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Measles virus receptors and the pathogenesis of measles

Research Project

Project/Area Number 13226089
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKYUSHU UNIVERCITY

Principal Investigator

YANAGI Yusuke  Kyushu University, Faculty of Medicine, Professor, 大学院医学研究院, 教授 (40182365)

Project Period (FY) 2001 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥64,600,000 (Direct Cost: ¥64,600,000)
Fiscal Year 2005: ¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 2004: ¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 2003: ¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 2002: ¥14,000,000 (Direct Cost: ¥14,000,000)
Keywordsmeasles virus / virus receptor / SLAM / CD150 / animal model / 麻疹ウイルス / インターフェロン / レセプター
Research Abstract

Measles virus (MV) causes a common acute infectious disease characterized by fever, cough and a generalized maculopapular rash. It mainly targets cells of the immune system, and induces profound immunosuppression. Signaling lymphocyte activation molecule (SLAM ; also called CD150), which is expressed on cells of the immune system, acts as a cellular receptor for MV. In this study, we have revealed the following findings.
1. Few viruses in the bodies of patients with measles use CD46, a receptor for vaccine strains of MV.
2. MV can, albeit inefficiently, infect SLAM-negative cells via a SLAM-and CD46-independent pathway.
3. MV may adapt to use CD46 as an alternative receptor through the changes in the H protein. The changes in M and L proteins may also allow MV to adapt to the efficient growth on cultured cells by facilitating MV replication at post-entry steps.
4. Measles, canine distemper and rinderpest viruses are members of the genus Morbillivirus. Canine distemper and rinderpest viruses use dog and cow SLAM as cellular receptors, respectively.
5. The V domain of the human SLAM is necessary and sufficient for MV receptor function, and a residue at position 61 and its adjacent residues in SLAM play important roles in its interaction with the H protein of MV
6. SLAM knockin mice in which the V domain of mouse SLAM is replaced by the corresponding human molecule reproduce the tropism of MV.
These results indicate that SLAM is the principal cellular receptor for MV in vivo, and that SLAM plays an important role in the tropism and pathogenesis of MV. Furthermore, SLAM knockin mice will prove a useful small animal model in elucidating detailed pathogenesis and immune responses during MV infection.

Report

(6 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (54 results)

All 2006 2005 2004 2003 2002 2001 Other

All Journal Article (39 results) Publications (15 results)

  • [Journal Article] Generation of measles virus with a segmented RNA genome2006

    • Author(s)
      Takeda M et al.
    • Journal Title

      J. Virol. 80

      Pages: 4242-4248

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Recombinant wild-type measles virus containing a single N481Y substitution in its haemagglutinin cannot use receptor CD46 as efficiently as that having the haemagglutinin of the Edmonston laboratory strain2006

    • Author(s)
      Seki et al.
    • Journal Title

      J. Gen. Virol. 87

      Pages: 1643-1648

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Generation of measles virus with a segmented RNA genome2006

    • Author(s)
      Takeda M, Nakatsu Y, Ohno S, Seki F, Tahara M, Hashiguchi T, Yanagi Y.
    • Journal Title

      J Virol 80

      Pages: 4242-4248

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Recombinant wild-type measles virus containing a single N481Y substitution in its haemagglutinin cannot use receptor CD46 as efficiently as that having the haemagglutinin of the Edmonston laboratory strain2006

    • Author(s)
      Seki F, Takeda M, Minagawa H, Yanagi Y.
    • Journal Title

      J Gen Virol 87

      Pages: 1643-1648

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Measles virus receptors and tropism2006

    • Author(s)
      Yanagi Y et al.
    • Journal Title

      Japanese Journal of Infectious Diseases 59

      Pages: 1-5

    • NAID

      40007325329

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Generation of measles virus with a segmented RNA genome2006

    • Author(s)
      Takeda M et al.
    • Journal Title

      Journal of Virology 80(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The recombinant wild-type measles virus containing a single N481Y substitution in its haemagglutinin cannot use receptor CD46 as efficiently as that having the haemagglutinin of the Edmonston laboratory strain2006

    • Author(s)
      Seki F et al.
    • Journal Title

      Journal of General Virology 87(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Contributions of matrix and large protein genes of the measles virus Edmonston strain to growth in cultured cells as revealed by recombianant viruses2005

    • Author(s)
      Tahara et al.
    • Journal Title

      J. Virol. 79

      Pages: 15218-15225

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Efficient rescue of measles virus from cloned cDNA using SLAM-expressing Chinese hamster ovary cells2005

    • Author(s)
      Takeda M et al.
    • Journal Title

      Virus Res. 108

      Pages: 161-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity2005

    • Author(s)
      Takeda M et al.
    • Journal Title

      J. Virol. 79

      Pages: 14346-14354

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Efficient rescue of measles virus from cloned cDNA using SLAM-expressing Chinese hamster ovary cells2005

    • Author(s)
      Takeda M, Ohno S, Seki F, Hashimoto K, Miyajima N, Takeuchi K, Yanagi Y.
    • Journal Title

      Virus Res 108

      Pages: 161-165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity2005

    • Author(s)
      Takeda M, Ohno S, Seki F, Nakatsu Y, Tahara M, Yanagi Y.
    • Journal Title

      J Virol 79

      Pages: 14346-14354

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Contributions of matrix and large protein genes of the measles virus edmonston strain to growth in cultured cells as revealed by recombinant viruses2005

    • Author(s)
      Tahara M, Takeda M, Yanagi Y.
    • Journal Title

      J Virol 79

      Pages: 15218-15225

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Efficient rescue of measles virus from cloned cDNA using SLAM-expressing Chinese hamster ovary cells2005

    • Author(s)
      Takeda M et al.
    • Journal Title

      Virus Research 108

      Pages: 161-165

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity2005

    • Author(s)
      Takeda M et al.
    • Journal Title

      Journal of Virology 79

      Pages: 14346-14354

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Contributions of matrix and large protein genes of the measles virus Edmonston strain to growth in cultured cells as revealed by recombinant viruses2005

    • Author(s)
      Tahara M et al.
    • Journal Title

      Journal of Virology 79

      Pages: 15218-15225

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Efficient rescue of measles virus from cloned cDNA using SLAM-expressing Chinese hamster ovary cells2005

    • Author(s)
      Takeda, M. et al.
    • Journal Title

      Virus Research 108(1-2)

      Pages: 161-165

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dissection of measles virus V protein in relation to its ability to block alpha/beta interferon signal transduction2004

    • Author(s)
      Ohno et al.
    • Journal Title

      J. Gen. Virol. 85

      Pages: 2991-2999

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dissection of measles virus V protein in relation to its ability to block alpha/beta interferon signal transduction2004

    • Author(s)
      Ohno S, Ono N, Takeda M, Takeuchi K, Yanagi Y.
    • Journal Title

      J Gen Virol 85

      Pages: 2991-2999

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dissection of measles virus V protein in relation to its ability to block alpha/beta interferon signal transduction2004

    • Author(s)
      Ohno, S. et al.
    • Journal Title

      Journal of General Virology 85(10)

      Pages: 2991-2999

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cell tropism of wild-type measles virus is affected by amino acid substitutions in the P, V and M proteins, or by a truncation in the C protein2004

    • Author(s)
      Miyajima, N. et al.
    • Journal Title

      Journal of General Virology 85(10)

      Pages: 3001-3006

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in TH2 cytokine regulation2004

    • Author(s)
      Davidson, D. et al.
    • Journal Title

      Immunity 21(5)

      Pages: 707-717

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus2004

    • Author(s)
      Ishida, H. et al.
    • Journal Title

      Microbiology and Immunology 48(4)

      Pages: 277-287

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Histidine at positon 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus2003

    • Author(s)
      Ohno et al.
    • Journal Title

      J. Gen. Virol. 84

      Pages: 2381-2388

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells2003

    • Author(s)
      Seki et al.
    • Journal Title

      J. Virol. 77

      Pages: 9943-9950

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus2003

    • Author(s)
      Ohno S, Seki F, Ono N, Yanagi
    • Journal Title

      J Gen Virol 84

      Pages: 2381-2388

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD 150) and their adaptability to marmoset B95a cells2003

    • Author(s)
      Seki F, Ono N, Yamaguchi R, Yanagi
    • Journal Title

      J Virol 77

      Pages: 9943-9950

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150)2002

    • Author(s)
      Tanaka et al.
    • Journal Title

      Arch. Virol. 147

      Pages: 195-203

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] SLAM (CD150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein2002

    • Author(s)
      Hashimoto et al.
    • Journal Title

      J. Virol. 76

      Pages: 6743-6749

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD 150)2002

    • Author(s)
      Tanaka K, Minagawa H, Xie MF, Yanagi Y.
    • Journal Title

      Arch Virol 147

      Pages: 195-203

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] SLAM (CD 150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein2002

    • Author(s)
      Hashimoto K, Ono N, Tatsuo H, Minagawa H, Takeda M, Takeuchi K, Yanagi Y.
    • Journal Title

      J Virol 76

      Pages: 6743-6749

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] V domain of human SLAM (CDw150) is essential for its function as a meales virus receptor2001

    • Author(s)
      Ono et al.
    • Journal Title

      J. Virol. 75

      Pages: 1594-1600

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor2001

    • Author(s)
      Ono et al.
    • Journal Title

      J. Virol. 75

      Pages: 4399-4401

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors2001

    • Author(s)
      Tatsuo et al.
    • Journal Title

      J. Virol. 75

      Pages: 5842-5850

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Induction of the measles virus receptor SLAM (CD150) on monocytes2001

    • Author(s)
      Minagawa et al.
    • Journal Title

      J. Gen. Virol. 82

      Pages: 2913-2917

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] V domain of human SLAM (CDw150) is essential for its function as a measles virus receptor2001

    • Author(s)
      Ono N, Tatsuo H, Tanaka K, Minagawa Yanagi Y.
    • Journal Title

      J Virol 75

      Pages: 1594-1600

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor2001

    • Author(s)
      Ono N, Tatsuo H, Hidaka Y, Aoki T, Minagawa H, Yanagi Y.
    • Journal Title

      J Virol 75

      Pages: 4399-4401

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Morbilliviruses use signaling lymphocyte activation molecules (CD 150) as cellular receptors2001

    • Author(s)
      Tatsuo H, Ono N, Yanagi Y.
    • Journal Title

      J Virol 75

      Pages: 5842-5850

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Induction of the measles virus receptor SLAM (CD 150) on monocytes2001

    • Author(s)
      Minagawa H, Tanaka K, Ono N, Tatsuo H, Yanagi Y.
    • Journal Title

      J Gen Virol 82

      Pages: 2913-2917

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Bouche, F.B.et al.: "Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant : a novel antigen to protect against measles"Vaccine. 21. 2074-2081 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shingai, M.et al.: "Receptor use by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with SSPE"Journal of General Virology. 84. 2133-2143 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Seki, F.et al.: "Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells"Journal of Virology. 77. 9943-9950 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohno, S.et al.: "Histidine at position 61 and its adjacent amino acid residues are critical for theability of SLAM (CD150) to act as a cellular receptor for measles virus"Journal of Virology. 84. 2381-2388 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka K, Minagawa H, Xie MF, Yanagi Y.: "The measles virus hemagglutinin downregulates the cellular receptor SLAM(CD150)"Archives of Virology. 147(1). 195-203 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Vincent S, Tigaud I, Schneider H, Buccholz C, Yanagi Y, Gerlier D: "Restriction of measles virus RNA synthesis by a mouse host cell line : trans-complementation by polymerase components or a human cellular factor(s)"Journal of Virology. 76(12). 6121-6130 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tatsuo H, Yanagi Y.: "The morbillivirus receptor SLAM(CD150)"Microbiology and Immunology. 46(3). 135-142 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hashimoto K, Yanagi Y et al.: "SLAM(CD150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein"Journal of Virology. 76(13). 6743-6749 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yanagi Y, Ono N, Tastuo H, Hashimoto K, Minagawa H.: "Measles virus receptor SLAM(CD150)"Virology. 299. 155-161 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Minagawa H, Tanaka K, Ono N, Tatsuo H, Yanagi Y.: "Induction of the measles virus receptor SLAM (CD15O) on monocytes"Journal of General Virology. 82. 2913-2917 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tatsuo.H, Ono N, Yanagi Y: "Morbilliviruses Use Signaling Lymphocyte Activation Molecules (CD150) as Cellular Receptors"Journal of Virology. 75. 5842-5850 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ono N, Tatsuo H, Hidaka Y, Aoki T, Minagawa H, Yanagi Y.: "Measles Viruses on Throat Swabs from Measles Patients Use SLAM (CDw15O) but Not CD46 as a Cellular Receptor"Journal of Virology. 75. 4399-4401 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yanagi Y.: "The cellular receptor for measles virus-elusive no more"Reviews in Medical Virology. 11. 149-156 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ono N, Tatsuo H, Tanaka K, Minagawa H, Yanagi: "V domain of human SLAM(CDw15O) is essential for itsfunction as a measles virus receptor"Journal of Virology. 75. 1594-1600 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tanaka K, Minagawa H, Xie M-F, Yanagi Y: "The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150)"Archives of Virology. 147. 195-203 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2018-03-28  

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