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Study on a network of gut signals and development of diabetes

Research Project

Project/Area Number 13204042
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

YAMADA Yuichiro  Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (60283610)

Project Period (FY) 2000 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥33,500,000 (Direct Cost: ¥33,500,000)
Fiscal Year 2004: ¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 2003: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2002: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2001: ¥10,000,000 (Direct Cost: ¥10,000,000)
KeywordsGIP / Incretin / knockout mouse / diabetes / obesity / osteoporosis / SNP / GLP-1 / incretin
Research Abstract

Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat.. Our studies revealed that GIP receptor knockout mice have higher blood glucose levels with impaired initial insulin response after oral glucose load., that GIP receptor knockout mice fed a high-fat diet were clearly protected from both the obesity and the insulin resistance, that the insulin response was almost completely lost in Kir6.2 and GIP receptor double knockout mice, and that bone formation parameters in the GIP receptor knockout mice were significantly lower and the GIP receptor knockout mice had thinner trabeculae. These results and the in vitro studies that GIP directly acts not onlypancreatic b-cells but also adipocytes and osteoblasts indicated that early insulin secretion mediated by GIP determines glucose tolerance after oral glucose load, that GIP directly links overnutrition to obesity, that GIP is the major insulinotropic factor in the secretion of insulin in response to glucose load in KATP channel-deficient mice, and that GIP directly links calcium contained in meal to calcium deposition on bone.
Therefore, GIP signaling should be activated by GIP receptor agonists or DPPIV inhibitors in diabetes with impaired insulin secretion, such as predominantly observed in Japan, and should be inhibited by GIP receptor antagonists in diabetes with insulin resistance, such as predominantly observed in western countries.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (129 results)

All 2006 2005 2004 2003 2002 2001 2000 Other

All Journal Article (113 results) Patent(Industrial Property Rights) (1 results) Publications (15 results)

  • [Journal Article] Nuclear sequestration of β-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca^<2+> channel regulation.2006

    • Author(s)
      Beguin P
    • Journal Title

      J Mol Biol 355

      Pages: 53-58

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Factors responsible for deteriorating glucose tolerance in newly diagnosed type 2 diabetes in Japanese men.2006

    • Author(s)
      Mitsui R
    • Journal Title

      Metabolism 55

      Pages: 53-58

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nuclear sequestration of β-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation.2006

    • Author(s)
      Beguin P
    • Journal Title

      J Mol Biol 3 5 5

      Pages: 53-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Factors responsible for deteriorating glucose tolerance in newly diagnosed type 2 diabetes in Japanese men.2006

    • Author(s)
      Mitsui R
    • Journal Title

      Metabolism 5 5

      Pages: 53-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chronic exposure to β-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents.2005

    • Author(s)
      Takehiro M
    • Journal Title

      Am J Physiol 288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity.2005

    • Author(s)
      Radu RG
    • Journal Title

      Am J Physiol 288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility.2005

    • Author(s)
      Miki T
    • Journal Title

      Diabetes 54

      Pages: 1056-1063

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus.2005

    • Author(s)
      Yorifuji T
    • Journal Title

      J Clin Endocrinol Metab 90

      Pages: 3174-3178

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G protein Rem2.2005

    • Author(s)
      Beguin P
    • Journal Title

      Biochem J 390

      Pages: 67-75

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity.2005

    • Author(s)
      Beguin P
    • Journal Title

      J Cell Sci 118

      Pages: 1923-1934

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Soluble TNF receptors and albuminuria in non-obese Japanese type 2 diabetic patients.2005

    • Author(s)
      Kawasaki Y
    • Journal Title

      Horm Metab Res 37

      Pages: 617-621

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nestin-positive cells in adult pancreas express amylase and endocrine precursor cells.2005

    • Author(s)
      Ueno H
    • Journal Title

      Pancreas 31

      Pages: 126-131

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of thorough mastication on postprandial plasma glucose concentrations in non-obese Japanese subjects.2005

    • Author(s)
      Suzuki H
    • Journal Title

      Metabolism 54

      Pages: 1593-1599

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.2005

    • Author(s)
      Zhou H
    • Journal Title

      Biochem Biophys Res Commun 335

      Pages: 937-942

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel therapeutic target for hyperglycemia : CDK5-dependent regulation of glucose-stimulated insulin secretion.2005

    • Author(s)
      Wei FY
    • Journal Title

      Nat Med 11

      Pages: 1104-1108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ATP enhances exocytosis of insulin secretory granules in pancreatic islets under Ca^<2+>-depleted condition.2005

    • Author(s)
      Shimono D
    • Journal Title

      Diabetes Res Clin Pract 69

      Pages: 216-223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Insulin secretion and insulin sensitivity in Japanese subjects with impaired fasting glucose and isolated fasting hyperglycemia.2005

    • Author(s)
      Nishi Y
    • Journal Title

      Diabetes Res Clin Pract 70

      Pages: 46-52

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chronic exposure to β-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents.2005

    • Author(s)
      Takehiro M
    • Journal Title

      Am J Physiol 2 8 8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity.2005

    • Author(s)
      Radu RG
    • Journal Title

      Am J Physiol 2 8 8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility.2005

    • Author(s)
      Miki T
    • Journal Title

      Diabetes 5 4

      Pages: 1056-1063

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus.2005

    • Author(s)
      Yorifuji T
    • Journal Title

      J Clin Endocrinol Metab 9 0

      Pages: 3174-3178

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the.small G protein Rem2.2005

    • Author(s)
      Beguin P
    • Journal Title

      Biochem J 3 9 0

      Pages: 67-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity.2005

    • Author(s)
      Beguin P
    • Journal Title

      J Cell Sci 1 1 8

      Pages: 1923-1934

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Soluble TNF receptors and albuminuria in non-obese Japanese type 2 diabetic patients.2005

    • Author(s)
      Kawasaki Y
    • Journal Title

      Horm Metab Res 3 7

      Pages: 617-621

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nestin-positive cells in adult pancreas express amylase and endocrine precursor cells.2005

    • Author(s)
      Ueno H
    • Journal Title

      Pancreas 3 1

      Pages: 126-131

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of thorough mastication on postprandial plasma glucose concentrations in non-obese Japanese subjects.2005

    • Author(s)
      Suzuki H
    • Journal Title

      Metabolism 5 4

      Pages: 1593-1599

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.2005

    • Author(s)
      Zhou H
    • Journal Title

      Biochem Biophys Res Commun 3 3 5

      Pages: 937-942

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel therapeutic target for hyperglycemia : CDK5-dependent regulation of glucose-stimulated insulin secretion.2005

    • Author(s)
      Wei FY
    • Journal Title

      Nat Med 1 1

      Pages: 1104-1108

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ATP enhances exocytosis of insulin secretory granules in pancreatic islets under Ca2+-depleted condition.2005

    • Author(s)
      Shimono D
    • Journal Title

      Diabetes Res Clin Pract 6 9

      Pages: 216-223

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Insulin secretion and insulin sensitivity in Japanese subjects with impaired fasting glucose and isolated fasting hyperglycemia.2005

    • Author(s)
      Nishi Y
    • Journal Title

      Diabetes Res Clin Pract 7 0

      Pages: 46-52

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity.2005

    • Author(s)
      Radu RG
    • Journal Title

      Am J Physiol 288(2)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic β cells.2004

    • Author(s)
      Inada A
    • Journal Title

      Mol Cell Biol 24

      Pages: 2831-2841

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory action of DPP-IV inhibitors.2004

    • Author(s)
      Hansotia T
    • Journal Title

      Diabetes 53

      Pages: 1326-1335

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gastric inhibitory polypeptide is the major insulinotropic factor in K_<ATP> null mice.2004

    • Author(s)
      Tsukiyama K
    • Journal Title

      Eur J Endocrinol 151

      Pages: 407-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Insulin secretion and insulin sensitivity at different stages of glucose tolerance : a cross-sectional study of Japanese type 2 diabetes.2004

    • Author(s)
      Fukushima M
    • Journal Title

      Metabolism 53

      Pages: 831-835

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without hyperglycemia.2004

    • Author(s)
      Suzuki H
    • Journal Title

      Diabetes Res Clin Pract 64

      Pages: 213-219

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic β cells.2004

    • Author(s)
      Inada A
    • Journal Title

      Mol Cell Biol 2 4

      Pages: 2831-2841

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory action of DPP-IV inhibitors.2004

    • Author(s)
      Hansotia T
    • Journal Title

      Diabetes 5 3

      Pages: 1326-1335

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gastric inhibitory polypeptide is the major insulinotropic factor in KATP null mice.2004

    • Author(s)
      Tsukiyama K
    • Journal Title

      Eur J Endocrinol 1 5 1

      Pages: 407-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Insulin secretion and insulin sensitivity at different stages of glucose tolerance : a cross-sectional study of Japanese type 2 diabetes.2004

    • Author(s)
      Fukushima M
    • Journal Title

      Metabolism 5 3

      Pages: 831-835

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without hyperglycemia.2004

    • Author(s)
      Suzuki H
    • Journal Title

      Diabetes Res Clin Pract 6 4

      Pages: 213-219

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Physiology of GIP--a lesson from GIP receptor knockout mice.2004

    • Author(s)
      Yamada Y
    • Journal Title

      Horm Metab Res 36(11-12)

      Pages: 771-774

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice.2004

    • Author(s)
      Tsukiyama K
    • Journal Title

      Eur J Endocrinol 151(3)

      Pages: 407-412

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Insulin secretion and insulin sensitivity at different stages of glucose tolerance : a cross-sectional study of Japanese type 2 diabetes.2004

    • Author(s)
      Fukushima M
    • Journal Title

      Metabolism 53(7)

      Pages: 831-835

    • Related Report
      2004 Annual Research Report
  • [Journal Article] IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia.2004

    • Author(s)
      Suzuki H
    • Journal Title

      Diabetes Res Clin Pract 64(3)

      Pages: 213-219

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.2004

    • Author(s)
      Hansotia T
    • Journal Title

      Diabetes 53(5)

      Pages: 1326-1335

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Impaired β-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance.2003

    • Author(s)
      Kuroe A
    • Journal Title

      Diabetes Res Clin Pract 59

      Pages: 71-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Factors responsible for development from normal glucose tolerance to isolated postchallenge hyperglycemia.2003

    • Author(s)
      Suzuki H
    • Journal Title

      Diabetes Care 26

      Pages: 1211-1215

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy.2003

    • Author(s)
      Sugawara F
    • Journal Title

      Diabetes Res Clin Pract 60

      Pages: 191-197

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Beneficial effect of pretreatment of islets with fibronectin on glucose tolerance after islet transplantation.2003

    • Author(s)
      Hamamoto Y
    • Journal Title

      Horm Metab Res 35

      Pages: 460-465

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients.2003

    • Author(s)
      Taniguchi A
    • Journal Title

      Metabolism 52

      Pages: 142-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Glucose-dependent insulino-tropic polypeptide receptor null mice (GIPR^<-/->) exhibit compensatory changes in the enteroinsular axis.2003

    • Author(s)
      Pamir N
    • Journal Title

      Am J Physiol 284

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impaired B-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance.2003

    • Author(s)
      Kuroe A
    • Journal Title

      Diabetes Res Clin Pract 5 9

      Pages: 71-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Factors responsible for development from normal glucose tolerance to isolated postchallenge hyperglycemia.2003

    • Author(s)
      Suzuki H
    • Journal Title

      Diabetes Care 2 6

      Pages: 1211-1215

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy.2003

    • Author(s)
      Sugawara F
    • Journal Title

      Diabetes Res ClinPract 6 0

      Pages: 191-197

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Beneficial effect of pretreatment of islets with fibronectin on glucose tolerance after islet transplantation.2003

    • Author(s)
      Hamamoto Y
    • Journal Title

      Horm Metab Res 3 5

      Pages: 460-465

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients.2003

    • Author(s)
      Taniguchi A
    • Journal Title

      Metabolism 5 2

      Pages: 142-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Glucose-dependent insulino-tropic polypeptide receptor null mice (GIPR-/-) exhibit compensatory changes in the enteroinsular axis.2003

    • Author(s)
      Pamir N
    • Journal Title

      Am J Physiol 2 8 4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets.2002

    • Author(s)
      Kajikawa M
    • Journal Title

      Diabetes 51

      Pages: 2522-2529

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hepatocyte nuclear factor-1α recruits the transcriptional co-activator p300 on the GLUT2 gene promoter.2002

    • Author(s)
      Ban N
    • Journal Title

      Diabetes 51

      Pages: 1409-1418

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inhibition of gastric inhibitory polypeptide signaling prevents obesity.2002

    • Author(s)
      Miyawaki K
    • Journal Title

      Nature Med 8

      Pages: 738-742

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of high dietary fat on insulin secretion in genetically diabetic Goto-Kakizaki rats.2002

    • Author(s)
      Shang W
    • Journal Title

      Pancreas 25

      Pages: 393-399

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets.2002

    • Author(s)
      Fujimoto S
    • Journal Title

      Endocrinology 143

      Pages: 213-221

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients.2002

    • Author(s)
      Taniguchi A
    • Journal Title

      Metabolism 51

      Pages: 1578-1581

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Treatment of streptozotocin-induced diabetes mellitus by trans-plantation of islet cells plus bone marrow cells via portal vein in rats.2002

    • Author(s)
      Ikebukuro K
    • Journal Title

      Transplantation 73

      Pages: 512-518

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets.2002

    • Author(s)
      Kajikawa M
    • Journal Title

      Diabetes 5 1

      Pages: 2522-2529

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Hepatocyte nuclear factor-1 a recruits the transcriptional co-activator p300 on the GLUT2 gene promoter.2002

    • Author(s)
      Ban N
    • Journal Title

      Diabetes 5 1

      Pages: 1409-1418

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of high dietary fat on insulin secretion in genetically diabetic Goto-Kakizaki rats.2002

    • Author(s)
      Shang W
    • Journal Title

      Pancreas 2 5

      Pages: 393-399

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets.2002

    • Author(s)
      Fujimoto S
    • Journal Title

      Endocrinology 1 4 3

      Pages: 213-221

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients.2002

    • Author(s)
      Taniguchi A
    • Journal Title

      Metabolism 5 1

      Pages: 1578-1581

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Treatment of streptozotocin-induced diabetes mellitus by trans-plantation of islet cells plus bone marrow cells via portal vein in rats.2002

    • Author(s)
      Ikebukuro K
    • Journal Title

      Transplantation 7 3

      Pages: 512-518

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients.2001

    • Author(s)
      Yamada Y
    • Journal Title

      Diabetes Metab Res Rev 17

      Pages: 213-216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel glucokinase regulator in pancreatic beta cells : precursor of propionyl-CoA carboxylase β subunit interacts with glucokinase and augments its activity.2001

    • Author(s)
      Shiraishi A
    • Journal Title

      J Biol Chem 276

      Pages: 2325-2328

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] S20G mutation of the amylin gene is associated with type II diabetes in Japanese.2001

    • Author(s)
      The Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus
    • Journal Title

      Diabetologia 44

      Pages: 906-909

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human TSC-22 gene : no association with type 2 diabetes.2001

    • Author(s)
      Sugawara F
    • Journal Title

      Intern Med 40

      Pages: 993-997

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Use of the insulin sensitivity index obtained from oral glucose tolerance test in Japanese subjects.2001

    • Author(s)
      Taniguchi T
    • Journal Title

      Diabetes Res Clin Pract 54

      Pages: 143-144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Recovery of function and mass of endogenous β-cells in streptozotocin-induced diabetic rats treated with islet transplantation.2001

    • Author(s)
      Hamamoto Y
    • Journal Title

      Biochem Biophys Res Commun 287

      Pages: 104-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Synergistic effect of polymorphisms of uncoupling protein 1 and β_3 adrenergic receptor genes on autonomic nervous system activity.2001

    • Author(s)
      Shihara N
    • Journal Title

      Int J Obes 25

      Pages: 761-766

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct effect of diazoxide on insulin secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets.2001

    • Author(s)
      Shen ZP
    • Journal Title

      Diabetes Res Clin Pract 53

      Pages: 9-16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Heat shock restores insulin secretion after injury by nitric oxide by maintaining glucokinase activity in rat islets.2001

    • Author(s)
      Takeda T
    • Journal Title

      Biochem Biophys Res Commun 284

      Pages: 20-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic variation in the hepatocyte nuclear factor (HNF)-3α gene does not contribute to maturity-onset diabetes of the young in Japanese.2001

    • Author(s)
      Yu L
    • Journal Title

      Horm Metab Res 33

      Pages: 163-166

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients.2001

    • Author(s)
      Yamada Y
    • Journal Title

      Diabetes Metab ResRev 1 7

      Pages: 213-216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel glucokinase regulator in pancreatic beta cells : precursor of propionyl-CoA carboxylase β subunit interacts with glucokinase and augments its activity.2001

    • Author(s)
      Shiraishi A
    • Journal Title

      J Biol Chem 2 7 6

      Pages: 2325-2328

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus S2OG mutation of the amylin gene is associated with type II diabetes in Japanese.2001

    • Journal Title

      Diabetologia 4 4

      Pages: 906-909

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human TSC-22 gene : no association with type 2 diabetes.2001

    • Author(s)
      Sugawara F
    • Journal Title

      Intern Med 4 0

      Pages: 993-997

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Use of the insulin sensitivity index obtained from oral glucose tolerance test in Japanese subjects.2001

    • Author(s)
      Taniguchi T
    • Journal Title

      DiabetesRes Clin Pract 5 4

      Pages: 143-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Recovery of function and mass of endogenous β-cells in streptozotocin-induced diabetic rats treated with islet transplantation.2001

    • Author(s)
      Hamamoto Y
    • Journal Title

      Biochem Biophys Res Commun 2 8 7

      Pages: 104-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Synergistic effect of polymorphisms of uncoupling protein 1 and β3-adrenergic receptor genes on autonomic nervous system activity.2001

    • Author(s)
      Shihara N
    • Journal Title

      Int J Obes 2 5

      Pages: 761-766

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distinct effect of diazoxide on insulin secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets.2001

    • Author(s)
      Shen ZP
    • Journal Title

      Diabetes Res Clin Pract 5 3

      Pages: 9-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Heat shock restores insulin secretion after injury by nitric oxide by maintaining glucokinase activity in rat islets.2001

    • Author(s)
      Takeda T
    • Journal Title

      Biochem Biophys Res Commun 2 8 4

      Pages: 20-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetic variation in the hepatocyte nuclear factor (HNF)-3 a gene does not contribute to maturity-onset diabetes of the young in Japanese.2001

    • Author(s)
      Yu L
    • Journal Title

      Horm Metab Res 3 3

      Pages: 163-166

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.2000

    • Author(s)
      Ban N
    • Journal Title

      Diabetes 49

      Pages: 1142-1148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Augmentation of basal insulin release from rat islets by preexposure to a high concentration of glucose.2000

    • Author(s)
      Fujimoto S
    • Journal Title

      Am J Physiol 279

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Serum 4-hydroxy-2-nonenal-modified albumin is elevated in the patients with type 2 diabetes mellitus.2000

    • Author(s)
      Toyokuni S
    • Journal Title

      Antiox Redox Signal 2

      Pages: 681-685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] α-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes.2000

    • Author(s)
      Ihara Y
    • Journal Title

      FEBS Lett 473

      Pages: 24-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The insulinotropic mechanism of the novel hypoglycaemic agent JTT-608 : direct enhancement of Ca^<2+> efficacy and increase of Ca^<2+> influx by phosphodiesterase inhibition.2000

    • Author(s)
      Mukai E
    • Journal Title

      Br J Pharmacol 129

      Pages: 901-908

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sustained enhancement of Ca^<2+> influx by glibenclamide induces apoptosis in RINm5F cells.2000

    • Author(s)
      Iwakura T
    • Journal Title

      Biochem Biophys Res Commun 271

      Pages: 422-428

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Wotmannin, PI3-kinase inhibitor : promoting effect on insulin secretion from pancreatic β cells through a cAMP-dependent pathway.2000

    • Author(s)
      Nunoi K
    • Journal Title

      Biochem Biophys Res Commun 270

      Pages: 798-805

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of epinephrine on GLUT2 protein content in mouse liver.2000

    • Author(s)
      Miura T
    • Journal Title

      Biol Pharm Bull 23

      Pages: 1374-1376

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] T-1095, a renal Na^+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic rats. M2000

    • Author(s)
      Adachi T
    • Journal Title

      Metabolism 49

      Pages: 990-995

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.2000

    • Author(s)
      Ban N
    • Journal Title

      Diabetes 49 2000

      Pages: 1142-1148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] a-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes.2000

    • Author(s)
      Ihara Y
    • Journal Title

      FEBS Lett 4 7 3

      Pages: 24-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The insulinotropic mechanism of the novel hypoglycaemic agent JTT-608 : direct enhancement of Ca2+ efficacy and increase of Ca2+ influx by phosphodiesterase inhibition.2000

    • Author(s)
      Mukai E
    • Journal Title

      Br J Pharmacol 1 2 9

      Pages: 901-908

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sustained enhancement of Ca2+ influx by glibenclamide induces apoptosis in RINm5F cells.2000

    • Author(s)
      Iwakura T
    • Journal Title

      Biochem Biophys Res Commun 2 7 1

      Pages: 422-428

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] PI3-kinase inhibitor : promoting effect on insulin secretion from pancreatic β cells through a cAMP-dependent pathway.2000

    • Author(s)
      Nunoi K Wotmannin
    • Journal Title

      Biochem Biophys Res Commun 2 7 0

      Pages: 798-805

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of epinephrine on GLUT2 protein content in mouse liver.2000

    • Author(s)
      Miura T
    • Journal Title

      Biol Pharm Bull 2 3

      Pages: 1374-1376

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] a renal Na+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic rats.2000

    • Author(s)
      Adachi T T-1095
    • Journal Title

      Metabolism 4 9

      Pages: 990-995

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Successful islet transplantation from non-heart-beating donor pancreata using modified Ricordi islet isolation method.

    • Author(s)
      Matsumoto S
    • Journal Title

      Transplantation (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement.

    • Author(s)
      Sassa M
    • Journal Title

      Diabetes Res Clin Pract (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation following food ingestion.

    • Author(s)
      Tsukiyama K
    • Journal Title

      Mol Endocrinol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Successful islet transplantation from non-heart-beating donor pancreata using modified Ricordi islet isolation method.

    • Author(s)
      Matsumoto S
    • Journal Title

      Transplantation (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement.

    • Author(s)
      Sassa M
    • Journal Title

      Diabetes Res Clin Pract (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation following food ingestion.

    • Author(s)
      Tsukiyama K
    • Journal Title

      Mol Endocrinol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] インスリン抵抗性及び/又は肥満の予防剤もしくは改善剤2001

    • Inventor(s)
      清野裕, 宮脇一真, 山田祐一郎, 坂信広, 鍔本義治, 武田基弘, 橋本洋幸, 山下篤行, 城森孝仁
    • Industrial Property Rights Holder
      清野裕, 宮脇一真, 山田祐一郎, 坂信広, 鍔本義治, 武田基弘, 橋本洋幸, 山下篤行, 城森孝仁
    • Industrial Property Number
      2001-144416
    • Filing Date
      2001-05-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Hansotia T et al.: "Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory action of DPP-IV inhibitors"Diabetes. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Inada A et al.: "Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic B cells."Mol Cell Biol. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugawara F et al.: "The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy."Diabetes Res Clin Pract. 60(3). 191-197 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Suzuki H et al.: "IGT with fasting hyperglycemia is more strongly associated with microalbuminuria that IGT without hyperglycemia."Diabetes Res Clin Pract. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyawaki K: "Inhibition of gastric inhibitory polypeptide signaling prevents obesity"Nature Med. 8(7). 738-742 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Pamir N: "Glucose-dependent Insulinotropic Polypeptide Receptor Null Mice (GIPR-/-) Exhibit Compensatory Changes in the Enteroinsular Axis"Am J Physiol Endocrinol Metab. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue S: "Mutation analysis in PKD1 of Japanese autosomal dominant polycystic kidney disease patients"Hum Mutat. 19(6). 622-628 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Taniguchi A: "C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients"Metabolism. 51(12). 1578-1581 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kuroe A: "Impaired β-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance"Diabetes Res Clin Pract. 59(1). 71-77 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shang W: "Effect of high dietary fat on insulin secretion in genetically diabetic Goto-Kakizaki rats"Pancreas. 25(4). 393-399 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sugawara F: "Human TSC-22 gene : no association with type 2 diabetes"Intern Med. 40(10). 993-997 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Taniguchi T: "Use of the insulin sensitivity index obtained from oral glucose tolerance test in Japanese subjects"Diabetes Res Clin Pract. 54(2). 143-144 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shihara N: "Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity"Int J Obes. 25(6). 761-766 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamada Y: "Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients"Diabetes Metab Res Rev. 17(3). 213-216 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shiraishi A: "A novel glucokinase regulator in pancreatic beta cells"J Biol Chem. 276(4). 2325-2328 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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