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The elucidation of the mechanisms of cardiovascular hypertrophy and hyperplasia and the establishment of angiogenesis by therapeutic electrical stimulation

Research Project

Project/Area Number 12832008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionTohoku University

Principal Investigator

YOSHIDA Kazunori  Tohoku University Hospital, Lecturer, 医学部・附属病院, 講師 (90292218)

Co-Investigator(Kenkyū-buntansha) KUROKAWA Yoshimochi  Tohoku University, Graduate School of Medicine, Lecturer, 大学院・医学系研究科, 講師 (80215087)
HIDA Wataru  Tohoku University, Graduate School of Informational Science, Professor, 大学院・情報科学研究科, 教授 (10142944)
KOHZUKI Masahiro  Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (70234698)
KUWAHARA Makoto  Astec Ltd., Division of Research and Development, Manager, 研究開発部, 課長(研究職)
TANAKA Shinobu  Kanazawa University, Graduate School of Technology, Associate Professor, 工学部, 助教授 (40242218)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2001: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2000: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywordspulmonary emphysema / activities of daily living / health related quality of life / quality of life / rehabilitation / respiration / lung volume reduction surgery
Research Abstract

We evaluated exercise performance, psychological state, activities of daily living (ADL) and health-related quality of life (HRQL) levels, assessed using the sickness impact profile (SIP) and the linear analogue scale (QOL Scale) in 61 Japanese in-patients with emphysema. About half of them had severe anxiety and depression tendencies. Disabilities of ADL were apparent in stage II of COPD lung function severity as defined by the American Thoracic Society (ATS). Patients who were stage III required help maintaining their ADL. In the SIP, the higher the ATS stages, the more exercise performance and ADL impaired. However, psychological state and HRQL are not significantly correlated with ATS stages. These results indicate that lung function is not a simple determinant of psychological state and HRQL in Japanese patients with emphysema.
We evaluated the long-term impact of lung volume reduction surgery (LVRS) for emphysema on HRQL assessed by the sickness impact profile (SIP) before and after LVRS in patients with severe emphysema who underwent pulmonary rehabilitation and LVRS (group A), along with measurements of lung function, exercise performance, and ADL. The patients with severe emphysema who underwent pulmonary rehabilitation but did not undergo LVRS served as a control group (group B).
Lung function, exercise performance and ADL were improved significantly at 3 months post-LVRS and even maintained at 12 months follow-up. In group A, both SIP-overall score and SIP-physical score were improved significantly at 3 months post-LVRS and maintained at 6 and 12 months follow-ups. SIP-psychosocial score was improved significantly at 12 months. In group B, SIP scores were significantly impaired compared with group A at 6 and 12 months after pulmonary rehabilitation.
These results suggest that LVRS improves not only lung function, exercise performance, and ADL, but also HRQL and these improvements are maintained for at least 12 months after the operation.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Kohzuki M: "Renal-protective effect of non-depressor dose of cicletanine in diabetic spontaneously hypertensive rats"Am J Hypertens. 13. 298-306 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshida T: "Effect of a two-week, hospitalized phase II cardiac rehabilitation program on physical capacity, lipid profiles and psychological variables in patients with acute myocardial infarction"Jpn Circ J. 65. 87-93 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshida K: "Renoprotective effects of troglitazonein spontaneously hypertensive rats with chronic renal failure"J Hypertens. 19. 503-510 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Watanabe M: "Marked Improvement of Neuropsychological Impairment in a Patient with Chronic Obstructive Pulmonary Disease after Lung Volume Reduction Surgery"Tohoku Journal of Experiment Medicine. 193. 67-72 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Goto Y: "Improved activities of daily living (ADL) and quatity of life (QOL) following lung volume reduction surgery (LVRS) for emphysema. Proceedings"Proceedings of the 1st World Congress of the International Society of Physical and Rehabilitation Medicine. 837-840 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kohzuki M: "Renal-protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with renal failure"J. Hypertens. 19. 1877-1882 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kohzuki M, et al.: "Renal-protective effect of non-depressor dose of cicletanine in diabetic spontaneously hypertensive rats"Am J Hypertens. 13. 298-306 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshida T, et al: "Effect of a two-week, hospitalized phase II cardiac rehabilitation program on physical capacity, lipid profiles and psychological variables in patients with acute myocardial infarction"Jpn Circ J. 65. 87-93 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshida K, et al.: "Renoprotective effects of troglitazone in spontaneously hypertensive rats with chronic renal failure"J Hypertens. 19. 503-510 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Watanabe M, et al.: "Marked Improvement of Neuropsychological Impairment in a Patient with Chronic Obstructive Pulmonary Disease after Lung Volume Reduction Surgery"Tohoku Journal of Experiment Medicine. 193. 67-72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Goto Y, et al.: "Improved activities of daily living (ADL) and quatity of life (QOL) following lung volume reduction surgery (LVRS) for emphysema"Proceedings of the 1st World Congress of the International Society of Physical and Rehabilitation Medicine, Monduzzi Editore, Bologna. 837-840 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kohzuki M, et al.: "Renal-protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with renal failure"J Hypertens. 19. 1877-1882 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kohzuki M: "Renal-protective effect of non-depressor dose of cicletanine in diabetic spontaneously hypertensive rats"Am J Hypertens. 13. 298-306 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshida T: "Effect of a two-week, hospitalized phase II cardiac rehabilitation program on physical capacity, lipid profiles and psychological variables in patients with acute myocardia infarction"Jpn Circ J. 65. 87-93 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshida K: "Renoprotective effects of troglitazonein spontaneously hypertensive rats with chronic renal failure"J Hypertens. 19. 503-510 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Watanabe M: "Marked lmprovement of Neuropsychological impairment in a Patient with Chronic Obstructive Pulmonary Disease after Lung Volume Reduction Surgery"Tohoku Journal of Experiment Medicine. 193. 67-72 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Goto Y: "Improved activities of daily living (ADL) and quatity of life (QOL) following lung volume reduction surgery (LVRS) for emphysema. Proceedings"Proceedings of the 1st World Congress of the International Society of Physical and Rehabilitation Medicine. 837-840 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kohzuki M: "Renal-protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with renal failure"J Hypertens. 19. 1877-1882 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kohzuki M: "Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumor and human gastric cancer using quantitative in vitro autoradiography."International Angiology. 19. 52-58 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kohzuki M: "Renal-protective effect of non-depressor dose of cicletanine in diabetic spontaneously hypertensive rats."Am J Hypertens. 13. 298-306 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshida K: "A case of lobenzarit disodium-induced hyperkalemia successfully treated with fludrocortisone acetate."Clin Exp Nephrol. 4. 67-70 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kohzuki M: "Rehabilitation to A Hepatopulmonary Syndrome Patient Who had Living-Related Orthotopic Liver Transplantation."Archives Physical Med & Rebabilitation. 81. 1527-1530 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshida T: "Effects of a two-week, hospitalized phase II cardiac rehabilitation program on physical capacity, lipid profiles and psychological variables in patients with acute myocardial infarction."Jpn Circ J. 65. 87-93 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshida K: "Renoprotective effects of troglitazone in spontaneously hypertensive rats with chronic renal failure."J Hypertens. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 上月正博 他: "心臓リハビリテーション・チーム医療の実際"日本心臓リハビリテーション学会編. 140 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 上月正博 他: "高齢者を知る事典(介護・医療・予防研究会編)"厚生科学研究所. 421 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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