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The effects of endocrine disrupters on macaque fetus/

Research Project

Project/Area Number 12836005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionKYOTO UNIVERSTY

Principal Investigator

KEIKO Shimizu  KYOTO UNIVERSTY, Primate Research Institute, Instructor (90135616)

Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsendocrine disrupters / steroids / inhibin / pregnancy / fetus / genistein / 甲状腺ホルモン / カニクイザル / 脳 / 内分泌攪乱物質
Research Abstract

Endocrine disrupters are exogenous substances that cause adverse effects in the endocrine systems. Diethylstilbestrol (DES) is the best-known endocrine disrupters and has caused abnormalities of sexual differentiation in both sexes. Moreover, some phytoestrogens have been discovered in soybeans but their effects to endocrine systems in humans have not been reported. To evaluate the mechanism of the effects of endocrine disrupters in humans, we used macaque monkeys as experimental animals. We evaluated the effects of DES and phytoestrogens on male and female adult macaque monkeys. Levels of plasma inhibin in DES feeding macaques were decreased. The genital skin and testes changed in color and size. In histological observation, sperm were decreased. We also evaluated those two endocrine disrupters on pregnant macaques. In pregnant females, all fetuses were died after DES feeding. Their mothers ate their fetuses after stillbirth and we did not investigate them. Then we fed 5mg genistein to pregnant macaques for two months. They delivered healthy babies. Their gestational days, body weight and crown rump lengths of newborn babies were normal. Levels of plasma inhibin in pregnant macaques were decreased. In newborn hypothalamus, the localization of estrogen receptors was changed. In genistein feeding to non-pregnant female macaques, their menstrual cycle lengths were significantly lengthened. The levels of LH surge became low. These results suggest that these endocrine disrupters effect on fetus and menstrual cycle of macaque monkeys.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (27 results)

All 2003 2002 2001 Other

All Journal Article (12 results) Book (1 results) Publications (14 results)

  • [Journal Article] Comparative study of urinary reproductive hormones in great apes.2003

    • Author(s)
      Keiko Shimizu
    • Journal Title

      Primates 44

      Pages: 183-190

    • NAID

      10017457438

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Urinarysteroids, FSH and CG measurements for monitoring the ovarian cycle and pregnancy in the chimpanzee.2003

    • Author(s)
      Keiko Shimizu
    • Journal Title

      Journal of Medical Primatology 32

      Pages: 15-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Comparative study of urinary reproductive hormonesn great apes.2003

    • Author(s)
      Shimizu K, Udono T, Tanaka C, Narushima E, Yoshihara M, Takeda M, Tanahashi A, van Elsacker L, Hayashi M, Takenaka O.
    • Journal Title

      Primates 44

      Pages: 183-190

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Urinary steroids, FSH and CG measurements for monitoring the ovarian cycle and pregnancy in the chimpanzee.2003

    • Author(s)
      Shimizu K, Douke C, Fujita S, Matsuzawa T, Tomonaga M, Tanaka M, Matsubayashi K, Hayashi M.
    • Journal Title

      J Med Primatol 32

      Pages: 15-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Circulating inhibin A and inhibin B in normal menstrual cycle during breeding seasons in Japanese monkeys.2002

    • Author(s)
      Keiko Shimizu
    • Journal Title

      Journal of Reproduction and Development 48

      Pages: 355-361

    • NAID

      10026617164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Changes in ciroulating relaxin levels during pregnancy and early lactation in the Japanese monkey (Macaca fuscata fuscata).2002

    • Author(s)
      Keiko Shimizu
    • Journal Title

      Journal of Reproduction and Development 48

      Pages: 383-391

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Cellular localization of nerve growth factor (NGF) and its receptors trkA and p75LNGFR in the ovary of the Japanese monkey (Macaca fuscata fuscata).2002

    • Author(s)
      Keiko Shimizu
    • Journal Title

      Journal of Reproduction and Development 48

      Pages: 377-381

    • NAID

      10026617246

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Circulating inhibin A and inhibin B in normal menstrual cycle during breeding seasons in Japanese monkeys.2002

    • Author(s)
      Shimizu K, Kojima C, Kondo M, Jin WZ, Ito M, Watanabe G, Groome NP, Taya K.
    • Journal Title

      J Reprod Dev 48

      Pages: 355-361

    • NAID

      10026617164

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Changes in circulating relaxin levels during pregnancy and early lactation in the Japanese monkey (Macaca fuscata fuscata).2002

    • Author(s)
      Shimizu K, Jin WZ, Kishi H, Noguchi J, Watanabe G, Taya K.
    • Journal Title

      J Reprod Dev 48

      Pages: 383-391

    • NAID

      10026617261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Cellular localization of nerve growth factor (NGF) and its receptors trkA and p75LNGFR in the ovary of the Japanese monkey (Macaca fuscata fuscata).2002

    • Author(s)
      Shimizu K, Jin WZ, Kojima C, Shi ZQ, Kondo M, Ito M, Watanabe G, Taya K.
    • Journal Title

      J Reprod Dev 48

      Pages: 377-381

    • NAID

      10026617246

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Non-instrumented enzyme-linked immunosorbant assay for detection of early pregnancy in macaques.2001

    • Author(s)
      Keiko Shimizu
    • Journal Title

      American Journal of Primatology 54

      Pages: 57-62

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Non-instrumented enzyme-linked immunosorbant assay for detection of early pregnancy in macaques.2001

    • Author(s)
      Shimizu K, Lohstroh PN, Laughlin LS, Gee NA, Todd H, Shideler SE, Lasley BL.
    • Journal Title

      Am J Primatol 54(1)

      Pages: 57-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Book] チンパンジーの認知と行動の発達2003

    • Author(s)
      清水慶子
    • Total Pages
      508
    • Publisher
      京都大学学術出版会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Keiko Shimizu: "Non-insrumented enzyme-linked immunosorbent assay for detection of early pregnancy In macaques"American Journal of Primatology. 54. 57-62 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Bardy Massimo: "Social behavior and hormonal correlates during the perinatal period in Japanese Macaques"Hormones and Behavior. 39. 239-246 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Bardy Massimo: "Hormonal correlates of maternal style in captive macaques (Macaca fuscata and M. mulatta)"International Journal of Primatology. 22. 647-662 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Keiko Shimizu: "Circulating inhibin A and inhibin B in normal menstrual cycle during breeding seasons in Japanese monkeys"Journal of Reproductoion and Development. 48. 355-361 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masumi Nozaki: "Blockade of menstrual cycle by thyroidectomy in Japanese monkeys (Macaca fuscata fuscata)"Endocrine. 19(In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Keiko Shimizu: "Comparative study of urinary reproductive hormones in great apes"Primates. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 清水 慶子: "チンパンジーの認知と行動の発達"京都大学学術出版会. 508 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Keiko Shimizu: "Non-instrumented enzyme-linked immunosorbant assay for detection of early pregnancy in macaques"American journal of Primatology. 54. 57-62 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Bardy Massimo: "Social behavior and hormonal correlates during the perinatal period in Japanese Macaques"Hormones and Behavior. 39. 239-246 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koji Ohira: "TrkB dimerization during development of the prefrontal cortex of the macaque"Journal of Neuroscience Research. 65. 463-469 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Bardy Massimo: "Hormonal correlates of maternal style in captive macaques (Macaca fuscata and M.mulatta)"International Journal of Primatology. 22. 647-662 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Barret Gordon: "Fecal testosterone immunoreactivity as a non-invasive index of functional testosterone dynamics in male Japanese macaques (Macaca fuscata)"Primates. (in press). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Barret Gordon: "Endocrine correlates of rank, reproduction and female-directed agression in male Japanese macaques (Macaca fuscata)"Hormones and Behavior. (in press). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Keiko Shimizu: "Non-instrumented enzyme-linked immunosorbant assay for detection of early pregnancy in macaques."American Journal of Primatology. 54. (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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