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Construction of a repertoire of genetically altered mice for evaluating the toxicity of chemicals

Research Project

Project/Area Number 13357005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Hygiene
Research InstitutionUniversity of Yamanashi (2003)
山梨医科大学 (2001-2002)

Principal Investigator

MAEDA Shuichiro  University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Professor, 大学院・医学工学総合研究部, 教授 (10117244)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Masayuki  University of Tsukuba, Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, Professor, 基礎医学系(先端学際領域研究センター), 教授 (50166823)
KOIZUMI Akio  Kyoto University, Department of Health and Environmental Sciences, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (50124574)
NAKAJIMA Tamie  Nagoya University, Department of Occupational and Environmental Health, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (10020794)
KAGAMI Yoshihiro  Ecogenomics, Inc., Chief Research Scientist, 主席研究員・研究職
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2003: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2002: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2001: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Keywordstoxic chemicals / genetically altered mice / bioassay system / toxicological assessment / dioxins / 環境リスク
Research Abstract

Currently, more than 100,000 chemicals have been used in industry. These chemicals have been released to the environment without any toxicological evaluation. To regulate these chemicals properly, the development of methods for toxicological assessment is required. Thus, we performed experiments to develop a repertoire of genetically altered mice for evaluating the toxicity of chemicals. The results of our experiments are as follows.
1)We established an extremely rapid, sensitive, easy, and specific assay for dioxin and dioxin like chemicals (Maeda, S.)
2)In the search for dioxin-responsive genes in the mouse fetal brain we used differential mRNA display and DNA microarray and found that secreted frizzled-related protein 2 and c-myc genes that encode a Wnt modulator and a Wnt target, respectively, were up-regulated by perinatal exposure of mice to dioxin (Maeda, S. & Kagami, Y.).
3)Nrf2-null mice were very sensitive to acetaminophane and very often suffered from acute hepatotoxicity (Yama … More moto, M.)
4)When AhRR, which was identified as a repressor of AhR, was deleted in mouse, the induction of AhR target genes were increased and prolonged (Yamamoto, M.).
5)We have conducted genetic analyses of individuals highly susceptible to goiter and found two linked regions on chromosome 3 and 4. We have sequenced solute carrier family genes, SLC26A1 and SLC2A9. The sequence, however, suggested that these two genes were not associated with familial goiter (Koizum, A.).
6)The role of peroxisome proliferators-activated receptor a (PPARa) in the di (2-ethylhexyl) phthalate (DEHP)-induced reduction of fertility, which was assessed by measuring the numbers of pups born and pups lived more than 16 weeks per breeding pair, was assessed using Sv/129 wild-type and PPARa-null mice. Our results suggested that the reduction of fertility without the maternal or paternal genital organ toxicity found in DEHP-exposed wild-type mice is partly caused by a signal triggering energy overconsumption via PPARa in the maternal body (Nakajima, T.). Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (81 results)

All 2005 2004 2003 2002 2001 Other

All Journal Article (56 results) Book (3 results) Publications (22 results)

  • [Journal Article] Fast-track DRESSA : A bioassay for fast, sensitive and selective detection of halogenated and polycyclic aromatic hydrocarbons.2005

    • Author(s)
      Kasai, A., Hiramatsu, N., Meng, Y., Yao, J., Maeda, S., Kitamura, M.
    • Journal Title

      Analytical Biochemistry 337

      Pages: 84-88

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Avoiding the effect of linked genes is crucial to elucidate the role of Apcs in autoimmunity.2005

    • Author(s)
      Tamaoki, T., Tezuka, H., Okada, Y., Ito, S., Shimura, H., Sakamoto, M., Endo, T., Ozaki, Y., Kanba, S., Maeda, S.
    • Journal Title

      Nature Medicine 11

      Pages: 11-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] AP-1-independent sensitization to oxidative stress-induced apoptosis by proteasome inhibitors.2004

    • Author(s)
      Hiramatsu, N., Kasai, A., Yao, J., Meng, Y., Takeda, M., Maeda, S., Kitamura, M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 316

      Pages: 545-552

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] DRESSA : biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase.2004

    • Author(s)
      Kasai, A., Hiramatsu, N., Meng, Y., Yao, J., Takeda, M., Maeda, S., Kitamura, M.
    • Journal Title

      Analytical Biochemistry 335

      Pages: 73-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Perfluorooctanoate and perfluorooctane sulfonate concentrations in surface water in Japan.2004

    • Author(s)
      Saito, N., Harada, K., Inoue, K., Sasaki, K., Yoshinaga, Y., Koizumi, A.
    • Journal Title

      J.Occup.Health. 46

      Pages: 49-59

    • NAID

      10012080949

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in ins2^<+/Akita> pancreatic β cells.2004

    • Author(s)
      Nozaki, J., Kubota, H., Yoshida, H., Naitoh, M., Yoshinaga, T., Mori, K., Koizumi, A., Nagata, K.
    • Journal Title

      Genes to Cells 9

      Pages: 261-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The influence of time sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years.2004

    • Author(s)
      Harada, K., Saito, N., Inoue, K., Yoshinaga, T., Watanabe, T., Sasaki, S., Koizumi, A.
    • Journal Title

      J.Occup.Health. 46

      Pages: 141-147

    • NAID

      110003722933

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] A survey of semen induces in insecticide sprayers.2004

    • Author(s)
      Kamijima, M., Hibi, H., Gotoh, M., Taki, K., Saito, I., Wang, H., Itohara, S., Yamada, T., Ichihara, G., SHibata, E., Nakajima, T., Takeuchi, Y.
    • Journal Title

      J.Occup.Health 46

      Pages: 109-118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Perfluorooctanoate and perfluorooctane sulfonate concentrations in surface water in Japan.2004

    • Author(s)
      Saito, N., Harada, K., Inoue, K., Sasaki, K., Yoshibaga, Y., Koizumi, A.
    • Journal Title

      J.Occup.Health. 46

      Pages: 49-59

    • NAID

      10012080949

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP 1 in ins2+/Akita pancreatic β cells.2004

    • Author(s)
      Nozaki, J., Kubota, H., Yoshida, H., Naitoh, M., Yoshinaga, T., Mori, K., Koizumi, A., Nagata, K.
    • Journal Title

      Genes to Cells 9

      Pages: 261-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years.2004

    • Author(s)
      Harada, K., Saito, N., Inoue, K., Yoshinaga, T., Watanabe, T., Sasaki, S., Koizumi, A.
    • Journal Title

      J.Occup.Health. 46

      Pages: 141-147

    • NAID

      110003722933

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] A survey of semen induces in insecticide sprayers.2004

    • Author(s)
      amijima, M., Hibi, H., Gotoh, M., Taki, K., Saito, I., Wang, H., Itohara, S., Yamada, T., Ichihara, G., Shibata, E., Nakajima, T., Takeuchi, Y.
    • Journal Title

      J.Occup.Health 46

      Pages: 109-118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Use of genetically altered mice to study the role of serum amyloid P component in amyloid deposition.2003

    • Author(s)
      Maeda, S.
    • Journal Title

      Amyloid : J.Protein Folding Disord 10(Suppl.1)

      Pages: 17-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Production of mouse ES cells homozygous for Cdk5-phosphorylated site mutation in c-Src alleles.2003

    • Author(s)
      Kato, G., Maeda, S.
    • Journal Title

      J.Biochem.(Tokyo). 133

      Pages: 563-569

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on brain development and function.2003

    • Author(s)
      Maeda, S., Kakeyama, M., Tohyama C.
    • Journal Title

      Organohalogen Conpounds 65

      Pages: 27-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] EPR imaging of reducing activity in Nrf2 transcriptional factor-deficient mice.2003

    • Author(s)
      Hirayama, A., Yoh, K., Nagase, S., Ueda, A., Itoh, K., Morito, N., Hirayama, K., Takahashi, S., Yamamoto, M., Koyama, A.
    • Journal Title

      Free Rad.Biol.Med. 34

      Pages: 1236-1242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse.2003

    • Author(s)
      Noda, S., Harada, N., Hida, A., Fujii-Kuriyama, Y., Motohashi, H., Yamamoto, M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 303

      Pages: 105-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.2003

    • Author(s)
      Moriguchi, T., Motohashi, H., Hosoya, T., Nakajima, O., Takahashi, S., Ohsako, S., Aoki, Y., Nishimura, T., Tohyama, C., Fujii-Kuriyama, Y., Yamamoto, M.
    • Journal Title

      Proc.Natul.Acad.Sci.USA 100

      Pages: 5652-5657

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H : quinone oxidoreductase 1 gene : reassessment of the ARE consensus sequence.2003

    • Author(s)
      Nioi, P., McMahon, M., Itoh, K., Yamamoto, M., Hayes, J.
    • Journal Title

      Biochem.J. 374

      Pages: 337-348

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.2003

    • Author(s)
      Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., Kotsuji, T., Otsuka, F., Roop, D.R., Harada, T., Engel, J.D., Yamamoto, M.
    • Journal Title

      Nature Genetics 35

      Pages: 238-245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element.2003

    • Author(s)
      Jowsey, I.R., Jiang, Q., Itoh, K., Yamamoto, M., Hayes, J.D.
    • Journal Title

      Mol.Pharmacol. 64

      Pages: 1018-1028

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway.2003

    • Author(s)
      Kwak, M.K., Wakabayashi, N., Greenlaw, J.L., Yamamoto, M., Kensler, T.W.
    • Journal Title

      Mol.Cell.Biol. 23

      Pages: 8786-8794

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Perfluorooctane Sulfonate Concentrations in Surface water in Japan.2003

    • Author(s)
      Saito, N., Sasaki, K., Nakatome, K., Harada, K., Yoshinaga, T., Koizumi, A.
    • Journal Title

      Arch.Environ.Contam.Toxicol. 45

      Pages: 149-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Perfluorooctane Sulfonate contamination of Drinking water in the Tama River, Japan : Estimated effects on Resident Serum Levels.2003

    • Author(s)
      Harada, K., Saito, N., Sasaki, K., Inoue, K., Koizumi, A.
    • Journal Title

      Bull.Environ.Contam.Toxicol. 71

      Pages: 31-36

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Impact of Airborne Perfluorooctane Sulfonate on the Human Body Burden and the Ecological System.2003

    • Author(s)
      Sasaki, K., Harada, K., Saito, N., Koizumi, A.
    • Journal Title

      Bull Environ Contam Toxicol. 71

      Pages: 408-413

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Generalized skin reactions in relation to trichloroethylene exposure : a review from the viewpoint of drug-metabolizing enzymes.2003

    • Author(s)
      Nakajima, T., Yamanoshita, O., Kamijima, M., Kishi, R., Ichihara, G.
    • Journal Title

      J.Occup.Health 45

      Pages: 8-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Exposure to 1-bromopropane caused ovarian dysfunction in rats.2003

    • Author(s)
      Yamada, T., Ichihara, G., Wang, H., Yu, X., Maeda, K., Tsukamura, H., Kamijima, M., Nakajima, T., Takeuchi, Y.
    • Journal Title

      Toxicol.Sci. 71

      Pages: 96-103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Use of genetically altered mice to study the role of serum amyloid P component in amyloid deposition.2003

    • Author(s)
      Maeda, S.
    • Journal Title

      Amyloid : J.Protein Folding Disord 1O (Suppl.1)

      Pages: 17-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Production of mouse ES cells homozygous for Cdk5-phosphorylated site mutation in c-Src alleles.2003

    • Author(s)
      Kato, G., Maeda, S.
    • Journal Title

      J.Biochem.(Tokyo) 133

      Pages: 563-569

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Effects of 2,3,7,8-tetrachlorodibenzo p-dioxin on brain development and function.2003

    • Author(s)
      Maeda, S., Kakeyama, M., Tohyama, C.
    • Journal Title

      Organohalogen Conpounds 65

      Pages: 27-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.2003

    • Author(s)
      Moriguchi, T., Motohashi, H., Hosoya, T., Nakajima, 0., Takahashi, S., Ohsako, S., Aoki, Y., Nishimura, T., Tohyama, C., Fujii-Kuriyama, Y., Yamamoto, M.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 100

      Pages: 5652-5657

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Antioxidants enhance mammalian proteasome expression through the Keapl-Nrf2 signaling pathway.2003

    • Author(s)
      Kwak, M.K., Wakabayashi, N., Greenlaw, J.L., Yamamoto, M., Kensler, T.W.
    • Journal Title

      Mol.Cell.Biol. 23

      Pages: 8786-8794

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Generalized skin reactions in relation to trichloro ethylene exposure: a review from the viewpoint of drug-metabolizing enzymes.2003

    • Author(s)
      Nakajima, T., Yamanoshita, 0., Kamijima, M., Kishi, R., Ichihara, G.
    • Journal Title

      J.Occup.Health 45

      Pages: 8-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Linkage analysis of susceptibility to hyperoxic lung injury: role of Nrf2 as a candidate gene.2002

    • Author(s)
      Cho, H.Y., Jedlika, A.E., Reddy, S.P.M., Zhang, L.Y., Yamamoto, M., Kensler, T.W., Kleeberger, S.R.
    • Journal Title

      Am.J.Res.Cell Mol.Biol. 26

      Pages: 175-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.2002

    • Author(s)
      Thimmulappa, R.K., Mai, K.H., Srisuma, S., Kensler, T.W., Yamamoto, M., Biswal, S.
    • Journal Title

      Cancer Res. 62

      Pages: 5196-5203

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.2002

    • Author(s)
      Chanas, S.A., Jiang, Q., McMahon, M., McWalter, G.K., McLellan, L.I., Elcombe, C.R., Henderson, C.J., Wolf, C.R., Moffat, G.J., Itoh, K., Yamamoto, M., Haves, J.D.
    • Journal Title

      Biochem.J. 365

      Pages: 405-416

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Genetic epidemiology of hereditary hemorrhagic telagioectasia in a localcommunity in the northern part of Japan.2002

    • Author(s)
      Dakeishi, M., Shioya, T., Wada, Y., Shindo, T., Otaka, K., Manabe, M., Nozaki, J., Inoue, S., Koizumi, A.
    • Journal Title

      Human Mut. 19

      Pages: 140-148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.2002

    • Author(s)
      Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Shizuo, A., Araki, E., Mori, M.
    • Journal Title

      J.Clin.Invest. 109

      Pages: 525-532

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Mutation Analysis in PKD1 of Japanese Autosomal Dominant Polycystic Kidney Disease Patients.2002

    • Author(s)
      Inoue, S., Inoue, K., Utsunomiya, M., Nozaki, J., Yamada, Y., Iwasa, T., Mori, E., Yoshinaga, T., Koizumi, A.
    • Journal Title

      Human Mut. 19

      Pages: 622-628

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Effects of aldehyde dehydrogenase-2 genetic polumorphisms on metabolism of structurally different aldehydes in human liver.2002

    • Author(s)
      Wang, R.S., Nakajima, T., Kawamoto, T., Honma, T.
    • Journal Title

      Drug.Met.Disp. 30

      Pages: 69-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Functional activation of peroxisome proliferators-activated receptor α (PPARα) by environmental chemicals in relation to their toxicities.2002

    • Author(s)
      Nakajima, T., Ichihara, G., Kamijima, M., Itohara, S., Aoyama, T.
    • Journal Title

      Nagoya J.Med.Sci. 65

      Pages: 85-94

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Identification of functions of peroxisome proliferator-activated receptor alpha in proximal tibules.2002

    • Author(s)
      Kamijo, Y., Hora, K., Tanaka, N., Usuda, N., Kiyosawa, K., Nakajima, T., Gonzalez, F.J., Aoyama, T.
    • Journal Title

      J.Am.Soc.Nephron. 13

      Pages: 1691-1702

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Role of NRF2 in Protein Against Hyperoxic Lung Injury in Mice.2002

    • Author(s)
      Cho, H.Y., Jedlika, A.E., Reddy, S.P.M., Zhang, L.Y., Yamamoto, M., Kensler, T.W., Kleeberger, S.R.
    • Journal Title

      Am.J.Res.Cell Mol.Biol. 26

      Pages: 175-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gstal, Gsta2, Gstml, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.2002

    • Author(s)
      Chanas, S.A., Jiang, Q., McMahon, M., McWalter, G.K., McLellan, L.I., Elcombe, C.R., Henderson, C.J., Wolf, C.R., Moffat, G.J., Itoh, K., Yamamoto, M., Hayes, J.D.
    • Journal Title

      Biochem.J. 365

      Pages: 405-416

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Genetic epidemiology of hereditary hemorrhagic telagioectasia in a local community in the northern part of Japan.2002

    • Author(s)
      Dakeishi, M., Shioya, T., Wada, Y., Shindo, T., Otaka, K., Manabe, M., Nozaki, J., Inoue, S., Koizumi, A.
    • Journal Title

      Human Mutt 19

      Pages: 140-148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Functional activation of peroxisome proliferators-activated receptor a (PPARα) by environmental chemicals in relation to their toxicities.2002

    • Author(s)
      Nakajima, T., Ichihara, G., Kamijima, M., Itohara, S., Aoyama, T.
    • Journal Title

      Nagoya J.Med.Sci. 65

      Pages: 85-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] High sensitivity of Nrf2 knockout mice to acetoaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzyme and antioxidant genes.2001

    • Author(s)
      Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., O'Connor, T., Harada, T., Yamamoto, M.
    • Journal Title

      Toxicol.Sci. 59

      Pages: 169-177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.2001

    • Author(s)
      Ramos-Gomez, M., Kwak, M-K., Dolan, P.M., Itoh, K., Yamamoto, M., Talalay, P., Kensler, T.W.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 98

      Pages: 3410-3415

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Accelerated DNA adducts formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust.2001

    • Author(s)
      Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K., Yamamoto, M.
    • Journal Title

      Toxicol.Appl.Pharmacol. 173

      Pages: 154-160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] A new locus for a dominant form of multinodular goiter on 3q26.1-q26.3.2001

    • Author(s)
      Takahashi, T., Nozaki, J., Komatsu, M., Wada, Y., Utsunomiya, M., Inoue, K., Takada, G., Koizumi, A.
    • Journal Title

      Biochem.Biophys.Res.Commun. 284

      Pages: 650-654

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Age-dependent odesity and hyperinsulinemia in PPARα(+/-) LDLR(+/-) male mice.2001

    • Author(s)
      Sugiyama, E., Tanaka, N., Nakajima, T., Kamijo, Y., Aoyama, T.
    • Journal Title

      J.Diabetes.Complications 16

      Pages: 51-56

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Tobacco use anf occupational exposure to carcinogens, but not N-acetyltransferase 2 genotypes are major risk factors for bladder cancer in the Japanese.2001

    • Author(s)
      Kontani, K., Kawakami, M., Nakajima, T., Katsuyama, T.
    • Journal Title

      Urol.Res. 29

      Pages: 199-204

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Four-week inhalation toxicity study of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) in guinea pigs.2001

    • Author(s)
      Kabe, I., Takebayashi, T., Nishiwaki, Y., Nakajima, T., Ikeda, E., Saito, T., Tanaka, S., Miyauchi, H., Endo, Y., Omae, K.
    • Journal Title

      J.Occup.Health 43

      Pages: 314-320

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] High sensi-tivity of Nrf2 knockout mice to acetoaminophen hepato-toxicity associated with decreased expression of ARE- regulated drug metabolizing enzyme and antioxidant genes.2001

    • Author(s)
      Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., O'Connor, T., Harada, T., Yamamoto, M.
    • Journal Title

      Toxicol.Sci. 59

      Pages: 169-177

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] A new locus for a dominant form of multinodular goiter on 3q26.1-q26.3.2001

    • Author(s)
      Takahashi, T., Nozaki, J., Komatsu, M., Wada, Y., tsunomiya, M., Inoue, K., Takada, G., Koizumi, A.
    • Journal Title

      Biochem.Biophys.Res.Commun. 284

      Pages: 650-654

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Age-dependent odesity and hyperinsulinemia in PPARa(+/-) LDLR(+/-) male mice.2001

    • Author(s)
      Sugiyama, E., Tanaka, N., Nakajima, T., Kamijo, Y., Aoyama, T.
    • Journal Title

      J.Diabetes.Complications 16

      Pages: 51-56

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Book] 分子予防環境医学、難分解性環境汚染物質2003

    • Author(s)
      原田浩二, 井上佳代子, 小泉昭夫
    • Total Pages
      10
    • Publisher
      本の泉社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Book] 環境化学物質の代謝とその周辺、フタル酸ジ-2-エチルヘキシル、フタル酸ジブチル、ペルオキシゾーム増殖剤活性化受容体2003

    • Author(s)
      荻野景規, 小栗一太編(那須民江分担)
    • Publisher
      日本公衆衛生協会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Book] 分子予防環境医学編 有機溶剤2003

    • Author(s)
      那須民江他, 分担
    • Publisher
      本の泉社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiramatasu, N., et al.: "AP-1-independent sensitization to oxidative stress-induced apoptosis by proteasome inhibitors."Biochem.Biophys.Res.Commun.. 316(2). 545-552 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kato, G., Maeda, S.: "Production of mouse ES cells homozygous for Cdk5-phosphorylated site mutation in c-Src alleles."J.Biochem.. 133(5). 563-569 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Itoh, K., et al.: "Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)."Mol.Cell.Biol.. 24(1). 36-45 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Wakabayashi, N., et al.: "Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation."Nature Genetics. 35(3). 238-245 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morito, N., et al.: "Nrf2 regulates the sensitivity of death receptor signals through intra- cellular glutathione levels."Oncogene. 18(58). 9275-9281 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Moriguchi, T., et al.: "Distinct specificity of xenobiotic response in AhR-humanized model mouse."Proc.Natl.Acad.Sci.USA. 100(10). 5652-5657 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noda, S., et al.: "Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse."Biochem.Biophys.Res.Commun.. 303(1). 105-111 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakajima (Nasu), T., et al.: "Generalized skin reactions in relation to trichloroethylene exposure : a review from the viewpoint of drug-metabolizing enzymes."J.Occup.Health. 45(1). 8-14 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nozaki, J., et al.: "Point mutation of isulin Cystein 96 stimulate endoplasmic reticulum stress response through the activation of transcription factors ATF6 and XBP1 in ins+/Akita pancreatic b cell lines."Genes to Cells. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Harada, K., et al.: "The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years."J.Occup.Health. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Saito, N., et al.: "Perfluorooctanoate and perfluorooctane sulfonate concentrations in surface water in Japan."J.Occup.Health.. 46(1). 49-59 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sasaki, K., et al.: "Impact of airborne perfluorooctane sulfonate on the human body burden and the ecological system."Bull.Environ.Contam.Toxicol.. 71(2). 408-413 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kato, G., Maeda, S.: "Production of mouse ES cells homozygous for Cdk5-phosphorylated site mutation in c-src alleles"J.Biochem.. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Thimmulappa, R.K., Mai, K.H., Srisuma, S., Kensler, T.W., Yamamoto, M., Biswal, S.: "Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray"Cancer Res.. 62(18). 5196-5203 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kwak, M.K., Itoh, K., Yamamoto, M., Kensler, T.: "Regulation of the expression of Nrf2 transcription factor by cancer chemopreventive agents through antioxidant response element (ARE)-like sequences in its proximal promoter region"Mol.Cell.Biol.. 22(9). 2883-2892 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Dakeishi, M., Shioya, T., Wada, Y., Shindo, T., Otaka, K., Manabe, M., Nozaki, J., Inoue, S., Koizumi, A.: "Genetic epidemiology of hereditary hemorrhagic telagioectasia in a local community in the northern part of Japan"Human Mut.. 19(2). 140-148 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kamijo, Y., Hora, K., Tanaka, N., Usuda, N., Kiyosawa, K., Nakajima.T., Gonzalez, F.J., Aoyama, T.: "Identification of functions of peroxisome proliferator-activated receptor alpha in proximal tibules"J.Am.Soc.Nephron. 13(7). 1691-1702 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Soma, M., Tamaoki, T., Kawano, H., Ito, S., Sakamoto, M., Okada, Y., Kanba, S., Hamada, Y., Ishihara, T., Maeda, S.: "Mice lacking serum amyloid P component do not necessarily develop severe autoimmune disease"Biochem. Biophys. Res. Commun. 286(1). 200-205 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Usui, I., Kawano, H., Ito, S., Hamada, Y., Ishihara, T., Maeda, S.: "Homozygous serum amyloid P component-deficiency does not enhance regression of AA amyloid deposits"Amyloid : J. Protein Folding Disord. 8(2). 101-104 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., O'Connor, T., Harada, T., Yamamoto, M.: "High sensitivity of Nrf2 knockout mice to acetoaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzyme and antioxidant genes"Toxicol. Sci. 59(1). 169-177 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ramos-Gomez, M., Kwak, M-K., Dolan, P.M., Itoh, K., Yamamoto, M., Talalay, P., Kensler, T.W.: "Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice"Proc. Natl. Acad. Sci. USA. 98(6). 3410-3415 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi, T., Nozaki, J., Komatsu, M., Wada, Y., Utsunomiya, M., Inoue, K., Takada, G., Koizumi, A.: "A new locus for a dominant form of multinodular goiter on 3q26.1-q26.3"Biochem. Biophys. Res. Commun. 284(3). 650-654 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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