• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

頭部形成の分子機構

Research Project

Project/Area Number 13138101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe Institute of Physical and Chemical Research (2002-2004)
Kumamoto University (2001)

Principal Investigator

相沢 慎一  独立行政法人理化学研究所, ボディプラン研究グループ, グループディレクター (60073011)

Co-Investigator(Kenkyū-buntansha) 影山 龍一郎  国立大学法人京都大学, ウイルス研究所, 教授 (80224369)
武田 洋幸  国立大学法人東京大学, 理学系研究科, 教授 (80179647)
倉谷 滋  独立行政法人理化学研究所, 形態進化研究チーム, チームリーダー (00178089)
松尾 勲  独立行政法人理化学研究所, ボディプラン研究グループ, 上級研究員 (10264285)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥38,600,000 (Direct Cost: ¥38,600,000)
Fiscal Year 2004: ¥9,200,000 (Direct Cost: ¥9,200,000)
Fiscal Year 2003: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 2002: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2001: ¥10,000,000 (Direct Cost: ¥10,000,000)
Keywords評価 / 助言 / 研究交流 / 脊椎動物 / 軸形成 / 胚葉形成 / 脳形成 / 比較発生 / 魚類 / 胚誘導 / 頭部形成 / 神経系形成
Research Abstract

各計画研究を効率よく推進するため、各計画研究についての評価・助言を求め、計画研究間の連携と共同研究の促進に、本領生き研究に密接に関連した研究分野の第一線の研究者に参画を要請し、本総括班を組織した。本年度総括班会議は6月、1月の2回開催した。
1.本領域研究の成果を問い、欧米の第一の研究者との研究交流を目的に、脳形成に関する国際ミーティングを7月に開催した。欧米からの参加者はArturo Alvarez-Buylla(UCSF, USA), Johan Ericson(Karolinska Institute, Sweden),Alexandra Joyner(New York Univ., USA), Antonio Simeone(King's College London, UK),Susan McConnell(Stanford Univ., USA),Dennis O'Leary(The Salk Institute), Andrew Peterson(UCSF, USA), Luis Puelles(University of Murcia, Spain),John Rubenstein(UCSF, USA), Stephen Wilson(University College London, UK)
2.平成16年度の領域研究会は最終年度として、各班員に今後の研究展望をも含めた総括的報告を求めた。
3.平成16年度に特に推進された研究交流は以下の通りである。
横田千夏(Cincinnati Children's Hospital Medical Center)、矢島浩(University of Chicago)、大沼信一(University of Cambridge)、本庶仁子(University of Oregon)

Report

(4 results)
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (38 results)

All 2005 2004 Other

All Journal Article (12 results) Publications (26 results)

  • [Journal Article] A type I DnaJ homolog, DjA1 regulates androgen receptor signaling and spermatogenesis.2005

    • Author(s)
      Terada, K., et al.
    • Journal Title

      EMBO J 24

      Pages: 611-622

    • Related Report
      2004 Annual Research Report
  • [Journal Article] cfm is a novel gene uniquely expressed in developing forebrain and midbrain, but its null mutant exhibits no obvious phenotype.2005

    • Author(s)
      Hirano, M., et al.
    • Journal Title

      Gene Expression Patterns 5

      Pages: 439-444

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Shisa Promotes Head Formation throuth the Inhibition of Receptor Protein Maturation for the Caudalizing Factors, Wnt and FGF2005

    • Author(s)
      Yamamoto, A., et al.
    • Journal Title

      Cell 120

      Pages: 223-235

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Characterization of Opr-deficiency in mouse brain : subtle defects in dorsomedial telencephalon and medioventral forebrain2005

    • Author(s)
      Furushima, K., et al.
    • Journal Title

      Developmental Dynamics (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Characterization of the pufferfish Otx2 cts-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification.2004

    • Author(s)
      Kimura-Yoshida, C., et al.
    • Journal Title

      Development 131

      Pages: 57-71

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.2004

    • Author(s)
      Kuwahara, K., et al.
    • Journal Title

      Proc.Natl.Acad.USA. 101

      Pages: 1010-1015

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Emx1 and Emx2 cooperate in initial phase of archipallium development.2004

    • Author(s)
      Shinozaki, K., et al.
    • Journal Title

      Mechanisms of Development 121

      Pages: 475-489

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.2004

    • Author(s)
      Kurokawa, D., et al.
    • Journal Title

      Development 131

      Pages: 3307-3317

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regulation of Otx2 expression and its functions in mouse forebrain and midbrain.2004

    • Author(s)
      Kurokawa, D., et al.
    • Journal Title

      Development 131

      Pages: 3319-3331

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Targeted disruption of the mouse ELYS gene results in embryonic lethality at peri-implantation development.2004

    • Author(s)
      Okita, K., et al.
    • Journal Title

      Genes to Cells 9

      Pages: 1083-1091

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increased Serum Leptin Protects From Adiposity Despite the Increased Glucose Uptake in White Adipose Tissue in Mice Lacing p85α Phosphoinositide 3-Kinase.2004

    • Author(s)
      Terauchi, Y., et al.
    • Journal Title

      Diabetes 53

      Pages: 2261-2270

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype.2004

    • Author(s)
      Murata, T., et al.
    • Journal Title

      Gene Expression Patterns 5

      Pages: 171-178

    • Related Report
      2004 Annual Research Report
  • [Publications] Saito, T., et al.: "Notch2 is Preferentially Expressed iin Mture B Cells and Indispensable for Marginal Zone B Lineage Development."Immunity. 18. 675-685 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Terauchi, Y., et al.: "Impact of Genetic Background and Ablation of Insulin Receptor Sustrate (IRS)-3 on IRS-2 Knock-out Mice."The Journal of Biological chemistry. 278. 14284-14290 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Terada, K., et al.: "Expression of Tom34 Splicing Isoforms in Mouse Testus and Knockout of Tom34 in Mice."J.Biochem.. 133. 625-631 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Wakabayashi, Y., et al.: "Bcl11b is required for differentiation and survival of α β T lymphocytes."Nature Immunology. 4. 533-539 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] UMEZU, T., et al.: "CHARACTERIZATION OF NEWLY ESTABLISHED CLONAL OVIDUCTAL CELL LINES AND DIFFERENTIAL HORMONAL REGULATION OF GENE EXPRESSION."In Vitro Cell.Dev.Biol.-Animal. 39. 146-156 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishida, A., et al.: "Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development."Nature Neuroscience. 6. 1255-1263 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hirabayashi, Y., et al.: "Evaluation of nonthreshold leukemogenic response to methy1 nitrosourea in p53-deficienct C3H/He mice."Toxicology and Applied Pharmacology. 190. 251-261 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kuwahara, K.et al.: "Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses."Proc.Natl.Acad.USA.. 10. 1073-1078 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kimura-Yoshida, C., et al.: "Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for the vertebrate head specification."Development. 131. 57-71 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Furukawa, T., et al.: "Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development."Nature Neurosci. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kurokawa, D., et al.: "Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm."Development. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kurokawa, D., et al.: "Regulatign of Otx2 expression and its functions in mouse forebrain and midbrain."Development. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shigetani, Y., et al.: "Heterotopic shift of epithelial-mesenchymal interactions for vertebrate jaw evolution"Science. 296. 1319-1321 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shinozaki, K., et al.: "Absence of Cajal-Retzius cells and subplate neurons associated with defect of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex"Development. 129. 3479-3492 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hide, H., et al.: "Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice"Development. 129. 4347-4357 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirata, H., et al.: "Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop"Science. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Koshida, S., et al.: "Inhibition of BMP activity by the FGF activity by the FGF signal promotes posterior neural development in zebrafish"Developmental Biology. 244. 9-20 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hanazono, M., et al.: "Establishment of an androgen-responsive prostanic cell line "PEA5" from a p53-deficient mouse"The Prostate. 46. 214-225 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suda, Y., et al.: "Emx2 directs the development of diencephalon in cooperation with Otx2"Development. 128. 2433-2450 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kimura, C., et al.: "Complementary Functions of Otx2 and Cripto in Initial Patterning of Mouse Epiblast"Developmental Biology. 235. 12-32 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ino, M., et al.: "Functional disorders of the sympathetic nervous system in mice lacking the a1B subunit (Cav2.2) of N-type calcium channels"PNAS. 98. 5323-5328 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kaji, T, et al.: "Establishment of Left-Right Asymmetic Innervation in the Lancelet Oral Region"The Journal of Comparative Neurology. 435. 394-405 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Myojin, M., et al.: "Isolation of Dlx and Emx Gene Congnates in an Agnathan Species, Lampetra japonica, and Their Expression Patterns During Embryonic and Larval Development : Conserved and Diversified Regulatory Patterns of Homeobox Genes in Vertebrate Head Evolution"Journal of Experimental Zoology (MOL DEV EVOL). 291. 68-84 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tamura, T., et al.: "Impairment in the Expression and Activity of Gyn During Differentiation of Naive CD4_+ T Cells into the Th2 Subset"The Journal of Immunology. 167. 1962-1969 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tian, E., et al.: "Otx2 Is Required to Respond to Signals from Anterior Neural Ridge for Forebrain Specification"Developmental Biology. 242. 204-223 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Inui, S., et al.: "BCR signal through a4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation"International Immunology. 14. 177-187 (2001)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi