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Synthetic analysis of metastasis related molecules from clinical point of view.

Research Project

Project/Area Number 13307036
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionThe University of Tokyo

Principal Investigator

NAGAWA Hirokazu  The University of Tokyo, Faculty of Medicine, Professor, 医学部附属病院, 教授 (80228064)

Co-Investigator(Kenkyū-buntansha) TSUNO Hirokazu  The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助手 (50282637)
KITAYAMA Joji  The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (20251308)
WATANABE Toshiaki  The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (80210920)
SASAKI Shin  The University of Tokyo, Faculty of Medicine, Assistant, 医学部附属病院, 助教授 (00292946)
甲斐崎 祥一  東京大学, 医学部附属病院, 助手 (70291325)
堀 信一  東京大学, 医学部附属病院, 助手 (90282631)
石黒 達昌  東京大学, 医学部・附属病院, 助手 (90292945)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2003: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2002: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2001: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Keywordsmetastasis / CXCR4 / angiogenesis / COX-2 / s-Flt-1 / catechin / SIP / LPA / VEGF-L / P16 / sFlt-1 / Edg / VEGF / リンパ管内皮 / VEGF-C / VEGF-D / shear stress
Research Abstract

As the metastasis related factors, the following findings were newly obtained.
(1)Sphingosine-1 phosphate (SIP) and Lysophosphatidic acid (LPA), two lysophospholipids regulate the function of cancer cells through their specific receptors.
(2)Cyclooxygenase(COX)-1 induces cell cycle arrests of endothelial cells and suppress angiogenesis.
(3)The detection of CFA mRNA in peritoneal lavage is a useful predictor for peritoneal recurrence in gastric cancer.
(4)Transduction of soluble Flt-1 gene in Peritoneal mesothelial cells efficiently suppress the development of peritoneal metastasis of gastric cancer in mice.
(5)Green tee derived epigallocatechin binds to CD9 molecule of T lymphocytes and modulate the immune reactions against cancer.
(6)In human samples, the expression of 16, CXCR4 as well as VEGF-C or -D shows the positive correlation with lymphain metastasis of cancer.
From these facts, many other unknown factors, especially fats, may closely related with metastatic spread of cancer.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Osada T.: "Peripheral blood dendritic cells, but not monocyte-derived dendritic cells can augment human NK cell function"Cellular Immunology.. 213. 14-23 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa M.et al.: "Expression of vascular endothelial growth factor C and D is an important risk factor for lymphatic metastasis in undifferentiated early gastric carcinoma"Jap.J.Clin Oncol.. 33. 21-27 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujii S, Kitayama J, Kaisaki S, Sasaki S, Seto Y, Tominaga O, Tsuno N., Umetani N., Yokota H, Kitamura K, Tsuruo T, Nagawa H.: "Carcinoemgryonic antigen mRNA in abdominal cavity as a useful predictor of peritoneal recurrence of gastric cancer with serosal exposure."J Exp.Clin.Cancer Res.. 21(4). 547-553 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi H et al.: "Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells."Biochemical J.. 374. 715-722 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shida D et al.: "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1"Cancer Research. 63. 1706-1711 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawai K, Tsuno NH, Kitamura J, Okaji Y, Yazawa K, Asakage M, Hori N, Watanabe T, Takahashi K, Nagawa H.: "Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding."Journal of Allergy & Clinical Im munology. 112(5). 951-957 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sato A et al.: "Vascular endothelial growth factor synthesis by human omental mesothelial cells is augmented by fibroblast growth factor-2"Journal of Surgical Research. 115. 113-120 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato M, Kitayama J, Kazama S, Nagawa H: "Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma."Breast-Cancer Research. 5(5). R144-R150 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Osada T., Nagawa H., Kitayama J., Tsuno NH., Ishihara S., Takamizawa M., Shibata Y.: "Peripheral blood dendritic cells, but not monocyte-derived dendritic cells, can augment humanNK cell function"Cellular Immunology. 213(1). 14-23 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa M., Kitayama J., Kazama S., Nagawa H.: "Expression of vascular endothelial growth factor C and D (VEGF-C and -D) is an important risk factor for lymphatic metastasis in undifferentiated early gastric carcinoma"Jap.J.Clin Oncol.. 33(1). 21-27 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujii S., Kitayama J., Kaisaki S., Sasaki S., Seto Y., Tominaga O., Tsuno N., Umetani N., Yokota H., Kitamura K., Tsuruo T., Nagawa H.: "Carcinoembryonic antigen mRNA in abdominal cavity as a useful predictor of peritoneal recurrence of gastric cancer with serosal exposure."J Exp.Clin.Cancer Res. 21(4). 547-553 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi H., Kitayama J., Takuwa N., Arikawa K., Inoki I., Takehara K., Nagawa H., Takuwa Y.: "Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells"Biochemical J.. 374. 715-722 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shida D., Kitayama J., Yamaguchi H., Okaji Y., Tsuno NH., Watanabe T., Takuwa Y., Nagawa H.: "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1"Cancer Research. 63(7). 1706-1711 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawai K., Tsuno NH., Kitayama J., Okaji Y., Yazawa K., Asakage M., Hori N., Watanabe T., Takahashi K., Nagawa H.: "Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding"Journal of Allergy & Clinical Immunology.. 112(5). 951-957 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sako A., Kitayama J., Yamaguchi H., Kaisaki S., Suzuki H., Fukatsu K., Fujii S., Nagawa H.: "Vascular endothelial growth factor synthesis by human omental mesothelial cells is a ugmented by fibroblast growth factor-2: possible role of mesothelial cell on the develop meat of peritoneal metastasis."Journal of Surgical Research. 115(1). 113-120 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato M., Kitayama J., Kazama S., Nagawa H.: "Expression pattern of CXC chemokine rece ptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma"Breast Cancer Research. 5(5). R1444-R150 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato, M et al.: "Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma"Breast Cancer Research. 5(5). 144-150 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sako, A et al.: "Vascular endothelial growth factor synthesis by human omental mesothelial cells is augmented by fibroblast growth factor-2 : possible role of mesothelial cell on the development of peritoneal metastasis"J.Surgical.Research. 115(1). 113-120 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kasai, K et al.: "Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding"J.Allergy & Clinical Immunology. 112(5). 951-957 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shida, D et al.: "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1"Cancer Research. 63(7). 1706-1711 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamaguchi H.et al.: "Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells"Biochemical J. 374. 715-722 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishikawa M., et al.: "Expression of Vascular Endothelial Growth Factor C and D (VEGF-C and -D) is an Important Risk Factor for Lymphatic Metastasis in Undifferentiated Early Gastric Carcinoma"Japanese Journal of Clinical Oncology. 33(1). 21-27 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fujii, S. et al.: "CEA mRNA in Abdominal Cavity as a Useful Predictor of Peritoneal Recurrence of Gastric Cancer with Serosal Exposure"J.exp.ad Clin. Cancer Research. 21・4. 547-554 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakayama H. et al.: "Rat Gastric Adenocarcinoma Cell Line BV9 Avidly Adheres to Lymphatic Endothelium under Lymphatic Flow Condition"J. exp. ad Clin. Cancer Research. 21・2. 289-294 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yano H. et al.: "Clustered cancer cells show a distinct adhesion behavior"J. Exp. Clin Cancer Research. 20,3. 407-412 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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