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Evaluation of drug interaction and interindividual differences of renal drug excretion based on the genetic polymorphism analysis

Research Project

Project/Area Number 13307068
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 応用薬理学・医療系薬学
Research InstitutionKYOTO UNIVERSTTY

Principal Investigator

INUI Ken-ichi  Kyoto University, Pharmacy, Professor, 医学研究科, 教授 (70034030)

Co-Investigator(Kenkyū-buntansha) MASUDA Satohiro  Kyoto University, Pharmacy, Instructor, 医学研究科, 助手 (90303825)
KATSURA Toshiya  Kyoto University, Pharmacy, Lecturer, 医学研究科, 講師 (10283615)
OKUDA Masahiro  Kyoto University, Pharmacy, Associate Professor, 医学研究科, 助教授 (70252426)
TERADA Tomohiro  Kyoto University, Pharmacy, Instructor, 医学研究科, 助手 (10324641)
MOTOHASHI Hideyuki  Kyoto University, Pharmacy, Instructor, 医学研究科, 助手 (30359822)
矢野 育子  京都大学, 医学研究科, 助手 (50273446)
齋藤 秀之  京都大学, 医学研究科, 助教授 (40225727)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
Fiscal Year 2003: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2002: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2001: ¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
KeywordsDrug transporter / Personalized pharmacotherapy / Interindividual differences / Genetic polymorphism / Expression profile / Detoxification system / Renal excretion / Organic ion / 尿細管分泌 / オーダーメイド薬物療法 / アニオン性薬物 / カチオン性薬物 / ペプチド類似薬物 / 有機カチオン / 有機アニオン / 腎疾患 / 薬物相互作用 / 薬物動態 / 遺伝子発現
Research Abstract

Drug transporters expressed in the kidney play important roles for elimination of number of hydrophilic compounds such as drugs, toxins and endogenous compounds. In the present study, we evaluated interindividual differences of pharmacokinetic (PK) properties based on the genetic information and expression profiles of human renal drug transporters.
We have identified and characterized novel renal specific transporters hOCT2-A and NaGLT1. Expression profiles for various drug transporters such as organic ion transporters in the human kidney were constructed. We have identified single nucleotide polymorphisms for coding region (cSNPs) of hOCT1 and hPEPT2 with decreasing the functional activities, but the appearance rates of these SNPs were very low. The correlation analyses between expression of drug transporters and PK properties in renal failure patients and model animals indicated that expression levels of renal drug transporters are responsible for interindividual differences of drug renal excretion. These findings could provide information for quantitative prediction and evaluation of PK based on the expression levels of renal drug transporters.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (122 results)

All Other

All Publications (122 results)

  • [Publications] Ishikawa et al.: "The genetic polymorphism of drug transporters : functional analysis approaches. [Review]"Pharmacogenomics. 5(1). 67-99 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terada, Inui: "Peptide transporters : structure, function, regulation and application for drug delivery. [Review]"Curr.Drug Metab.. 5(1). 85-94 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Horiba et al.: "Gene expression variance based on random sequencing in rat remnant kidney."Kidney Int.. (印刷中). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urakami et al.: "Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney."Pharm.Res.. 21(6). 982-987 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamura et al.: "Decreased expression of glucose and peptide transporters in rat remnant kidney."Drug Metab.Pharmacokin.. 19(2). 41-47 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terada et al.: "Genetic variant Arg57His in human H^*/peptide cotransporter 2 causes a complete loss of transport function."Biochem.Biophys.Res.Commun.. 316(2). 416-420 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uwai et al.: "Common Single nucleotide polymorphisms of MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese."J.Hum.Gen.. 49(1). 40-45 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi et al.: "Effect of cisplatin-induced acute failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats."Pharm.Res.. 21(2). 330-338 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai et al.: "Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases."Pharm.Res.. 21(1). 61-67 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masuda: "Functional characteristics and pharmacokinetic significance of kidney specific organic anion transporters, OAT-K1 and OAT-K2, in the urinary excretion of anionic drugs. [Review]"Drug Metab.Pharmacokin.. 18(1). 1-15 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeuchi et al.: "Decreased function of genetic variants, Pro283Leu and Arg287Gly, in human organic cation transporer hOCT1."Drug Metab.Pharmacokin.. 18(6). 409-412 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Igarashi et al.: "Decreased cyclosporin A concentrations in the absorption phase using microemulsion preconcentrate formulation in rats with cisplatin-induced acute renal failure."Biol.Pharm.Bull.. 26(11). 1591-1595 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Habu et al.: "Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney ; Roles of Organic ion transporters, rOAT1, rOAT3 and rOCT2."Biochem.Pharmacol.. 66(6). 1107-1114 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Horiba et al.: "Na^*-dependent fructose transport via rNaGLT1 in rat kidney"FEBS Lett.. 546(2-3). 276-280 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Horiba et al.: "Clonign and characterization of a novel Na^+-dependent glucose transporter NaGLT1 in rat kidney."J.Biol.Chem.. 278(17). 14669-14676 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohnishi et al.: "Distinct transport activity of tetraehylannmonium from L-carnitine in rat renal brush-border membranes."Biochim.Biophys.Acta. 1609(2). 218-224 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fukada et al.: "Involvement of specific transport system of renal basolateral membranes in distribution of nicotine in rats."Drug Metab.Pharmacokin.. 17(6). 554-560 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Habu et al.: "p-Aminohippurate transport at the apical membrane in the OK kidney epithelial cell line."Pharm.Res.. 19(12). 1822-1826 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Pan et al.: "Diurnal rhythm of H^*-peptide cotransporter in rat small intestine."Am.J.Physiol. Gastrointest.Liver Physiol.. 283(1). G57-G64 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urakami et al.: "cDNA cloning functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney."J.Am.Soc.Nephrol.. 13(7). 1703-1710 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ji et al.: "Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy."Kidney Int.. 16(2). 514-524 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kodawara et al.: "Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver."Pharm.Res.. 19(6). 738-743 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uwai et al.: "Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone."Drug Metabol.Pharmacokin.. 17(2). 125-129 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Motohashi et al.: "Gene expression levels and immunolocalization of organic ion transporters in the human kidney."J.Am.Soc.Nephrol.. 13(4). 866-874 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urakami et al.: "Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules."Pharm.Res.. 18(11). 1528-1534 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi et al.: "Upregulation of H^+-peptide cotransporter PEPT2 in rat remnant kidney"Am.J.Physiol.Renal Physiol.. 281(6). F1109-F1116 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sawada et al.: "Distinct transport characteristics of basolateral peptide transporters between MDCK and Caco-2 cells."Pflugers Arch. -Eur.J.Physiol.. 443(1). 31-37 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeuchi et al.: "Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2."J.Pharmacol.Exp.Ther.. 299(1). 261-267 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeuchi et al.: "Role of Kidney-Specific organic anion transporters in the urinary excretion of methotrexate."Kidney Int.. 60(3). 1058-1068 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuo et al.: "Transport of levofloxacin in the OK kidney epithelial cell line : interaction with p-aminohippurate transport."Pharm.Res.. 18(5). 573-578 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohnishi et al.: "Independent organic cation transport activity of Na^+-L-carnitine cotransport system in LLC-PK, cells."Am.J.Physiol.Renal Physiol.. 281(2). F273-F279 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kodawara et al.: "Interaction of azole antifungal agents with human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK_1."Xenobio.Metabol.and Dispos.. 16(1). 5-11 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 乾 賢一, 土井俊夫編著: "改訂腎機能別薬剤使用マニュアル"じほう. 194 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 乾 賢一: "臨床薬理学(第2版)"医学書院. 600 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 寺田智祐, 乾 賢一: "Annual Review腎蔵2002"中外医学社. 275 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 乾 賢一監修: "薬剤師が変える薬物治療 病院薬剤部から"じほう. 214 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 乾 賢一: "生物薬剤学"南江堂. 284 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 齋藤秀之, 乾 賢一: "薬物代謝からみた肝・腎・心疾患患者への医薬品投与時の注意"医薬ジャーナル. 78 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa et al.: "The genetic polymorphism of drug transporters: functional analysis approaches [Review]"Pharmacogenomics. 5(1). 67-99 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terada, Inui: "Peptide transporters : structure, function, regulation and application for drug delivery [Review]"Curr. Drug Metab.. 5(1). 85-94 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Horiba et al.: "Gene expression variance based on random sequencing in rat remnant kidney"(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urakami et al.: "Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney"Pharm.Res.. 21(6). 982-987 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamura et al.: "Decreased expression of glucose and peptide transporters in rat remnant kidney"Drug Metab.Pharmacokin.. 19(2). 41-47 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terada et al.: "Genetic variant Arg57His in human H+/peptide cotransporter 2 causes a complete loss of transport function"Biochem. Biophys.Res.Common.. 316(2). 416-420 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uwai et al.: "Common single nucleotide polymorphisms of MDRI gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese"J.Hum.Gen.. 49(1). 40-45 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi et al.: "Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats"Pharm.Res.. 21(2). 330-338 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai et al.: "Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases"Pharm.Res.. 21(1). 61-67 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masuda: "Functional characteristics and pharmacokinetic significance of kidney specific organic anion transporters, OAT-K1 and OAT K2, in the urinary, excretion of anionic drugs [Review]"Drug Metab.Pharmacokin.. 18(1). 1-15 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeuchi et al.: "Decreased function of genetic variants, Pro283Leu and Arg287G1y, in human organic cation transporter hOCTI"Drug Metab.Pharmacokin.. 18(6). 409-412 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Igarashi et al.: "Decreased cyclosporin A concentrations in the absorption phase using microemulsion preconcentrate formulation in rats with cisplatin-induced acute renal failure"Biol.Pharm.Bull.. 26(11). 1591-1595 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Habu et al.: "Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: Roles of organic ion transporters, rOAT1, rOAT3 and rOCT2"Biochem.Pharmacol.. 66(6). 1107-1114 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Horiba et al.: "Na+-dependent fructose transport via rNaGLT1 in rat kidney"FEBS Lett.. 546(2-3). 276-280 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Horiba et al.: "Cloning and characterization of a novel Na+-dependent glucose transporter NaGLT1 in rat kidney"J.Biol.Chem.. 278(17). 14669-14676 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohnishi et al.: "Distinct transport activity of tetraethylannmonium from L-carnitine in rat renal brush-border membranes"Biochim.Biophys.Acta. 1609(2). 218-224 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fukada et al.: "Involvement of specific transport system of renal basolateral membranes in distribution of nicotine in rats"Drug Metab.Pharmacokin.. 17(6). 554-560 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Habu et al.: "p-Aminohippurate transport at the apical membrane in the OK kidney epithelial cell line"Pharm.Res.. 19(12). 1822-1826 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Pan et al.: "Diurnal rhythm of H+-peptide cotransporter in rat small intestine"Am.J.Physiol.Gastrointest.Liver Physiol.. 283(1). G57-G64 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urakami et al.: "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney"J.Am.Soc Nephrol.. 13(7). 1703-1710 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ji et al.: "Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy"Kidney Int.. 16(2). 514-524 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kodawara et al.: "Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver"Pharm.Res.. 19(6). 738-743 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uwai et al.: "Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone"Drug Metabol.Pharmacokin.. 17(2). 125-129 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Motohashi et al.: "Gene expression levels and immunolocalization of organic ion transporters in the human kidney"J.Am.Soc.Nephrol.. 13(4). 866-874 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urakami et al.: "Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules"Pharm.Res.. 18(11). 1528-1534 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takahashi et al.: "Upregulation of H+-peptide cotransporter PEPT2 in rat remnant kidney"Am.J.Physiol.Renal Physiol.. 281(6). F1109-F1116 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sawada et al.: "Distinct transport characteristics of basolateral peptide transporters between MDCK and Caco-2 cells"Pflugers Arch. -Eur.J.Physiol.. 443(1). 31-37 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeuchii et al.: "Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OATK2"J.Pharmacol.Exp.Ther.. 299(1). 261-267 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeuchi et al.: "Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate"Kidney Int.. 60(3). 1058-1068 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuo et al.: "Transport of levofloxacin in the OK kidney epithelial cell line: interaction with p-aminohippurate trapsport"Pharm.Res.. 18(5). 573-578 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohnishi et al.: "Independent organic cation transport activity of Na+-L-carnitine cotransport system in LLC-PK, cells"Am.J.Physiol.Renal Physiol.. 281(2). F273-F279 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kodawara et al.: "Interaction of azole antifungal agents with human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1"Xenobio.Metabol.and Dispos.. 16(1). 5-11 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Urakami et al.: "Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney"Pharm.Res.. (印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Horiba et al.: "Gene expression variance based on random sequencing in rat remnant kidney"Kidney Int.. (印刷中). (2004)

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  • [Publications] Terada et al.: "Genetic variant Arg57His in human H^+/peptide cotransporter 2 causes a complete loss of transport function"Biochem.Biophys.Res.Commun.. 316・2. 416-420 (2004)

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  • [Publications] Terada, Inui: "Peptide transporters : structure, function, regulation and application for drug delivery (Review)"Curr.Drug Metab.. 5・1. 85-94 (2004)

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  • [Publications] Ishikawa et al.: "The genetic polymorphism of drug transporters : functional analysis approaches (Review)"Pharmagogenomics. 5・1. 67-99 (2004)

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  • [Publications] Uwai et al.: "Common single nucleotide polymorphisms of MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese"J.Hum.Genet.. 49・1. 40-45 (2004)

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  • [Publications] Yamaguchi et al.: "Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats"Pharm.Res.. 21・2. 330-338 (2004)

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  • [Publications] Sakurai et al.: "Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases"Pharm.Res.. 21・1. 61-67 (2004)

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  • [Publications] Takeuchi et al.: "Decreased function of genetic variants, Pro283Leu and Arg287Gly, in human organic cation transpoter hOCT1"Drug Metab.Pharmacokin.. 18・6. 409-412 (2003)

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  • [Publications] Igarashi et al.: "Decreased cyclosporin A concentrations in the absorption phase using microemulsion preconcentrate formulation in rats with cisplatin-induced acute renal failure"Biol.Pharm.Bull.. 26・11. 1591-1595 (2003)

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  • [Publications] Pan et al.: "Altered diurnal rhythm of intestinal peptide transporter by fasting and its effect on the pharrmacokinetics of ceftibuten"J.Pharmacol.Exp.Ther.. 307・2. 626-632 (2003)

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  • [Publications] Habu et al.: "Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney : Roles of organic ion transporters, rOAT1, rOAT3 and rOCT2"Biochem.Pharmacol.. 66・6. 1107-1114 (2003)

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  • [Publications] Masuda: "Functional characteristics and pharmacokinetic significance of kidney specific organic anion transporters. OAT-K1 and OAT-K2, in the urinary excretion of anionic drugs (Review)"Drug Metab.Pharmacokin.. 18・2. 91-103 (2003)

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  • [Publications] Okamura et al.: "Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and β-lactam antibiotics in human intestinal cell line Caco-2"Pharm.Res.. 20・9. 1389-1393 (2003)

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  • [Publications] Horiba et al.: "Na^+-dependent fructose transport via rNaGLT1 in rat kidney"FEBS Lett.. 546・2-3. 276-280 (2003)

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  • [Publications] Goto et al.: "Decreased expression of P-glycoprotein during differentiation in human intestinal cell line Caco-2"Biochem.Pharmacol.. 66・1. 163-170 (2003)

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  • [Publications] Horiba et al.: "Cloning and characterization of a novel Na^+-dependent glucose transporter NaGLT1 in rat kidney"j.Biol.Chem.. 278・17. 14669-14676 (2003)

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  • [Publications] Katsura, Inui: "Intestinal absorption of drugs mediated by drug transporters : mechanisms and regulation"Drug Metab.Pharmacokin.. 18・1. 1-15 (2003)

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  • [Publications] 乾 賢一, 土井俊夫編著: "改訂腎機能別薬剤使用マニュアル"じほう. 194 (2003)

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  • [Publications] 乾 賢一: "臨床薬理学(第2版)"医学書院. 600 (2003)

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  • [Publications] 伊賀立二, 乾 賢一編集: "じほう"薬剤師・薬学生のための実践TDMマニュアル(印刷中). (2004)

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  • [Publications] Horiba et al.: "Cloning and characterization of a novel Na^+-dependent glucose transporter NaGLT1 in rat kidney"J.Biol.Chem.. (印刷中). (2003)

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  • [Publications] Ohnishi et al.: "Distinct transport activity of tetraethylammonium from L-carnitine in rat renal brush-border membranes"Biochim.Biophys.Acta. 1609・2. 218-224 (2003)

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  • [Publications] Fukada et al.: "Involvement of specific transport system of renal basolateral membranes in distribution of nicotine in rats"Drug Metab.Pharmacokin.. 17・6. 554-560 (2002)

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  • [Publications] Habu et al.: "P-aminohippurate transport at the apical membrane in the OK kidney epithelial cell line"Pharm.Res.. 19・12. 1822-1826 (2002)

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  • [Publications] Jiko et al.: "Evaluation of pharmacokinetic interaction between cyclosporin A and probucol in rats"Pharm.Res.. 19・9. 1362-1637 (2002)

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  • [Publications] Goto et al.: "C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation"Pharmacogenetics. 12・6. 451-457 (2002)

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  • [Publications] Fukada et al.: "Transport mechanisms of nicotine across the human intestinal epithelial cell line Caco-2"J.Pharmacol.Exp.Ther.. 302・2. 532-538 (2002)

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  • [Publications] Kodawara et al.: "Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver"Pharm.Res.. 19・6. 738-743 (2002)

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  • [Publications] Ji et al.: "Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy"Kidney Int.. 62・2. 514-524 (2002)

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  • [Publications] Urakami et al.: "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney"J.Am.Soc.Nephrol.. 13・7. 1703-1710 (2002)

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  • [Publications] Uwai et al.: "Rat renal organic anion transporter rOAT1 mediates urinary-excreted cephalosporins, but not of biliary excreted cefoperazone"Drug Metab.Pharmacokin.. 17・2. 125-129 (2002)

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  • [Publications] Pan et al.: "Diurnal rhythm of H^+-peptide cotransporter in rat small intestine"Am.J.Physiol.Gastrointest.Liver Physiol.. 283・1. G57-G64 (2002)

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  • [Publications] Shimomura et al.: "Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus"J.Surg.Res.. 103・2. 215-222 (2002)

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  • [Publications] Motohashi et al.: "Gene expression levels and immunolocalization of organic ion transporters in the human kidney"J.Am.Soc.Nephrol.. 13・4. 866-874 (2002)

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  • [Publications] Ashida et al.: "Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells"Am.J.Physiol.Gastrointest.Liver Physiol.. 282・4. G617-G623 (2002)

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  • [Publications] 桂 敏也: "看護のための最新医学講座第31巻 薬物療法"中山書店. 425 (2002)

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  • [Publications] 寺田智祐: "Annual Review 腎臓2002"中外医学社. 275 (2002)

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  • [Publications] 乾 賢一 監修: "薬剤師が変える薬物治療 病院薬剤部から"じほう. 214 (2002)

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  • [Publications] Motohashi H: "Gene expression levels and immunolocalization of organic anion transporters in the human kidney"J. Am. Soc. Nephrol.. 13・4(印刷中). (2002)

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  • [Publications] Yamaguchi H: "Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo"J. Pharmacol. Exp. Ther.. 300・3. 1063-1069 (2002)

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  • [Publications] Okabe H: "Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction"J. Pharm. Pharmacol.. 54・1. 65-70 (2002)

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  • [Publications] Urakami Y: "Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules"Pharm. Res.. 18・11. 1528-1534 (2001)

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  • [Publications] Yamaguchi H: "Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2"Eur. J. Pharmacol.. 431・3. 297-303 (2001)

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  • [Publications] Takahashi K: "Upregulation of H+-peptide cotransporter PEPT2 in rat remnant kidney"Am. J. PhySiol. Renal Physiol.. 281・6. F1109-F1116 (2001)

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  • [Publications] Fukatsu S: "Population pharmacokinetics of tacrolimus in adult recipients receiving living-donor liver transplantation"Eur. J. Clin. Pharmacol.. 57・6-7. 479-484 (2001)

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  • [Publications] Takeuchi A: "Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2"J. Pharmacol. Exp. Ther.. 299・1. 261-267 (2001)

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  • [Publications] Takeuchi A: "Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate"Kidney Int.. 60・3. 1058-1068 (2001)

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  • [Publications] Motohashi H: "Effects of tacrolimus and cyclosporin A on peptide transporter PEPT1 in Caco-2 cells"Pharm. Res.. 18・5. 713-717 (2001)

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  • [Publications] Ohnishi S: "Independent organic cation transport activity of Na+-L-carnitine cotransport system in LLC-PK1 cells"Am. J. Physiol. Renal Physiol.. 282・2. F273-F279 (2001)

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  • [Publications] 乾 賢一: "生物薬剤学"南江堂. 284 (2001)

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  • [Publications] 齋藤 秀之: "薬物代謝からみた肝・腎・心疾患患者への医薬品投与時の注意"医薬ジャーナル社. 78 (2001)

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Published: 2001-04-01   Modified: 2016-04-21  

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