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Analysis and control of the fluids, interfaces of liquid-liquid and liquid-solid in microchannels

Research Project

Project/Area Number 13124209
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionWaseda University

Principal Investigator

SHOJI Shuichi  Waseda University, Dept. of Electrical Engineering and Bioscience, Professor, 理工学部, 教授 (00171017)

Co-Investigator(Kenkyū-buntansha) HOMMA Takayuki  Waseda University, Dept. of Applied Chemistry, Associate Professor, 理工学部, 助教授 (80238823)
FUNATSU Takashi  The University of Tokyo, Dept. of Bioorganic Chemistry, Professor, 大学院・薬学系研究科, 教授 (00190124)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥26,000,000)
Fiscal Year 2003: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2002: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2001: ¥9,000,000 (Direct Cost: ¥9,000,000)
KeywordsMicrocell / Micro Total Analysis Systems / Microreactor / Microfluidics / Microflow observation / Micromachining / Finite element model flow analysis / Interface control / 微量流体制御 / 流体解析 / 蛍光観察 / 液体-液体界面 / 固体-液体界面
Research Abstract

Nano/micro flow systems open up the new possibilities for chemical and biochemical analysis and synthesis. For the design of nano/micro flow systems LSI designing concepts is applicable considering the symmetries between the electric devices and the flow devices. Nano/micro flow devices and elements which have micro meter scale sizes and nano liter volumes developed so far are described. Microvalves of negligible leakage and dead volumes were developed for chemical/biochemical applications. Micro mixers and sample injectors were obtained by using microfluidic behaviors in micro scale channels. In channel micro filters and electrochemical biosensors were fabricated using high aspect ratio UV photolithographic technologies. 3D metal electrodes implanted PDMS microflow cell was fabricated using 3D assembly method. Biological cell observation micro cell integrated on chip microvalve for regent injection was fabricated on Si substrate using deep RIE. Biomolecules sorting microsystems were. also realized using sol-gel transfer of hydrogels.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] M.Kanai, S.Ikeda, J.Tanaka, J.S.Go, H.Nakanishi, S.Shoji: "The multiple sample injector using improved sheath flow to prevent sample dilution"Sensors & Actuators A. 111. 32-36 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Sato, T.Kakinuma, J.S.Go, S.Shoji: "In-channel 3-D micromesh structures using maskless multi-angle exposure and their microfilter application"Sensors & Actuators A. 111. 87-92 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] J.S.Go, S.Shoji: "Digital sorting of flow-through droplet phase microfluid"Jpn.J.Appl.Phys. 42. L449-L450 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Honda, K.Emi, T.Kaxagiri, T.Irita, S.Shoji, H.Sato, T.Homma, T.Osaka, M.Saito: "3-D comb electrodes for amperometric immuno sensors"Conf.On Solid-State Sensors, Actuators and Microsystems : Transducers'03. 2. 1132-1135 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Ishizuka, M.Abe, H.Houjou, S.Shoji, J.Mizuno, Y.Wada: "Design and fabrication of multi-metal electrodes implanted-PDMS structures for micro flow devices using 3-D assembly"Conf.On Solid-State Sensors, Actuators and Microsystems : Transducers'03. 1. 999-1002 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] J.S.Go, T.Yamazaki, K.Kanai, H.Sato, S.Kawakami, S.Shoii: "A disposable, dead volume-free and leak-h-free monolithic PDMS microvalve"Conf.On Solid-State Sensors, Actuators and Microsystems : Transducers'03. 1. 643-646 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Shoji, K.Tashiro, T.Sekiguchi, H.Sato, N.Honda, T.Funatu: "Lab-on-a-chip, Miniaturies Systems for (Bio) Chemical Anaysis and Synthesis"Elsevier B.V., Amsterdam. 205-214 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Kanai, S.Ikeda, J.Tanaka, J.S.Go, H.Nakanishi, S.Shoji: "The multiple sample injector using improved sheath flow to prevent sample dilution"Sensors & Actuators A. Vol.111. 32-36 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] H.Sato, T.Kakinuma, J.S.Go, S.Shoji: "In-channel 3-D micromesh structures using maskless multi-angle exposure and their microfilter application"Sensors & Actuators A. Vol.111. 87-92 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] J.S.Go, S.Shoji: "Digital sorting of flow-through droplet phase microfluid"Jpn. J. Appl. Phys.. Vol.42. L449-L450 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Honda, K.Emi, T.Katagiri, T.Irita, S.Shoji, H.Sato, T.Homma, T.Osaka, M.Saito, J.Mizuno, Y.Wada: "3-D comb electrodes for amperometric immuno sensors"12^<th> Int. Conf. On Solid-State Sensors, Actuators and Microsystems : Transducers'03, Boston. Vol.2. 1132-1135 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.Honda, K.Emi, T.Katagiri, T.Irita, S.Shoji, H.Sato, T.Homma, T.Osaka, M.Saito, J.Mizuno, Y.Wada: "3-D comb electrodes for amperometric immuno sensors"12^<th> Int. Conf. On Solid-State Sensors, Actuators and Microsystems : Transducers'03, Boston. Vol.2. 1132-1135 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] J.S.Go, T.Yamazaki, K.Kanai, H.Sato, S.Kawakami, S.Shoji: "A disposable, dead volume-free and leak-free monolithic PDMS microvalve"12^<th> Int. Conf. On Solid-State Sensors, Actuators and Microsystems : Transducers'03, Boston. Vol.1. 643-646 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Shoji, K.Tashiro, T.Sekiguchi, H.Sato, N.Honda, T.Funatu: "Particles and molecules handling in micro channels"Lab-on-a-chip, Miniaturies Systems for (Bio) Chemical Analysis and Synthesis, Elsevier B. V., Amsterdam. 205-214 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Kanai, D.Uchida, S.Sugiura, H.Sato, S.Shoji: "Optimal Design of the Micromixer using Nonhomogeneous Laminar Flow"Proc. Micro Total Analysis Systems 2002 ; mTAS2002. Vol.1. 73-75 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Ishizuka, H.Hojo, M.Abe, S.Shoji: "Design and Fabrication of Metal Electrode Implanted PDMS Structure for Micro Flow Device"Proc. Micro Total Analysis Systems 2002 ; mTAS2002. Vol.1. 413-415 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Shirasaki, H.Makazu, S.lkeda, S.Shoji, T.Funatsu: "A Novel Biomolecule Sorter Using Thermosensitive Hydrogel in Micro Flow Systems"Proc. Micro Total Analysis Systems 2002 ; mTAS2002. Vol.2. 925-927 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Ikeda, S.Shoji, H.Makazu, Y.Shirasaki, T.Funatsu: "Biomolecules Sorting System using Thermal Gelation of aMethyl Cellulose Solution"Dig. Int. Microprocesses and Nanotechnology Conf. ; MNC2002. 170-171 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N.Honda, K.Emi, T.Katagiri, S.Shoji, H.Sato, T.Honma: "Fabrication and Evaluation of Amperometric Sensors for Micro Flow Cell using 3-D Comb Electrodes"Dig. Int. Microprocesses and Nanotechnology Conf. ; MNC2002. 290-291 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Kanai, S.Ikeda, S.Shoji: "Development of the Multiple Sample Injector Using Stepwise Flow to Prevent Sample Dilution"16th Int. Micro Electro Mechanical Systems Conference : MEMS2003. 189-192 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Shoji: "Recent Trends of Micro Flow Devices and Systems for Chemical/biochemical Applications"15th Conf. On Combinatorial Chemistry : JCCF. 137-149 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shuichi Shoji, Hironobu Sato, Takashi Funatsu: "Micro Flow Devices/Systems and Biomolecules Handling in Micro Flow Channels"1st Int. Meeting on Microsensors & Microsystems. 17-23 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Tashiro, S.Ikeda, T.Sekiguchi, H.Sato, S.Shoji: "Micro Flow Switches Using Thermal Gelation of Methyl Cellulose for Biomolecules Handling"Dig. 11<th> Int. Conf. on Solid-State Sensors & Actuators ; Transducers'01. Vol.2. 932-935 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Homma, L.Komatsu, A.Tamaki, H.Nakai, T.Osaka: "Molecular Orbital Study on the Reaction Mecha-nisms of Electroless Deposition Processes"Electrochim. Acta. 47(1-2). 47-53 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tadakuma, H., Yamaguchi, J., Ishihama, Y., Funatsu: "Imaging of Single Fluorescent Molecules Using Video-rate Confocal Microscopy"Biochem Biophys Res Commun. 287. 323-327 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] N.Honda, S.Shoji, M.Isomura, Y.Ashihara, K.Akahori, H.Sato: "Fabrication of Micro Flow Cell for Multi-Analyte Sandwich Immunoassay, Using Teflon Micro Check Valves"Proc. Micro Total Analysis Systems 2001:μTAS2001. 403-404 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Tashiro, S.Ikeda, T.Sekiguchi, S.Shoji, H.Makazu, T.Funatsu, S.Tsukita: "A Particle and Biomolecules Sorting Micro Flow System Using Thermal Gelation of Methyl Cellulose Solution"Proc. Micro Total Analysis Systems 2OO1:μTAS2001. 471-473 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] N.Honda, S.Shoji, M.Isomura, Y.Ashihara, K.Akahori, H.Sato: "Prototype of Micro Flow Cell for Multi-Analyte Sandwich Immunoassay"Proc. Microprocess & Nanotechnology Conference : MNC2001. 24-25 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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