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Super-microsurgeryを応用した肛門機能再建研究

Research Project

Project/Area Number 12J05321
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Plastic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

荒木 淳  東京大学, 医学系研究科, 特別研究員(DC1)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2014: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2013: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2012: ¥900,000 (Direct Cost: ¥900,000)
Keywords同種複合組織移植 / 国際情報交換 アメリカ / 国際情報交換 フランス / 国際情報交換 トルコ / 国際情報交換 ブラジル / 肛門機能再建 / 人工肛門 / 創傷治癒 / WOC (Wound, Ostomy, Continence) / 創傷治療
Outline of Annual Research Achievements

排便機能障害の原因は、先天性疾患、炎症性腸疾患などによる難治性痔瘻、直腸癌術後など様々であり、これに対する治療法も多岐にわたるが、機能再生・再建に関する方法は未だ確立されていない。顔面、前腕や子宮などQOL(quality of life)の向上を目的とした移植医療が、近年著しい発展を遂げる中で、新たな同種複合組織移植に関する研究を進めている。
排便機能障害では、薬物療法、バイオフィードバック、仙骨神経刺激療法などの現存の治療で改善が見込まれる場合がある。しかし高度排便機能障害や排便機能が廃絶している場合は永久人工肛門となることが少なくない。永久人工肛門を回避する新たな治療として、ビーグル犬を用いた肛門移植モデルを作成した。陰部神経、陰部動静脈を同定し、外肛門括約筋、肛門挙筋を含めた移植片を直腸レベルで摘出し、顕微鏡下に神経、血管を吻合した後に、骨盤底筋群を再建し、同所性自家移植モデルを完成させた。現在長期機能を経過観察中である。
肛門機能障害に対する治療には様々なニーズが存在するため、オーダーメードな治療が重要であり、肛門移植に対するニーズも存在すると考えている。今後は、再生医療と移植医療をコラボレーションさせた治療モデルの開発のほか、神経機能の重要性からバイオフィードバックなどの機能強化を組み合わせた、総合的な排便機能改善に関する研究が求められる。
今後は、サンパウロ大学移植外科(ブラジル)、中国医薬大学形成外科(台湾)、アンタルヤ大学形成外科(トルコ)、ピッツバーグ大学移植外科(アメリカ)などと国際共同研究を進めていく予定である。

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (16 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Functional outcome of autologous anorectal transplantation in an experimental model.2015

    • Author(s)
      Seid VE, Galvão FH, Vaidya A, Waisberg DR, Cruz RJ Jr, Chaib E, Nahas SC, Araujo SE, D'Albuquerque LA, Araki J.
    • Journal Title

      Br J Surg

      Volume: 102 Issue: 5 Pages: 558-562

    • DOI

      10.1002/bjs.9762

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Normothermic Preservation of the Rat Hind Limb With Artificial Oxygen-carrying Hemoglobin Vesicles.2015

    • Author(s)
      Araki J, Sakai H, Takeuchi D, Kagaya Y, Tashiro K, Naito M, Mihara M, Narushima M, Iida T, Koshima I.
    • Journal Title

      Transplantation

      Volume: 99 Issue: 4 Pages: 687-692

    • DOI

      10.1097/tp.0000000000000528

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of normobaric hyperoxygenation to an ischemic flap and a composite skin graft.2014

    • Author(s)
      Araki J, Kato H, Doi K, Kuno S, Kinoshita K, Mineda K, Kanayama K, Yoshimura K.
    • Journal Title

      Plast Reconstr Surg Glob Open

      Volume: 6 Issue: 5 Pages: e152-e152

    • DOI

      10.1097/gox.0000000000000029

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anorectal autotransplantation in a canine model: the first successful report in the short term with the non-laparotomy approach.2014

    • Author(s)
      Araki J, Nishizawa Y, Nakamura T, Sato T, Naito M, Hatayama N, Hirai S, Tashiro K, Koshima I.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 6312-6312

    • DOI

      10.1038/srep06312

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anorectal transplantation in human cadavers : mock anorectal allotransplantatian2013

    • Author(s)
      Araki J, Nishizawa Y, Sato T, Naito M, Akita K, Tashiro K, Iida T, Koshirna I
    • Journal Title

      PLoS ONE

      Volume: 8(7) Issue: 7 Pages: e68977-e68977

    • DOI

      10.1371/journal.pone.0068977

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The development of a canine anorectal autotransplantation model based on blood supply: a preliminary case report2012

    • Author(s)
      Araki J, Nishizawa Y, Nakamura l, Sato l, Naito M, Fujii S, Mihara M, Koshima l
    • Journal Title

      PLoS ONE

      Volume: 7(9) Issue: 9 Pages: e44310-e44310

    • DOI

      10.1371/journal.pone.0044310

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Experimental study of new type of multivisceral transplantation: Anorectal transplantation with rats, dogs, and human cadavers2014

    • Author(s)
      Jun Araki
    • Organizer
      World Transplant Congress
    • Place of Presentation
      Moscone West Convention Center San Francisco
    • Year and Date
      2014-07-26 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of perfusate for composite tissue graft: New maneuvers extending the ischemic golden period.2014

    • Author(s)
      Jun Araki
    • Organizer
      World Transplant Congress
    • Place of Presentation
      Moscone West Convention Center San Francisco
    • Year and Date
      2014-07-26 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Experimental study of anorectal transplantation with rats, dogs, and human cadavers2013

    • Author(s)
      Jun Araki
    • Organizer
      the XI Meeting of the International Hand and Composite Tissue Allotransplantation Society
    • Place of Presentation
      Faculty of Law, Administration and Economics, in Wroclaw, Poland
    • Year and Date
      2013-08-30
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] New Composite Tissue Allotransplantation : Vascularized Anal Transplantation for Whole-Bowel Transplantation2013

    • Author(s)
      Jun Araki
    • Organizer
      5th European Plastic Surgery Research Council
    • Place of Presentation
      the MS Cap San Diego in Hamburg, Germany
    • Year and Date
      2013-08-23
    • Related Report
      2013 Annual Research Report
  • [Presentation] Experimental study of anorectal transplantation for stoma patients2013

    • Author(s)
      Jun Araki
    • Organizer
      the 25th Southern African Transplantation Society Congress and Global Alliance fbr Transplantatio nWorkshop
    • Place of Presentation
      the Southern Sun Elangeni Hotel, Durban, South Africa
    • Year and Date
      2013-07-30
    • Related Report
      2013 Annual Research Report
  • [Presentation] Experimental study of new vascularized composite allotxansplantation : Anorectal transplantation with rats, dogs, and human cadavers2013

    • Author(s)
      Jun Araki
    • Organizer
      7th biennial meeting of the World Society for Reconstructive Microsurgery
    • Place of Presentation
      the Fairmont Chicago, Chicago, Ilinois, USA
    • Year and Date
      2013-07-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大腸肛門外科・小児外科・移植外科とのコラボレーション:同種肛門移植研究2012

    • Author(s)
      荒木 淳
    • Organizer
      第21回形成外科基礎学術集会
    • Place of Presentation
      福島/日本
    • Year and Date
      2012-10-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] New Composite Tissue Allotransplantation: Vascularized Anal Transplantation for Whole-Bowel Transplantation2012

    • Author(s)
      Jun Araki
    • Organizer
      he 24th International Congress of The Transplantation Society
    • Place of Presentation
      Berlin/Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] Leading Edge in Surgery: Clinical practice and Basic research of Super-microsurgery2012

    • Author(s)
      Jun Araki
    • Organizer
      The 3rd Lanzhou International Conference Oil Surgery
    • Place of Presentation
      Lanzhou/China(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Book] 日本外科学会雑誌2015

    • Author(s)
      荒木淳、西澤祐吏、齋藤典男、光嶋勲
    • Total Pages
      5
    • Publisher
      日本外科学会
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-04-25   Modified: 2024-03-26  

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