| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Research Abstract |
The analysis of dystonia by using the magnetic stimulation clinically, and the action mechanism to brain of rat by the transcranial magnetic stimulation from the behavior and biochemical point. The accessory nerve innevated the sternocleidomastoideus muscle, which is responsible for dystonia, is stimulated by magnetic stimulation, and the somatosensory evoked potential (SEP) is recorded. The amplitude of it is higher than healthy side. The nerve block of its accessory nerve decreases the amplitude of SEP with decreased dystonia, without marked decrease of muscle strength. These observation suggests that the dysregulation of sensory system might be related with the dystonia, in addition to the abnormal motor output.
In magnetic stimulation the pulsed change of magnetic fields induces the eddy current in brain and this stimulates the neurone, The cortical function would be changed by repetitive transcranial magnetic stimulation. The behavior and neurochemical study are analyzed after repetitive transcranial magnetic stimulation (rTMS)(25Hz, 125times) to the frontal cortex of rats. The increased stay in open arm is observed after rTMS, with 40% and 60% output strength of rTMS, but not with 20% and 80%, and it is observed by stimulation for 3 days, not for one day. In vivo microdialysis of frontal cortex, 5-HT is changed, without change in dopamine.
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