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Risk Evaluation for the Incidence of Congenital Hypothyroidism in Prenatal Multiple Exposure to Toxic Chemical Compounds

Research Project

Project/Area Number 13308031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 環境影響評価(含放射線生物学)
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

NAGAYAMA Junya  Kyushu University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (90136466)

Co-Investigator(Kenkyū-buntansha) TAKASUGA Takumi  Shimadzu Techno-Research Inc., Analytical Chemistry Branch, Section Head, 分析本部, 室長(研究職)
YANAGAWA Takashi  Kurume University, Biostatistical Center, Professor, バイオ統計センター, 教授 (80029488)
田辺 信介  愛媛大学, 沿岸環境科学センター, 教授 (60116952)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2004: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2003: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2002: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2001: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
KeywordsPCDDs / PCDFs / PCBs / Organochlorine Pesticides / Toxic Chemical Compounds / Prenatal Exposure / Congenital Hypothyroidism / Risk Evaluation / 胎児期復号曝露
Research Abstract

Serum concentrations (Mean±S.D.) of TSH, fT_3 and fT_4, respectively, were 35.4±49.7 μIU/ml, 3.07±0.89 pg/ml and 1.09±0.32 ng/dl in 64 (male:38,female:26) positive neonates in the mass-screening for congenital hypothyroidism or cretinism. In 108 (male:58,female:50) negative neonates in this mass-screening, the respective serum concentrations were 8.56±5.62 μIU/ml, 3.60±0.84 pg/ml and 2.46 ± 0.67 ng/dl. Concentrations of TSH were significantly higher in the positive neonates than in the negative neonates, and those of fT_3 and fT_4 lower in the former ones than in the latter ones.
Contamination levels (Mean±S.D., neonates with cretinism : normal neonates) of the organochlorine compounds in the breast milk samples which were collected within 4 weeks after childbirth were as follows: Dioxins (TEQ-pg/g);0.52±0.40:0.28±0.15,PCBs (ng/g);2.6±2.:1.5±1.3,DDT (ng/g) ;7.2±6.8:3.7±3.7,HCH (ng/g);2.7±3.4:1.3±1.2,Chlordane (ng/g);1.6±1.7:0.76±0.68 and HCB (ng/g);0.30±0.22:0.17±0.18. According to these analytical results, concentrations of the organochlorine compounds except HCH in the breast milk were significantly higher in the mothers who gave birth to neonates with congenital hypothyroidism than in those who gave birth to normal neonates.
Consequently, this study suggests higher prenatal multiple exposures to such organochlorine compounds may cause congenital hypothyroidism in Japan.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (35 results)

All 2004 Other

All Journal Article (15 results) Book (2 results) Publications (18 results)

  • [Journal Article] Effects of perinatal exposure to organochlorine pesticides, PCBs and dioxins on total development in 10-month-old Japanese male and female infants2004

    • Author(s)
      J.Nagayama et al.
    • Journal Title

      Organohalogen Compounds 66

      Pages: 3165-3171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Effects of lactational exposure to organochlorine pesticides, PCBs and dioxins on immune response and thyroid hormone systems in 10-month-old Japanese male and female infants2004

    • Author(s)
      J.Nagayama et al.
    • Journal Title

      Organohalogen Compounds 66

      Pages: 3172-3177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Maternal-infant transfer of polybrominated diphenyl ethers and polychlorinated biphenyl ethers2004

    • Author(s)
      T.Hirai et al.
    • Journal Title

      Organohalogen Compounds 66

      Pages: 2422-2427

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Impact of fermented brown rice with Aspergillus oryzae (FEBRA) intake and concentrations of polybrominated diphenylethers (PBDEs) in blood of humans from Japan2004

    • Author(s)
      T.Takasuga et al.
    • Journal Title

      Chemosphere 57

      Pages: 795-811

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impact of FEBRA (fermented brown rice with Aspergillus oryzae) intake and concentrations of PCDDs, PCDFs and PCBs in blood of humans from Japan2004

    • Author(s)
      T.Takasuga et al.
    • Journal Title

      Chemosphere 57

      Pages: 1409-1426

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 残留性有機汚染物質(POPs)による愛媛県在住初産婦の母乳汚染2004

    • Author(s)
      國末 達也 等
    • Journal Title

      環境科学会誌 17

      Pages: 37-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Effects of perinatal exposure to organochlorine pesticides, PCBs and dioxins on total development in 10-month-old Japanese male and female infants2004

    • Author(s)
      J.Nagayama, J.Fukushige, T.Iida, R.Nakagawa et al.
    • Journal Title

      Organohalogen Compounds 66

      Pages: 3165-3171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of lactational exposure to organochlorine pesticides, PCBs and dioxins on immune response and thyroid hormone systems in 10-month-old Japanese male and female infants2004

    • Author(s)
      J.Nagayama, H.Tsuji, T.Iida, R.Nakagawa et al.
    • Journal Title

      Organohalogen Compounds 66

      Pages: 3172-3177

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Maternal-infant transfer of polybrominated diphenyl ethers2004

    • Author(s)
      T.Hirai, Y.Fujimine, S.Watanabe, Y.Nakamura, H.Shimomura, J.Nagayama
    • Journal Title

      Organohalogen Compounds 66

      Pages: 2422-2427

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impact of fermented brown rice with Aspergillus oryzae (FEBRA) intake and concentrations of polybrominated diphenylethers (PBDEs) in blood of humans from Japan2004

    • Author(s)
      T.Takasuga, K.Senthilkumar, H.Takemori, E.Ohi, H.Tsuji, J.Nagayama
    • Journal Title

      Chemosphere 57

      Pages: 795-811

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impact of FEBRA (fermented brown rice with Aspergillus oryzae) intake and concentrations of PCDDs,PCDFs and PCBs in blood of humans from Japan2004

    • Author(s)
      T.Takasuga, K.Senthilkumar, H.Takemori, E.Ohi, H.Tsuji, J.Nagayama
    • Journal Title

      Chemosphere 57

      Pages: 1409-1426

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Contamination by persistent organic pollutants (POPs) in human breast milk collected from primiparas in Ehime prefecture2004

    • Author(s)
      T.Kunisue, M.Someya, M.Watanabe, T.Toyota, Y.Kuroda, J.Nagayama, S.Tanabe
    • Journal Title

      Environmental Science 17

      Pages: 37-48

    • NAID

      10012085124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Environment and Health : Data science for risk evaluation2004

    • Author(s)
      T.Yanagawa
    • Journal Title

      Epidemiology of Industrial Cancer (ed.R.Kishi)(Shinohara Publishing Corp., Tokyo, Japan)

      Pages: 133-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Impact of fermented brown rice with Aspergillus oryzae(FEBRA) intake and concentrations of polybrominated diphenylethers(PBDEs) in blood of humans from Japan2004

    • Author(s)
      T.Takasuga et al.
    • Journal Title

      Chemosphere 57

      Pages: 795-811

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Impact of FEBRA(fermented brown rice with Aspergillus oryzae) intake and concentrations of PCDDs, PCDFs and PCBs in blood of humans from Japan2004

    • Author(s)
      T.Takasuga et al.
    • Journal Title

      Chemosphere 57

      Pages: 1409-1426

    • Related Report
      2004 Annual Research Report
  • [Book] 環境と健康:リスク評価のデータサイエンス,職業がんの疫学2004

    • Author(s)
      柳川 堯
    • Publisher
      篠原出版新社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 環境と健康:リスク評価のデータサイエンス,職業がんの疫学(監修 岸玲子)2004

    • Author(s)
      柳川 堯
    • Publisher
      篠原出版新社
    • Related Report
      2004 Annual Research Report
  • [Publications] J.Nagayama, H.Tsuji, T.Iida, R.Nakagawa, T.Matsueda, et al.: "Effects of PCDDs, PCDFs and coplanar PCBs on immune response and thyroid hormone systems in Japanese mothers"Organohalogen Compounds. 63. 393-396 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] J.Nagayama, H.Tsuji, T.Iida, R.Nakagawa, T.Matsueda, et al.: "Sexual distinction in effects of perinatal exposure to organochlorine pesticides, PCBs and dioxins on immune response and thyroid hormone systems in Japanese infants"Organohalogen Compounds. 65. 190-194 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] J.Nagayama, H.Tsuji, T.Iida, R.Nakagawa, T.Matsueda, et al.: "Sexual distinction in effects of perinatal exposure to organochlorine pesticides, PCBs and dioxins on frequency of sister chromatid exchanges in Japanese infants"Organohalogen Compounds. 65. 246-249 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] J.Nagayama, T.Takasuga, H.Tsuji, M.Umehara, T.Sada, T.Iwasaki: "Active elimination of causative PCDFs/DDs congeners of Yusho by one year intake of FBRA in Japanese people"Fukuoka Acta Med.. 94. 118-125 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] J.Nagayama, M.Nagayama, T.Iida, H.Hirakawa, T.Matsueda, et al.: "Frequency of SCEs in Japanese infants exposed to dioxins and PCBs through the breast milk"Fukuoka Acta Med.. 94. 158-165 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Yanagawa, Y.Kobayashi, J.Nagayama: "Assessing the joint effects of chlorinated dioxins, some pesticides and polychlorinated biphenyls on thyroid hormone status in Japanese breast-fed infants"Environmetrics. 14. 121-128 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] J.Nagayama et al.: "Decrease in blood levels and body burdens of highly toxic dioxin congeners after one year intake of FBRA in Japanese"Organohalogen Compounds. 55. 327-330 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] J.Nagayama et al.: "Effects of organochlorine compounds such as pesticides, PCBs and dioxins on immune response system in Japanese mothers"Organohalogen Compounds. 55. 425-428 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] J.Nagayama et al.: "Frequency of sister chromatid exchanges in Japanese infants lactationally exposed to organochlorine pesticides and dioxins"Organohalogen Compounds. 55. 429-432 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] J.Nagayama et al.: "Effects of organochlorine compounds such as pesticides, PCBs and dioxins on thyroid hormone system in Japanese mothers"Organohalogen Compounds. 56. 115-118 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] J.Nagayama et al.: "Sexual difference in effects of dioxins on immune response system in Japanese infants"Organohalogen Compounds. 59. 135-138 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] J.Nagayama et al.: "Sexual difference in effects of dioxins on thyroid hormone system in Japanese infants"Organohalogen Compounds.

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagayama J. et al.: "Effects of contamination level of dioxins and related chemicals on thyroid hormone and immune response systems in patients with "Yusho""Chemosphere. 43. 1005-1010 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagayama J. et al.: "Comparison between "Yusho" patients and healthy Japanese in contamination level of dioxins and related chemicals and frequency of sister chromatiid exchanges"Chemosphere. 43. 931-936 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagayama J. et al.: "Effects of donor age and contamination level of dioxins and related chemicals on frequency of sister chromatid exchanges in human lymphocytes cultured in vitro"Chemosphere. 43. 845-849 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagayama J. et al.: "Thyroid hormone status in Japanese infants lactationally exposed to organochlorine pesticides, PCBs and dioxins"Organohalogen Compounds. 53. 140-144 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagayama J. et al.: "Status of helper and suppressor T lymphocyte subpopulations in Japanese infants lactationally exposed to organochlorine pesticides, PCBs and dioxins"Organohalogen Compounds. 53. 121-125 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagayama J. et al.: "Frequency of sister chromatid exchanges in Japanese infants perinatally exposed to chlorinated dioxins and related compounds"Organohalogen Compounds. 53. 100-102 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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