| Project/Area Number |
13307010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | CHIBA UNIVERSITY |
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Principal Investigator |
NODA Masatoshi CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院・医学研究院, 教授 (60164703)
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| Co-Investigator(Kenkyū-buntansha) |
YAHIRO Kinnosuke CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSISTANT, 大学院・医学研究院, 助手 (80345024)
KUWABARA Satoshi CHIBA UNIVERSITY, UNIVERSITY HOSPITAL LECTURER, 医学部付属病院, 講師 (70282481)
MORINAGA Naoko CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 大学院・医学研究院, 助教授 (20092108)
三宅 眞実 千葉大学, 大学院・医学研究院, 助手 (10251175)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2002: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2001: ¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000)
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| Keywords | Guillain-Barre syndrome / Haemophilus influenza / Ganalioside GM1 / ganglioside GM1-like structure / cytotoxin / ギラン・バレー症候群(GBS) / Campylobacter jejuni / 急性下痢症 / Haemophilus influenzae / 呼吸器感染症 / 上気道炎 / 抗カングリオシドGM1 / ガングリオシドGM / リポ多糖 / 神経障害 / ガングリオシドGQ1b |
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| Research Abstract |
It has been reported recently that Haemophilus influenzas can elicit an axonal form of Guillain-Barre syndrome. It is very important to know which Haemophilus influenzas can induce the Guillain-Barre syndrome. Group A of Haemophilus influenzae which were isolated from patients with Guillain-Barre syndrome were characterized and compared with Group B of Haemophilus influenzae which were isolated from patients without Guillain-Barre syndrome. It is concluded that Haemophilus influenzae in Group A has a ganglioside GM1-like structure and a cytotoxin whose molecular weight is approximately 40,000. The ganglioside GM1-like structure and the cytotoxin may be the most important characters of Haemophilus influenzae which can induce the Guillain-Barre syndrome. By using these two characters we are now developing a quick diagnosis of Haemophilus influenzae which can induce the Guillain-Barre syndrome.
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