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Proton pump ATPase as nano motors

Research Project

Project/Area Number 13142204
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionMicrobial Chemistry Research Center (2004-2005)
Osaka University (2001-2003)

Principal Investigator

FUTAI Masamistu  Microbial Chemistry Research Center, Futai Special Laboratory, Special Researcher, 微生物化学研究センター・二井特別研究室, 特別研究員 (50012646)

Co-Investigator(Kenkyū-buntansha) SUN-WADA Ge-hong  Doshisya Womens' College pharmaceutical, Assistant Professor, 薬学部, 助教授 (00314427)
TAKAZAWA Shinn  Tohoku University, Graduate School of Medicine, Assistant Professor, 医科学系研究科, 助教授 (50187944)
和田 洋  大阪大学, 産業科学研究所, 助教授 (50212329)
岡本 宏  東北大学, 医学系研究科, 教授 (60025632)
三本木 至宏  大阪大学, 産業科学研究所, 助手 (10222027)
Project Period (FY) 2001 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥79,700,000 (Direct Cost: ¥79,700,000)
Fiscal Year 2005: ¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2004: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2003: ¥17,900,000 (Direct Cost: ¥17,900,000)
Fiscal Year 2002: ¥17,000,000 (Direct Cost: ¥17,000,000)
Fiscal Year 2001: ¥13,500,000 (Direct Cost: ¥13,500,000)
KeywordsATP / F-TPase / V-ATPase / Lisosom / nano machine / nano motors / プロトンポンプ / V型ATPase / ATP合成酵素 / インスリン / 蛋白質 / 生体分子 / 酵素 / 細胞組織 / F型ATPase / 分泌顆粒 / ランゲルハンス島
Research Abstract

Three classes of proton pumping ATPase are known : P-TPase, F-TPase and V-ATPase. F-ATPase (ATP synthase) and V-ATP(prothn pump of endomembrance organelles such as lysosome and endosome) are closely similar in subunit structure and mechanism. They couples proton transport and ATPase chemistry through subunit rotation. Our extensive research results are showing:(1) Purified and membrane-bound F-ATPases are rotating during ATP hydrolysis. Their rotations are stochastic, and driven by hinge domain of the β subunit. (2) V-ATPases are also rotating proton pump, and their diverse isoforms specific for unique cells were found. (3) V-ATPase has domains required for specific localization and possibly for sensing organeller luminal pH. These results have been widely recognized in the field biochemistry and cell biology.

Report

(6 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (102 results)

All 2006 2005 2004 2003 2002 2001 Other

All Journal Article (72 results) Book (5 results) Publications (25 results)

  • [Journal Article] High-speed rotation of Escherichia coli ATP synthase F_1 sector : ε subunit-sensitive rotation2006

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 281

      Pages: 4126-4131

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] V-ATPase interact with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway2006

    • Author(s)
      M, Futai.
    • Journal Title

      Nature Cell Biol. 8

      Pages: 124-136

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Selective assembly of subunit isoforms in mouse kidney.2006

    • Author(s)
      K, Son.
    • Journal Title

      J.Bioenerg.Biomemb.(2006) (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis2006

    • Author(s)
      M, Futai.
    • Journal Title

      Biol.Reprod. 74

      Pages: 185-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stochastic proton pumping ATPases : from single molecules to Diverse physiological roles.2006

    • Author(s)
      M, Futai.
    • Journal Title

      UBMB Life (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High-speed rotation of Escherichia coli ATP synthase F1 sector : s subunit-sensitive rotation2006

    • Author(s)
      Masamistu Futai., Mayumi Nakanishi
    • Journal Title

      J. Biol. Chem. 281

      Pages: 4126-4131

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] V-ATPase interact with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway2006

    • Author(s)
      Masamistu Futai
    • Journal Title

      Nature Cell Bio1. 8

      Pages: 124-136

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Selective assembly of subunit isoforms in mouse kidney.2006

    • Author(s)
      Ge-Hong., Sun-Wada
    • Journal Title

      J. Bioenerg. Biomemb. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis2006

    • Author(s)
      Masamistu Futai
    • Journal Title

      Biol. Reprod. 74

      Pages: 185-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stochastic proton pumping ATPases : from single molecules to diverse physiological roles.2006

    • Author(s)
      Masamistu Futai
    • Journal Title

      UBMB Life. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High-speed rotation of Escherichia coli ATP synthase F_1 sector : ε subunit-sensitive rotation2006

    • Author(s)
      二井 將光, 中西 真弓
    • Journal Title

      J.Biol.Chem. 281

      Pages: 4126-4131

    • Related Report
      2005 Annual Research Report
  • [Journal Article] V-ATPase interact with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway2006

    • Author(s)
      二井 將光
    • Journal Title

      Nature Cell Biol. 8

      Pages: 124-136

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Simple and straight forward construction of a mouse gene targeting vector using in vitro transposition reaction2005

    • Author(s)
      M, Futai.
    • Journal Title

      Nucleic Acid Res. 33, No5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ATP-dependent rotation of mutant ATP synthases lacking proton transport2005

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 28

      Pages: 23797-23801

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Simple and straight forward construction of a mouse gene targeting vector using in vitro transposition reaction2005

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Journal Title

      Nucleic Acid Res. 33,No5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ATP-dependent rotation of mutant ATP synthases lacking proton transport2005

    • Author(s)
      Masamistu Futai
    • Journal Title

      J. Biol. Chem. 280

      Pages: 23797-23801

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Simple and straight forward construction of a mouse gene targeting vector2005

    • Author(s)
      二井 將光, 孫 戈虹
    • Journal Title

      Nucleic Acid Res. 33,No5

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ATP-dependent rotation of mutant ATP synthases lacking proton transport2005

    • Author(s)
      二井 將光
    • Journal Title

      J.Biol.Chem. 280

      Pages: 2379-23801

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Simple and straight forward construction of a mouse gene targeting vector using in vitro transposition reaction2005

    • Author(s)
      二井 將光, 孫 戈虹
    • Journal Title

      Nucleic Acid Res. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A Unique proton pump (V-ATPase) in mouse pancreatic secretory granules.2005

    • Author(s)
      孫 戈虹, 二井 將光
    • Journal Title

      (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ATP-dependent rotation of mutant ATP synthases lacking proton transport2005

    • Author(s)
      二井 將光
    • Journal Title

      J.Biol.Chem. (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mouse proton pump ATPase C subunit Isoforms (C2-a and C2-b) sp ecifically expressed in kidney and lung.2004

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 44843-44851

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Regulatory elements, directing gut-specific expression of GATA6 gene during mouse early development.2004

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biochem 135

      Pages: 165-169

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diverse and essential roles of mammalian vacuolar-type proton pump ATPase : Toward physiological understanding of inside acidic compartments.2004

    • Author(s)
      M, Futai.
    • Journal Title

      Biochim.Biophys.Acta 1658

      Pages: 106-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mouse proton pump ATPase C subunit Isoforms (C2-a and C2-b) specifically expressed in kidney and lung.2004

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Journal Title

      J. Biol. Chem. 278

      Pages: 44843-44851

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Regulatory elements, directing gut-specific expression of GATA6 gene during mouse early development.2004

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Journal Title

      J. Biochem. 135

      Pages: 165-169

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diverse and essential roles of mammalian vacuolar-type proton pump ATPase : Toward physiological understanding of inside acidic compartments.2004

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Journal Title

      Biochim. Biophys. Acta. 1658

      Pages: 106-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diverse and essential roles of mammalian vacuolar-type proton pump ATPase Toward physiological understanding of inside acidic compartments2004

    • Author(s)
      二井 將光, 孫 戈虹
    • Journal Title

      Biochim.Biophys.Acta. 1658

      Pages: 106-114

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Diversity of mouse proton-translocating ATPase : Presence of multiple isoforms of the C, d and G subunits.2003

    • Author(s)
      M, Futai.
    • Journal Title

      Gene. 302

      Pages: 147-153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Subunit rotation in vacuolar-type proton pumping ATPase : relative rotation of G as to c subunit.2003

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 23714-23719

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Vacuolar H^+ pumping ATPase in luminal acidic organelles and extracellular compartments : Common rotational mechanism and diverse physiological roles2003

    • Author(s)
      M, Futai.
    • Journal Title

      J.Bioenerg.Biomemb. 35

      Pages: 347-358

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Specific recognition of Leishmania major poly-β-galactosyl epitopes by galectm-9 : Possible implication of galectm-9 in interaction between2003

    • Author(s)
      M, Futai.
    • Journal Title

      L.major and host cells J.Biol.Chem. 278

      Pages: 22223-22230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA.2003

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 25585-25590

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] From lysosomes to plasma membrane : Localization of vacuolar type H^+-ATPase with the a3 isoform during osteoclast differentiation.2003

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 22023-22030

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The vacuolar-type H^+-ATPase : a revised nomenclature for Mammalian vacuolar-type H^+-ATPase subunit genes.2003

    • Author(s)
      M, Futai.
    • Journal Title

      Mol. Cell 12

      Pages: 801-803

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Detection of protein-protein interactions on SiO_2/Si surface by spectroscopic ellipsometry.2003

    • Author(s)
      M, Futai.
    • Journal Title

      Anal.Biochem. 312

      Pages: 65-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms.2003

    • Author(s)
      M, Futai.
    • Journal Title

      Cell Struct.Func. 28

      Pages: 455-463

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diversity of mouse proton-translocating ATPase : Presence of multiple isoforms of the C, d and G subunits.2003

    • Author(s)
      Masamistu Futai
    • Journal Title

      Gene 302

      Pages: 147-153

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Subunit rotation in vacuolar-type proton pumping ATPase : relative rotation of G as to c subunit.2003

    • Author(s)
      Masamistu Futai
    • Journal Title

      J. Biol. Chem. 278

      Pages: 23714-23719

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Vacuolar H+ pumping ATPase in luminal acidic organelles and extracellular compartments : Common rotational mechanism and diverse physiological roles2003

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Journal Title

      J. Bioenerg. Biomemb. 35

      Pages: 347-358

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori produced cytotoxin VacA.2003

    • Author(s)
      Masamistu Futai
    • Journal Title

      J. Biol. Chem. 278

      Pages: 25585-25590

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] From lysosomes to plasma membrane : Localization of vacuolar type H+ATPase with the a3 isoform during osteoclast differentiation.2003

    • Author(s)
      Masamistu Futai
    • Journal Title

      J. Biol. Chem. 278

      Pages: 22023-22030

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The vacuolar-type H^+-ATPase : a revised nomenclature for mammalian vacuolar-type H^+-ATPase subunit genes.2003

    • Author(s)
      Masamistu Futai
    • Journal Title

      Mol. Ce11. 12

      Pages: 801-803

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Detection of protein-protein interactions on Si0_2/Si surface by spectroscopic ellipsometry.2003

    • Author(s)
      Masamistu Futai
    • Journal Title

      Anal. Biochem. 321

      Pages: 65-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms.2003

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Journal Title

      Cell Struct. Func. 28

      Pages: 455-463

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sodium and sulfate ion transport in yeast vacuole2002

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biochem. 131

      Pages: 261-265

    • NAID

      130003534348

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A proton pump ATPase with testis-specific E1 subunit isoform Required for acrosome acidification2002

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 277

      Pages: 18098-18105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel water-soluble hantzsh 1, 4-dihydropyridine compound that functions in biological processes through NADH2002

    • Author(s)
      M, Futai.
    • Journal Title

      J.Org.Chem. 10

      Pages: 3499-3501

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A human gene, ATP6E1, encoding a testis-specific isoform of H^+ATPase subunit E2002

    • Author(s)
      M, Futai.
    • Journal Title

      Gene. 289

      Pages: 7-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential localization of V-type H+ pump with γ subunit isoforms (G1 and G2) in mouse neurons.2002

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 277

      Pages: 36296-36303

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Subunit rotation of ATP synthase embedded in membranes : a or β subunit rotation relative to the c subunit ring.2002

    • Author(s)
      M, Futai.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 99

      Pages: 13448-13452

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sodium and sulfate ion transport in yeast vacuole,2002

    • Author(s)
      Masamistu Futai., Yo Wada
    • Journal Title

      J. Biochem. 131

      Pages: 261-265

    • NAID

      130003534348

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel water-soluble hantzsh 1, 4-dihydropyridine compound that functions in biological processes through NADH2002

    • Author(s)
      Masamistu Futai
    • Journal Title

      J. Org. Chem. 10

      Pages: 3499-3501

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A human gene, ATP6E1, encoding a testis-specific isoform of H^+ATPase subunit E2002

    • Author(s)
      Masamistu Futai
    • Journal Title

      Gene 289

      Pages: 7-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential localization of V-type H+ pump with y subunit isoforms (G1 and G2) in mouse neurons.2002

    • Author(s)
      Masamistu Futai
    • Journal Title

      J. Biol. Chem. 277

      Pages: 36296-36303

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Subunit rotation of ATP synthase embedded in membranes : a or β2002

    • Author(s)
      Masamistu Futai
    • Journal Title

      Proc. Natl. Acad. Sci. USA 99

      Pages: 13448-13452

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rotation of a complex of the γ subunit and c ring of Escherichia coli ATP synthase : the rotor and stator are interchangeable.2001

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 276

      Pages: 15269-15274

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of mouse sorting nexin 1 oligomer with early endosomes.2001

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biochem. 130

      Pages: 765-7771

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Four Subunit a Isoforms of Caenorhabditis elegans vacuolar H^+-ATPase : Cell-specific expression during development.2001

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 276

      Pages: 33079-33085

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase.2001

    • Author(s)
      M, Futai.
    • Journal Title

      Gene. 274

      Pages: 93-99

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ATP synthase F_1 sector rotation; defective torque generation in the b subunit Ser-174 to Phe mutant and its suppression by second mutations.2001

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 276

      Pages: 47508-47511

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The murine genome contain one functional gene and two pseudomones coding for the 16kDa proteolipid subunit of vacuolar H+ -ATPase2001

    • Author(s)
      K, Son.
    • Journal Title

      Gene 273

      Pages: 199-206

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] a4, a unique kidney-specific isoform of mouse vacuolar H^+-ATPase subunit a2001

    • Author(s)
      M, Futai.
    • Journal Title

      J.Biol.Chem. 276

      Pages: 40050-40054

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rotation of a complex of the y subunit and c ring of Escherichia coli ATP synthase : the rotor and stator are interchangeable.2001

    • Author(s)
      Masamistu Futai
    • Journal Title

      J. Biol. Chem. 276

      Pages: 15269-15274

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Association of mouse sorting nexin 1 oligomer with early endosome2001

    • Author(s)
      Masamistu Futai Ge-Hong Sun-Wada
    • Journal Title

      J. Biochem. 130

      Pages: 765-7771

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Four Subunit a Isoforms of Caenorhabditis elegansvacuolar H+-ATPase : Cell-specific expression during development.2001

    • Author(s)
      Masamistu Futai
    • Journal Title

      J Biol. Chem. 276

      Pages: 33079-33085

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase.2001

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Journal Title

      Gene 274

      Pages: 93-99

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ATP synthase Fi sector rotation; defective torque generation in the b subunit Ser 174 to Phe mutant and its suppression by second mutations2001

    • Author(s)
      Masamistu Futai
    • Journal Title

      J. Biol. Chem. 276

      Pages: 47508-47511

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The murine genome contain one functional gene and two pseudomonas coding for the 16kDa proteolipid subunit of vacuolar H+-ATPase,2001

    • Author(s)
      Ge-Hong Sun-Wada
    • Journal Title

      Gene 273

      Pages: 199-206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] a4, a unique kidney-specific isoform of mouse vacuolar H^+-ATPase subunit a,2001

    • Author(s)
      Masamistu Futai Ge-Hong Sun-Wada
    • Journal Title

      J. Biol. Chem. 276

      Pages: 40050-40054

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A proton pump ATPase with testis-specific El subunit isoform required for acrosome acidification,2001

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Journal Title

      J. Biol. Chem. 277

      Pages: 18098-18105

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Specific recognition of Leishmania major poly-β-galactosyl epitopes by galectin-9 : Possible implication of galectin-9 in interaction between

    • Author(s)
      Masamistu Futai
    • Journal Title

      L. major and host cells J. Biol. Chem. 278

      Pages: 22223-22230

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Vacuolar-type proton ATPases : subunit isoforms and tissue-specific function. In "Handbook of ATPases : Biochemistry, Cell Biology, Pathophysiology"(Ed.by M.Futai, Y.Wada, J.Kaplan)2004

    • Author(s)
      M, Futai.
    • Total Pages
      24
    • Publisher
      Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Vacuolar-type proton ATPases : subunit isoforms and tissue-specific function. In "Handbook of ATPases Biochemistry, Cell Biology, Pathophysiology"(Ed.by M.Futai, Y.Wada, J.Kaplan)2004

    • Author(s)
      M, Futai.
    • Total Pages
      16
    • Publisher
      Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Vacuolar-type proton ATPases : subunit isoforms and tissue-specific function. In "Handbook of ATPases Biochemistry, Cell Biology, Pathophysiology"2004

    • Author(s)
      Masamistu Futai., Yo Wada
    • Total Pages
      24
    • Publisher
      (Ed. by M. Futai, Y. Wada and J. Kaplan) Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Vacuolar-type proton ATPases : subunit isoforms and tissue-specific function. In "Handbook of ATPases : Biochemistry, Cell Biology, Pathophysiology"2004

    • Author(s)
      Masamistu Futai., Ge-Hong Sun-Wada
    • Total Pages
      16
    • Publisher
      (Ed. by M. Futai, Y. Wada and J. Kaplan) Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Handbook of ATPase : Biochemistry, Cell Biology, Pathophysiology2004

    • Author(s)
      二井 將光, 和田 洋, Jack Kaplan
    • Total Pages
      469
    • Publisher
      Wiley-VCH Verlag GmbH & Co.KgaA, Weinheim, Germany(in press)
    • Related Report
      2004 Annual Research Report
  • [Publications] G.-H.Sun-Wada, T.Yoshimizu, Y.Imai-Senga, Y.Wada, M.Futai: "Diversity of mouse proton-translocating ATPase : Presence of multiple isoforms of the C, d and G subunits"Gene. 302. 147-153 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Hirata, A.Iwamoto-Kihara, T.Okajima Y.Wada, M.Futai: "Subunit rotation in vacuolar-type Proton Pumping ATPase : Relative Rotation of G as to c Subunit"J.Biol.Chem.. 278. 23714-23719 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] G.-H.Sun-Wada, Y.Wada, M.Futai: "Vacuolar H^+ pumping ATPase in luminal acidic organelles and extracellular compartments : Common rotational mechanism and diverse physiological roles"J.Bioenerg.Biomemb.. 35. 347-358 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] I.Pelletier, T.Hashidate, T.Urashima, M.Futai, M.Hirashima, N.Nishi, T.Nakamura, K.Kasai, J.Hirabayashi: "Specific recognition of Leishmania major poly-b-galactosyl epitopes by galectin-9 : Possible implication of galectin-9 in interaction between L.major and host cells"J.Biol.Chem.. 278. 22223-22230 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] J.Suzuki, H.Ohnishi, A.Wada, T.Hirayama, H.Ohno, N.Ueda, H.Yasuda, T.Iiri, Y.Wada, M.Futai, H.Mashima: "Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA."J.Biol.Chem.. 278. 25585-25590 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Toyomura, Y.Murata, A.Yamamoto, T.Oka, G.-H.Sun-Wada, Y.Wada, M.Futai: "From lysosomes to plasma membrane : Localization of vacuolar type H+-ATPase with the a3 isoform during osteoclast differentiation."J.Biol.Chem.. 278. 22023-22030 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] G.-H.Sun Wada, Y.Kamei, Y.Wada, M.Futai: "Analysis of regulatory elements directing gut-specific expression of GATA6 gene during mouse early development."J.Biol.Chem.. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.N.Smith, R.Lovering, M.Futai, J.Takeda, D.Brown, F.E.Karet: "The vacuolar-type H+-ATPase : a revised nomenclature."Molecular Cell. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Kodera, T.Okajima, H.Iwabuki, D.Kitaguchi, S.Kuroda, T.Yoshinobu, K.Tanizawa, M.Futai, H.Iwasaki: "Detection of protein-protein interactions on SiO2/Si surface by spectroscopic ellipsometry."Analytical Biochemistry. 321. 65-70 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sun-Wada, G-H, Wada, Y., Futai, M.: "Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms."Cell Struct.Func.. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] G.-H.Sun Wada, Y.Murata, M.Namba, A.Yamamoto, Y.Wada, Y., Futai, M.: "Mouse proton pump ATPase C subunit Isoforms (C2-a and C2-b) specifically expressed in kidney and lung"J Biol Chem.. 278. 44843-44851 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] G.-H.Sun-Wada, T.Yoshimizu, Y.Imai-Senga, Y.Wada, M.Futai: "Diversity of mouse proton-translocating ATPase : Presence of multiple isoforms of the C, d and G subunits"Gene. 302. 147-153 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Nishio, A.Iwamoto-Kihara, A.Yamamoto, Y.Wada, M.Futai: "Subunit rotation of ATP synthase embedded in membranes : a or β subunit rotation relative to the c subunit ring"Proc. Natl. Acad Sci. USA. 99. 13448-13452 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Murata, G.-H.Sun-Wada, T.Yoshimizu, A.Yamamoto, Y.Wada, M.Futai: "Differential localization of V-type H^+ pump with G subunit isoforms (G1 and G2) in mouse neurons"J. Biol. Chem.. 277. 36296-36303 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Imai-Senga, G.-H.Sun-Wada, Y.Wada, M.Futai: "A human gene, ATP6E1, encoding a testis-specific isoform of H^+ATPase subunit E"Gene. 289. 7-12 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Sambongi, H.Nitta, K.Ichihashi, M Futai, I.Ueda: "A novel water-soluble hantzsh 1,4-dihydropyridine compound that functions in biological processes through NADH regeneration"J. Org. Chem.. 3499-3501 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] G.-H.Sun-Wada, Y.Imai-Senga, A.Yamamoto, Y.Murata, T Hirata, Y Wada, M.Futai: "A proton pump ATPase with testis-specific E1 subunit isoform required for acrosome acidification"J. Biol. Chem.. 277. 18098-18105 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Hirata, Y.Wada, M.Futai: "Sodium and sulfate Ion transport in yeast vacuole"J. Biochem. 131. 266-265 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] J.Hirabayashi, T.Hashidate, Y.Arata, N.Nishi, T.Nakamura, M.Hirashima, T.Urashima, T.Oka, M.Futai, W.E.Muller, F.Yagi F, K.Kasai: "Oligosaccharide specificity of galectins : a search by frontal affinity chromatography"Biochim. Biophys. Acta.. 19. 232-254 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Tanabe, K.Nishio, Y.Iko, Y.Sambongi, A.Iwamoto-Kihara, H.Omote, I.Ueda, Y.Wada, M.Futai: "Rotation of a complex of the γ subunit and c ring of Escherichia coli. ATP synthase : the rotor and stator are interchangeable"J.Biol.Chem.. 276. 15269-15274 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.Iko, Y.Sambongi, M.Tanabe, A.Iwamoto-Kihara, K.Saito, I.Ueda, Y.Wada, M.Futai: "ATP synthase F1 sector rotation ; defective torque generation in the β subunit Ser-174 to Phe mutant and its suppression by second mutations"J.Biol.Chem.. 276. 47508-47611 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] G-H.Sun-Wada, H.Murakami, H.Nakai, Y.Wada, M.Futai: "Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase"Gene. 274. 93-99 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Oka, Y.Murata, M.Namba, T.Yoshimizu, T.Toyomura, A.Yamamoto, G.-H.Sun-Wada, N.Hamasaki, Y.Wada, M.Futai: "a4, a unique kidney-specific isoform of mouse vacuolar H^+-ATPase subunit a"J.Biol.Chem.. 276. 40050-40054 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Oka, T.Toyomura, K.Honjo, Y.Wada, M.Futai: "Four subunit a isoforms of Caenorhabditis elegans vacuolar H^+-ATPase : cell-specific expression during development"J.Biol.Chem.. 276. 33079-33085 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] G.-H.Sun-Wada, Y.Imai-Senga, A.Yamamoto, Y.Murata, T.Hirata, Y.Wada, M.Futai: "A proton pump ATPase with testis-specific E1 subunit isoform required for acrosome acidification"J.Biol.Chem.. 277(in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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