| Project/Area Number |
12832004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
KASAHARA Satoshi Hokkaido Univ., College of Medical Technology, Reserch Associate, 医療技術短期大学部, 助手 (10312422)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Junko Hokkaido Univ., College of Medical Technology, Professor, 医療技術短期大学部, 教授 (40208939)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | primary motor cortex / rehabilitative training / experimental strokes / reorganization / compensatory movement |
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| Research Abstract |
It is reported that rehabilitative intervention improves the functional outcome of patients after strokes. However, it is still unclear how it assists recovery from hemi-or monoparesis. In order to address this question, we examined voluntary movements of impaired forelimbs during recovery after experimental strokes in monkeys.
(1) The forelimb movements to retrieve food pellets were analyzed with videotape recording (VTR). To take food pellets in a shallow well, intact monkeys used thumb adduction toward the first finger, while he flexed the first and the second fingers for the deep well.
(2) Under Pentobarbital Na anesthesia, we examined somatotopy of the primary motor cortex of the dominant hemisphere by applying intracortical microstimulation. Representation of forelimb was almost similar to the previous reports. The distal forelimb representation (digit, wrist/forearm) was bounded medially. Movements of proximal areas (elbow and shoulder) are represented laterally. A small infarction was made by coagulating blood vessels in the area of the distal forelimb.
(3) Recovery process from experimental stroke was evaluated by measuring the time required for taking pellets (Hand Performance Test : HPT) and VTR until 1 month after stroke.
Monkeys could not use their impaired hands during the first 2 days. The failure to retrieve food pellets and compensatory movements such as changing posture and involvement of other joints were often observed during the first week. The time for retrieving pellets was prolonged than that before the lesion until the first month. After that, they no longer showed motor deficit in the performance test. This animal model for studying functional recovery after experimental stroke is useful for the evaluation of motor deficit. With this model, we will be able to examine further how the recovery process and reorganization in the brain are taken place.
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