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Effects of endocrine disruptors on female rat reproductive function

Research Project

Project/Area Number 12836009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionTottori University

Principal Investigator

OHTA Yasuhiko  Tottori University, Agriculture, Professor, 農学部, 教授 (60069078)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsEndocrine disruptors / Rat / Uterus / Inplantation / Hormone receptor
Research Abstract

Progesterone and estrogen receptor (PR and ER) expressions were examined immunohistochemically in female rats exposed to andogen and bisphenol-A (BPA) to evaluate effect of endocrine disrupter on female reproductive function.
PR and ER expressions following a series of hormonal regime after ovariectomy as adults were affected in persistent estrous rats given andogen neonatally. Changes in expressions of EGF, TGF-α and EGF receptor (EGF-R) in the endometrial cells after the treatment were less evident compared with those in the PR and ER expressions.
Adult rats given BPA for 7 day from the day of bith showed regular estrous cycles on day 60 and their ovaries contained follicles and corpora lutea. In BPA-treated rats, however, the ovaries were significantly smaller than in the controls. The uteri were markedly heavier in these BPA-treated rats than in the controls. Uterine response to the ovarian hormones was essentially the same between BPA-treated and control rats.
These findings indicate that steroid hormone receptor is a potent marker for evaluation of endocrine disruptor in female reproduction, and that neonatal exposure of the female rat to BPA has some effects on both the central nervous system controlling female reproduction and peripheral organs.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Yamamura, Y. et al.: "Metallothionein expression in transplantable mouse mammary tumors"Anticancer Res.. 20. 379-384 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamura, Y. et al.: "Metallothionein expression and apoptosis in pregnancy dependent and -independent mouse mammary tumors"Anticancer Res.. 21. 1145-1150 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamura, Y. et al.: "Metallothionein expression and tumor progression in transplantable pregnancy-independent mouse mammary tumors"J. Vet. Med. Sci.. 63. 687-689 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okada, A. et al.: "Effect of diethylstilbestrol on cell proliferation and expression of epidermal growth factor in the developing female rat reproductive tract"J. Endocrinol.. 170. 539-554 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miyagawa, S. et al.: "Characterization of diethylstilbestrol-induced hypospadias in female mice"Anat. Rec.. 266. 43-50 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamura, Y. et al.: "Metallothionein expression in transplantable mouse mammary tumors"Anticancer Res.. 20. 379-384 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamura, Y. et al.: "Metallothionein expression and apoptosis in pregnancy-dependent and -independent mouse mammary tumors"Anticancer Res.. 21. 1145-1150 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamura, Y. et al.: "Metallothionein expression and tumor progression in transplantable pregnancy-independent mouse mammary tumors"J. Vet. Med. Sci.. 63. 687-689 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okada, A. et al.: "Effect of diethylstilbestrol on cell proliferation and expression of epidermal growth factor in the developing female rat reproductive tract"J. Endocrinol.. 170. 539-554 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miyagawa, S. et al.: "Characterization of diethylstilbestrol-induced hypospadias in female mice"Anat. Rec.. 266. 43-50 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamura, Y. et al.: "Metallothionein expression and apoptosis in pregnancy-dependent and -independent mouse mammary tumors"Anticancer Res.. 21. 1145-1150 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamura, Y. et al.: "Metallothionein expression and tumor pregression in transplantable pregnancy-independent mouse mammary tumors"J.Vit.Med.Sci.. 63. 687-689 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okada, A. et al.: "Effect of diethylstilbestrol on cell proliferation and expression of epidermal growth factor in the developing female rat reproductive tract"J.Endocri.. 170. 539-554 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Miyagawa, S.et al.: "Characteruzatuib if diethylstilb-estrik-induced hypospadias in female mice"Anat.Rec.. 266. 43-50 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamura,Y et al.: "Metallothionein expression in transplantable mouse mammary tumors."Anticancer Res.. 20. 397-384 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamamura,Y et al.: "Metallothionein expression and apeplosis in pregnancy-dependent and-independent mouse mammary tumors"Anticancer Res.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamamura et al.: "Metallothionein expression and tumor pregression in transplantable prognancy-independent mouse mammary tumors."J.Vet.Sci.. (in press).

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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