| Project/Area Number |
12832029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
MURATA Jun Faculty of Medicine, Hiroshima University, Research Associate, 医学部, 助手 (00304428)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Jun-ich Faculty of Medicine, Hiroshima University, Assistant Professor, 医学部, 助教授 (10126584)
MATSUKAWA Kanji Faculty of Medicine, Hiroshima University, Professor, 医学部, 教授 (90165788)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | cardiac vagal nerve activity / cardiac sympathetic nerve activity / heart rate / arterial blood pressure / muscle mechanoreflex / muscle metaboreflex / decerebrate cats / 反射性循環調節 / 筋受容器 / 筋収縮 |
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| Research Abstract |
We measured directly both cardiac vagal efferent nerve activity (CVNA) and cardiac sympathetic efferent nerve activity (CSNA) during passive stretch and static contraction of skeletal muscle in cats decerebrated at the level of the precollicular-premammillary body. CVNA gradually decreased during passive stretch of the hindlimb, which was sustained throughout the stretched during passive stretch of the hindlimb, which was sustained throughout the stretch. CSNA increased at the onset of passive stretch but this increase was not sustained. CVNA and CSNA responded differentially to the passive stretch of the triceps surae muscle as well as the hindlimb. The time course and direction of the cardiac autonomic responses to muscle stretch were not affected by partial sinoaortic denervation, although the magnitude of the CSNA response was augmented. On the other hand, CVNA was decreased during static muscle contraction evoked by electrical stimulation of the tibial nerve and CSNA was increased. These responses in CVNA and CSNA were augmented, as the muscle tension was increased. It is concluded that a reflex arising from skeletal muscle during passive stretch and static contraction contributes to differential regulation of cardiac parasympathetic and sympathetic efferent discharges.
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