• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Transcriptome Analysis of Atherosclerosis

Research Project

Project/Area Number 13307023
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

KODAMA Tatsuhiko  Research Center for Advanced Science and Technology, Professor, 先端科学技術研究センター, 科学技術振興特任教員(常勤形態) (90170266)

Co-Investigator(Kenkyū-buntansha) WADA Yoichiro  Komaba Open Laboratory, Research Assistant, 駒場オープンラボラトリー, 助手 (10322033)
DOI Takefumi  Osaka University, Graduate school of Pharmaceutical, Professor, 大学院・薬学研究科, 教授 (00211409)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥54,210,000 (Direct Cost: ¥41,700,000、Indirect Cost: ¥12,510,000)
Fiscal Year 2002: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2001: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
KeywordsDNA microarray / Atherosclerosis / transcription factor / GATA / WTAP / NFATc
Research Abstract

The changes in gene expression profiles during atherogenesis in vascular wall cells including vascular endothelial cell, vascular smooth muscle cell, monocyte and macrophage were studied using oligonucleotide DNA microarray. Following three targets were mainly analyzed comprehensively.
(1)Molecular mechanism of monocyte/endothelial cell interaction :
(2)Molecular mechanism of lipid accumulation in vascular smooth muscle cell :
(3)Transcriptome analysis of monocyte macrophage differentiation :

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC.: "Thrombin stimulation of VCAM-1 in endothelial cells is mediated by PKC-delta-NF-kappa B and PKC-zeta-GATA signaling pathways"J Biol Chem.. (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Santiago-Garcia J, Kodama T, Pitas RE.: "The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix"J Biol Chem.. (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takayanagi H, Kim S, Koga T.Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T.: "Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts"Dev Cell.. 3(6). 889-901 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saiura A, Sugawara Y, Harihara Y, Sata M, Hamakubo T, Kodama T, Makuuchi M.: "Gene expression profile during acute rejection in rat-to-mouse concordant cardiac xenograft by means of DNA microarray"Transpl Int. 15. 535-540 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, Suzuki A, Aoi R, Iwanari H, Jiang SY, Naito M, Tachibana K, Doi T, Shulman AI, Mangelsdorf DJ, Reiter R, Auwerx J, Hamakubo T, Kodama T.: "The Generation of Monoclonal Antibodies against Human Peroxisome Proliferator-activated Receptors (PPARs)"J Atheroscler Thromb.. 9(2). 233-242 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Wada H, Hashimoto K, Wada Y, Kobayashi M, Izumi A, Sugiyama A, Kohro T, Hamakubo I, Kodama T: "Extensive oligonucleotide microarray transcriptome analysis of the rat cerebral artery and arachnoid tissue"J Atheroscler Thromb.. 9(2). 24-32 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC.: "Thrombin stimulation of VCAM-1 in endothelial cells is mediated by PKC-delta -NF-kappa B and PKC-zeta-GATA signaling pathways"J Biol Chem.. epub ahead of print. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Santiago-Garcia J, Kodama T, Pitas RE.: "The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix"J Biol Chem.. epub ahead of print. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T.: "Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts"Dev Cell.. 3(6). 889-901 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Saiura A, Sugawara Y, Harihara Y, Sata M, Hamakubo T, Kodama T, Makuuchi M.: "Gene expression profile during acute rejection in rat-to-mouse concordant cardiac xenograft by means of DNA microarray"Transpl Int.. 15. 535-540 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, Suzuki A, Aoi R, Iwanari H, Jiang SY, Naito M, Tachibana K, Doi T, Shulman Al, Mangelsdorf DJ, Reiter R, Auwerx J, Hamakubo T,Kodama T.: "The Generation of Monoclonal Antibodies against Human Peroxisome Proliferator-activated Receptors(PPARs)"J Atheroscler Thromb.. 9. 233-242 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Wada H, Hashimoto K, Wada Y, Kobayashi M, Izumi A, Sugiyama A, Kohro T, Hamakubo T, Kodama T: "Extensive oligonucleotide microarray transcriptome analysis of the rat cerebral artery and arachnoid tissue"J Atheroscler Thromb.. 9. 224-232 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC.: "Thrombin stimulation of VCAM-1 in endothelial cells is mediated by PKC-delta-NF-kappa B and PKC-zeta-GATA signallng pathways"J Biol Chem.. (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Santiago-Garcia J, Kodama T, Pitas RE.: "The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix"J Biol Chem.. (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T.: "Induction and Activation of the Transcription Factor NFATc1(NFAT2)Integrate RANKL Signaling in Terminal Differenliation of Osteoclasts"Dev Cell.. 3(6). 889-901 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Saiura A, Sugawara Y, Harihara Y, Sata M, Hamakubo T, Kodama T, Makuuchi M.: "Gene expression profile during acute rejection in rat-to-mouse concordant cardiac xenograft by means of DNA microarray"Transpl lnt. 15. 535-540 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanaka T, Takeno T, Watanabe Y, Uchiyama Y, Murakami T, Yamashita H, Suzuki A, Aoi R, Iwanari H, Jiang SY, Naito M, Tachibana K, Doi T, Shulman Al, Mangelsdorf DJ, Reiter R, Auwerx J, Hamakubo T, Kodama T: "The Generation of Monoclonal Antibodies against Human Peroxisome Proliferator-acivated Receptors(PPARs)"J Atheroscler Thromb. 9(2). 233-242 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Wada H, Hashimoto K, Wada Y, Kobayashi M, Izumi A, Sugiyama A, Kohro T, Hamakubo T, Kodama T.: "Extensive oligonucleotide microarray transcriptome analysis of the rat cerebral artery and arachnoid tissue"J Atheroscler Thromb. 9(2). 24-32 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakamura T, Hinagata Ji J, Tanaka T, Imanishi T, Wada Y, Kodama T, Doi T: "HSP90, HSP70, and GAPDH Directly Interact with the Cytoplasmic Domain of Macrophage Scavenger Receptors"Biochem Biophys Res Commun. 290. 858-864 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hippo Y, Taniguchi H, Tsutsumi S, Machida N, Chong JM, Fukayama M, Kodama T, Aburatani H: "Global Gene Expression Analysis of Gastric Cancer by Oligonucleotide Microarrays"Cancer Res. 62. 233-240 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mashiba S, Wada Y, Takeya M, Sugiyama A, Hamakubo T, Nakamura A, Noguchi N, Niki E, Izumi A, Kobayashi M, Uchida K, Kodama T: "In Vivo Complex Formation of Oxidized alpha(1)-Antitrypsin and LDL"Arterioscler Thromb Vasc Biol. 21. 1801-1808 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takabe W, kodama T, Hamakubo T, Tanaka K, Suzuki T, Aburatani H, Matsukawa N, Noguchi N: "Anti-atherogenic antioxidants regulate the expression and function of proteasome {alpha}-type subunits in human endothelial cells"J Biol Chem. 276. 40497-40501 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Husemann J, Obstfeld A, Febbraio M, Kodama T, Silverstein SC.: "CD11b/CD18 mediates production of reactive oxygen species by mouse and human macrophages adherent to matrixes containing oxidized LDL"Arterioscler Thromb Vasc Biol. 21. 1301-1305 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Umetani M, Mataki C, Minegishi N, Yamamoto M, Hamakubo T, Kodama T.: "Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-alpha"Arterioscler Thromb Vasc Biol. 21. 917-922 (2001)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi