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Microarray analysis for detecting biological characteristics in neuroblastoma

Research Project

Project/Area Number 13307050
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

HIYAMA Eiso  Hiroshima University Medical Hospital, Associate Professor, 医学部附属病院, 助教授 (00218744)

Co-Investigator(Kenkyū-buntansha) HIYAMA Keiko  Hiroshima University,Research Institute for Radiation Biology and Medicine, Associate Professor, 原爆放射線医科学研究所, 助教授 (60253069)
TAKAHASHI Norio  Radiation Effect Research Foundation, Chief of a laboratory, 放射線影響研究所・遺伝学部, 室長 (40333546)
YOKOYAMA Takashi  Hiroshima University Medical Hospital, Professor, 医学部附属病院, 教授 (60034104)
YAMAOKA Hiroaki  Hiroshima University Medical Hospital, Research Associate, 医学部附属病院, 助手 (90311810)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000)
Fiscal Year 2002: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2001: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Keywordsneuroblastoma / microarray / CGH array / microsort / telomerase / malignant grade / heat shock protein / Taylor-made therapy / MYCN / hTERT / オーダーメイド療法 / Caspase
Research Abstract

DNA samples of neuroblastoma tissues were examined CGH array using bacterial artificial chromosomes derived from human chromosome 1, 2, 3, 11, 13, 17, 19, 21, 22. Alterations of signals, especially chromosomes 1, 11 and 17, were detected in unfavorable neuroblastomas but not in favorable tumors. Analysis of cDNA microarray using approximately 6500 clones derived from embryonal brain revealed 43 upregulated genes in unfavorable tumors, 20 and 32 upregulated genes in regressing and maturing tumors, respectively. On the other hand, microsort analysis revealed 63 and 39 genes upregulated in unfavorable and favorable tumors, respectively. Real time quantitative RT-PCR in the upregulated genes identified by above technologies identified 21 known genes including MYCN, hTERT, VGEF, Cyclin G1, CD44, NGF, and Caspase 8. In the "composite type" tumor tissues which have heterogeneity of tumor findings in the same tumors, we collected tumor cells in the part with highly dismorphologic findings or in the part with telomerase positive cells by microdissection technique. And we also microdissected the viable tumor cells remained in the postchemotherapeutic tumor sections. Then, total RNA isolated from these collected cells was amplified and then used for microarray. These results identified 23 genes upreglated in the highly malignant cells. Almost all genes were included in the genes identified in the unfavorable tumors. Regressing neuroblastomas showed the up-regulation of apoptosis-relating genes such as caspase 8 and 9 and maturing tumors showed the up-regulation of the neuronal differentiating factors such as NTRK1 and NGF. The comparison between telomerase upregulating tumor and others revealed 102 different expressing genes including hsp 90 and Rad 50, which may directly regulate telomerase. These results suggested that the useful markers for classification of neuroblastoma are the expression of 21 genes and gene dosage of chromosome 1, 11, and 17.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (75 results)

All Other

All Publications (75 results)

  • [Publications] Hiyama E., Hiyama K.: "Telomerase as tumor marker"Cancer Letters. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morifuji, M. et al.: "Fluorescent-based BAT-26 analysis for distinct screening of microsatellite instability in colorectal cancers"International Journal of Oncology. 22. 807-813 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uemura K. et al.: "Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours"Oncology Reports. 10. 277-283 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishimura S. et al.: "High-dose chemotherapy in children with metastatic hepatoblastoma"Pediatrics International. 44. 300-305 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamei N et al.: "A case of anti-Ku antibody-positive scleroderma-dermatomyositis overlap syndrome developing Graves' disease and immune thrombocytopenic purpura"Internal Medicine. 41. 1199-1203 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 檜山英三 他: "小児固形悪性腫瘍とマイクロアレイ法"小児外科. 34. 798-803 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Murakami Y. et al.: "Successful preoperative diagnosis of malignant intraductal papillary mucinous tumor of pancreas by detecting telomerase activity"International Journal of Gastrointestinal Cancer. 31. 117-121 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 檜山桂子, 檜山英三: "肺癌における染色体テロメアとテロメラーゼ"日本臨床. 60. 737-742 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 檜山英三 他: "ショック時におけるサイトカインプロフィール解析のためのマイクロアレイ法の導入とその意義"ショック. 16. 28-33 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 加藤恭博 他: "緊急腫瘤摘出術を要した頸部原発先天性神経芽細胞腫の一乳児例"小児科. 43. 974-976 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama E., et al.: "Clinical utility of telomerase in cancer"Oncogene. 21. 643-649 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 檜山英三, 他: "マイクロアレイ法によるサイトカインプロフィール解析"侵襲と免疫. 10. 81-88 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda H., et al.: "Experience with International Neuroblastoma Staging System and Pathology Classification"British Journal of Cancer. 86. 1110-1116 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama E., et al.: "Immunohistochemical detection of telomerase (hTERT) in human cancer tissues and a subset of cells in normal tissues"Neoplasia. 3. 17-26 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shay, J.W.et al.: "Telomerase and cancer"Human Molecular Genetics. 10. 677-685 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 山岡裕明, 他: "肺転移を有する肝芽腫に対する治療戦略"日本外科系連合学会誌. 26. 1317-1323 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 槍山英三, 他: "小児固形悪性腫瘍のテロメラーゼ活性とその意義"広島医学. 54. 692-697 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama E., et al.: "Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1"Medical and Pediatric Oncology. 36. 67-71 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mendoza C., et al.: "Allelotype and loss of heterozygosity around the L-myc gene locus in primary lung cancers"Lung Cancer. 26. 117-125 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 檜山桂子, 他: "肺癌のテロメラーゼと分子標的"内科. 88. 689-692 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 檜山桂子, 他: "肺癌の進展・転移に伴う分子遺伝学的変化について示唆に富む症例-剖検例"分子呼吸器病学. 5. 359-365 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] NAKAMURA N, et al.: "Genetic effects of atomic-bomb radiation-future prospect of DNA and cytogenetic studies"Radiation Biology Research Communication. 36. 1-11 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] TAKAHASHI N, et al.: "Identification of base substitutions in ten types of rare variants of phosphoglucomutase-1(PGM1) encountered in Japanese"Human Biology. 79. 755-762 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kumagai K., et al.: "Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese"Pharmacogenetics. 11. 275-278 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takayasu H. et al.: "Frequent Deletions and Mutations of the β-catenin gene are associated with overexpression of cycline D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma"Clinical Cancer Research. 10. 677-685 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama E, Hiyama K: "Clinical application of microarrays as a tool of understanding cancer biology. Recent Research Developments in Cancer"Research Signpost (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama K: "Polymorphisms and Respiratory Diseases. In : S.G.Pandalai (ed.), Recent Research Developments in Human Genetics"Research Signpost (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama K, Hiyama E, Kohno N: "Non-RI protocols for L-myc allelotyping and deletion mapping of chromosome 1p in primary lung cancers. In Lung Cancer"Chiba Univ. 9 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama K, Hiyama E: "Detection of telomerase activity in lung cancer tissues. In : B.Driscoll (ed.), Lung Cancer (Methods in Molecular Medicine series)"Humana Press. 12 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 槍山桂子, 他: "肺癌のテロメア・テロメラーゼ/肺癌の最新医療"先端医療技術研究所. 6 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama E., Hiyama K.: "Telomerase as tumor marker."Cancer Letters. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uemura, K., Hiyama, E., Murakami, Y., Kanehiro, T., Ohge, H., Sueda, T., and Yokoyama, T.: "Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours."Oncology Reports. 10. 277-283 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Morifuji, M., Hiyama, E., Murakami, Y., Imamura, Y., Sueda, T., and Yokoyama, T.: "Fluorescent-based BAT-26 analysis for distinct screening of micrpsatepite instability in colorectal cancers."International Journal of Oncology. 22. 807-813 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Budhi A,j Hiyama K, Isobe T, Oshima Y, Hara H Maeda H, Kohno N.: "Genetic susceptibility for emphysematous changes of the lung in Japanese."Internatiobal Journal of Molecular Medicine. 11(3). 321-329 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kumagai K, Hiyama K, Oyama T, Maeda H, Kohno N: "Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis."International Journal of Molecular Medicine. 11(5). 593-600 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Murakami Y, Yokoyama T, Hiyama E, Yokoyama Y, Kanehiro T, Uemura K, Sasaki M, Morifuji M, and Sueda T.: "Successful preoperative diagnosis of malignant intraductal papillary mucinous tumor of the pancreas by detecting telomerase activity."International Journal of Gastrointestinal Cancer. 31. 117-121 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishimura, S., Sato, T., Fujita, N., Yamaoka, H., Hiyama, E, Yokoyama, T., and Ueda, K.: "High-dose chemotherapy in children with metastatic hepatoblastoma."Pediatric International. 44. 300-305 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda, H., Iehara, T., Tsuchida, Y., Kaneko, M., Hata, J., Naito, H., Iwafuchi M., Ohnuma, N., Mugishima, H., Toyoda, Y., Hamazaki, M., Mimaya, J., Kondo, S., Kawa, K., Okada, A., Hiyama, E., Suita, S., and Takamatsu, H.: "Experience with Internatiional Neuroblastoma Staging Systemand Pathology Classification."British Journal of Cancer. 86. 1110-1116 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama, E. Hiyama, K.: "Clinical utility of telomerase in cancer."Oncogene. 21. 643-649 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toyofuku, M., Imazu, M., Sumii, K., Yamamoto, H., Hayashi, Y., Hiyama, K., and Kohno, N.: "Influence of angiotensinogen M2S3T gene polymorphism and an angiotensin converting enzyme inhibitor on restenosis after percutaneous coronary intervention."Atherosclerosis. 160. 339-344 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi N.: "Methodology to study genetic effects of A-bomb radiation efficiently - Introduction of microarray-based comparative genome hybridization-"Nagasaki Medical Journal. 77. 192-720 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sasaki K, Tsuyama N, Kodaira M, Itoh M, Sugita K, Katayama H, Fujiyama A, Hiyama K, Hiyama E, Takahashi N.: "Study of genetics effects of atomic-bomb radiation by using microarray-based comparative genomic hybridization (array CGH) Preliminary experiment"Nagasaki Medical Journal. 77. 316-320 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sasaki K, Tsuyama N, Itoh M, Kodaira M, Danjo I, Kyoizumi S, Niikawa N, Fujiyama A, Takahashi N.: "Application of microarray system to CGH."Journal of Hiroshima Medical Association. 55(3). 280-283 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takayasu H., Horie, H., Hiyama, E., Matsunaga, T., Hayashi, Y., Watanabe, Y., Suita, S., Kaneko, M., Sasaki, F., Hashizume, K., Ozaki, T., Furuuchi, K., Tada, M.t Ohnuma, N., and Nakagawara, A.: "Frequent deletions and mutations of the beta-catenin gene are associated with overexpreission of cyclin Dl and fibronectin and poorly differentiated histology in childhood hepatoblastoma."Clinical Cancer Research. 7. 901-908 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shay, J. W., Zou, Y., Hiyama, E., and Wright, W. E.: "Telomerase and cancer."Human Molecular Genetics. 10. 677-685 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakamitsu, A., Hiyama, E., Imamura, Y., Matsuura, Y., and Yokoyama, T.: "Kupffer cell function in ischemic and nonischemic livers after hepatic partial ischemia/reperfusion."Surgery Today. 31. 140-148 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama, E., Hiyama, K., Shay, J. W., and Yokoyama, T.: "Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues."Neoplasia. 3. 17-26 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama, E., Hiyama, K., Ohtsu, k., Yamaoka, H, Fukuba, I., Matsuura, Y., and Yokoyama, T.: "Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1."Medical and Pediatric Oncology. 36. 67-74 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ishioka, S., Terada, M., Haruta, Y., Hiyama, K., Hozawa, S., and Yamakido, M.: "Multiple Logistic Regression Analysis of Risk Factors for the Development of Steroid-Dependent Asthma in the Elderly: A Comparison with Younger Asthmatics."Respiration. 68. 35-40 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kumagai,j K., Hiyama, K., Ishioka, S., Sato, H., Yamanishi, Y., McLeod, H. L., Konishi, F, Maeda, H., and Yamakido, M.: "Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese."Pharmacogenetics. 11. 275-278 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiyama E., Hiyama K.: "Telomerase as tumor marker"Cancer Letter. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Morifuji, M. et al.: "Fluorescent-based BAT-26 analysis for distinct screening of microsatellite instability in colorectal cancers"International Journal of Oncology. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Myrakami Y. et al.: "Successful preoperative diagnosis of malignant intraductal"International Journal of Gastrointestinal Cancer. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Uemura K. et al.: "Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours"Oncology Reports. 10・2. 277-283 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishimura S. et al.: "High-dose chemotherapy in children with metastatic hepatoblastoma"Pediatrics International. 44・2. 300-305 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kamei N et al.: "A case of anti-Ku antibody-positive scleroderma-dermatomyositis overlap syndrome developing Graves' disease and immune thrombocytopenic purpura"Internal Medicine. 41. 1199-1203 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiyama E, Hiyama K: "Clinical Application of Microarrays as a Tool of Understanding Cancer Biology. Recent Research Developments in Cancer"Research Signpost(In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiyama K, Hiyama E, Kohno N: "Non-RI protocols for L-myc allelotyping and deletion mapping of chromosome 1p in primary lung cancers. In Lung Cancer"Chiba Univ. 9 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiyama E. et al.: "Clinical utility of telomerase in cancer"Oncogene. 21・1. 643-640 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 侵襲と免疫: 侵襲と免疫. in press. (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 檜山英三 他: "ショック時におけるサイトカインプロフィール解析のためのマイクロアレイ法の導入とその意義"ショック. 10・8. 677-685 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ikeda H., et al.: "Experience with International Neuroblastoma Staging System and Pathology Classification"British Journal of Cancer. in press. (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiyama E. et al.: "Immunohistocheical detection of telomerase (hTERT) in human cancer tissues and a subset of cells in normal tissues"Neoplasia. 3・1. 17-26 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shya, J.W.et al.: "Telomerase and cancer"Human Molecular Genetics. 10・8. 677-685 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山岡裕明 他: "肺転位を有する肝芽腫に対する治療戦略"日本外科系連合学会誌. 26・5. 1317-1323 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 檜山英三 他: "小児固形悪性腫瘍のテロメラーゼ活性とその意義"広島医学. 54・8. 692-697 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiyama E. et al.: "Biological characteristics of neuroblastoma with partial deletion in the short arm of Chromosome l"Medical and Pediastric Oncology. 36・1. 67-71 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mendoza C. et al.: "Allelotype and loss of heterozygosity around the L-myc gene locus in primary lung cancers"Lung cancer. 28・1. 117-125 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 檜山桂子 他: "肺癌のテロメラーゼと分子標的"内科. 88・5. 889-892 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 檜山桂子 他: "肺癌の進展・転位に伴う分子遺伝学的変化について示唆に富む症例-剖検例"分子呼吸器病学. 5・4. 359-365 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] NAKAMURA N et al.: "Genetic effects of atomic-bomb radiation-future prospect of DNA and cytogenetic studies"Radiation Biology Research Communication. 36・1. 1-11 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] TAKAHASHI N et al.: "Identification of base substitutions in ten types of rare variants of phosphoglucomutase-1(PGM1) encountered in Japanese"Hum. Biol.. 73・7. 755-762 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiyama K. et al.: "Recent research developments in human genetics"polymorphisms and respiratory diseases (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiyama K. et al.: "Lung Cancer (Methods in Molecular Medicine series)"Detection of telomerase activity in lung cancer tissues (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiyama K. et al.: Non-Rl protocols for L-myc allelotyping and deletion mapping of chromosome 1p in primary lung cancers(in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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