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THE EFFCTS OF ENDOCRINE DISRUPTING CHEMICALS ON GENERATION AND DIFFERENTIATION OF GERMLINE CELL

Research Project

Project/Area Number 12836018
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research InstitutionNational Institute of Public Health

Principal Investigator

YAMAZAKI TOMOMI  NATIONAL INSTITUTE OF PUBLIC HEALTH DEPARTMENT OF NUTRITION AND BIOCHEMISTRY SENIOR RESEARCH OFFICER, 栄養生化学部, 主任研究官 (00218439)

Co-Investigator(Kenkyū-buntansha) OKADA YUMIKO  NATIONAL INSTITUTE OF PUBLIC HEALTH DEPARTMENT OF VETERINARY PUBLIC HEALTH SENIOR RESEARCH OFFICER, 衛生獣医学部, 主任研究官 (50232137)
KAYAMA FUJIO  NATIONAL INSTITUTE OF PUBLIC HEALTH DEPARTMENT OF HEALTH SCIENCE PROFESSOR, 保健科学講座, 教授 (50177614)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2000: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsENDOCRINE DISRUPTING CHEMICALS / GERMLINE CELL / 植物エストロジェン / 内分泌かく乱化学物質
Research Abstract

ENDOCRINE DISRUPTING CHEMICALS ARE THOUGHT TO AFFECT THE GENERATION AND DIFFERENTIATION OF GERM LINE CELL. WE FEED MOUSE ENDOCRINE DISRUPTING CHEMICALS AND OBSERVED THE GENITAL RIDGES OF MOUSE EMBRYO ON GESTATION DAY 13.5.THERE WERE NO DIFFERENCES BETWEEN CONTROL AND SUBJECTS.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Ikeda K, Arao Y, Otsuka H, Nomoto S, Horiguchi H, Kato S, Kayama F: "Terpenoids found in the umbelliferae family act as agonist/antagonists forER alpha and ER beta : differential transcription activity between ferutinine-liganded ER alpha and ER beta"Biochem. Biophys. Res. Commun.. 291(2). 354-360 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arao Y, Kikuchi A, Ikeda K, Nomoto S, Horiguchi H, Kayama F: "A+U-rich element RNA-binding factor 1/heterogeneous nuclear ribonucleoprotein D gene expression is regulated by oestrogen in the rat uterus"Biochem. J. 361(1). 125-132 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamazaki T, Okada Y, Hisamatsu Y, F.Kayama: "Effects of endocrine disrupting chemicals s on lymphocyte responses"Organohalogen Compounds. 49. 394-396 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Horiguchi H, Kayama F, Oguma E, William G.Willmore, Pavel Hradecky., H.Franklin Bunn: "Cadmium and platinum suppression of erythropoietin production in cell culture : clinical implications"Blood. 96(12). 3743-3747 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] To H, Kikuchi A, Tsuruoka S, Sugimoto K, Fujimura A, Higuchi S, Kayama F, Hara K, Matsuno K, Kobayashi E: "Time-depenndent Nephrotoxicity Associated with Daily Admistration of Cisplatin in Mice"J. Pharm. Pharmacol.. 52. 1499-1504 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 香山不二雄: "環境ホルモン問題と健康問題"小児科. 41. 68-75 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 香山不二雄: "内分泌撹乱物質による健康問題-DES子宮内曝露の教訓から-"産婦人科の実際. 49(8). 1039-1044 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ikeda K, Arao Y, Otsuka H, Nomoto S, Horiguchi H, Kato S, Kayama F: "Terpenoids found in the umbelliferae family act as agonist/antagonists forER alpha and ER beta : differential transcription activity between ferutinine-liganded ER alpha and ER beta"Biophys. Res. Commum. 291(2). 354-360 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Arao Y, Kikuchi A, Ikeda K, Nomoto S, Horiguchi H, Kayama F: "A+U-rich element RNA-binding factor 1/heterogeneous nuclear ribonucleoprotein D gene expression is regulated by oestrogen in the rat uterus"Biochem. J. 361(1). 125-132 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamazaki T, Okada Y, Hisamatsu Y, and F. Kayama: "Effects of endocrine disrupting chemicals s on lymphocyte responses"Organohalogen Compounds. 49. 394-396 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] To H, Kikuchi A, Tsuruoka S, Sugimoto K, Fujimura A, Higuchi S, Kayama F, Kara K, Matsuno K, and Kobayashi E: "Time-depenndent Nephrotoxicity Associated with Daily Administration of Cisplatin in Mice"J. Pharm. Pharmacol. 52. 1499-1504 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Horiguchi H, Kayama F, Oguma E, William G. Willmore, Pavel Hradecky, and H. Franklin Bunn: "Cadmium and platinum suppression of erythropoietin production in cell culture : clinical implications"Blood. 96(12). 3743-3747 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ikeda K, Arao Y, Otsuka H, Nomoto S, Horiguchi H, Kato S, Kayama F: "Terpenoids found in the umbelliferac family act as agonist/antagonists for ER alpha and ER beta : differential transcription activity between ferutinine-liganded ER alpha and ER beta"Biochem. Biophys. Res. Commun.. 291(2). 354-360 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Arao Y, Kikuchi A, Ikeda K, Nomoto S, Horiguchi H, Kayama F: "A+U-rich element RNA-binding factor 1/heterogeneous nuclear ribonucleoprotein D gene expression is regulated by oestrogen in the rat uterus"Biochem. J. 361(1). 125-132 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ishii S, Hisamatsu Y, Inazu K, Aika K: "Environmental occurrence of nitrotriphenylene observed in airbone particulate matter"Chemosphere. 44(4). 681-690 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamazaki T,Okada Y,Hisamatsu Y,and F.Kayama: "Effects of endocrine disrupting chemicals s on lymphocyte responses"Organohalogen Compounds. 49. 394-396 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Horiguchi H,Kayama F,Oguma E,William G,Willmore,Pavel Hradecky,and H.Franklin Bunn: "Cadmium and platinum suppression of erythropoietin production in cell culture : clinical implications"Blood. 96(12). 3743-3747 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] To H,Kikuchi A,Tsuruoka S,Sugimoto K,Fujimura A,Higuchi S,Kayama F,Hara K,Matsuno K,and Kobayashi E: "Time-depenndent Nephrotoxicity Associated with Daily Administration of Cisplatin in Mice"J.Pharm.Pharmacol.. 52. 1499-1504 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 香山不二雄: "環境ホルモン問題と健康問題"小児科. 41. 68-75 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 香山不二雄: "内分泌撹乱物質による健康問題-DES子宮内曝露の教訓から-"産婦人科の実際. 49(8). 1039-1044 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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