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Preparation of Nucleic Acid-Biopolymer Composites with Regular Structure

Research Project

Project/Area Number 13132201
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

NISHI Norio  Hokkaido University, Graduate School of Environmental Earth Science, Professor, 大学院地球環境科学研究科, 教授 (70001857)

Co-Investigator(Kenkyū-buntansha) SAKAIRI Nobuo  Hokkaido University, Graduate School of Environmental Earth Science, Professor, 大学院地球環境科学研究科, 教授 (60153863)
NOMIZU Motoyoshi  Tokyo University of Pharmacy and Life Science, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (00311522)
OHNO Hiroyuki  Tokyo University of Agriculture and Technology, Faculty of Technology, Professor, 工学部, 教授 (00176968)
FURUIKE Tetsuya  Hokkaido University, Graduate School of Environmental Earth Science, Instructor, 大学院地球環境科学研究科, 助手 (10360942)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥36,800,000 (Direct Cost: ¥36,800,000)
Fiscal Year 2004: ¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 2003: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2002: ¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 2001: ¥9,500,000 (Direct Cost: ¥9,500,000)
Keywordsnucleic acid / DNA / biopolymer / regular structure composite / DNA-collagen composite / DNA-synthetic polymer composite / DNA-metal composite / DNA-silica composite / DNA-コラーゲンコンポジット / DNA-シリカコンポジット / DNA-高分子複合ゲル / ダイオキシン誘導体 / DNA-金属コンポジット / DNA-イオン性液体コンポジット / 紫外線照射 / DNA-高分子複合体ゲル / DNAフィルム / 環境ホルモン / ゾル-ゲル法 / DNA-キトサン二層式膜 / コラーゲン / コンポジット / DNA含有コンポジット
Research Abstract

Following DNA-containing composites were prepared to find the functional materials with novel functions caused by the DNA structure.
1. DNA-collagen composites. (1)salmon sperm DNA-collagen composite (2) plasmid DNA-collagen composite
2. DNA-synthetic polymer composites. (1)DNA-polyacrylmnide composite (2)interpenetrate network of DNA-polyvinyl alcohol composite.
3. DNA-metal composites. (1)DNA-Cu^<2+> composite (2)DNA-Al^<3+> composite
4. DNA-silica composite by sol-gel method.
5. DNA composites with ion conductivity.
These DNA-containing composites would have possibilities to be used in various fields as sophisticated functional materials such as medical polymers, separating devices for the DNA-binding materials and ion conductive materials.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (41 results)

All 2005 2004 2003 Other

All Journal Article (18 results) Book (2 results) Publications (21 results)

  • [Journal Article] Functional DNA-Silica Composite Prepared by Sol-Gel Method2005

    • Author(s)
      Shuya Satoh
    • Journal Title

      Polymer J. 37 (2)

      Pages: 94-101

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of DNA structure on the formation of collagen-DNA complex2005

    • Author(s)
      Michiko Kaya
    • Journal Title

      Int.J.Biol.Macromol. 35

      Pages: 39-46

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Functional DNA-Silica Composite Prepared by Sol-Gel Method2005

    • Author(s)
      Shuya Satoh et al.
    • Journal Title

      Polymer J. 37(2)

      Pages: 94-101

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of DNA structure on the formation of collagen-DNA complex2005

    • Author(s)
      Michiko et al.
    • Journal Title

      Int. J. Biol. Macromol. 35

      Pages: 39-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of DNA Structure on the Formation of Collagen-DNA Complex2005

    • Author(s)
      Michiko Kaya
    • Journal Title

      Int.J.Biol.Macromol (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional DNA-Silica Composite Prepared by Sol-Gel Method2005

    • Author(s)
      Shuya Satoh
    • Journal Title

      Polym.J. (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Preparation and Characterization of DNA Hydrogel Bead as Selective Adsorbent of Dioxins2005

    • Author(s)
      XiangDong Liu
    • Journal Title

      Int.J.Biol.Macromol (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Preparation of Polysulfone Hollow Microspheres Encapsulating DNA and their Functional Utilization2004

    • Author(s)
      Changsheng Zhao
    • Journal Title

      J.Microencapsulation 21(3)

      Pages: 283-291

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Preparation of DNA-Loaded Polysulfone microspheres by Liquid-Liquid Phase Separation and its Functional Utilization2004

    • Author(s)
      Changsheng Zhao
    • Journal Title

      J.Colloid Interface Sci. 275

      Pages: 470-476

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Preparation of Polyion Complex Fibers and Capsules of DNA and Chitosan at an Aqueous Interface2004

    • Author(s)
      Ayako Nishida
    • Journal Title

      Bull.Chem.Soc.Jpn. 77

      Pages: 1783-1787

    • NAID

      10013585016

    • Related Report
      2004 Annual Research Report
  • [Journal Article] DNA Aqueous Solution Used for Dialytical Removal and Enrichment of Dioxin Derivatives2003

    • Author(s)
      Xiang Dong Liu
    • Journal Title

      Int.J.Biol.Macromol 32

      Pages: 121-127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA-Chitosan Bilayer Membrane as a Bi-Functional Biomedical Adhesive2003

    • Author(s)
      Satoshi Rikimaru
    • Journal Title

      Polymer J. 35 (3)

      Pages: 255-260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA with γ-Aminopropyltriethoxy-Silane Switches between B-and C-Form Structures under Thermal Control2003

    • Author(s)
      Masanori Yamada
    • Journal Title

      Chem Bio Chem 2003 (2-3)

      Pages: 232-234

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of DNA on Collagen Fibrillogenesis2003

    • Author(s)
      Michiko Kaya
    • Journal Title

      Peptide Sci. 2002

      Pages: 379-382

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA Aqueous Solution Used for Dialytical Removal and Enrichment of Dioxin Derivatives2003

    • Author(s)
      Xiang Dong Liu et al.
    • Journal Title

      Int. J. Biol. Macromo 132

      Pages: 121-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA-Chitosan Bilayer Membrane as a Bi-Functional Biomedical Adhesive2003

    • Author(s)
      Satoshi Rikimaru et al.
    • Journal Title

      Polymer J. 35(3)

      Pages: 255-260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA with γ-Aminopropyltriethoxy-Silane Switches between B-and C-Form Structures under Thermal Control2003

    • Author(s)
      Masanori Yamada et al.
    • Journal Title

      Chem Bio Chem 2003 (2-3)

      Pages: 232-234

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of DNA on Collagen Fibrillogenesis2003

    • Author(s)
      Michiko Kaya et al.
    • Journal Title

      Peptide Sci. 2002

      Pages: 379-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 高分子材料・技術総覧(高分子材料・技術総覧編集委員会編集、産業技術サービスセンター発行)2004

    • Author(s)
      西 則雄
    • Total Pages
      5
    • Publisher
      生体高分子材料(コラーゲン、DNA、糖など)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 高分子材料・技術総覧(高分子材料・技術総覧編集委員会編集)2004

    • Author(s)
      西 則雄
    • Total Pages
      5
    • Publisher
      産業技術サービスセンター
    • Related Report
      2004 Annual Research Report
  • [Publications] Masanori Yamada: "DNA with γ-Aminopropyltriethoxy-Silane Switches between B-and C-Form Structures under Thermal Control"Chem Bio Chem. 2003(2-3). 232-234 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Xiang Dong Liu: "DNA Aqueous Solution Used for Dialytical Removal and Enrichment of Dioxin Derivatives"Int.J.Biol.Macromol. 32. 121-127 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] C.S.Zhao: "Blood Compatible Aspects of DNA-Modified Polysulfone Membrane, Protein Adsorption and Platelet Adhesion"Biomaterials. 24. 3747-3755 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Satoshi Rikimaru: "DNA-Chitosan Bilayer Membrane as a Bi-Functional Biomedical Adhesive"Polymer J.. 35(3). 255-260 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shuya Satoh: "Accumulation- Exclusion Combined System for the DNA-Binding Harmful Chemicals with Insolubilized DNA"Polymer J.. 35(11). 872-878 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Benjamas Jonganurakkun: "Survival of Lactic Acid Bacteria in Simulated Gastrointestinal Juice Protected by a DNA-Based Complex Gel"J.Biomater.Sci.Polymer Edn.. 14(11). 1269-1281 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 西 則雄: "汚染物質除去材としてのDNA"社団法人 高分子学会. 4 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masanori Yamada: "UV-Irradiated DNA Matrixes Selectively Bind Endocrine Disruptors with a Planar Structure"Environ. Sci. & Technol.. 36. 949-954 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masanori Yamada: "Preparation and Characterization of DNA Films Induced by UV Irradiation"Chem. Eur. J.. 8・6. 1407-1412 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Benjamas Jonganurakkun: "DNA Complex Gel for Protection of Lactic Acid Bacteria in the Digestive System"Proceeding of International Symposium on Biomaterials and Drug Delivery Systems(in Taiwan). 456-459 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satoshi Rikimaru: "DNA-Chitosan Bilayer Membrane for Surgical Use"Proceeding of International Symposium on Biomaterials and Drug Delivery Systems(in Taiwan). 206-209 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masanori Yamada: "UV-irradiated DNA matrix selectively accumulates heavy metal ions"Bull. Chem. Soc. Jpn.. 75. 1627-1632 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] X.D.Liu: "Surface modification of nonporous glass beads with chitosan and their adsortion property for transition ions"Carbohydrate Polymers. 49. 103-108 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山田真路: "サケ白子DNAの環境分野への応用 -DNAによる環境ホルモン・重金属の除去-"化学的DNA/RNA機能化研究ニュースレターVol.2. 15 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Isao Ohiso: "Conformational Study of the Tandem Repeat Sequence in RNA Polymerase II by Circular Dichroism Spectroscopy"Bull.Chem.Soc.Jpn.. 74. 1139-1143 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masanori Yamada: "UV-irradiation-induced DNA immobilization and functional utilization of DNA on nonwoven cellulose fabric"Biomaterials. 22. 3121-3126 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Isao Ohiso: "Theoretical Conformational Analysis of the Tandem Repeat Sequence in RNA Polymerase II"Bull.Chem.Soc.Jpn.. 74. 1847-1855 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] X.D.Liu: "Chitosan coated cotton fiber : preparation and physical properties"Carbohydrate Polymers. 44. 233-238 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Motoyoshi Nomizu: "Identification of Homologous Biologically Active Sites on the N-Terminal Domain of Laminin Alpha Chains"Biochemistry. 40・50. 15310-15317 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masanori Yamada: "UV-Irradiated DNA Matrixes Selectively Bind Endocrine Disruptors with a Planar Structure"ENVIRON.SCI. & TECHNOL.. 36(5). 949-954 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 西 則雄: "ぼくもノーベル賞をとるぞ"高分子学会出版部. 175 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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