| Project/Area Number |
13357012
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
General surgery
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
KITAJIMA Masaki Keio University, School of Medicine, Professor, 医学部, 教授 (90112672)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Atsushi Keio University, School of Medicine, Professor, 医学部, 教授 (90051771)
KAWAKAMI Yutaka Keio University, School of Medicine, Professor, 医学部, 教授 (50161287)
KITAGAWA Yuko Keio University, School of Medicine, Assistant Professor, 医学部, 講師 (20204878)
FUJII Hirofumi Keio University, School of Medicine, Assistant Professor, 医学部, 講師 (80218982)
MUKAI Makio Keio University, School of Medicine, Associate Professor, 医学部, 助教授 (50101895)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2003: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2002: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2001: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
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| Keywords | Sentinel lymph node / micrometastasis / breast cancer / gastrointestinal cancer / minimally invasive surgery / navigation surgery / 微小リンバ節転移 |
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| Research Abstract |
The first possible sites of metastasis along the route of lymphatic drainage from the primary lesion are known as sentinel nodes (SNs) and these are detectable using injection of dyes or radioactive tracers. To develop individualized minimally invasive surgery for solid tumors without lymph node metastasis based on SN status, we have performed validation study of radio-guided SN mapping for more than 800 cases of solid tumors. From clinical data for these cases, an adequate indication of this methodology was determined. Optimal particle sizes in radio-guided method in each organ were also investigated. Performance and limitations of currently available laparoscopic gamma probes were analyzed and requirements for the gamma probes in the next generation were proposed. Quality of preoperative lymphoscintigrams to detect the number and distribution of sentinel node was significantly improved by modified technology of imaging data. Portable gamma camera to visualize SNs in operation theater was developed and evaluated in this study. Sensitivity of intra-operative evaluation of SN is crucial factor for successful and safe clinical application of SNNS. A Prototype of intra-operative semi-quantitative real time RT PCR to detect molecular metastasis was established. Now we are currently investigating novel local chemotherapy based on SN concept using special particle with anti-tumor reagent in animal model. These findings from this project would contribute a development of novel minimally invasive treatments for solid tumors.
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