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Study on pathogenesis and treatment of periodontal disease which is focused in bone metabolism

Research Project

Project/Area Number 13307059
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

NAGATA Toshihiko  The University of Tokushima, Department of Periodontology and Endodontology, School of Dentistry, Professor, 歯学部, 教授 (10127847)

Co-Investigator(Kenkyū-buntansha) NISHIHARA Tatsuji  Kyushu Dental College, Department of Oral Microbiology, Professor, 歯学部, 教授 (80192251)
KURIHARA Hidemi  Hiroshima University, Department of Periodontal Medicine, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (40161765)
ABIKO Yoshimitsu  Nihon University, Department of Biochemistry, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (70050086)
MURAKAMI Shinya  Osaka University, Department of Periodontology, Division of Oral Biology and Disease Control, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (70239490)
MAEDA Katsumasa  Kyushu University, Faculty of Dental Science, Department of Periodontology, Division of Oral Rehabilitation, Professor, 大学院・歯学研究院, 教授 (00117243)
前野 正夫  日本大学, 歯学部, 助教授 (60147618)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥54,730,000 (Direct Cost: ¥42,100,000、Indirect Cost: ¥12,630,000)
Fiscal Year 2003: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2002: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2001: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Keywordsbone metabolism / periodontal diseases / alveolar bone / periodontal ligaments / regenerative therapy / growth factors / cytokines / gene / ストローマ細胞
Research Abstract

Fibroblasts derived from gingiva and periodontal ligaments showed osteoinductive properties ; regulation of osteoclast differentiation and life period (Kobayashi) and expression of osteoclastgenesis inhibitory factor (OCIF) in human periodontal ligament cells (Kurihara). It was also found that mouse clonal periodontal ligament cells expressed bone-related extracellular matrix proteins such as type-1 collagen, osteocalcin (OCN) and osteopontin (OPN) (Murakami)
Lipopolysaccharide (LPS) is a potent pathogenic factor in periodontal diseases. LPS decreased bone nodule formation in rat calvaria cells and substance P, which is associated with mental stress, augumented the inhibitory action of LPS, suggesting that LPS and substance P influence in periodontal bone differentiation (Nagata). LPS-induced TNF-α factor (LITAF) was identified as a novel transcription factor in human monocytic cells and characterization of LITAF promoter revealed that a 34-bp sequence domain located from nucleotides -7 … More 6 to -43 in the promoter and this new sequence domain contributed the up-regulation of LITAF gene transcription (Myoukai). The receptors of calcitonin gene-related peptide (CGRP) expressed in immature osteoblastic human MG63 cells (Okuda). LPS promoted the survival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to LPS is different from that of macrophages (Nishihara). Also, capsular polysaccharide from A.actinomycetemcomitans inhibited IL-6 and IL-8 production in human gingival fibroblasts (Nishihara)
Macrophages are involved in both progression and resolution of apical periodontitis, and macrophages expressing TGF-β1 may play an important role in reducing the destructive mediators in periapical lesions and in the activation of new bone formation (Maeda). The combination of rhBMP-2 and barrier membrane had advantagees in producing and maintaining bone in the intended shape by inducing osteoblasts directly on the inner surface of the membrane (Irie). BMP-4, -5, -6 affected on DNA synthesis and expression of bone-related proteins in cultured periodontal ligament cells (Kurihara). Attachment of human periodontal ligament cells to enamel matrix-derived protein was mediated via interaction between bone sialoprotein (BSP)-like molecules and integrin αvβ3 (Maeno). Propeptide of type-1 procollagen (P1CP) in gingival crevicular fluid was a useful marker for bone turnover in periodontitis (Nagata). Stimulatory effect of low-level laser irradiation (LLLI) on bone formation was evaluated and the increased expression of osteoglycin gene by LLLI was associated with bone formation in concert with matrix proteins and growth factors (Abiko). Radiographic observation revealed that alveolar bone treated with flap operation was recovered after 10 years in severe destructive periodontitis (Yaegashi)
Cycloxygenase-2 (COX-2) inhibitor not only inhibited the production of inflammatory bone-resorptive factors but also increased the production of OCIF (Kurihara). Matrix metaloprotease (MMP) administration inhibited alveolar bone resorption in hamster's experimental periodontitis (Nagata). Local administration of bisphosphonate also inhibited alveolar bone resorption in rats and dogs (Shibutani). Although statin did not increase alkaline phosphatase activity in human periodontal ligament cells, amount of IL-6 in culture medium of human gingival fibroblasts was decreased by statin, suggesting that statin has anti-inflammatory action as well as bone-forming action (Yamamoto) Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (97 results)

All Other

All Publications (97 results)

  • [Publications] Ninomiya M.et al.: "Application of enamel matrix derivative in autotransplantation of an impacted maxillary premolar. A case report."Journal of Periodontology. 73(3). 346-351 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中村輝夫 ほか: "歯周炎患者の歯肉溝滲出液中に含まれるI型プロコラーゲンペプチドおよびオステオカルシンの定量分析"日本歯周病学会会誌. 44(1). 73-81 (2002)

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      2003 Final Research Report Summary
  • [Publications] 浅野将宏 ほか: "思春期後に歯槽骨吸収が自然停止した早期発症型歯周炎患者の一症例"日本歯周病学会会誌. 45(3). 279-288 (2003)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Azuma H.et al.: "Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Poryhyromonas gingivalis."Journal of Periodontology. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 安孫子宜光: "差分化遺伝子クローニングによる骨芽細胞への低出力レーザー照射の生物学的効果の機序解明"日本レーザー歯学会誌. 3(2). 79-88 (2002)

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      2003 Final Research Report Summary
  • [Publications] Hamajima S. et al.: "Effect of low-level laser irradiation on osteoglycin gene expression in osteoblasts."Lasers Mededical Sciences. 18(2). 78-82 (2003)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawahara M. et al.: "Effect of Low-Level Laser Irradiation on Macrophage Inhibitory Factor Gene Expression in Osteoblasts."日本口腔インプラント学会誌. (印刷中). (2004)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakata M. et al.: "Osteoprotegrin levels increased by interleukin-1β in human periodontal ligament cells are suppressed through prostaglandin E2 synthesized de novo."Cytokine. 18(3). 133-139 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okahashi N. et al.: "Involvement of cyclin-dependent kinase inhibitors p21WAF1/CIP1 and p27KIP1 in the differentiation of osteoclasts."Journal of Cellular Biochemistry.. 80(3). 339-345 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishihara T. et al.: "Effect of aging on interleukin-6 release from human gingival fibroblasts stimulated with interleukin-1β."Dentistry in Japan.. 37(1). 20-25 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murase Y. et al.: "Possible involvement of protein kinases and Smad2 signaling pathways on osteoclast differentiation enhanced by activin A."Journal of Cellular Physiology. 188(2). 236-242 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Koseki T. et al.: "Role of TGF-β family in osteoclastogenesis induced by RANKL."Cellular Signalling. 14(1). 31-36 (2001)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 宇田川信之 ほか: "破骨細胞分化因子(Osteoclast Differentiation Factor : ODF)の生理的役割の解明"日本歯科医学会誌. 20(1). 86-91 (2001)

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      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] 西原達次: "歯周組織の破壊と再生におけるサイトカインの役割について"九州歯科学会雑誌. 55(5). 314-317 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Li X.et al.: "p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function."Endocrinology. 143(5). 3105-3113 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Itoh K.et al.: "Lipopolysaccharide promotes the suivival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to lipopolysaccharide is different from that of macrophages."Journal of Immunology.. 170(3). 3688-3695 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohguchi Y. et al.: "Capsular polysaccharide from Actinobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast."Journal of Periodontal Research. 38(3). 190-197 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Maeda K. et al.: "Immunobiology and bone formation of experimentally induced periapical lesions in rats."Proceedings of the International Conference on Dentin / Pulp Complex 2001.. (-). 19-23 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki n. et al.: "Attachment of human periodontal ligament cells to enamel matrix-derived protein is mediated via interaction between BSP-like molecules and integrin ανβ3."Journal of Periodontology. 72(11). 1520-1526 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohyama M. et al.: "Effect of enamel matrix derivative on the differentiation of C2C12 cells."Journal of Periodontology. 73(5). 543-550 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Maeno M. et al.: "Carnosine modulate osteoblastic and chondroblastic differentiation of human neriodontal ligament cells."Dentistry in Japan. 39(1). 114-118 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Maeno M. et al.: "Effect of β-alanyl-L-histidinato zinc on the differentiation pathway of human periodontal ligament cells."Life Sciences. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito-Kato E. et al.: "Effect of carnosine on RUNX2/Cbfa1 and Sox9 expression of human periodontal ligament cells."Journal of Periodontal Research. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie K.et al.: "Immunohistochemical localization of membrane type 1-matrix metalloproteinase (MT1-MMP) in osteoclats in vivo."Tissue and Cell. 33(5). 478-482 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeishi H. et al.: "Molded bone augmentation by a combination of barrier membrane and recombnant human bone morphogenetic protein-2."Oral Diseases. 7(5). 281-286 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kondo Y. et al.: "Role of stromal cells in osteoclast differentiation in bone marrow."Journal of Bone and Mineral Metabolism. 19(6). 352-358 (2001)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie K.et al.: "Changes of osteopontin distribution and matrix mineralization during remodeling in experimental bone formation."Acta Histochem Cytochem. 35(2). 109-114 (2002)

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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie K.et al.: "Osteoclast differentiation in ectopic bone formation induced by recombinant human bone morphogenetic protein-2 (rhBMP-2)."Journal of Bone and Mineral Metabolism. 21(3). 363-369 (2003)

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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yaegashi T. et al.: "A case of periodontal therapy for a central upper incisor with two roots."Dental Journal of Iwate Medical University. 26(2). 195-199 (2001)

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      2003 Final Research Report Summary
  • [Publications] Yaegashi T. et al.: "A case report of periodontal therapy for a patient with severe periodontitis."Dental Journal of Iwate Medical University. 27(1). 81-86 (2002)

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      2003 Final Research Report Summary
  • [Publications] Yaegashi T. et al.: "Cases of periodontal therapy in need of orthodontic treatment."Dental Journal of Iwate Medical University. 27(1). 74-80 (2002)

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      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] Kawase T. et al.: "Immature human osteoblastic MG63 cells predominantly express a subtype 1-like culcitonin gene-related peptide receptor that inactivates extracellular signal response kinase by a cAMP-dependent mechanism."European Journal of Pharmacology. 470(3). 125-137 (2003)

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      「研究成果報告書概要(和文)」より
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      2003 Final Research Report Summary
  • [Publications] Shibutani T. et al.: "Bisphosphonate Inhibits Alveolar Bone Resorption in Peri-implantitis in Dogs."Clinical Oral Implant Research. 12(2). 109-114 (2001)

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      2003 Final Research Report Summary
  • [Publications] 岡松良昌 ほか: "ヒト歯肉線維芽細胞が産生する細胞画分IL-1αは細胞接触により単核破骨細胞の延命および多核破骨細胞への癒合を促進する"炎症・再生. 21(5). 583-592 (2001)

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      2003 Final Research Report Summary
  • [Publications] Nukaga J. et al.: "Regulatory Effects of Interleukin-1β and Prostaglandin E2 on Expression of Receptor Activator of Nuclear Factor-eB Ligand in Human Periodontal Ligament Cells."Journal of Periodontology. (印刷中). (2004)

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      2003 Final Research Report Summary
  • [Publications] 永田俊彦: "歯周治療における薬物療法の将来展望・その着眼点と研究の方向性"ザ・クインテッセンス. 22(9). 32-34 (2003)

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      2003 Final Research Report Summary
  • [Publications] 柴 秀樹 ほか: "炎症性歯槽骨吸収におけるCOX-2選択的阻害薬の有用性"ザ・クインテッセンス. 22(9). 35-40 (2003)

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      2003 Final Research Report Summary
  • [Publications] 二宮雅美 ほか: "MMP阻害剤の歯槽骨吸収抑制作用"ザ・クインテッセンス. 22(9). 41-47 (2003)

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      2003 Final Research Report Summary
  • [Publications] 澁谷俊昭: "ビスフォスフォネートの歯槽骨代謝への影響"ザ・クインテッセンス. 22(9). 48-52 (2003)

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      2003 Final Research Report Summary
  • [Publications] 山本松男: "スタチンの歯周病治療薬としての可能性"ザ・クインテッセンス. 22(9). 53-57 (2003)

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      2003 Final Research Report Summary
  • [Publications] 安孫子宜光: "生活習慣病としての歯周病対策"ザ・クインテッセンス. 22(4). 186-190 (2003)

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      2003 Final Research Report Summary
  • [Publications] Azuma H, Kido J, Ikedo D, Kataoka M, Nagata T.: "Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Porphyromonas gingivalis"J Periodontol. (in press).

    • Description
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    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamajima S, Hiratsuka K, Kiyama-Kishikawa M, Tagawa T, Kawahara M, Ohta M, Sasahara H, 1 Lasers: "Effect of low-level laser irradiation on osteoglycin gene expression in osteoblasts"Med.Sci.. 18(2). 78-82 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakata M, Shiba H, Komatsuzawa H, Fujita T, Uchida Y, Yoshino H, Ogawa T, Kawaguchi H, Kurihara H: "Osteoprotegrin levels increased by interleukin-1β in human periodontal ligament cells are suppressed through prostaglandin E2 synthesized de novo"Cytokine. 18(3). 133-139 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okahashi N, Murase Y, Koseki T, Sato T, Yamato K, Nishihara T: "Involvement of cyclin-dependent kinase inhibitors p21WAF1/CIP1 and p27KIP1 in the differentiation of osteoclasts"J.Cell Biochem.. 80. 339-345 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishihara T, Kawai O, Nakashima K, Mori M, Kato S, Kowashi Y.: "Effect of aging on interleukin-6 release from human gingival fibroblasts stimulated with interleukin-1β"Dentistry in Japan. 37. 20-25 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murase Y, Okahashi N, Koseki T, Itoh K, Udagawa N, Hashimoto O, Sugino H, Noguchi T, Nishihara T.: "Possible involvement of protein kinases and Smad2 signaling pathways on osteoclast differentiation enhanced by activin A"J.Cell Physiol.. 188. 236-242 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Koseki T, Gao Y, Okahashi N, Murase Y, Tsujisawa T, Sato T, Yamato K, Nishihara T.: "Role of TGF-β family in osteoclastogenesis induced by RANKL"Cell Signal.. 14. 31-36 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Li X, Udagawa N, Itoh K, Suda K, Murase Y, Nishihara T, Suda T, Takahashi N.: "p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function"Endocrinology. 143. 3105-3113 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Itoh K, Udagawa N, Kobayashi K, Suda K, Li X, Takami M, Okahashi N, Nishihara T, Takahashi N.: "Lipopolysaccharide promotes the survival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to lipopolysaccharide is different from that of macrophages"J.Immunol.. 170. 3688-3695 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohguchi Y, Ishihara Y, Ohguchi M, Koide M, Shirozu N, Naganawa N, Nishihara T, Noguchi T.: "Capsular polysaccharide from Actinobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast"J.Periodont. Res.. 38. 190-197 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Maeda K, Anan H, Matsumoto A, Kimura R, Yoneda M, Murakawa T.: "Immunobiology and bone formation of experimentally induced periapical lesions in rats"Proceedings of the O International Conference on DentinA^Pulp Complex 2001, Quintessence Publishing Co., Ltd.. 19-23 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki N, Ohyama M, Maeno M, Ito K, Otsuka K.J: "Attachment of human periodontal ligament cells to enamel matrix-derived protein is mediated via interaction between BSP-like molecules and integrin avb3"Periodontol. 72(11). 1520-1526 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohyama M, Suzuki N, Yamaguchi Y, Maeno M, Otsuka K.: "Effect of enamel matrix derivative on the differentiation of C2C12 cells"J Periodontol. 73(5). 543-550 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Maeno M, Ito E, Suzuki N, Takada T, Ito K, Otsuka K.: "Carnosine modulate osteoblastic and chondroblastic differentiation of human periodontal ligament cells"Dent Jpn. 39. 114-118 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Maeno M, Ito-Kato E, Suzuki N, Takada T, Takayama T, Ito K, Otsuka K.: "Effect of b-alanyl-L-histidinato zinc on the differentiation pathway of human periodontal ligament cells"Life Sciences. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito-Kato E, Suzuki N, Maeno M, Takada T, Tanabe N, Takayama T, Ito K, Otsuka K.: "Effect of carnosine on RUNX2/Cbfal and Sox9 expression of human periodontal ligament cells"J Periodont Res. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie K, Tsuruga E, Sakakura Y, Muto T, Yajima T.: "Immunohistochemical localization of membrane type 1-matrix metalloproteinase (MT1-MMP) in osteoclats in vivo"Tissue & Cell. 33(5). 478-482 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeishi H, Irie K, Okuda K, Ozawa H, Yajima T, Ejiri S.: "Molded bone augmentation by a combination of barrier membrane and recombnant human bone morphogenetic protein-2"Oral Diseases. 7(5). 281-286 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kondo Y, Irie K, Ikegame M, Ejiri S, Hanada K, Ozawa H.: "Role of stromal cells in osteoclast differentiation in bone marrow"J Bone Miner Metab. 19(6). 352-358 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Irie, Takeishi H, Tsuruga E, Sakakura Y, Nomura S, Ozawa H, Ejiri S, Yajima T.: "Changes of osteopontin distribution and matrix mineralization during remodeling in experimental bone formation"Acta Histochem Cytochem. 35(2). 109-114 (2002)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Irie K, Alpaslan C Takahashi K, Kondo Y, Izumi N, Sakakura Y, Tsuruga E, Nakajima T, Ejiri S, Ozawa H, Yajima T.: "Osteoclast differentiation in ectopic bone formation induced by recombinant human bone morphogenetic protein-2 (rhBMP-2)"J Bone Miner Metab. 21. 363-369 (2003)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Takashi Yaegashi, Kazuyuki Uyeno: "A case of periodontal therapy for a central upper incisor with two roots"Dent.J.Iwate Med.Univ.. 26. 195-199 (2001)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Takashi Yaegashi, Kazuyuki Uyeno: "A case report of periodontal therapy for a patient with severe periodontitis"Dent. J.Iwate Med.Univ.. 27. 81-86 (2002)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Tomoyuki Kawase, Kazuhiro Okuda, Douglas M.Burns: "Immature human osteoblastic MG63 cells predominantly express a subtype 1-like calcitonin gene-related peptide receptor that inactivates extracellular signal response kinase by a cAMP-dependent mechanism"European Journal of Pharmacology. 470(3). 125-137 (2003)

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      「研究成果報告書概要(欧文)」より
    • Related Report
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  • [Publications] Shibutani T, Inuduka A, Horiki I, Luan QX, Iwayama Y.: "Bisphosphonate Inhibits Alveolar Bone Resorption in Peri-implantitis in Dogs"Clin.Oral.Impl.Res. 12. 109-114 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
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  • [Publications] Jun Nukaga, Makoto Kobavashi, Toshimasa Shinki, Hong Song, Takatora Takada, Takashi Takiguchi, Ryutaro, Kamijo, Kohji Hasegawa: "Regulatory Effects of Interleukin-1b and Prostaglandin E2 on Expression of Receptor Activator of Nuclear Factor-eB Ligand in Human Periodontal Ligament Cells"Journal of Periodontology. February (in press). (2004)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] 浅野将宏 ほか: "思春期後に歯槽骨吸収が自然停止した早期発症型歯周炎患者の一症例"日本歯周病学会会誌. 45(3). 279-288 (2003)

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  • [Publications] Azuma H.et al.: "Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Porphyromonas gingivalis"Journal of Periodontology. (印刷中). (2004)

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  • [Publications] Hamajima S.et al.: "Effect of low-level laser irradiation on osteoglycin gene expression in osteoblasts"Lasers Mededical Sciences. 18(2). 78-82 (2003)

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  • [Publications] Kawahara M.et al.: "Effect of Low-level Laser Irradiation on Macrophage Inhibitory Factor Gene Expression in Osteoblasts"日本口腔インプラント学会誌. (印刷中). (2004)

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  • [Publications] Itoh K.et al.: "Lipopolysaccharide promotes the survival of osteoclasts via Toll-like receptor 4,but cytokine production of osteoclasts in response to lipopolysaccharide is different from that of macrophages"Journal of Immunology. 170(3). 3688-3695 (2003)

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  • [Publications] Ohguchi Y.et al.: "Capsular polysaccharide from Actinobacillus actinomycetemcomitans inhibits IL-6 and IL-8 production in human gingival fibroblast"Journal of Periodontal Research. 38(3). 190-197 (2003)

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  • [Publications] Maeno M.et al.: "Camosine modulate osteoblastic and chondroblastic differentiation of human periodontal ligament cells"Dentistry in Japan. 39(1). 114-118 (2003)

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  • [Publications] Maeno M.et al.: "Effect of β-alanyl-L-histidinato zinc on the differentiation pathway of human periodontal ligament cells"Life Sciences. (印刷中). (2004)

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  • [Publications] Ito-Kato E.et al.: "Effect of carnosine on RUNX2/Cbfa1 and Sox9 expression of human periodontal ligament cells"Journal of Periodontal Research. (印刷中). (2004)

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  • [Publications] Irie K.et al.: "Osteoclast differentiation in ectopic bone formation induced by recombinant human bone morphogenetic protein-2(rhBMP-2)"Journal of Bone and Mineral Metabolism. 21(3). 363-369 (2003)

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  • [Publications] Kawase T.et al.: "Immature human osteoblastic MG63 cells predominantly express a subtype 1-like calcitonin gene-related peptide receptor that inactivates extracellular signal response kinase by a cAMP-dependent mechanism"European Journal of Pharmacology. 470(3). 125-137 (2003)

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  • [Publications] Nukaga J.et al.: "Regulatory Effects of Interleukin-1β and Prostaglandin E2 on Expression of Receptor Activator of Nuclear Factor-eB Ligand in Human Periodontal Ligament Cells"Journal of Periodontology. (印刷中). (2004)

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  • [Publications] 永田俊彦: "歯周治療における薬物療法の将来展望・その着眼点と研究の方向性"ザ・クインテッセンス. 22(9). 32-34 (2003)

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  • [Publications] 柴 秀樹 ほか: "炎症性歯槽骨吸収におけるCOX-2選択的阻害薬の有用性"ザ・クインテッセンス. 22(9). 35-40 (2003)

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  • [Publications] 二宮雅美 ほか: "MMP阻害剤の歯槽骨吸収抑制作用"ザ・クインテッセンス. 22(9). 41-47 (2003)

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  • [Publications] 澁谷俊昭: "ビスフォスフォネートの歯槽骨代謝への影響"ザ・クインテッセンス. 22(9). 48-52 (2003)

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  • [Publications] 山本松男: "スタチンの歯周病治療薬としての可能性"ザ・クインテッセンス. 22(9). 53-57 (2003)

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  • [Publications] 安孫子宜光: "生活習慣病としての歯周病対策"ザ・クインテッセンス. 22(4). 186-190 (2003)

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  • [Publications] Sakata M: "Osteoprotegerin levels-increased by interleukin-lbeta in human periodontal ligament cells are suppressed through prostaglandin E_2"Cytokine. 18・3. 133-139 (2002)

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  • [Publications] Li X: "P38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function"Endocrinology. 143・8. 3105-3113 (2002)

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  • [Publications] Ohyama M: "Effect of enamel matrix derivative on the differentiation of C2C12 cells"Journal of Periodontology. 73・5. 543-550 (2002)

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  • [Publications] Irie K: "Changes of osteopontin distribution and matrix mineralization during remodeling in experimental bone formation"Acta Histochem Cytochemistry. 35・2. 109-114 (2002)

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  • [Publications] Maeda K: "Immunobiology and bone formation of experimentally induced periapical lesions in rats"Proceedings in the International Conference on Dentin/Pulp Complex 2001. 19-23 (2002)

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  • [Publications] Shiomi N: "Characterization of LITAF detected as a novel TNF-α transcription factor"Journal of Dental Research. (印刷中).

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  • [Publications] Murase Y.: "Possible involvement of protein kinases and Smad2 signaling pathways on osteoclast differentiation enhanced by activin A"Journal of Cellar Physiology. 188・2. 236-242 (2001)

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  • [Publications] Koseki T.: "Role of TGF-β family in osteoclastgenesis induced by RANKL"Cell. Signal. 14・1. 31-36 (2001)

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  • [Publications] Irie K.: "Immunohistochemical localization of membrane type1-matorix metalloproteinase (MTI-MMP) in osteoclasts in vivo"Tissue and Cell. 33・5. 478-782 (2001)

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  • [Publications] Suzuki N.: "Attachment of human periodontal ligament cells to enamel matrix derives protein is mediated via interaction between BMP and DVβ3"Journal of Periodontology. 72・11. 1520-1526 (2001)

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  • [Publications] Maeda K.: "Immunobiology and bone formation of experimentally induced periapical lesions in rats"Proceedings of the International Conferense on Dentin/Pulp. (in press). (2002)

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  • [Publications] 岡松 良昌: "ヒト歯肉線維芽細胞が産生する細胞画分IL-1αは細胞接着により単核破骨細胞の延命および多核破骨細胞への癒合を促進する"日本炎症・再生医学会雑誌. 21・5. 583-592 (2001)

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Published: 2001-04-01   Modified: 2016-04-21  

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