| Project/Area Number |
12832016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Institution | Faculty of Medicine, Kanazawa University |
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Principal Investigator |
HAIDA Nobuhide Kanazawa University, Faculty of Medicine, Professor, 医学部, 教授 (00135089)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Toshiaki Kanazawa University, Faculty of Medicine, Assistant, 医学部, 助手 (00220319)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Muscle repair / Therapeutic exercise / Extracellular matrix / Myoblast / Nerve innervation / surviving fiber / 細胞外マトリックスの発現 |
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| Research Abstract |
From a functional viewpoint, a repair of the muscular tissue is an important problem on rehabilitation medicine. We examined a role of the therapeutic exercise in the muscular tissue repair. The therapeutic exercise from immediately after a muscle damage induces the activation and proliferation of muscle satellite cell, and earlier appearance of the myotube cell was recognized. And, it became clear that the regeneration of the muscular tissue is accelerated. In the case, fibronectin, laminine and type IV collagen were proved to ambient of the myotube. These extracellular matrix play an important role to the bonding and a shift of the cell. It is conjectured that these are getting involved in a shift and proliferation to a damage site of a myoblast, in order that the constitution of the muscular tissue breaks out in the damage muscle. It is conceivable that even the reinforcement of survival maintenance of the muscle fiber that is not necrosing and resist to the muscle damage to muscle regeneration besides, a control of the proliferation and differentiation of a myoblast is important. Furthermore, reinnervation is essential to regeneration fibrous function acquisition.Also, even extracellular matrix such as laminine and type IV collagen have important relation as an adjustment role of muscle regeneration. Not only muscle regeneration is examined only the regeneration but also we need to recognize the interaction between "the neuromusculer system and the extracellular matrix".
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