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3D micro/nano structures for micro-chemo-mechatoronics

Research Project

Project/Area Number 13124202
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAO Masayuki  University of Tokyo, Dept. of Engineering, Professor, 大学院・工学系研究科, 教授 (90242007)

Co-Investigator(Kenkyū-buntansha) MITSUISHI Mamoru  University of Tokyo, Dept. of Engineering, Professor, 大学院・工学系研究科, 教授 (90183110)
MATSUMOTO Kiyoshi  University of Tokyo, Dept. of Engineering, Associated Professor, 大学院・理工専攻, 助教授 (10282675)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥26,000,000)
Fiscal Year 2003: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2002: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2001: ¥9,000,000 (Direct Cost: ¥9,000,000)
Keywords3-dimentional fine structure / electron beam deposition method / focused ion beam machining / Laser welding / sintered glass / near-field optics / 形質転換 / ウォータージェット加工法 / DNAハンドリング / マイクロディスペンサ / 撥水剤
Research Abstract

The purpose of this research is establishing the technology to create the 3-dimensional fine structures for micro-chemo-mechatronics with semiconductor processing technology and machining technology.
In addition to the conventional MEMS technique and chemical modification technology, mechanical ultra-fine processing technology, such as electrolysis polish, electrical discharge machining, beam deposition, assembly, bonding, embossing, injection molding, and so on is used to create microchemistry instruments equipped with the 3-dimensional fine structures for chemical analysis. In this research, we classified micro/nano structure into needlelike, tubular, and channel-like structure as the following items.
Needlelike structure : The electron beam depositing (EBD) method which generates carbon nano-wire using the beam of a scanning electron microscope was developed as manufacturing technology of the nano meter scaled needlelike structure. Using this needlelike structure, handing tool of DNA … More and scattering probe for near-field optical microscope was developed. Furthermore, conductive control of an EBD probe was tried for the application to a micro electrode, micro sensor, etc. In order to generate crystalline graphite structure instead of amorphous EBD, we arranged the source feeder of carbon, a catalyst, and the heating equipment for activation of the catalyst in an electron microscope. As the result, the carbon deposition considered to be crystalline was generable.
Tubular structure : Research which processes a micro glass pipe using focused ion beam and produces tubular structure has been done. As an example of application, micro pipet which performs fixed quantity dispensing by preparing hydrophilic area of the fixed volume of pico liter order in the interior of the pipet was developed. And also, the system which generates droplet on a substrate with the combination of the micro pipet verticaly drived by the piezo-electric device, and the substrate with controlled hydrophilicity was developed.
Channel-like structure : The mechanical processing method for manufacturing glass channel chips mainly manufactured by the chemical technique such as a wet or dry etching at this stage, at high speed and low cost has been developed for mass-production of micro chemical analysis instruments. For example, processing method which coat a substrate with the glass flit by an injector, form channels, sinters and produces a glass chip was tried. Furthermore, in order to treat the reagent which makes glass corrode, and the reaction which generates excessive heat and pressure, the metal micro-reactor excellent in heat transfer and shock resistance was developed. It was shown that combining the cutting method for formation of the groove, and the bonding technology of the cover by the YAG laser-welding method, the multilayer chip made from stainless steel with 400 micrometers width channels is producible. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (43 results)

All Other

All Publications (43 results)

  • [Publications] Takeshi Ooi, et al.: "Metal Microreactors for Chemical Synthesis Multilayered by Laser Welding"Proceeding of the International Symposium on Microchemistry and Microsystem 2003. 33-34 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Ooi, K.Kasuya, K.Tsuchiya, T.Hamaeuchi, M.Nakao: "Pinpoint chemical vapor deposition of carbon nanowire for Nanometer-scale electronic devices"Proc.ASPS Annual meeting 2003. (CD-ROM). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Tsuehiya, et al.: "Precise gastight sealing for bio/chemical microchip"Proc.ASPS Annual meeting 2003. (CD-ROM). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Tsuchiya, A.Yamaji, T.Ooi, T.Hamaguchi, M.Nakao: "A Laser Welded Multilayered Metal Micro-Reactor for Chemical Synthesis"MICRO SYSTEM Technologies 2003. 320-327 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masaaki FUJISAKI, et al.: "ON-CHIP CULTURE FOR MONITORING SINGLE CELLS"EMBEC '02. 302-303 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeshi OOI, Yusuke OKABE, Masayuki NAKAO, Keisuke IWATA: "Laminated electrodes chip far pulse-immunoassay"Micro Total Analysis Systems. 121-123 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 竹中良, 大井健, 中尾政之, 長森英二, 福井希一: "遺伝子封入用マイクロカプセルの開発"医用電子と生体工学. 40. 81-81 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masayuki NaKao, Takesni Ooi, Kensuke Tsuchiva: "A nano channel is made to a microchip"(CD-ROM). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kensuke Tsuchiya, Takeshi Ooi, Yuki Sakamaki, Masavuki Nakao: "High aspect ratio SNOM probe fabricated using Electron Beam Deposition and Focused Ion Beam"Proceedings from ASPE 2002 Annual Meeting. 27. 20-23 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 藤岡聡太, 大井健, 中尾政之, 畑村洋太郎: "ナノメータサイズのプローブを用いた単一DNAの切断と断片の単離"医用電子と生体工学. 39巻特別号. 280-280 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中尾政之, 大井健: "ナノチャネルとナノツール"化学工業. 52. 18-22 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中尾政之, 大井健, 土屋健介: "マイクロチップにナノチャネルを作る"BME(Bio Medical Engineering). 15. 57-62 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Ooi: "3D-nano Wire-frame for Handling and Observing a single DNA Probe"Proc. of MEMS.'00. 580-583 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masayuki Nakao, Takeshi Ooi, Kensuke Tsuchiya: "A nano channel is made to a microchip"BME (Bio Medical Engineering). Vol.15, No.10. 57-62 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masayuki Nakao, Takeshi Ooi: "A nano channel and a nano tool"Chemical industry. Vol.52, No.1. 18-22 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sota Fujioka, Takeshi Ooi, Masayuki Nakao, Yotaro Hatamura: "Cutting of single DNA and isolation of a fragment using the probe of nano meter size"BME. Vol.39. 280 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yuke Sakamaki, Takeshi Ooi, Masayuki Nakao, Yotaro Hatamura: "Development of the near-field optical microscope using a high aspect ratio scattering probe"BME. Vol.39. 278 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masayuki Nakao, Takeshi Ooi, Kensuke Tsuchiya: "A nano channel is made to a microchip"BME (Bio Medical Engineering). Vol.15, No.10. 57-62 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ryo Takenaka, Takeshi Ooi, Masayuki Nakao, Kiichi Fukui: "Development of the microcapsule for gene enclosure"The 6th conference of chemistry and micro nano system. 51 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ryo Takenaka, Takeshi Ooi, Masayuki Nakao, Eiji Nagamori, Kiichi Fukui: "Development of the microcapsule for gene enclosure"BME. Vol.40. 81 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeshi OOI, Yusuke OKABE, Masayuki NAKAO, Keisuke IWATA: "Laminated electrodes chip for pulse-immunoassay"Micro Total Analysis Systems 2002. 121-123 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masaaki FUJISAKI: "ON-CHIP CULTURE FOR MONITORING SINGLE CELLS"EMBEC'02. 302-303 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeshi Ooi: "Metal Microreactors for Chemical Synthesis Multilayered by Laser Welding"Proceeding of the International Symposium on Microchemistry and Microsystem 2003. 33-34 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Ooi, K.Kasuya, K.Tsuchiya, T.Hamaguchi, M.Nakao: "Pinpoint chemical vapor deposition of carbon nanowire for Nanometer0scale electronic devices"Proc. ASPE Annual meeting 2003, CD-ROM. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Tsuchiya: "Precise gastight sealing for bio/chemical microchip"Proc. ASPE Annual meeting 2003, CD-ROM. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Tsuchiya, A.Yamaji, T.Ooi, T.Hamaguchi, M.Nakao: "A Laser Welded Multilayered Metal Micro-Reactor for Chemical Synthesis"MICRO SYSTEM Technologies 2003. 320-327 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeshi Ooi, et al.: "Metal Microreactors for Chemical Synthesis Multilayered by Laser Welding"Proceeding of the International Symposium on Microchemistry and Microsystem 2003. 33-34 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Ooi, K.Kasuya, K.Tsuchiya, T.Hamaguchi, M.Nakao: "Pinpoint chemical vapor deposition of carbon nanowire for Nanometer-scale electronic devices"Proc.ASPE Annual meeting 2003. (CD-ROM). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tsuchiya, et al.: "Precise gastight sealing for bio/chemical microchip"Proc.ASPE Annual meeting 2003. (CD-ROM). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Tsuchiya, A.Yamaji, T.Ooi, T.Hamaguchi, M.Nakao: "A Laser Welded Multilayered Metal Micro-Reactor for Chemical Synthesis"MICRO SYSTEM Technologies 2003. 320-327 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中尾政之, 畑村洋太郎: "ナノ・マイクロマシンを設計する"マイクロマシン技術総覧. 397-405 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中尾政之: "マイクロ・ナノプリンティング・モールディング"ナノテクノロジー大事典. 5.5章. 549-556 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 竹中良, 大井健, 中尾政之, 福井希一: "遺伝子封入用マイクロカプセルの開発"第6回化学とマイクロ・ナノシステム研究会講演予稿集. 51 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 竹中良, 大井健, 中尾政之, 長森英二, 福井希一: "遺伝子封入用マイクロカプセルの開発"医用電子と生体工学. 第40巻特別号. 81 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeshi OOI, Yusuke OKABE, Masayuki NAKAO, Keisuke IWATA: "Laminated electrodes chip for pulse-immunoassay"Micro Total Analysis Systems 2002. 121-123 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masaaki FUJISAKI, et al.: "ON-CHIP CULTURE FOR MONITORING SINGLE CELLS"EMBEC '02. 302-303 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kensuke Tsuchiya, Takeshi Ooi, Yuki Sakamaki, Masayuki Nakao: "High aspect ratio SNOM probe fabricated using Electron Beam Deposition and Focused Ion Beam"Proceedings from ASPE 2002 Annual Meeting. Vol.27. 20-23 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 坂巻勇紀, 大井健, 中尾政之, 畑村洋太郎: "高アスペクト比散乱プローブを用いた近接場光学顕微鏡の開発"医用電子と生体工学. 39巻特別号. 278 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 藤岡聡太, 大井健, 中尾政之, 畑村洋太郎: "ナノメータサイズのプローブを用いた単一DNAの切断と断片の単離"医用電子と生体工学. 39巻特別号. 280 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sota FUJIOKA Takeshi OOI, Masayuki NAKAO: "IN-SITU SINGLE DNA MANIPULATION WITH φ2Onm ELECTRON-BEAM-DEPOSITED PROBE"Proc. of 3rd annual Int'l Conference of the IFEE Eng. in Med. & Biol. Soc.. (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中尾政之, 大井健: "ナノチャネルとナノツール"化学工業. Vol.52 No.1. 18-22 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中尾政之, 大井健, 土屋健介: "マイクロチップにナノチャネルを作る"BME (Bio Medical Engineering). Vol.15 No.10. 57-62 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 土屋健介, 中田圭, 中本与一, 大井健, 藤岡聡太, 中尾政之: "ピコリットル分注のためのマイクロディスペンサの開発"日本機械学会第14回バイオエンジニアリング講演会講演論文集. No.02-04. 207-208 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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