| Project/Area Number |
13024236
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
NISHIDA Yoshihiro DEPARTMENT OF MOLECULAR DESIGN & ENGINEERING, GRADUATE SCHOOL OF ENGINEERING, ASSOCIATE PROFESSOR, PhD, 工学研究科, 助教授 (80183896)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Kazuhiro DIVISON OF VIRUS, NATIONAL CANCER INSTITUTE, CHIEF RESEARCHER, PhD, ウイルス部, 主任研究官 (80251502)
KOBAYASHI Kazukiyo DEPARTMENT OF MOLECULAR DESIGN & ENGINEERING, GRADUATE SCHOOL OF ENGINEERING, PROFESSOR, PhD, 工学研究科, 教授 (10023483)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Mycoplasma fermentans / glycolipids / α-glycosylation / glycerolipids / infection / cell surface matrix / saccharide / phosphoryl choline / グルコシル化 |
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| Research Abstract |
6-O-phosphorylcholine-α-D-glucopyranosyl-sn-l,2-diglycerides (GGPLs) constitute main cell surface glycolipids of Mycoplasma fermentans. To elucidate the structurepathogen relations of the novel glycolipids, a series of natural and unnatural GGPLs involving sn-2,3-diglycerides and multivalent GGPLs models were assembled by α-selective α-glycosylation method which was developed in this project. GGPLS were found to play a major role in both homo- and hetero-philic association as a result of the Zwitter-ion of phosphoryl choline and show stereochemical dependent-immunological response.
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