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MUTATIONAL ANALYSIS OF THE PARKIN GENE AND FUNCTIONAL ANALYSIS OF THE PARKIN PROTEIN

Research Project

Project/Area Number 13210122
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionJUNTENDO UNIVERSITY

Principal Investigator

MIZUNO Yoshikuni  JUNTENDO UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF NEUROLOGY, PROFESSOR, 医学部, 教授 (30049043)

Co-Investigator(Kenkyū-buntansha) HATTORI Nobutaka  JUNTENDO UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF NEUROLOGY, ASSOCIATE PROFESSOR, 医学部, 助教授 (80218510)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥66,000,000 (Direct Cost: ¥66,000,000)
Fiscal Year 2004: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2003: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2002: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2001: ¥18,000,000 (Direct Cost: ¥18,000,000)
KeywordsParkinson's disease / Parkin / Alpha-synulcein / PINK1 / DJ-1 / LRRK2 / Pathogenesis / Familial Parkinson's disease / 神経細胞死 / 14-3-3蛋白 / ドパミンキノン / ドパミン自動酸化 / CDCrel-1 / シヌクレイン
Research Abstract

We investigated mutations in the parkin gene, which had been cloned by our group, in more than 500 families with Parkinsons's disease. We found parkin mutations in approximately 50% of autosomal recessive families. In addition, among parkin-negative families, we found 8 families with PINK] mutations (PARK6), 10 families with LRRK2 mutations (PARK8), and 2 families with duplication of the alpha-synuclein gene (PARK 1). We did not find DJ-1 mutations (PARK7). Regarding the function of Parkin protein, we found that 14-3-3 protein was a regulatory protein for Parkin, in that 14-3-3 was attaching the linger region of Parkin and negatively regulating the enzymatic activity of Parkin as E3 of the ubiquitin system. Upon oxidative stress, alpha-synuclein is upregulated and attaches to 14-3-3; then the conjugate of these two proteins detaches from Parkin releasing the activity of Parkin as E3. We further revealed that parkin knockout SH-SY5Y cells showed increase in dopamine quinone formation in … More ducing oxidative stress. These two observations are consistent with each other indicating a possible mechanism for selective damage of nigral neurons in PARK2, in that neurons not exposed to oxidative stress do not require much of Parkin activity. It has been a question why Parkin-interacting proteins were not accumulated in nigral neurons of PARK2 patients. As an answer for this question, we found an evidence to indicate lysine-63 mediated polyubiquitilation by Parkin. We found that LMO4, a transcription regulatory protein, underwent Lys-63 mediated polyubiqutilationm which did not confer a signal for degradation by 26S proteasome. Lys-63 mediated polyubiquitylated proteins have different biological roles such as DNA repair and endocytosis among others. This observation opens new approaches for the investigation of the pathogenesis of PARK2. Furthermore, we succeeded in the production of hemi-parkinsonism rat model by transfecting alpha-synuclein gene using AAV vector. Co-transfection of parkin partially prevented the loss of nigral neurons in this model. This approach can be extended to gene therapy of human patients with Parkinson's disease. Less

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (72 results)

All 2005 2004 2003 2002 2001 Other

All Journal Article (52 results) Book (2 results) Publications (18 results)

  • [Journal Article] Parkin gene therapy for a-synucleinopathy : A rat model of Parkinson's disease2005

    • Author(s)
      Yamada et al.
    • Journal Title

      Hum Gene Therapy 16

      Pages: 262-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Phosphtorylated I κ ka is a component of Lewy body of Parkinson's disease2005

    • Author(s)
      Noda K, Mizuno Y. et al.
    • Journal Title

      Biochem Biophy Res Commun 331

      Pages: 309-317

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Phosphtorylated I κ kα is a component of Lewy body of Parkinson's disease.2005

    • Author(s)
      Noda K, Kitami T, Gai WP, Chegini F, Jensen PH, Fimura T, Murayama K, Tanaka K, Mizuno Y, Hattori N.
    • Journal Title

      Biom Biophy Res Commun 331

      Pages: 309-317

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin gene therapy for α-synucleinopathy : A rat model of Parkinson's disease.2005

    • Author(s)
      Yamada M, Mizuno Y, Mochizuki H.
    • Journal Title

      Hum Gene Therapy 16

      Pages: 262-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pathophysiology of Parkinson's Disease, Neurochemical Pathology2005

    • Author(s)
      Mizuno Y
    • Journal Title

      CEC Press

      Pages: 443-477

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease2004

    • Author(s)
      Hattori N, Mizuno Y
    • Journal Title

      Lancet 364

      Pages: 722-724

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel PINK1 mutations in early-onset parkinsonism2004

    • Author(s)
      Hatano et al.
    • Journal Title

      Ann Neurol 56

      Pages: 424-427

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Overexpression of a-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of a-synuclein and activation of caspase-9 : resemblance to pathogenetic changes in Parkinson's disease2004

    • Author(s)
      Yamada et al.
    • Journal Title

      J Neurochem 91

      Pages: 451-461

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interl eukin-1 β,and expression of caspase-11 in mice.2004

    • Author(s)
      Arai H, Mizuno Y. et al.
    • Journal Title

      J Biol Chem 279

      Pages: 51647-51653

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] PARK6-linked autosomal recessive early-onset parkinsonism In Asian populations2004

    • Author(s)
      Hatano Y, Mizuno Y. et al.
    • Journal Title

      Neurology 63

      Pages: 1482-1485

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin attenuates manganese-induced dopaminergic cell death.2004

    • Author(s)
      Higashi Y, Mizuno Y. et al.
    • Journal Title

      J Biol Chem 89

      Pages: 1490-1497

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin and endoplasimic reticulum stress.2004

    • Author(s)
      Takahashi R, Mizuno Y. et al.
    • Journal Title

      Ann NY Acad Sci 99

      Pages: 101-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ubiquitin, proteasome and parkin2004

    • Author(s)
      Tanaka K, Mizuno Y. et al.
    • Journal Title

      Biochim Biophys Acta 1695

      Pages: 235-247

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1 β, and expression of caspase-11 in mice.2004

    • Author(s)
      Arai H, Furuya T, Yasuda T, Miura M, Mizuno Y, Mochizuki H.
    • Journal Title

      J Biol Chem 279

      Pages: 51647-51653

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel PINK 1 mutations in early-onset parkinsonism.2004

    • Author(s)
      Hatano Y, Li Y, Sato K, Asakwa S, Yamamura Y, Tomiyama H, Yoshino H, Asahina M, Kobyshi S, Ng Ar, Rosals RL, Hassin-Bear S, Shinar Y, Lu CS, Shimizu N, Toda T, Mizuno Y, Hattori N.
    • Journal Title

      Ann Neuro 56

      Pages: 424-427

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] PARK6-linked autosomal recessive early-onset parkinsonism In Asian populations.2004

    • Author(s)
      Hatano Y, Sato K, Elibol B, Yoshino H, Yamamura Y, Bonifati V Shinotoh H, Asahina M, Kobayshi S, Ng Ar, RosalesRL, Hassin-Bear S, Shinar Y, Lu CS, Chang HC, Wu Chou Y, Atac FB, Kobayashi T, Toda T, Mizuno Y, Hattori N.
    • Journal Title

      Neurology 63

      Pages: 1482-1485

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease.2004

    • Author(s)
      Hattori N, Mizuno Y.
    • Journal Title

      Lancet 364

      Pages: 722-724

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin attenuates manganese-induced dopaminergic cell death.2004

    • Author(s)
      Higashi Y, Asanuma M, Miyazaki I, Hattori N, Mizuno Y, Ogawa N.
    • Journal Title

      J Biol Chem 89(6)

      Pages: 1490-1497

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin and endoplasimic reticulum stress.2004

    • Author(s)
      Takahashi R, Imai Y, Hattori N, Mizuno Y.
    • Journal Title

      Ann NY Acad Sci 99

      Pages: 101-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ubiquitin, proteasome and parkin.2004

    • Author(s)
      Tanaka K, Suzuki T, Hattori N, Mizuno Y.
    • Journal Title

      Biochim Biophys Acta 29 1695

      Pages: 235-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Over expression of a-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of a-synuclein and activation of caspase-9 : resemblance to pathogenetic changes in Parkinson's disease.2004

    • Author(s)
      Yamada M, Iwatubo T, Mizuno Y, Mochizuki H.
    • Journal Title

      J Neurochem 91

      Pages: 451-461

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] PARK6-linked sutosomal recessive early-onset parkinsonism in Asian populations.2004

    • Author(s)
      Hatano Y et al.
    • Journal Title

      Neurology 63

      Pages: 1482-1485

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Parkin attenuates manganese-induced dopaminergic cell death2004

    • Author(s)
      Higashi Y et al.
    • Journal Title

      J Neurochem 89

      Pages: 1490-1497

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.2004

    • Author(s)
      Furuya T et al.
    • Journal Title

      J Neurosci 24

      Pages: 1865-1872

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pathogenetic mechanisms of parkin in Parkinson's disease.2004

    • Author(s)
      Hattori N et al.
    • Journal Title

      Lancet 364

      Pages: 722-724

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Blepharospasm associated with multiple system atrophy : a case report and review of the literature.2004

    • Author(s)
      Kagohashi M et al.
    • Journal Title

      Parkinsonism Rel Disord 10

      Pages: 169-171

    • Related Report
      2004 Annual Research Report
  • [Journal Article] verexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of casepase-9 : resemblance to pathogenetic changes in Parkinson's disease.2004

    • Author(s)
      Yamada M et al.
    • Journal Title

      J Neurochem 91

      Pages: 451-461

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Haploinsufficiency at the α-synuclein gene underlies phenotypic severity in familial Parkinson's disease2003

    • Author(s)
      Kobayashi H et al.
    • Journal Title

      Brain 126

      Pages: 32-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology.2003

    • Author(s)
      Kobayashi T, Mizuno Y. et al.
    • Journal Title

      Ann. Neurol 53

      Pages: 133-137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain.2003

    • Author(s)
      Kim SJ, Mizuno Y. et al.
    • Journal Title

      J Biol Chem. 278

      Pages: 41890-41899

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology.2003

    • Author(s)
      Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M, Mizuno Y, Mori H.
    • Journal Title

      Ann.Neurol. 53

      Pages: 133-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain.2003

    • Author(s)
      Kim SJ, Sung JY, Urn JW, Hattori N, Mizuno Y, Tanaka K, Paik SR, Kim J, Chung KC.
    • Journal Title

      J Biol Chem. 278

      Pages: 41890-41899

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Haploinsufficiency at the a-synuclein gene underlies phenotypic severity in familial Parkinson's disease.2003

    • Author(s)
      Kobayashi H, Kruger R, Markopoulou K, Wszolek Z, Chase B, Taka H, Mineki R, Murayama K, Riess O, Mizuno Y, Hattori N.
    • Journal Title

      Brain. 126(Pt 1)

      Pages: 32-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genetics of Movement Disorders2003

    • Author(s)
      Mizuno Y et al.
    • Journal Title

      Academic Press

      Pages: 305-314

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of wild-type or mutant Parkin on oxidative damagnitic oxide antioxidant defenses, and the proteasome2002

    • Author(s)
      Hyun DH, Mizuno Y. et al.
    • Journal Title

      J Biol Chem 277

      Pages: 28572-28577

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.2002

    • Author(s)
      Schossmacher MG, Mizuno Y. et al.
    • Journal Title

      Am J Pathol 160

      Pages: 1655-1667

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of wild-type or mutant Parkin on oxidative damage nitic oxide antioxidant defenses, and the proteasome.2002

    • Author(s)
      Hyun DH, Lee M, Hattori N, Kubo S, Mizuno Y, Halliwell B, Jenner P.
    • Journal Title

      J Biol Chem 277(32)

      Pages: 28572-28577

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.2002

    • Author(s)
      Schossmacher MG, Frosch MP, Ping-Gai W, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik K.
    • Journal Title

      Am J Pathol 160

      Pages: 1655-1667

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin is associated with cellular vesicles2001

    • Author(s)
      Kubo et al.
    • Journal Title

      J Neurochem 78

      Pages: 42-54

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin.2001

    • Author(s)
      Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R
    • Journal Title

      Cell 105

      Pages: 891-902

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin and Parkinson's disease.2001

    • Author(s)
      Mizuno Y, Hattori N, Mori H, Suzuki T, Tanaka K
    • Journal Title

      Curr Opin Neurol 14

      Pages: 477-482

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An AAV-derived apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease.2001

    • Author(s)
      Mochizuki H, Mizuno Y. et al.
    • Journal Title

      PNAS 98

      Pages: 10918-10923

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ubiquitination of a new form of a-synuclein by parkin from Human brain : Implications for Parkinson's disease.2001

    • Author(s)
      Shimura H, Mizuno Y. et al.
    • Journal Title

      Science 293

      Pages: 263-269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin is linked to the ubiquitin pathway.2001

    • Author(s)
      Tanaka K, Mizuno Y. et al.
    • Journal Title

      J Mol Med 79

      Pages: 482-494

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rato brain.2001

    • Author(s)
      Wang M, Mizuno Y. et al.
    • Journal Title

      J Neurochem 77

      Pages: 1561-1568

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin.2001

    • Author(s)
      Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R.
    • Journal Title

      Cell 105

      Pages: 891-902

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin is associated with cellular vesicles.2001

    • Author(s)
      Kubo S, Kitami T, Noda S, Shimura H, Uchiyama Y, Asakawa S, Minoshima S, Shimizu N, Mizuno Y, Hattori N.
    • Journal Title

      J Neruochem 78

      Pages: 42-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin and Parkinson's disease.2001

    • Author(s)
      Mizuno Y, Hattori N, Mori H, Suzuki T, Tanaka K.
    • Journal Title

      Curr Opin Neurol 14

      Pages: 477-482

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An AAV-derived apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease.2001

    • Author(s)
      Mochizuki H, Hayakawa H, Migita M, Shibata M, Tanaka R, Suzuki A, Shimo-Nakanishi Y, Urabe T, Yamada M, Tamayose K, Shimada T, Miura M, Mizuno Y.
    • Journal Title

      PNAS 98

      Pages: 10918-10923

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ubiquitination of a new form of a-synuclein by parkin from Human brain : Implications for Parkinson's disease.2001

    • Author(s)
      Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.
    • Journal Title

      Science 293

      Pages: 263-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Parkin is linked to the ubiquitin pathway.2001

    • Author(s)
      Tanaka K, Suzuki T, Chiba T, Shimura H, Hattori N, Mizuno Y.
    • Journal Title

      J Mol Med 79

      Pages: 482-494

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rato brain.2001

    • Author(s)
      Wang M, Suzuki T, Kitada T, Asakawa S, Minoshima S, Shimizu N, Tanaka K, Mizuno Y, Hattori N.
    • Journal Title

      J Neurochem 77

      Pages: 1561-1568

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Pathophysiology of Parkinson's Disease, Neurochemical Pathology2005

    • Author(s)
      Mizuno Y
    • Publisher
      CEC Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Genetics of Movement Disorders2003

    • Author(s)
      Mizuno Y et al.
    • Publisher
      Academic Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Sakata E et al.: "Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitn-like domain"EMBO Rep. 4. 301-306 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Gouider-Khouja N et al.: "Autosomal recessive parkinsonism linked to parkin gene in Tunisian family. Clinical, genetic and pathological study"Parkinsonism Rel Disord. 9. 247-251 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kobayashi H et al.: "Haploinsufficiency at the α-synuclein gene underlies phenotypic severity in familial Parkinson's disease"Brain. 126. 32-42 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kobayashi T et al.: "Pseudo-autosomal dominant inheritance of PARK2 : two families with parkin gene mutations"J Neurol Sci. 207. 11-17 (2000, 2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inzelberg R et al.: "Camptocoemia, axial dystonia, and parkinsonism : Phenotypic heterogeneity of a parkin mutation"Neurology. 60. 1393-1394 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mizuno Y et al.: "Randomized, double-blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease"Mov Disord. 18. 1149-1156 (2003)

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      2003 Annual Research Report
  • [Publications] Kobayashi H, et al.: "Haploinsufficiency at the a-synuclein gene underlies phenotypic severity in familial Parkinson's disease"Brain. (in press). (2003)

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      2002 Annual Research Report
  • [Publications] Mori H, et al.: "Genotype-Phenotype Correlation: Familial Parkinson Disease"Neuropathology. (in press). (2003)

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      2002 Annual Research Report
  • [Publications] Takanashi M, et al.: "Expression patterns of tau mRNA isoforms correlate with susceptible lesions in progressive supranuclear palsy and corticobasal degeneration"Mol Brain Res. (in press). (2003)

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      2002 Annual Research Report
  • [Publications] Schlossmacher MG et al.: "Parkin localizes to the lewy bodies of Parkinson disease and dementia with lewy bodies"Amer J Pathol. 166. 1655-1667 (2002)

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      2002 Annual Research Report
  • [Publications] Suzuki A et al.: "Feasibility of ex vivo gene therapy for neurological disorders using the new retroviral GCDNsap packaged in the vesicular stomatitis virus G protein"J Neurochem. 82. 953-960 (2002)

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      2002 Annual Research Report
  • [Publications] Tanaka R et al.: "Induction of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in rat brain after focal ischemia/reperfusion"J Cereb Blood Flow Metab. 22. 280-288 (2002)

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      2002 Annual Research Report
  • [Publications] Imai Y, , et al.: "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin"Cell. 105. 891-902 (2001)

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      2001 Annual Research Report
  • [Publications] Kubo S, et al.: "Parkin is associated with cellular vesicles"J Neruochem. 78. 42-54 (2001)

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      2001 Annual Research Report
  • [Publications] Lu CS, et al.: "Clinical and genetic studies on familial parkinsonism : The first report on a parkin gene mutation in a Taiwanese family"Mov Disord. 253. 164-166 (2001)

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  • [Publications] Shimura H, et al.: "Ubiquitination of a new form of α-synuclein by parkin from human brain : Implications for Parkinson's disease"Science. 293. 263-269 (2001)

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      2001 Annual Research Report
  • [Publications] Takanashi M, et al.: "ron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP)"Parkinsonism Related Disord. 7. 311-314 (2001)

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      2001 Annual Research Report
  • [Publications] Wang M, et al.: "Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme in rato brain"J Neurochem. 77. 1561-1568 (2001)

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Published: 2001-04-01   Modified: 2018-03-28  

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