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MECHANISMS AND REHABILITATION OF UNILATERAL SPATIAL NEGLECT : ANALYSIS OF INTERACTION BETWEEN ATTENTION AND MOTOR EXECUTION

Research Project

Project/Area Number 12832071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field リハビリテーション科学・福祉工学
Research InstitutionTOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEACH

Principal Investigator

ISHIAI Sumio  TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEACH, TOKYO METOROPOLITAN INSTITUTE FOR NEUROSCIENCE, STAFF SCIENTIST, 東京都神経科学総合研究所, 副参事研究員 (80193241)

Project Period (FY) 2000 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsunilateral spatial neglect / mechanism / rehabilitation / attention / motor execution / personal computer / cordless tablet / 液晶ディスプレイ / タブレット
Research Abstract

The present study aimed to elucidate the attentional-representational and motor mechanisms that cause unilateral spatial neglect after right hemisphere damage and to develop diagnostic and rehabilitation technique for neglect.
In the symmetric positioning task, patients with left neglect were presented with a test sheet where a central vertical bar and a right small circle were printed. They were required to mark a circle at the horizontally symmetric point on the left side. The movements of the eyes and the hand were recorded and analyzed to explore the characteristics of perceptual and motor interaction in neglect. When such a crossed response is required into contralesional space, the representational map for that space may be activated also in the brain of patients with neglect. Besides, preparation of a leftward response may result in an effective orientation of the eyes and the hand into the left space, which would be hardly explored in the ordinary stimulus-response compatible condition.
A line image task using a computer display with a touch panel was devised to explore representational image for lines when patients with neglect were asked to touch the left endpoint and perceived the whole extent reliably. The image for a fully perceived line may be represented far enough into left space even when left neglect occurs after a lesion that involves the right parietal lobe. However, left neglect may occur in estimation of the subjective midpoint on the representational image, which may be explained by a rightward bias of attentional distribution.
A system with personal computer and cordless tablet was introduced to record performances of patients with neglect in the Behavioral inattention test (BIT, PC version). This system enabled analysis of time course and spatial scanning and gave detailed information to improve detection of problems due to mild neglect.

Report

(5 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (57 results)

All Other

All Publications (57 results)

  • [Publications] Ishiai S, Koyama Y, Seki K, Izawa M: "Line versus representational bisections in unilateral spatial neglect"J Neurol Neorosurg Psychiatry. 69・6. 745-750 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Seki K, Ishisi S, Koyama Y, Sato S, Hirabayashi H, Inaki K: "Why are some patients with severe neglect able to copy a cube? The significance of verbal intelligence"Nearopsychologia. 38・11. 1466-1472 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S, Koyama Y, Seki K: "Significance of paradoxical leftward error of line bisection in left unilateral spatial neglect"Brain Cogn. 45・2. 238-248 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S.Koyama Y, Foruya T: "Conflict and integration of spatial attention between disconnected hemispheres"J Neurol Neurosurg Psychiatry. 71・4. 472-477 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 御園生 香, 石合純夫, 小山康正, 関 啓子, 平林 一: "BIT日本版通常検査における右半球損傷患者の誤反応分布 -Laterality indexによる検討-"神経心理学. 17・2. 121-129 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 御園生 香, 石合純夫, 小山康正, 関 啓子, 前島伸一郎: "BIT行動性無視検査日本版の行動検査における右半球損傷患者の誤反応分析"神経心理学. 17・3. 213-222 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合 純夫: "半側空間無視の病態と診断"リハビリテーション医学. 38・2. 93-96 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合 純夫: "特集 半側空間無視 病態と診断"総合リハビリテーション. 29・1. 7-13 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合純夫: "視覚性方向性注意"臨床神経学. 41・12. 1128-1130 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Seki K, Ishiai S, Koyama Y, Nakano N, Koizumi T: "Effects of verbalization on deficits of general attention in patients with unilateral spatial neglect"Bulletin of Health Sciences Kobe. 18. 1-10 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合 純夫: "半側空間無視 新たなメカニズム論と無視改善への手がかり"神経心理学. 18・3. 182-187 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合 純夫: "半側空間無視研究の動向と将来への展望"Monthly Book Medical Rehabilitation. 20. 66-73 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合 純夫: "方向性注意障害のメカニズムとリハビリテーション"脳の科学. 24・6. 531-539 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中野直美, 石合純夫, 小山康正, 関 啓子, 平林 一, 稲木康一郎: "左半側空間無視患者の線分二等分試験結果に与えるフレームと線分配置の影響"神経心理学. 18・3. 200-207 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 森田秋子, 石合純夫: "半側空間無視の長期経過とMini-Mental Stateの関連について"神経心理学. 18・4. 212-218 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合純夫: "視覚性注意の神経機構"Clinical Neuroscience. 21・7. 818-820 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合 純夫: "「注意」の障害-その評価と介入戦略"理学療法ジャーナル. 37・12. 1029-1037 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S, Koyama Y, Nakano N, Seki K, Nishida K, Hayashi K: "Image of a line is not shrunk but neglected. Absence of crossover in unilateral spatial neglect"Neuropsyhologia. 42・2. 251-256 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Misonou K, Ishiai S, Seki K, Koyama Y, Nakano N: "How do patients with neglect see a horizontal line? Analysis of performances in coloured line bisection task"J Neurol. in press. (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合 純夫: "失認・無視症候群. リハビリテーションMOOK 4,高次脳機能障害とリハビリテーション(大橋正洋,木村彰男,蜂須賀研二編集)"金原出版. 22-29 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S: "Perceptual and motor interaction in unilateral spatial neglect. In : The Cognitive and Neural Bases of Spatial Neglect (Kurnath H-O, Milner D, Vallar G, editors)"Oxford University Press. 181-193 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合純夫: "左に注意が向かない,何が考えられるか-半側空間無視とその対策,脳卒中最前線 -急性期の診断からリハビリテーションまで-第3版"医歯薬出版. 260-267 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石合 純夫: "高次脳機能障害学"医歯薬出版. 228 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S, Koyama Y, Seki K, Izawa M.: "Line versus representational bisections in unilateral spatial neglect."J Neurol Neurosurg Psychiatry. 69. 745-750 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Seki K, Ishiai S, Koyama Y, Sato S, Hirabayashi H, Inaki K.: "Why are some patients with severe neglect able to copy a cube? The significance of verbal intelligence."Neuropsychologia. 38. 1466-1472 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sato S, Ishiai S, Seki K, Koyama Y, Mizusawa H.: "Leftward movement in severe neglect."Neurocase. 6. 45-50 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S, Koyama Y, Seki K.: "Significance of paradoxical leftward error of line bisection in left unilateral spatial neglect."Brain Cogn. 45. 238-248 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S, Koyama Y, Furuya T.: "Conflict and integration of spatial attention between disconnected hemispheres."J Neurol Neurosurg Psychiatry. 71. 472-477 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Seki K, Ishiai S, Koyama Y, Nakano N, Koizumi T: "Effects of verbalization on deficits of general attention in patients with unilateral spatial neglect."Bulletin of Health Sciences Kobe. 18. 1-10 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S: "Perceptual and motor interaction in unilateral spatial neglect."The Cognitive and Neural Bases of Spatial Neglect(Karnath H-O, Milner D, Vallar D, editors)(Oxford University Press), Oxford. 181-193 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S, Koyama Y, Nakano N, Nishida Y, Hayashi K: "Image of a line is not shrunk but neglected : absence of crossover in unilateral spatial neglect."Neuropsychologia. 42. 251-256 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Misonou K, Ishiai S, Seki K, Koyama Y, Nakano N: "How do patients with neglect see a horizontal line? Analysis of performances in colored line bisection task."J Neurol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishiai S, Koyama Y, Nakano N, Seki K, Nishida K, Hayashi K: "Image of a line is not shrunk but neglected Absence of crossover in unilateral spatial neglect"Neuropsychologia. 42・2. 251-256 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Misonou K, Ishiai S, Seki K, Koyama Y, Nakano N: "How do patients with neglect see a horizontal line? Analysis of performances in coloured line bisection task"Journal of Neurology. in press.

    • Related Report
      2003 Annual Research Report
  • [Publications] 石合 純夫: "「注意」の障害-その評価と介入戦略"理学療法ジャーナル. 37・12. 1029-1037 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 石合 純夫: "Behavioural inattention test (BIT)"日本臨床. 61・増刊号9. 374-378 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 石合 純夫: "視覚性注意の神経機構"CLINICAL NEUROSCIENCE. 21・7. 818-820 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小泉 智枝, 石合 純夫: "血管性痴呆の診断と治療"Mebio. 20・3. 63-69 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 石合 純夫: "高次脳機能障害学"医歯薬出版. 228 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishiai S, Koyama Y, Nakano N, Seki K, Nishida Y, Hayashi K: "Image of a line is not shrunk but neglected. Absence of crossover in unilateral spatial neglect"Neuropsychologia. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] 中野直美, 石合純夫, 小山康正, 関 啓子, 平林 一, 稲木康一郎: "左半側空間無視患者の線分二等分試験結果に与えるフレームと線分配置の影響"神経心理学. 18巻3号. 200-207 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石合純夫: "半側空間無視-新たなメカニズム論と無視改善への手がかり-"神経心理学. 18巻3号. 182-187 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石合純夫: "方向性注意障害のメカニズムとリハビリテーション"脳の科学. 24巻6号. 531-539 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石合純夫: "脳障害(認知機能障害)の特殊性からみたリハビリテーションアプローチ"総合臨床. 51巻12号. 3169-3176 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石合純夫: "半側空間無視研究の動向と将来への展望"Monthly Book Medical Rehabilitation. 20巻. 66-73 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishiai S(分担執筆): "Perceptual and motor interaction in unilateral spatial neglect. In : Karnath H-O, Milner AD, Vallar G, editors. The cognitive and neural bases of spatial neglect"Oxford University Press. 153-166 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishiai S, Koyama Y, Seki K: "Significance of paradoxical leftward error of line bisection in left unilateral spatial neglect"Brain and Cognition. 45・2. 234-248 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ishiai S, Koyama Y, Furuya T: "Conflict and integration of spatial attention between disconnected hemispheres."Journal of Neurology, Neurosurgery, and Psychiatry. 71・4. 472-477 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 御園生香, 石合純夫, 小山康正, 関啓子, 平林一: "BIT日本版通常検査における右半球損傷患者の誤反応分布-Laterality indexによる検討-"神経心理学. 17・2. 121-129 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 御園生香, 石合純夫, 小山康正, 関啓子, 平林一: "BIT行動性無視検査日本版の行動検査における右半球損傷患者の誤反応分析"神経心理学. 17・3. 213-222 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石合純夫: "半側空間無視の病態と診断"リハビリテーション医学. 38・2. 93-96 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石合純夫: "半側空間無視 病態と診断"総合リハビリテーション. 29・1. 7-13 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石合純夫(編著): "言語聴覚障害学 基礎・臨床"新興医学出版社. 367 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ishiai S,Koyama Y,Seki K,and Izawa M: "Line versus representational bisections in unilateral spatial neglect."Journal of Neurology, Neurosurgery, and Psychiatry. 69・6. 745-750 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Seki K,Ishiai S,Koyama Y,Sato S,and Hirabayashi H,Inaki K: "Why are some patients with severe neglect able to copy a cube? The significance of verbal intelligence."Neuropsychologia. 38・11. 1466-1472 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sato S,Ishiai S,Seki K,Koyama Y,and Mizusawa H: "Leftward movement in severe neglect."Neurocase. 6・1. 45-50 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ishiai S,Koyama Y,and Seki K: "Significance of paradoxical leftward error of line bisection in left unilateral spatial neglect"Brain and Cognition. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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