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The relationship between the various dosage parameters of therapeutic ultrasound in the treatment of soft-tissue injuries and hyperthermic treatment of cancer cells.

Research Project

Project/Area Number 12832020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionSHINSHU UNIVERSITY

Principal Investigator

GOH Ah Cheng  Shinshu University, Faculty of Medicine, Associate Professor, 保健学科, 助教授 (00283276)

Co-Investigator(Kenkyū-buntansha) MIYOSHI Kei  Shinshu University, Faculty of Medicine, Assistant, 医学部, 助手 (30293509)
FUJIWARA Takayuji  Shinshu University, Faculty of Medicine, Professor, 医学部, 教授 (40181416)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
KeywordsTherapeutic ultrasound / Electrophysical Agents / Thermotherapy / Hyperthermia / Cancer / Physical Therapy / Ultrasound / Thermotherapy / Cancer / 超音波
Research Abstract

This series of experiments was conducted to investigate the relationship between frequency, output intensity, duration of exposure and depth of target tissue on increase in temperature in post-mortem pig tissues exposed to therapeutic ultrasound. Prior to the main study, a few procedural pre-studies were conducted, as the results were necessary to formulate the procedure for the main study. The first pre-study was a reliability study to determine the pre and post test reliability of the measurement devices: the infrared spot thermometer (Minolta HT-11) and the infrared video thermography unit (Avio TVS 2000) (unpublished data). The second pre-study examined the effect of varying the speed of the moving transducer (1Hz, 2Hz and 3Hz) on temperature increase. The results showed that there was no difference in temperature increase at all three speeds. However, for practical reasons, 2Hz was the recommended speed for subsequent studies. The next pre-study examined the effect of low and high … More intensities on irreversible thermal injuries in "fresh" post-mortem pig tissues. This qualitative histological study was carried out at 1 and 3 MHz, and eight intensities: 0 (control), 0.5, 1.0, 1.5 w/cm2 (1 and 3MHz) and 2.0 w/cm2 (1MHz). Results showed that the highest intensity (2.0 w/cm2, 1 MHz) was the only intensity that caused irreversible thermal injuries to the epidermis.
The main study was conducted at 2 frequencies (1 and 3MHz), eight intensities (0.1, 0.3, 0.5, 0.7, 0.9, 1.1 and 1.5 w/cm2), for 10 minutes exposure, followed by 10 minutes post-exposure at 6 depths of target tissue (0 or skin surface, and 1, 2, 3, 4 and 5 cm below skin surface). The results showed that a higher frequency, a higher intensity, a higher duration of exposure, and a superficial target site, all contribute to a greater increase in tissue temperature. The results of this study was used to formulate a model to assist clinicians and users of therapeutic ultrasound to determine the most appropriate dosage (based on expected increase in tissue temperature at a specific target site) for the treatment of soft tissue injuries and for hyperthermic treatment of cancer cells. Less

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Goh Ah Cheng, 藤原孝之: "いわゆる筋肉痛(筋原性疼痛)に対する温熱療法"理学療法. 18・5. 493-499 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Goh Ah Cheng, 藤原孝之: "物理療法領域"理学療法学. 27・8. 288-297 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Goh AC, Fujiwara T: "Thermotherapy for myogenic pain."Physical Therapy Journal. 18(5). 493-499 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Goh AC, Fujiwara T: "The effectiveness of electro-physical agents."Journal of Physical Therapy. 27(8). 288-297 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] GohAh Cheng, 藤原孝之: "いわゆる筋肉痛(筋原性疼痛)に対する温熱療法"理学療法. 18・5. 493-499 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Goh Ah Cheng, 藤原孝之: "物理療法領域"理学療法学. 27・8. 288-297 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Goh AC, Chok B, Wong WP, Fujiwara T: "Therapeutic Ultrasound : Rate of Usage, Knowledge of Use, and Opinions on Dosimetry"Physiotherapy Singapore. 2・2. 69-83 (1999)

    • Related Report
      2001 Annual Research Report
  • [Publications] 楊箸隆哉, Goh Ah Cheng, 藤原孝之, 西村尚志, 木村貞治: "ウォーター・スティミュレーション・ベッド"理学療法. 15・9. 731-736 (1998)

    • Related Report
      2001 Annual Research Report
  • [Publications] Goh AC, Fujiwara T, Kimura T, Ohira M, Kamikojima M, Miyoshi K: "Detection of Biceps Brachii and Triceps Brachii Muscle Fatigue Using Tri-Axial Accelerometer and Integrated EMG"Proceedings of the 2^<nd> National Congress of the Singapore Physiotherapy Association, July 25-27. (1997)

    • Related Report
      2001 Annual Research Report
  • [Publications] 楊箸隆哉, 藤原孝之: "入浴が及ぼす生理・心理作用 I. 脳波の周波数解析"日本看護研究学会雑誌. 19・2. 43-50 (1996)

    • Related Report
      2001 Annual Research Report
  • [Publications] 楊箸隆哉, 藤原孝之, 井出久美子: "入浴が及ぼす生理・心理作用 II. 脳波α波のゆらぎ解析"日本看護研究学会雑誌. 19・3. 7-12 (1996)

    • Related Report
      2001 Annual Research Report
  • [Publications] Miyoshi K, Ohira M, Kimura T, Karasuno H, Tanabe M, Uchida T, Manzen K: "Difficulties in Care of Incontinence for the Bedridden Elderly-Main Factor of Care Burden in Changing the Diaper"Journal of Physical Therapy(Japan),. 14. 64-68 (1997)

    • Related Report
      2001 Annual Research Report
  • [Publications] Goh AC,Chok B,Wong WP,Fujiwara T: "Therapeutic Ultrasound : Rate of Usage, Knowledge of Use, and Opinions on Dosimetry"Physiotherapy Singapore. 2・2. 69-83 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 楊箸隆哉,Goh Ah Cheng,藤原孝之,西村尚志,木村貞治: "ウォーター・スティミュレーション・ベッド"理学療法. 15・9. 731-736 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Goh AC,Fujiwara T,Kimura T,Ohira M,Kamikojima M,Miyoshi K: "Detection of Biceps Brachii and Triceps Brachii Muscle Fatigue Using Tri-Axial Accelerometer and Integrated EMG"Proceedings of the 2^<nd> National Congress of the Singapore Physiotherapy Association, July 25-27. (1997)

    • Related Report
      2000 Annual Research Report
  • [Publications] 楊箸隆哉,藤原孝之: "入浴が及ぼす生理・心理作用 I.脳波の周波数解析"日本看護研究学会雑誌. 19・2. 43-50 (1996)

    • Related Report
      2000 Annual Research Report
  • [Publications] 楊箸隆哉,藤原孝之,井出久美子: "入浴が及ぼす生理・心理作用 II.脳波α波のゆらぎ解析"日本看護研究学会雑誌. 19・3. 7-12 (1996)

    • Related Report
      2000 Annual Research Report
  • [Publications] Miyoshi K,Ohira M,Kimura T,Karasuno H,Tanabe M,Uchida T,Manzen K: "Difficulties in Care of Incontinence for the Bedridden Elderly-Main Factor of Care Burden in Changing the Diaper"Journal of Physical Therapy (Japan),. 14. 64-68 (1997)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2021-04-07  

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