic myeloid leukemia"Blood. 95. 2188-2189 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshino H: "Natural killer cell depletion by anti-asialo GM1 antiserum treatment enhances human hematopoietic stem cell engraftment in NOD/Shi-scid mice"Bone Marrow Transplant. 26. 1211-1216 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ishii T: "Improvement in bronchiolitis obliterans organizing pneumonia in a child after allogeneic bone marrow transplantation by a combination of oral prednisolone and low dose erythromycin"Bone Marrow Transplant. 26. 907-910 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yusa N: "Transcription factor Sp3 activates the liver/bone/kidney-type alkaline phosphatase promoter in hematopoietic cells"J.Leukoc Biol.. 68. 72-77 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Wu MS: "MHC(Major histocompatibility Complex)-DRB genes and polymorphisms in common marmoset"J Mol Evol.. 51. 214-222 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanabe T: "Oncogene inactivation in a mouse model"Nature. 406. 473-474 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Watari K: "Hyperfunction of neutrophils in a patient with BCR/ABL negative chronic myeloid leukemia: a case report with in vitro studies"Cancer. 89. 551-560 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagayama H: "IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells"J Immunol.. 165. 59-66 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda T: "Hematopoietic repopulating ability of cord blood CD34(+)cells in NOD/Shi-scid mice"Stem Cells. 18. 204-213 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Moriya N: "In vitro pancreas formation from Xenopus ectoderm treated with activin and retinoic acid"Dev Growth Differ.. 42. 593-602 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Chan Tc: "A role for xlim-1 in pronephros development in xenopus laevis"Dev Biol.. 228. 256-269 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanegashima K: "Expression cloning of xantivin, a xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction"Mech Dev.. 99. 3-14 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takahashi S: "Two novel nodal-related genes initiate early inductive events in xenopus nieuwkoop center"Development. 127. 5319-5329 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukui A: "Effects of rat Axin domains on axis formation in Xenopus embryos"Dev Growth Differ.. 42. 489-498 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Cheong SW: "Spontaneous thyroid-containing teratoma associated with impaired development in the african clawed frog, xenopus laevis"J Comp Pathol.. 123. 110-118 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kadoya T: "Inhibition of wnt signaling pathway by a novel axin-binding protein"J Biol Chem.. 275. 37030-37037 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Asashima M: "In vitro control of organogenesis and body patterning by activin during early amphibian development"Comp Biochem Physiol B Biochem Mol Biol.. 126. 169-178 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Asashima M: "Bioassays for studying the role of the peptide growth factor activin in early amphibian embryogenesis"Methods Mol Biol.. 136. 15-26 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Moriya N: "In vitro organogenesis of pancreas in Xenopus laevis dorsal lips treated with retinoic acid"Dev Growth Differ.. 42. 175-185 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kuroda H: "Cloning a novel developmental regulating gene, Xotx5: its potential role in anterior formation in Xenopus laevis"Dev Growth Differ.. 42. 87-93 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Eisaki A: "XSIP1,a member of two-handed zinc finger proteins, induced anterior neural markers in Xenopus laevis animal cap"Biochem Biophys Res Commun.. 271. 151-157 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Arakawa E: "A mouse bone marrow stromal cell line, TBR-B, shows inducible expression of smooth muscle-specific genes"FEBS Lett.. 481. 193-196 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inoue T: "MIDA1 is a sequence specific DNA binding protein with novel DNA binding properties"Genes Cells. 5. 699-709 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okubo T: "Stroma-dependent maintenance of cytokine responsive hematopoietic progenitor cells derived from long-term bone marrow culture"Cell Struct Funct.. 25. 133-139 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Furusawa T: "Isolation of a novel PDZ-containing myosin from hematopoietic supportive bone marrow stromal cell lines"Biochem Biophys Res Commun.. 270. 67-75 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanaka Y: "Endothelin-1 is involved in the growth promotion of vascular smooth muscle cells by hyaluronic acid"Int J Cardiol.. 76. 39-47 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kaul SC: "Transcriptional inactivation of p53 by deletions and single amino acid changes in mouse mot-1 protein"Biochem Biophys Res Commun.. 279. 602-606 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kaul SC: "Structurally and functionally distinct mouse hsp7O family members Mot-1 and Mot-2 proteins are encoded by two alleles"DNA Res.. 7. 229-231 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sano Y: "Increased Affinity of c-Myb for CREB-binding Protein(CBP)after CBP-induced Acetylation"J Biol Chem.. 276. 3674-3682 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanaka Y: "Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein"Mech Dev.. 95. 133-145 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shinagawa T: "The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice"EMBO J.. 19. 2280-2291 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawasaki Y: "Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae"Genes Cells. 5. 975-989 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohya T: "Structure and function of the fourth subunit (Dpb4p) of DNA polymerase varepsilon in saccharomyces cerevisiae"Nucleic Acids Res.. 28. 3846-3852 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Izumi M: "Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor,and Sp1"Biochim Biophys Acta.. 1492. 341-352 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kihara M: "Characterization of the yeast Cdc7p/ Dbf4p complex purified from insect cells. ITS PROTEIN KINASE ACTIVITY IS REGULATED BY rad53p"J Biol Chem.. 275. 35051-35062 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Johnston LH: "A Cdc7p-Dbf4p protein kinase activity is conserved from yeast to humans"Prog Cell Cycle Res.. 4. 61-69 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Masumoto H: "Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast"Mol Cell Biol.. 20. 2809-2817 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Baba I: "Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells"Cancer Res.. 60. 6886-6889 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukui Y: "Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact"Proc.Natl.Acad.Sci.USA. 97. 13760-13765 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ries S: "Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF"Cell. 103. 321-330 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Toh H: "Changes at the floor of the peptide-binding groove induce a strong preference for proline at position 3 of the bound peptide: molecular dynamics simulations of HLA-A^*0217"Biopolymers. 54. 318-327 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawamura K: "Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice"J Clin Invest.. 105. 977-984 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inoue TK: "Linkage analysis of moyamoya disease on chromosome 6"J Child Neurol.. 15. 179-182 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hamaguchi K: "Analysis of tumor necrosis factor-alpha promoter polymorphism in type 1 diabetes: HLA-B and -DRB1 alleles are primarily associated with the disease in Japanese"Tissue Antigens.. 55. 10-16 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tamura K: "Interleukin-6 decreases estrogen production and messenger ribonucleic acid expression encoding aromatase during in vitro cytodifferentiation of rat granulosa cell"Mol Cell Endocrinol.. 170. 103-111 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Oda A: "Thrombopoietin and interleukin-2 induce association of CRK with STAT5"Biochem Biophys Res Commun. 278. 299-305 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ito Y: "Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and ras pathways during hepatic development"Hepatology. 32. 1370-1376 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Morikawa Y: "Expression of interleukin-6 receptor, leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar purkinje cells"Neuroscience. 100. 841-848 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kojima N: "Cell density-dependent regulation of hepatic development by a gp130-independent pathway"Biochem Biophys Res Commun.. 277. 152-158 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Wang Y: "Baumann H.Receptor subunit-specific action of oncostatin M in hepatic cells and its modulation by leukemia inhibitory factor"J Biol Chem.. 275. 25273-25285 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ariyoshi K: "Constitutive activation of STAT5 by a point mutation in the SH2 domain"J Biol Chem. 275. 24407-24413 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Miyajima A: "Role of Oncostatin M in hematopoiesis and liver development"Cytokine Growth Factor Rev.. 11. 177-183 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamada K: "Constitutively active STAT5A and STAT5B in vitro and in vivo : mutation of STAT5 is not a frequent cause of leukemogenesis"Int J Hematol.. 71. 46-54 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mukouyama Y: "The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region"Dev Biol.. 220. 27-36 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kanai F: "TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins"EMBO J.. 19. 6778-6791 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Zhang YW: "A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia"Proc Natl Acad Sci USA. 97. 10549-10554 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kai E: "Detection of PCR products of escherichia coli O157:H7 in human stool samples using surface plasmon resonance (SPR)"FEMS Immunol Med Microbiol.. 29. 283-288 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sugihara K: "Molecular Characterization of cDNA Encoding Oxygen Evolving Enhancer Protein 1 Increased by Salt Treatment in the Mangrove Bruguiera gymnorrhiza"Plant Cell Physiol.. 15. 1279-1285 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kato T: "Bioassay of bile acids using an enzyme-linked DNA aptamer"Analyst. 125. 1371-1373 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kato T: "In vitro selection of DNA aptamers which bind to cholic acid"Biochim Biophys Acta. 1493. 12-18 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kim YC: "Photocatalytic sensor for chemical oxygen demand determination based on oxygen electrode"Anal Chem.. 72. 3379-3382 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohiso I: "A fluorescence polarization assay using oligonucleotide probes for the rapid detection of verotoxin-producing Escherichia coli"J Biotechnol.. 81. 5-25 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Lim T: "Detection of atrazine based on the SPR determination of P450 mRNA levels in Saccharomyces cerevisiae"Anal Chem.. 72. 2856-2860 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Miyachi H: "Application of polymer-embedded proteins to fabrication of DNA array"Biotechnol Bioeng.. 69. 323-329 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Muguruma H: "Thin-film glucose biosensor based on plasma-polymerized film: simple design for mass production"Anal Chem.. 72. 2671-2675 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kato T: "Interaction of three-way DNA junctions with steroids"Nucleic Acids Res.. 28. 1963-1968 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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