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Plasticity and diversity of hematopoietic stem cells

Research Project

Project/Area Number 13307028
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionTHE UNIVERSITY OF TOKYO (2002-2003)
University of Tsukuba (2001)

Principal Investigator

NAKAUCHI Hiromitsu  THE UNIVERSITY OF TOKYO, INSTITUTE OF MEDICAL SCIENCE, PROFESSOR, 医科学研究所, 教授 (40175485)

Co-Investigator(Kenkyū-buntansha) IWAMA Atsushi  THE UNIVERSITY OF TOKYO, INSTITUTE OF MEDICAL SCIENCE, LECTURER, 医科学研究所, 講師 (70244126)
EMA Hideo  THE UNIVERSITY OF TOKYO, INSTITUTE OF MEDICAL SCIENCE, ASSISTANT PROF., 医科学研究所, 助教授 (50344445)
中村 幸夫  筑波大学, 基礎医学系, 講師 (60231479)
渋谷 彰  筑波大学, 基礎医学系, 助教授 (80216027)
小野寺 雅史  筑波大学, 臨床医学系, 講師 (10334062)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥53,950,000 (Direct Cost: ¥41,500,000、Indirect Cost: ¥12,450,000)
Fiscal Year 2003: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2002: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2001: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Keywordshematopoietic stem cells / self-renewal / plasticity / 造血肝細胞 / 血管内皮前駆細胞 / lnk / アダプター分子 / Gfi-1B / 肝幹細胞 / 自己複製能 / SP細胞 / ABC transporter / bcrp-1 / ABCG2
Research Abstract

Hematopoietic stem cells (HSCs) are able to both self-renew and differentiate to multilineages. Clonal assay is therefore essential for their characterization. We have succeeded in a high degree of HSC purification and then established a clonal analysis for HSC potential after transplantation of one HSC into a mouse. Using this method, this study addressed two major issues regarding their plasticity and self-renewal limitation. We examined the distribution of HSC-derived cells in a variety of organs and tissues after transplantation of single HSCs isolated from GFP transgenic mice. GFP+ cells were widely distributed in various tissues, but most of them appeared to be positive for blood cell markers, and very few cells were considered to have non-hematopoietic phenotypes. These data suggest that HSCs have too little plasticity to contribute the regeneration of non-hematopoietic tissues. The clonal analysis of HSC self-renewal revealed that degrees to which they self-renew vary and that their self-renewal is extensive, but limited. It was further clarified that Bmi-1 belonging to Polycomb group genes is one of the molecules that restrict this capacity and that the signal adaptor protein, Lnk is strongly involved in events where HSCs decide to either self-renew or differentiate. Their precise mechanisms are under investigation.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (84 results)

All Other

All Publications (84 results)

  • [Publications] Takano H.et al.: "Asymmetric Division and Lineage Commitment at the Level of Hematopoietic Stem Cells : Inference from Differentiation in Daughter Cell and Granddaughter Cell Pairs."J.Exp Med.. 199(3). 295-302 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibuya K.et al.: "CD226(DNAM-1)Is Involved in Lymphocyte Function-associated Antigen 1 Costimulatory Signal for Nive T Cell Differentiation and Proliferation."J.Exp Med.. 198(12). 1829-1839 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kojima H.et al.: "A.CD226 Mediates Platelet and Megakaryocytic Cell Adhesion to Vascular Endothelial Cells."The Journal of Biological Chemistry.. 278(38). 36748-36753 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yotsumoto K.et al.: "Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation."J.Exp.Med.. 198. 223-233 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujio M et al.: "Full reconstitution of hematopoietic system by murine umbilical cord blood."Transplantation.. 75(11). 1820-1826 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A.et al.: "Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells."Proc Natl Acad Sci U S A.. 100. 5034-5039 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A.et al.: "Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells."Development.. 130. 2513-2524 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujiki Y: "Successful multilineage engraftment of human cord blood cells in pigs after in utero transplantation."Transplantation.. 75. 916-922 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A.et al.: "Identification and propagation of liver stem cells."Cell Dev Biol.. 13. 455-461 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kunisato A.et al.: "HES-1 preserves purified hematopoietic stem cells ex vivo and accum ulates side population cells in vivo."Blood.. 101. 1777-1783 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A.et al.: "Establishment of clonal colony-forming as say system for pancreatic stem/progenitor cells."Cell Transplant.. 11. 451-453 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyashita H.et al.: "Evidence for hepatocyte differentiation from embryonic stem cells in vitro."Cell Transplant.. 11. 429-434 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoshida F.et al.: "Cell cycle dependence of boron uptake from two boron compounds used for clinical neutron capture therapy."Cancer Lett.. 187. 135-141 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Osawa M.et al.: "Erythroid expansion mediated by the Gfi-1B zinc finger protein : role in normal hematopoiesis."Blood.. 100(8). 2769-2777 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiwasawa R: "Essential and instructive roles of GATA factors in eosinophil development."J.Exp.Med.. 195. 1379-1386 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakai A.et al.: "Bone marrow chimerism prevents atherosclerosis in arterial walls of mice deficient in Apolipoprotein E."Atherosclerosis. 161. 27-34 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iwama A.et al.: "Reciprocal Roles for CCAAT/Enhancer Binding (C/EBP) and PU.1 Transcription Factors in Langerhans Cell Commitment Protein."J Exp Med.. 195. 547-558 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyoshi S.et al.: "A transmembrane trap method for efficient cloning of genes encoding proteins possessing transmembrane domain."Biochem.Biophys.Res.Commu.. 289. 1192-1198 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tahara-H.S.et al.: "Lentiviral Vector-Mediated Transduction of Murine CD34- Hematopoietic Stem Cells."Exp.Hematology.. 30. 11-17 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki.A.et al.: "Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver."Journal of Cell Biology. 156. 173-184 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shimizu Y.et al.: "Fca/m receptor is a single gene-family member closely related to polymeric immunoglobulin receptor on chromosome 1."Immunogenetics. 8. 709-711 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A.et al.: "Clonal expansion of hepatic stem/progenitor cells following flow cytometric cell sorting."Cell Transplant.. 10. 393-396 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Motohashi T.et al.: "Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia."European Journal of Haematology. 67. 88-93 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tokoro Y.et al.: "Molecular Cloning and Characterization of mouse Tspan-3, A Novel Member of the Tetraspanin Superfamily, Expressed on Resting Dendritic Cells."Biochem.Biophys.Res.Commu. 288. 178-183 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhou S.et al.: "The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype."Nat Med. 7. 1028-1034 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A: "Clonal expansion of hepatic stem/progenitor cells following flow cytometric cell sorting."Cell Transplant. 10. 393-396 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Osada H.et al.: "Detection of fetal HPCs in maternal circulation after delivery."Transfusion.. 41. 499-503 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakauchi H.et al.: "Quantitative assessment of the stem cell self-renewal capacity. Stem Cell III."Ann N Y Acad Sci. 938. 18-25 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroyama T.et al.: "Fractalkine Shares Signal Sequence with TARC : Gene Structures and Expression Profiles of Two Chemokine genes."Genomics. 75. 3-5 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakamoto N.et al.: "A novel Fc receptor for IgA and IgM is expressed ν on both hematopoietic and non-hematopoietictissue."Eur.J.Immunol.. 31. 1310-1316 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A.et al.: "Hepatic stem/progenitor cells with high proliferative potential in liver organ formation."Transplant Proc. 33. 585-586 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaneko S.et al.: "Simplified Retroviral Vector GCsap with Murine Stem Cell Virus Long Terminal Repeat Allows High and Continued Expression of Enhanced Green Fluorescent Protein by Human Hematopoietic Progenitors Engrafted in Nonobese Diabetic/Severe Combined Immunodeficient Mice."Hum Gene Ther. 12. 35-44 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takano H, Ema H, Sudo K, Nakauchi H.: "Asymmetric Division and Lineage Commitment at the Level of Hematopoietic Stem Cells : Inference from Differentiation in Daughter Cell and Granddaughter Cell Pairs."J.Exp Med.. 199(3). 295-302 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibuya K, Shirakawa J, Kameyama T, Honda S, Tahara-Hanaoka S, Miyamoto A, Onodera M, Sumida T, Nakauchi H, Miyoshi H, Shibuya A.: "CD226(DNAM-1)Is Involved in Lymphocyte Function-associated Antigen 1 Costimulatory Signal for Nive T Cell Differentiation and Proliferation."J.Exp Med.. 198(12). 1829-1839 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kojima H, kanada H, Shimizu S, Kasama E, Shibuya K, Nakauchi H, Nagasawa T, Shibuya A: "CD226 Mediates Platelet and Megakaryocytic Cell Adhesion to Vascular Endothelial Cells."The Journal of Biological Chemistry. 278(38). 36748-36753 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yotsumoto K, Okoshi Y, Shibuya K, Yamazaki S, Tahara-Hanaoko S, Honda S, Osawa M, Kuroiwa A, Matsuda Y, G.Tenen D, Iwama A, Nakauchi H, Shibuya A.: "Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation."J.Exp.Med.. 198. 223-233 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujio M, Oikawa A, Kondo S, Ema H, Morita Y, Nakauchi H, Yokoyama M, Song S-Y, Nishijima M, Okabe M, Shinohara N.: "Full reconstitution of hematopoietic system by murine umbilical cord blood."Transplantation.. 75(11). 1820-1826 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A, Nakauchi H, Taniguchi H.: "Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells."Proc Natl Acad Sci U S A. 100. 5034-5039 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A, Iwama A, Miyashita H, Nakauchi H, Taniguchi H.: "Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells."Development. 130. 2513-2524 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujiki Y, Fukawa K, Kameyama K, Kudo O, Onodera M, Nakamura Y, Yagami K, Shiina Y, Hamada H, Shibuya A, Nakauchi H.: "Successful multilineage engraftment of human cord blood cells in pigs after in utero transplantation."Transplantation.. 75. 916-922 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A, Nakauchi H.: "Identification and propagation of liver stem cells."Semin Cell Dev Biol.. 13. 455-461 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kunisato A, Chiba S, Nakagami-Yamaguchi E, Kumano K, Saito T, Masuda S, Yamaguchi T, Osawa M, Kageyama R, Nakauchi H, Nishikawa M, Hirai H.: "HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo."Blood. 101. 1777-1783 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A, Oyama K, Fukao K, Nakauchi H, Taniguchi H.: "Establishment of clonal colony-forming as say system for pancreatic stem/progenitor cells."Cell Transplant. 11. 451-453 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyashita H, Suzuki A, Fukao K, Nakauchi H, Taniguchi H.: "Evidence for hepatocyte differentiation from embryonic stem cells in vitro."Cell Transplant. 11. 429-434 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yoshida F, Matsumura A, Shibata Y, Yamamoto T, Nakauchi H, Okumura M, Nose T.: "Cell cycle dependence of boron uptake from two boron compounds used for clinical neutron capture therapy."Cancer Lett.. 187. 135-141 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Osawa M, Yamaguchi T, Nakamura Y, Kaneko S, Onodera M, Sawada K, Jegalian A, Wu H, Nakauchi H, Iwama A.: "Erytliroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis."Blood. 100-8. 2769-2777 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiwasawa R, Shimizu R, Takahashi S, Osawa M, Takayanagi S, Kato Y, Onodera M, Minegishi N, Yamamoto M, Fukao K, Taniguchi H, Nakauchi H, Iwama A: "Essential and instructive roles of GATA factors in eosinophil development."J.Exp.Med.. 195. 1379-1386 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yutaka Sakai, Dong Ku Kim, Satoshi Iwasa, Teruo Watanabe, Masafumi Onodera, Hiromitsu Nakauchi.: "Bone marrow chimerism prevents atherosclerosis in arterial walls of mice deficient in Apolipoprotein E."Atherosclerosis. 161. 27-34 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Iwama A, Osawa M, Hirasawa R, Uchiyama N, Kaneko S, Onodera M, Shibuya K, Shibuya A, Vinson C, Tenen DG, Nakauchi H.: "Reciprocal Roles for CCAAT/Enhancer Binding (C/EBP) and PU.1 Transcription Factors in Langerhans Cell Commitment Protein."J Exp Med.. 195. 547-558 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sousuke Miyoshi, Tsutomu Motohashi, Yukio Nakamura, Mitsujiro Osawa, Takashi Hiroyama, Dong-Ku Kim, Yasuhito Tokumoto, Hiromitsu Nakauchi.: "A transmembrane trap method for efficient cloning of genes encoding proteins possessing transmembrane domain."Biochem.Biophys.Res.Commu.. 289. 1192-1198 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tahara-H.S, Sudo K., Ema H., Miyoshi H., Nakauchi H.: "Lentiviral Vector-Mediated Transduction of Murine CD34-Hematopoietic Stem Cells."Exp.Hematology.. 30. 11-17 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Atsushi Suzuki, Yun-wen Zheng, Shin Kanako, Masafumi Onodera, Katashi Fukao, Hiromitsu Nakauchi, Hideki Taniguchi.: "Clonal identification and characterization of self renewing pluripotent stem cells in the developing liver."Journal of Cell Biology. 156. 173-184 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shimizu Y., Honda S., Yotsumoto K., Tahara-Hanaoka S., Eyre HJ., Sutherland G., Endo Y., Shibuya K., Koyama A., Nakauchi H., Shibuya A.: "Fca/m receptor is a single gene-family member closely related to polymeric immunoglobulin receptor on chromosome 1."Immunogenetics. 8. 709-711 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A.Zheng YW, Fukao K, Nakauchi H, Taniguchi H.: "Clonal expansion of hepatic stem/progenitor cells following flow cytometric cell sorting."Cell Transplant.. 10. 393-396 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tsutomu Motohashi, Yukio Nakamura, Mitsujiro Osawa, Takashi Hiroyama, Atsushi Iwama, Akira Shibuya, Hiromitsu Nakauchi.: "Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia."European Journal of Haematology. 67. 88-93 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tokoro Y., Shibuya K., Osawa M., Tahara-Hanaoka S., Iwama A., Kitamura T., Nakauchi H., Shibuya A.: "Molecular Cloning and Characterization of mouse Tspan-3, A Novel Member of the Tetraspanin Superfamily, Expressed on Resting Dendritic Cells."Biochem.Biophys.Res.Commu. 288. 178-183 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP: "The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype."Nat Med. 7. 1028-1034 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A, Zheng YW, Fukao K, Nakauchi H, Taniguchi H: "Clonal expansion of hepatic stem/progenitor cells following flow cytometric cell sorting."Cell Transplant. 10. 393-396 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Osawa H, Doi S, Fukushima T, Nakauchi H, Seki K, Sekiya S: "Detection of fetal HPCs in maternal circulation after delivery."Transfusion. 41. 499-503 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiromitsu Nakauchi, Kazuhiro Sudo, Hideo Ema: "Quantitative assessment of the stem cell self renewal capacity. Stem Cell III."Ann N Y Acad Sci. 938. 18-25 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takashi Hiroyama, Atsushi Iwama, Yukio Nakamura, Hiromitsu Nakauchi: "Fractalkine Shares Signal Sequence with TARC : Gene Structures and Expression Profiles of Two Chemokine genes."Genomics. 75. 3-5 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Norihisa Sakamoto, Kazuko Shibuya, Yoshio Shimizu, Katsumi Yotsumoto, Tomoyuki Miyabayashi, Seiji Sakano, Takao Tsuji, Eiichi Nakayama, Hiromitsu Nakauchi, Akira Shibuya: "A novel Fc receptor for IgA and IgM is expressed v on both hematopoietic and non-hematopoietictissue."Eur.J.Immunol.. 31. 1310-1316 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki A, Zheng YW, Fukao K, Nakauchi H, Taniguchi H: "Hepatic stem/progenitor cells with high proliferative potential in liver organ formation."Transplant Pros. 33. 585-586 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaneko S, Onodera M, Fujiki Y, Nagasawa T, Nakauchi H: "Simplified Retroviral Vector GCsap with Murine Stem Cell Virus Long Terminal Repeat Allows High and Continued Expression of Enhanced Green Fluorescent Protein by Human Hematopoietic Progenitors Engrafted in Nonobese Diabetic/Severe Combined Immunodeficient Mice."Hum Gene Ther. 12. 35-44 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takano H.et al.: "Asymmetric Division and Lineage Commitment at the Level of Hematopoietic Stem Cells : Inference from Differentiation in Daughter Cell and Granddaughter Cell Pairs."J.Exp Med.. 199(3). 295-302 (2004)

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  • [Publications] Shibuya K.et al.: "CD226(DNAM-1)Is Involved in Lymphocyte Function-associated Antigen 1 Costimulatory Signal for Nive T Cell Differentiation and Proliferation."J.Exp Med.. 198(12). 1829-1839 (2003)

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  • [Publications] Kojima H.et al.: "CD226 Mediates Platelet and Megakaryocytic Cell Adhesion to Vascular Endothelial Cells."The Journal of Biological Chemistry. 278(38). 36748-36753 (2003)

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  • [Publications] Yotsumoto K.et al.: "Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation."J.Exp.Med.. 198. 223-233 (2003)

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  • [Publications] Fujio M et al.: "Full reconstitution of hematopoietic system by murine umbilical cord blood."Transplantation. 75(11). 1820-1826 (2003)

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      2003 Annual Research Report
  • [Publications] Suzuki A.et al.: "Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells."Proc Natl Acad Sci U S A.. 100. 5034-5039 (2003)

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      2003 Annual Research Report
  • [Publications] Suzuki A.et al.: "Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells."Development. 130. 2513-2524 (2003)

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  • [Publications] Fujiki Y: "Successful multilineage engraftment of human cord blood cells in pigs after in utero transplantation."Transplantation. 75. 916-922 (2003)

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  • [Publications] Kunisato A.et al.: "HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo."Blood. 101. 1777-1783 (2003)

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  • [Publications] Osawa M., et al.: "Erythroid expansion mediated by the Gfi-1B zinc finger protein : role in normal hemaoroiesis"Blood. 100. 2769-2777 (2002)

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  • [Publications] Hirasawa R., et al.: "Essential and Instructive Roles of GATA Factors in Eosinophil Development"J Exp Med. 195. 1379-1386 (2002)

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  • [Publications] SuzukiA, et al.: "Establishment of clonal colony-forming assay system for pancreatic stem/progenitor cells"Cell Transplant. 11. 451-453 (2002)

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  • [Publications] Shimizu Y., et al.: "Fca/m receptor is a single gene-family member closely related to polymeric immunoglobulin receptor on chromosome 1"Immunogenetics. 53(8). 709-711 (2001)

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  • [Publications] Yutaka Sakai, et al.: "Bone marrow of chimerism prevents atherosclerosis in arterial walls of mice. deficient in Apolipoprotein E."Atherosclerosis. 161. 27-34 (2002)

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  • [Publications] Iwama A, et al.: "Reciprocal Roles for CCAAT/Enhancer Binding(C/EBP)and PU.1 Transcription Factors in Langerhans Cell Commitment Protein."J Exp Med.. 195巻. 547-558 (2002)

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  • [Publications] Sousuke Miyoshi, et al.: "A transmembrane trap method for efficient cloning of genes encoding proteins possessing transmembrane domain."Biochem. Biophys. Res. Commu.. 289巻. 1192-1198 (2002)

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  • [Publications] Tahara-H.S, et al.: "Lentiviral Vector-Mediated Transduction of Murine CD34-Hematopoietic Stem Cells."Exp. Hematology.. 30巻. 11-17 (2002)

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  • [Publications] Atsushi Suzuki, et al.: "Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver."Journal of Cell Biology. 156巻. 173-184 (2002)

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  • [Publications] Zhou S, et al.: "The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype."Nat Med. 7巻. 1028-1034 (2001)

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  • [Publications] Hiromitsu Nakauchi, et al.: "Quantitative assessment of the stem cell self-renewal capacity."Ann N Y Acad Sci. 938巻. 18-25 (2001)

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Published: 2001-04-01   Modified: 2016-04-21  

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