| Project/Area Number |
13357018
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Periodontal dentistry
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
KAWAGUCHI Hiroyuki Hiroshima University, Graduate school of Biomedical Sciences, Associate professor, 医歯薬学総合研究科, 助教授 (10224750)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Mitsuhiro Nihon Univrsity, School or Dentistry, Research associate, 歯学部, 助手 (30194145)
ABIKO Yoshimitsu Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (70050086)
UMEDA Makoto Tokyo Medical and Dental University, Graduate School, Research Associate, 大学院・医歯学総合研究科, 助手 (90193937)
KAWABATA Yoshikatsu Asahi University, School of Dentistry, Research associate, 歯学部, 助手 (80329490)
KOBAYASHI Tetsuo Niigata University, Dental Hospital, assistant professor, 歯学部附属病院, 講師 (00215344)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2002: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2001: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
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| Keywords | Periodontal Disease / Diagnosis / Screening / Preiodontal Pathogen / PCR method / cytokine |
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| Research Abstract |
We developed a new method to detect periodontal pathogens. PCR method is very useful for making periodontal treatment plan and decision of prognosis. DNA microarray is also useful to know state of periodontal disease. On the other hand, we developed useful diagnosis method for disease sensitivity. Fc γ receptor gene regulates the production of inflammatory cytokines. Fc γ receptor polymorphisms affect the host response to bacterial attack. Profile analysis of inflammatory related factors from tissues, saliva, or gingival crevicular fluids (GCF) is available for the development of new therapy. Glycosaminoglycan level in GCF correlated with alveolar bone resorption. The measurement of calprotectin from GCF is associated with the activity of periodonttitis. Moreover we identified that volatile sulfer compound of expiration is closely correlated with periodontal disease. We developed a new method to detect traumatic occlusion using tooth fixation. To examine the effect of periodontitis for the body, we identified that high sensitivity CRP is very useful.
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