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Role of Phytochemicals in Lifestyle-related Disease Prevention

Research Project

Project/Area Number 13376001
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionMukogawa Women's University (2003-2004)
University of East Asia (2002)
Research Institute for Production Development (2001)

Principal Investigator

IKEDA Katsumi (2003-2004)  Mukogawa Women's University, School of Health Sciences, Professor, 生活環境学部, 教授 (80273499)

奈良 安雄 (2002)  東亜大学, 総合学術研究科, 教授 (80116417)

家森 幸男 (2001)  財団法人生産開発科学研究所, 予防栄養医学研究室, 研究員 (80025600)

Co-Investigator(Kenkyū-buntansha) YAMORI Yukio  Kinjogakuin University, School of Nutritional Environment, Professor, 生活環境学部, 教授 (80025600)
NARA Yasuo  Shujistu University, School of Pharmacy, Professor, 薬学部, 教授 (80116417)
YAMAMOTO Junko  Mukogawa Women's University, School of Health Sciences, Lecture, 生活環境学部, 講師 (30329651)
細田 公則  京都大学, 大学院・人間・環境学研究科, 助手 (40271598)
池田 克巳  (財)生産開発科学研究所, 予防栄養医学研究室, 研究員 (80273499)
山形 一雄  東亜大学, 総合学術研究科, 助教授 (10299323)
堀内 孝  東亜大学, 総合学術研究科, 教授 (10201758)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2004: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2003: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2002: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2001: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywordsphytochemicals / lifestyle-related diseases / WHO-CARDIAC study / isoflavones / SHRSP / NADPH oxidase / eNOS / Hypertension / オーストラリア / アフリカ / タンザニア / 血圧 / ポリフェノール / セサミン / 脳卒中易発症ラット / 疫学調査 / 食塩 / イフラボン / 酸化ストレス / 高血圧 / 生活習慣病危険因子 / 介入試験
Research Abstract

We investigated the effect of several phytochemicals on lifestyle-related disease prevention using a cell culture system and animal models that we developed. Among these phytochemicals, we clarified that soy isoflavones were effective for lifestyle-related disease prevention, and were good for human health.
Investigating the effects of soy protein and isoflavones on blood pressure and cholesterol levels among high risk middle-aged Scottish men, we could observed significant reductions from the baselines in systolic blood pressure(SBP) and diastolic blood pressure, total cholesterol and non-high density lipoprotein cholesterol in the group consuming a diet containing soy nutrients. To further investigate dietary factors preventing cardiovascular diseases, we divided world-wide populations examined by the WHO-CARDIAC study covering 60 study sites in 25 countries into the eaters and non-eaters of soybeans and evaluated risk factors for cardiovascular diseases. Among 1801 examinees whose 24h isoflavones were assayed, soy eaters had significantly lower body mass index, SBP and total-cholesterol than non-eaters.
To clarify the mechanism of this effect of isoflavones, we tested the hypothesis that genistein, one of the phytochemicals, may exert significant endothelial protection. Genistein acts as an antioxidant at the transcription level by the downregulation of p22phox and AT1 receptor expression. Our data also showed that the PPAR γ pathway was involved, at least in part, in the inhibitory effect of genistein on the expression of p22phox and AT1 receptors. We further studied the effects of isoflavone aglycones(IFA) on the production of nitric oxide(NO) and SBP in stroke-prone spontaneously hypertensive rats(SHRSP). After the administration of IFA, significant decreases in SBP were confirmed in the IFA group compared to the control group. Significantly higher levels of eNOS mRNA were also confirmed in the IFA group than in the control group.

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (174 results)

All 2004 2003 2002 2001 Other

All Journal Article (128 results) Publications (46 results)

  • [Journal Article] Geoethnic-sensitive and cross-culture differences of dietary patterns and blood pressure among five ethnic populations in China.2004

    • Author(s)
      Liu L
    • Journal Title

      International Congress Seroes 1262 Atherosclerosis XII.(Ed.Y Matuzawa et al.)

      Pages: 168-172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Obesity and other risk factors for cardiovascular diseases among Africans : results from CARDIAC study in Tanzania.2004

    • Author(s)
      Njelekela M
    • Journal Title

      International Congress Seroes 1262 Atherosclerosis XII.(Ed.Y Matuzawa et al.)

      Pages: 372-375

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats.2004

    • Author(s)
      Negishi H
    • Journal Title

      J Nutr. 134(1)

      Pages: 38-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Establishment of a new animal model of metabolic syndrome : SHRSP fatty (fa/fa) rats2004

    • Author(s)
      Hiraoka-Yamamoto J
    • Journal Title

      Clin Exp Pharmacol Physiol. 31(1-2)

      Pages: 107-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland.2004

    • Author(s)
      Sagara M
    • Journal Title

      J Am Coll Nutr. 23(1)

      Pages: 85-91

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Biological markers confirmed low cardiovascular disease(CVD) risks in fish and soy bean eaters in the world.2004

    • Author(s)
      Sagara M
    • Journal Title

      Abstract Book, 20^<th> Scientific Meeting of the International Society of Hypertension 2004, Feb 15-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment.2004

    • Author(s)
      Xu JW
    • Journal Title

      Hypertension. 44

      Pages: 217-222

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase.2004

    • Author(s)
      Xu JW
    • Journal Title

      FEBS Letters. 10

      Pages: 176-180

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genistein inhibits expressions of nadph oxidase p22phox and angiotensin ii type 1 receptor in aortic endotherial cells from stroke-prone spontaneously hypertensive rats.2004

    • Author(s)
      Xu JW
    • Journal Title

      Hypertens.Res. 27

      Pages: 675-683

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nutritional Prevention on Hypertension, Cerebral Hemodynamics and Thrombosis in Stroke-Prone Spontaneously Hypertensive Rats.2004

    • Author(s)
      Noguchi T
    • Journal Title

      Cellular and Molecular Neuobiology. 24(5)

      Pages: 599-638

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Exaggerated response to cold stress in a congenic strain for the quantitative trait locus for blood pressure.2004

    • Author(s)
      Cui ZH
    • Journal Title

      J Hypertens. 22(11)

      Pages: 2103-2109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Obesity, emerging risk in china : trend of increasing prevalence of obesity and its association with hypertension and hypercholesterolaemia among the Chinese.2004

    • Author(s)
      Liu L
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fish and lifestyle-related disease prevention : experimental and epidemiological evidence for anti-atherogenic potential of taurine.2004

    • Author(s)
      Yamori Y
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats2004

    • Author(s)
      Noguchi T
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Serum lipid effects of a monounsaturated (palmitoleic) Fatty Acid-rich diet based on macadamia nuts in healthy, young Japanese women.2004

    • Author(s)
      Hiraoka-Yamamoto J
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Soy isoflavones improve bone metabolism in postmenopausal Japanese women.2004

    • Author(s)
      Mori M
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of a soybean product on serum lipid levels in female university students.2004

    • Author(s)
      Takahashi K
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Soy isofravone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women.2004

    • Author(s)
      Mori M
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of voluntary exercise on cerebral thrombosis and endothelial function in spontaneously hypertensive rats(SHRSP/IZM).2004

    • Author(s)
      Sasaki Y
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 酸化ストレスに強くなる食品2004

    • Author(s)
      根岸 裕子
    • Journal Title

      血圧 11(12)

      Pages: 55-58

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 肥満高血圧自然発症ラットSHR/NDmcr-cp2004

    • Author(s)
      山本 潤子
    • Journal Title

      肥満研究 10(3)

      Pages: 83-84

    • NAID

      10016999496

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 豆イソフラボン含有タブレットの摂取が中高年女性の尿中骨吸収マーカー量に及ぼす影響2004

    • Author(s)
      北田 好男
    • Journal Title

      健康・栄養食品研究 17(1)

      Pages: 1-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Geoethnic-sensitive and cross-culture differences of dietary patterns and blood pressure among five ethnic populations in China.2004

    • Author(s)
      Liu L
    • Journal Title

      Inernational Congress Seroes 1262 Atherosclerosis XII

      Pages: 168-172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Obesity and other risk factors for cardiovascular diseases among Africans : results from CARDIAC study in Tanzania.2004

    • Author(s)
      Njelekela M
    • Journal Title

      Inernational Congress Seroes 1262 Atherosclerosis XII

      Pages: 372-375

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Establishment of a new animal model of metabolic syndrome : SHRSP fatty (fa/fa) rats.2004

    • Author(s)
      Hiraoka-Yamamoto J
    • Journal Title

      Clin Exp Pharmacol Physiol. 31(1-2)

      Pages: 107-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Biological markers confirmed low cardiovascular disease(CVD) risks in fish and soy bean eaters in the world.2004

    • Author(s)
      Sagara M
    • Journal Title

      Abstract Book 20^<th> Scientific Meeting of the International Society of Hypertension Feb 15-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment.2004

    • Author(s)
      Xu JW
    • Journal Title

      Hypertension 44

      Pages: 217-222

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nutritional Prevention on Hypertension, Cerebral Hemodynamics and Thrombosis in Stroke-Prone Spontaneously Hypertensive Rats2004

    • Author(s)
      Noguchi T
    • Journal Title

      Cellular and Molecular Neuobiology. 24(5)

      Pages: 599-638

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats.2004

    • Author(s)
      Noguchi T
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of voluntary exercise on cerebral thrombosis and endothelial function in spontaneously hypertensive rats (SHRSP/IZM).2004

    • Author(s)
      Sasaki Y
    • Journal Title

      Clin Exp Pharmacol Physiol. Suppl2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 酸化ストレスに強くなる食品2004

    • Author(s)
      根岸裕子
    • Journal Title

      血圧 11(12)

      Pages: 55-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 肥満高血圧自然発症ラットSHR/NDmcr-cp2004

    • Author(s)
      山本潤子
    • Journal Title

      肥満研究 10(3)

      Pages: 83-84

    • NAID

      10016999496

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 豆イソフラボン含有タブレットの摂取が中高年女性の尿中骨吸収マーカー量に及ぼす影響2004

    • Author(s)
      北田好男
    • Journal Title

      健康・栄養食品研究 17(1)

      Pages: 1-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Obesity and other risk factors for cardiovascular diseases among Africans : results fro CARDIAC study in Tanzania.2004

    • Author(s)
      Njelekela M, Ikeda K, Mtabaji J, Yamori Y.
    • Journal Title

      Inernational Congress Seroes 1262 Atherosclerosis XII. (Ed. Y. Matuzawa et al.)

      Pages: 372-375

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Geoethnic-sensitive and cross-culture differences of dietary patterns and blood pressure among five ethnic populations in China..2004

    • Author(s)
      Liu L, Ikeda K, Yin X, Yang T, Mu L, Zhao H, Mizushima S, Miki T, Nara Y, Yamor Y.
    • Journal Title

      Inernational Congress Seroes 1262 Atherosclerosis XII. (Ed. Y. Matuzawa et al.)

      Pages: 168-172

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genistein Inhibits Expressions of NADPH Oxidase p22phox and Angiotensin II Type I Receptor in Aortic Endotherial Cells from Stroke-prone Spontaneously Hypertensive Rats2004

    • Author(s)
      Xu JW, Ikeda K, Yamori Y
    • Journal Title

      Hypertens.Res 27

      Pages: 675-683

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prevention on Hypertension, Cerebral Hemodynamics and Thrombosis in Stroke-Prone Spontaneously Hypertensive Rats,2004

    • Author(s)
      Noguchi T, Ikeda K, Sasaki Y, Yamori Y
    • Journal Title

      Cellular and Molecular Neuobiology 24

      Pages: 599-638

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Exaggerated response to cold stress in a congenic strain for the quantitative trait locus for blood pressure.2004

    • Author(s)
      Cui ZH, Ikeda K, Kawakami K, Gonda T, Masuda J, Nabika T.
    • Journal Title

      J Hypertens 22(11)

      Pages: 2103-2109

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Obesity, Emerging Risk In China: Trend of Increasing Prevalence of Obesity and Its Association with Hypertension and Hypercholesterolaemia among the Chinese2004

    • Author(s)
      Liu L, Ikeda K, Chen M, Yin W, Mizushima S, Miki T, Nara Y, Yamori Y.
    • Journal Title

      Clin Exp Pharmacol Physiol. 31.supl2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Fish and Lifestyle-Related Disease Prevention : Experimental and Epidemiological evidence foror Anti-atherogenic Potential of Taurine2004

    • Author(s)
      Yamori Y, Murakami S, Ikeda K, Nara Y
    • Journal Title

      Clin Exp Pharmacol Physiol. 31.supl2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of vitamin e and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats.2004

    • Author(s)
      Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Yamori Y
    • Journal Title

      Clin Exp Pharmacol Physiol. 31.supl2

    • NAID

      10009565814

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Serum liid effects of a monounsaturated (palmitoleic) Fatty Acid-rich diet based on macadamia nuts in healthy, young Japanese women.2004

    • Author(s)
      Hiraoka-Yamamoto J, Ikeda K, Negishi H et al.
    • Journal Title

      Clin Exp Pharmacol Physiol. 31.supl 2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Soy isoflavones improve bone metabolism in postmenopausal Japanese women.2004

    • Author(s)
      Mori M, Sagara M, Ikeda K, Miki T, Yamori Y.
    • Journal Title

      Clin Exp Pharmacol Physiol. 31.supl2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of a soybean product on serum lipid levels in female university students.2004

    • Author(s)
      Takahashi K, Kamada Y, Hiraoka-Yamamoto J, Mod M, Nagata R, Hashimoto K, Aizawa T, Matsuda K, Kometani T, Ikeda K, Yamori Y
    • Journal Title

      Clin Exp Pharmacol Physiol. 31.supl2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Soy Isofravone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women.2004

    • Author(s)
      Mori M, Aizawa T, Tokoro M, Miki T, Yamori Y.
    • Journal Title

      Clin Exp Pharmacol Physiol. 31.supl2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of Voluntary Exercise on Cerebral Thrombosis and Endothelial Function in Spontaneously Hvpertensive Rats2004

    • Author(s)
      Sasaki Y, Noguchi T, Yamamoto E, Giddings JC, Ikeda K, Yamamoto J, Yamori Y.
    • Journal Title

      Clin Exp Pharmacol Physiol. 31.supl2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 大豆イソフラボン含有タブレットの摂取が中高年女性の尿中骨吸収マーカー量に及ぼす影響2004

    • Author(s)
      北田好男, 松本剛, 森真理, 池田克巳, 家森幸男
    • Journal Title

      健康・栄養食品研究 7(1)

      Pages: 1-12

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 肥満高血圧自然発症ラットSHR/NDmcr-cp2004

    • Author(s)
      山本潤子, 池田克巳, 奈良安雄, 家森幸男
    • Journal Title

      肥満研究 110(3)

    • NAID

      10016999496

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 酸化ストレスに強くなる食品2004

    • Author(s)
      根岸裕子, 許錦文, 池田克巳
    • Journal Title

      血圧 111(12)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation is astrocytes.2003

    • Author(s)
      Yamagata K
    • Journal Title

      Glia. 41(2)

      Pages: 199-206

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of Undaria Pinnatifida (Wakame) on the development of cerebrovascular diseases in Stroke-Prone Spontaneously Hypertensive Rats.2003

    • Author(s)
      Ikeda K
    • Journal Title

      Clin Exp Pharmacol Physiol. 30(1-2)

      Pages: 44-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Peroxisome proliferative drugs do not induce an increase of rat mevalonate pyrophosphate decarboxylase.2003

    • Author(s)
      Michihara A
    • Journal Title

      Biol Pharm Bull. 26(1)

      Pages: 93-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony.2003

    • Author(s)
      Kato N
    • Journal Title

      J Hypertens. 21(2)

      Pages: 295-330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Determinants of hyperleptinaemia in an African population.2003

    • Author(s)
      Njelekela M
    • Journal Title

      East Afr Med J. 30(4)

      Pages: 195-199

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nutritional variation and cardiovascular risk factors in Tanzania-rural-urban difference.2003

    • Author(s)
      Njelekela M
    • Journal Title

      S Afr Med J. 93(4)

      Pages: 295-299

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Subcellular distribution of mouse mevalonate pyrophosphate decarboxylase.2003

    • Author(s)
      Michihara A
    • Journal Title

      Biol Pharm Bull. 26(5)

      Pages: 579-584

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Antioxidant nutrients and hypoxia/ischemia brain injury in rodents.2003

    • Author(s)
      Ikeda K
    • Journal Title

      Toxicolog. 189(1-2)

      Pages: 55-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus.2003

    • Author(s)
      Chui ZH
    • Journal Title

      J.Clin Exp Pharmacol Physiol. 30(7)

      Pages: 464-469

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Change in the protein level of mevalonate pyrophosphate decarboxylase in tissues of mouse of pravastatin.2003

    • Author(s)
      Michihara A
    • Journal Title

      Biol Pharm Bull. 26(8)

      Pages: 1082-1085

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pharmacological studies of alcohol susceptibility and brain monoamine function in stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR).2003

    • Author(s)
      Yoshimoto K
    • Journal Title

      Tohoku J Exp Med. 201(1)

      Pages: 11-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver.2003

    • Author(s)
      Michihara A
    • Journal Title

      Biol Pharm Bull. 26(10)

      Pages: 1484-1486

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Isolation of a chromosome 1 region affecting blood pressure and vascular disease traits in the stroke-prone rat model.2003

    • Author(s)
      Kato N
    • Journal Title

      Hypertension. 42(6)

      Pages: 1191-1197

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Estimation of hydroxyl radicals based on the salicylate trapping method in hippocampus of stroke prone spontaneously hypertensive rats (SHRSP) during transient ischemia and recirculation.2003

    • Author(s)
      Negishi H
    • Journal Title

      Adv Exp Med Biol. 510

      Pages: 313-317

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tea Polyphenols regulate NADPH oxidase subunits expression and ameliorate angiotensin ii-induced hyperpermeability in endothelial cells.2003

    • Author(s)
      Ying CJ
    • Journal Title

      Hypertens Res. 26

      Pages: 823-828

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells.2003

    • Author(s)
      Yamagata K
    • Journal Title

      Neuroscience. 116(3)

      Pages: 649-656

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes.2003

    • Author(s)
      Yamagata K
    • Journal Title

      Glia. 41(2)

      Pages: 199-206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Determinants of hyperleptinaemia in an African population.2003

    • Author(s)
      Njelekela M
    • Journal Title

      East Afr Med J. 80(4)

      Pages: 195-199

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nutritional variation and cardiovascular risk factors in Tanzania--rural-urban difference.2003

    • Author(s)
      Njelekela M
    • Journal Title

      S Afr Med J. 93(4)

      Pages: 295-299

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Antioxidant nutrients and hypoxia/ischemia brain injury in rodents.2003

    • Author(s)
      Ikeda K
    • Journal Title

      Toxicology 189(1-2)

      Pages: 55-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus.2003

    • Author(s)
      Cui ZH
    • Journal Title

      Clin Exp Pharmacol Physiol. 30(7)

      Pages: 464-469

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Change in the protein level of mevalonate pyrophosphate decarboxylase in tissues of mouse by pravastatin.2003

    • Author(s)
      Michihara A
    • Journal Title

      Biol Pharm Bull. 26(8)

      Pages: 1082-1085

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Isolation of a chromosome 1 region affecting blood pressure and vascular disease traits in the stroke-prone rat model.2003

    • Author(s)
      Kato N
    • Journal Title

      Hypertension 42(6)

      Pages: 1191-1197

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Estimation of hydroxyl radicals based on the salicylate trapping method in hippocampus of stroke-prone spontaneously hypertensive rats (SHRSP) during transient ischemia and recirculation.2003

    • Author(s)
      Negishi H
    • Journal Title

      Adv Exp Med Biol. 510

      Pages: 313-317

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differential regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats2002

    • Author(s)
      Yamagata K
    • Journal Title

      Glia. 37(1)

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.2002

    • Author(s)
      Mizutani K
    • Journal Title

      Hypertens Res. 25(1)

      Pages: 135-140

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of dementia in the older Japanese-Brazilian population.2002

    • Author(s)
      Yamada T
    • Journal Title

      Psychiatry Clin Neurosci. 56(1)

      Pages: 71-75

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inverse relationship between urinary of animal protein intake and blood pressure in Chinese : results from the WHO Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study2002

    • Author(s)
      Liu L
    • Journal Title

      Int J Epidemiol. 31(1)

      Pages: 227-233

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Obesity and lipid profiles in middle aged men and women in Tanzania.2002

    • Author(s)
      Njelekela M
    • Journal Title

      East Afr Med J. 79(2)

      Pages: 58-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Purification and characterization of mouse mevalonate pyrophosphate decarboxylase.2002

    • Author(s)
      Michihara A
    • Journal Title

      Biol Pharm Bull. 25(3)

      Pages: 302-306

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal japanese women : a four-week study2002

    • Author(s)
      Uesugi T
    • Journal Title

      J Am Coll Nutr. 21(2)

      Pages: 97-102

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of subcellular distribution of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive rat and Wistar Kyoto rat2002

    • Author(s)
      Michihara A
    • Journal Title

      Biol Pharm Bull. 25(6)

      Pages: 734-737

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Diet-related factors, educational levels and blood pressure in a Chinese population sample : findings from the Japan-China Cooperative Research Project.2002

    • Author(s)
      Yamori Y
    • Journal Title

      Hypertens Res. 25(4)

      Pages: 559-564

    • NAID

      10009568904

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Evaluation of the atrial natriuretic peptide gene in stroke.2002

    • Author(s)
      Kato N
    • Journal Title

      Atherosclerosis. 153(2)

      Pages: 279-286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inhibitor for advanced glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats.2002

    • Author(s)
      Mizutani K
    • Journal Title

      J Hypertens. 20(8)

      Pages: 1607-1614

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epidemiological evidence of the association between dietary protein intake and blood pressure : a meta-analysis of published data.2002

    • Author(s)
      Lin L
    • Journal Title

      Hypertens Res. 25(5)

      Pages: 689-695

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of overweight and hypertension in Tanzania : special emphasis on resting energy expenditure and leptin2002

    • Author(s)
      Kuga S
    • Journal Title

      J.Clin Exp Pharmacol Physiol Suppl. 29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of obesity and dyslipidemia in middle-aged men and women in Tanzania, Africa : relationship with resting energy expenditure and dietary factors.2002

    • Author(s)
      Njelekela M
    • Journal Title

      J Nutr Sci Vitaminol(Tokyo). 48(5)

      Pages: 352-358

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of Ginkgo biloba extract (EGb 761) on cerebral thrombosis and blood pressure in stroke-prone spontaneously hypertensive rats.2002

    • Author(s)
      Sasaki Y
    • Journal Title

      J.Clin Exp Pharmacol Physiol. 29(11)

      Pages: 963-967

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Proposition of a feasible protocol to evaluate salt sensitivity in a population-based setting.2002

    • Author(s)
      Kato N
    • Journal Title

      Hypertens Res. 25(6)

      Pages: 801-809

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Soybean isoflavones reduce postmenopausal bone resorption in female Japanese immigrants in Brazil : a ten-week study.2002

    • Author(s)
      Yamori Y
    • Journal Title

      J Am Coll Nutr. 21(6)

      Pages: 560-563

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] SHRSP胸部大動脈由来の内皮細胞における植物性エストロゲンによるアンギオテンシンII誘導のERK経路の阻止はエストロゲン受容体非依存性である2002

    • Author(s)
      許 錦文
    • Journal Title

      Ther.Res. 23(10)

      Pages: 2051-2054

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differential regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats.2002

    • Author(s)
      Yamagata K
    • Journal Title

      Glia. 37(1)

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Inverse relationship between urinary markers of animal protein intake and blood pressure in Chinese : results from the WHO Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study.2002

    • Author(s)
      Lin L
    • Journal Title

      Int J Epidemiol. 31(1)

      Pages: 227-233

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of subcellular distribution of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive rat and Wistar Kyoto rat.2002

    • Author(s)
      Michihara A
    • Journal Title

      Biol Pharm Bull. 25(6)

      Pages: 734-737

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Evaluation of the atrial natriuretic peptide gene in stroke.2002

    • Author(s)
      Kato N
    • Journal Title

      Atherosclerosis. 163(2)

      Pages: 279-286

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epidemiological evidence of the association between dietary protein intake and blood pressure : a meta-analysis of published data.2002

    • Author(s)
      Liu L
    • Journal Title

      Hypertens Res. 25(5)

      Pages: 689-695

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of overweight and hypertension in Tanzania : special emphasis on resting energy expenditure and leptin.2002

    • Author(s)
      Kuga S
    • Journal Title

      Clin Exp Pharmacol Physiol Suppl. (29)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prevalence of obesity and dyslipidemia in middle-aged men and women in Tanzania, Africa : relationship with resting energy expenditure and dietary factors.2002

    • Author(s)
      Njelekela M
    • Journal Title

      J Nutr Sci Vitaminol (Tokyo) 48(5)

      Pages: 352-358

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of Ginkgo biloba extract (EGb 761) on cerebral thrombosis and blood pressure in stroke-prone spontaneously hypertensive rats.2002

    • Author(s)
      Sasaki Y
    • Journal Title

      Clin Exp Pharmacol Physiol. 29(11)

      Pages: 963-967

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Soybean isoflavones reduce postmenopausal bone resorption in female Japanese immigrants in Brazil : a ten-week study.2002

    • Author(s)
      Yamori Y
    • Journal Title

      Coll Nutr. 21(6)

      Pages: 560-563

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] SHRSP胸部大動脈由来の内皮細胞における植物性エストロゲンによるアンギオテンシンII誘導のERK経路の阻止はエストロゲン受容体非依存性である2002

    • Author(s)
      許錦文
    • Journal Title

      Ther.Res. 23(10)

      Pages: 2051-2054

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats.2001

    • Author(s)
      Pan W
    • Journal Title

      J Nutr 131(4)

      Pages: 1154-1158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ethnic and environmental differences in various markers of dietary intake and blood pressure among Chinese Han and three other minority peoples China.2001

    • Author(s)
      Liu L
    • Journal Title

      Hypertens Res. 24(3)

      Pages: 315-322

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells.2001

    • Author(s)
      Hiroyuki Y
    • Journal Title

      Biosci Biotechnol Biochem. 65(5)

      Pages: 1211-1213

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cardiovascular risk factors in Tanzania : a revisit.2001

    • Author(s)
      Njelekela M
    • Journal Title

      Acta Trop 79(3)

      Pages: 231-239

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.2001

    • Author(s)
      Negishi H
    • Journal Title

      Acta Trop. 79(3)

      Pages: 231-239

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries from the WHO-CARDIAC study.2001

    • Author(s)
      Yamori Y
    • Journal Title

      Hypertens Res. 24(4)

      Pages: 453-457

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Changes in stroke mortality rates for 1950 to 1997 : a great slowdown of decline trend in Japan.2001

    • Author(s)
      Liu L
    • Journal Title

      Stroke. 32(8)

      Pages: 1745-1749

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats.2001

    • Author(s)
      Noguchi T
    • Journal Title

      Hypertens Res 24(6)

      Pages: 735-742

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 食生活と未病-アンデスの長寿村の教訓2001

    • Author(s)
      家森 幸男
    • Journal Title

      医学の歩み 137(9)

      Pages: 11-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats2001

    • Author(s)
      Kondo S
    • Journal Title

      Biosci Biotechnol Biochem. 65(12)

      Pages: 2690-2694

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nutritional pathogenesis and prevention of stroke.2001

    • Author(s)
      Yamori Y
    • Journal Title

      Perform Programme. 5

      Pages: 231-244

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Implications from and for food cultures for cardiovascular diseases : Japanese food, particularly Okinawan diets.2001

    • Author(s)
      Yamori Y
    • Journal Title

      Asia Pac J Clin Nutr. 10(2)

      Pages: 144-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 生活習慣病:高血圧と遺伝的要因2001

    • Author(s)
      池田 克巳
    • Journal Title

      ファルマシア 37(9)

      Pages: 795-798

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 特別講演 疾患モデルからヒトへ-予知・予防医学への貢献2001

    • Author(s)
      家森 幸男
    • Journal Title

      関西動物研究会会報 22

      Pages: 3-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats.2001

    • Author(s)
      Pan W
    • Journal Title

      J Nutr. 131(4)

      Pages: 1154-1158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Ethnic and environmental differences in various markers of dietary intake and blood pressure among Chinese Han and three other minority peoples of China : results from the WHO Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study.2001

    • Author(s)
      Liu L
    • Journal Title

      Hypertens Res. 24(3)

      Pages: 315-322

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells.2001

    • Author(s)
      Yoshida H
    • Journal Title

      Biosci Biotechnol Biochem. 65(5)

      Pages: 1211-1213

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells.2001

    • Author(s)
      Njelekela M
    • Journal Title

      Acta Trop. 79(3)

      Pages: 231-239

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.2001

    • Author(s)
      Negishi H
    • Journal Title

      Neurosci Lett. 306(3)

      Pages: 206-208

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries : results from the WHO-CARDIAC study.2001

    • Author(s)
      Yamori Y
    • Journal Title

      Hypertens Res. 24(4)

      Pages: 453-457

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Changes in stroke mortality rates for 1950 to 1997: a great slowdown of decline trend in Japan.2001

    • Author(s)
      Liu L
    • Journal Title

      Stroke. 32(8)

      Pages: 1745-1749

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats.2001

    • Author(s)
      Noguchi T
    • Journal Title

      Hypertens Res. 24(6)

      Pages: 735-742

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Journal Article] 食生活と未病-アンデスの長寿村の教訓2001

    • Author(s)
      家森幸男
    • Journal Title

      医学の歩み 137(9)

      Pages: 11-24

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Journal Article] Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats.2001

    • Author(s)
      Kondo S
    • Journal Title

      Biosci Biotechnol Biochem. 65(12)

      Pages: 2690-2694

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Journal Article] Nutritional pathogenesis and prevention of stroke.2001

    • Author(s)
      Yamori Y
    • Journal Title

      Nestle Nutr Workshop Ser Clin Perform Programme. (5)

      Pages: 231-244

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Journal Article] 生活習慣病:高血圧と遺伝的要因2001

    • Author(s)
      池田克巳
    • Journal Title

      ファルマシア 37(9)

      Pages: 795-798

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Journal Article] 特別講演 疾患モデルからヒトへ-予知・予防医学への貢献2001

    • Author(s)
      家森幸男
    • Journal Title

      関西動物研究会会報 22

      Pages: 3-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
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  • [Publications] Njelekela M, Kuga S, Hiraoka J, Masesa Z, Ntogwisangu J, Mashalla Y, Ikeda K, Mtabaji J, Nara Y, Yamori Y, Tsuda K.: "Determinants of hyperleptinaemia in an African population"East Afr Med J.. Apr;80(4). 195-199 (2003)

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  • [Publications] Njelekela M, Sato T, Nara Y, Miki T, Kuga S, Noguchi T, Kanda T, Yamori M, Ntogwisangu J, Masesa Z Mashalla Y, Mtabaji J, Yamori Y.: "Nutritional variation and cardiovascular risk factors in Tanzania--rural-urban difference."S Afr Med J.. Apr;93(4). 295-299 (2003)

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  • [Publications] Katsumi Ikeda, Hiroko Negishi, Yukio Yamori: "Antioxidant nutrients and hypoxia/ischemia brain injury in rodents"Toxicology. Jul 15;189. 55-61 (2003)

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  • [Publications] Katsumi Ikeda, Akiko Kitamura, Hiroko Machida, Miyuki Watanabe, Hiroko Negishi, Junko Hiraoka, Takahisa Nakano: "Effect of Undaria Pinnatifida (Wakame) on the development of cerebrovascular diseases in Stroke-Prone Spontaneously Hypertensive Rats"Clin Exp Pharmacol Physiol. Jan-Feb;30. 44-48 (2003)

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  • [Publications] Kato N, Nabika T, Liang YQ, Mashimo T, Inomata H, Watanabe T, Yanai K, Yamori Y, Yazaki Y, Sasazuki T.: "Isolation of a chromosome 1 region affecting blood pressure and vascular disease traits in the stroke-prone rat model."Hypertension. Dec;42(6). 1191-1197 (2003)

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  • [Publications] Michihara A, Sawamura M, Yamori Y, Akasaki K, Tsuji H.: "Probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver."Biol Pharm Bull. Oct;26(10). 1484-1486 (2003)

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  • [Publications] Michihara A, Akasaki K, Yamori Y, Tsuji H.: "Change in the protein level of mevalonate pyrophosphate decarboxylase in tissues of mouse by pravastatin."Biol Pharm Bull.. Aug;26(8). 1082-1085 (2003)

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  • [Publications] Michihara A, Akasaki K, Yamori Y, Tsuji H: "Subcellular distribution of mouse mevalonate pyrophosphate decarboxylase."Biol Pharm Bull. May;26(5). 579-584 (2003)

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  • [Publications] Yamagata K, Tagami M, Takenaga F, Yamori Y, Nara Y, Itoh S.: "Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells"Neuroscience.. 116(3). 649-656 (2003)

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  • [Publications] Yamagata K, Tagami M, Torii Y, Takenaga F, Tsumagari S, Itoh S, Yamori Y, Nara Y.: "Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes"Glia. Jan15;41(2). 199-206 (2003)

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  • [Publications] Negishi H, Ikeda K, Nara Y, Yamori Y.: "Estimation of hydroxyl radicals based on the salicylate trapping method in hippocampus of stroke-prone spontaneously hypertensive rats (SHRSP) during transient ischemia and recirculation"Adv Exp Med Biol.. 510. 313-317 (2003)

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  • [Publications] Kato N, Mashimo T, Nabika T, Cui ZH, Ikeda K, Yamori Y.: "Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony."J Hypertens. Feb;21(2). 295-303 (2003)

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  • [Publications] Chen-Jiang YING, Jin-Wen XU, Katsumi IKEDA, Kyoko TAKAHASHI, Yasuo NARA, Yukio YAMORI: "Tea Polyphenols Regulate NADPH Oxidase Subunits Expression and Ameliorate Angiotensin II-Induced Hyperpermeability in Endothelial Cells."Hypertens.Res.. Oct;26(10). 823-828 (2003)

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  • [Publications] Cui ZH, Ikeda K, Kawakami K, Gonda T, Nabika T, Masuda J.: "Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus"Clin Exp Pharmacol Physiol.. Jul;30(7). 464-469 (2003)

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  • [Publications] Michihara A, Sawamura M, Yamori Y, Akasaki K, Tsuji H: "Peroxisome proliferative drugs do not induce an increase of rat mevalonate pyrophosphate decarboxylase."Biol Pharm Bull.. Jan;26(1). 93-95 (2003)

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  • [Publications] Yoshimoto K, Komura S, Hattori H, Yamori Y, Miura A, Yoshida T, Hioki C, Kato B, Fukuda F, Tanaka S, Hirai A, Nishimura A, Sawai Y, Yasuhara M: "Pharmacological studies of alcohol susceptibility and brain monoamine function in stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR)"Tohoku J Exp Med. Sep;201(1). 11-22 (2003)

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  • [Publications] Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y.: "Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats."J Nutr.. Jan;134(1). 38-42 (2004)

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  • [Publications] Sagara M, Kanda T, NJelekera M, Teramoto T, Armitage L, Birt N, Birt C, Yamori Y.: "Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland."J Am Coll Nutr.. Feb;23(1). 85-91 (2004)

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  • [Publications] Hiraoka-Yamamoto J, Nara Y, Yasui N, Onobayashi Y, Tsuchikura S, Ikeda K.: "Establishment of a new animal model of metabolic syndrome : SHRSP fatty (fa/fa) rats."Clin Exp Pharmacol Physiol. Jan-Feb;31(1-2). 107-109 (2004)

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  • [Publications] Mizutan K, Sugimoto K, Okuda T, Katsuya T, Miyata T, Tanabe T, Higaki J, Ogihara T, Yamori Y, Tsujita Y, Tago N, Iwai N: "Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats"Hypertens Res. Jan;25 (1). 135-140 (2002)

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  • [Publications] Yamada T, Kadekaru H, Matsumoto S, Inada H, Tanabe M, Moriguchi EH, Moriguchi Y, Ishikawa P, Ishikawa AG, Taira K, Yamori Y: "Related Articles, Books, LinkOut Prevalence of dementia in the older Japanese-Brazilian population"Psychiatry Clin Neurisci. Feb;56(1). 71-75 (2002)

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  • [Publications] Njelekela MA, Negishi H, Nara Y, Sato T, Tomohiro M, Kuga S, Noguchi T, Kanda T, Yamori M, Mashalla Y, Liu LJ, Ikeda K, Mtabaji J, Yamori Y: "Obesity and lipid profiles in middle aged men and women in Tanzania. East Afr Med J"East Afr Med J. Feb;79(2). 58-64 (2002)

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  • [Publications] Liu L, Ikeda K, Yamori Y: "Inverse relationship between urinary markers of animal protein intake and blood pressure in Chinese results from the WHO Cardiovascular Diseases and Alimentary Comparison(CARDIAC) Study"Int J Epidemiol. Feb;3(1). 227-233 (2002)

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  • [Publications] Uesugi T, Fukui Y, Yamori Y: "Beneficial effects of soybean soflavone supplementation on bone metabolism and serum lipids in postmenopausal japanese women : a four-week study"J Am Coll Nutr. Apr;2l(2). 97-102 (2002)

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  • [Publications] Michihara A, Sawamura M, Yamori Y, Akasaki K, Tsuji H: "Comparison of subcellular distribution of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive rat and Wistar Kyoto rat"Biol Pharm Bull. Jun;25(6). 734-737 (2002)

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  • [Publications] Yamori Y, Liu L, Mu L, Zhao H, Pen Y, Hu Z, Kuga S, Negishi H, Ikeda K: "Diet related factors, educational levels and blood pressure in a Chinese population sample : findings from the Japan-China Cooperative Research Project"Hypertens Res. Jul;25(4). 559-564 (2002)

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  • [Publications] Mizutani K, Ikeda K, Tsuda K, Yamori Y: "Inhibitor for advanced glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats"J Hypertens. Aug;20(8). 1607-1614 (2002)

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  • [Publications] Kato N, Ikeda K, Nabika T, Morita H, Sugiyama T, Gotoda T, Kurihara H, Kobayashi S, Yazaki Y, Yamori Y: "Evaluation of the atrial natriuretic peptide gene in storke"Atherosclerosis. Aug;163(2). 279-286 (2002)

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  • [Publications] Liu L, Ikeda K, Sullivan DH, Ling W, Yamori Y: "Epidemiological evidence of the association between dietary protein intake and blood pressure a meta-analysis of published data"Hypertens Res. Sep;25(5). 689-695 (2002)

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  • [Publications] Kuga S, Njelekela M, Noguchi T, Kanda T, Yamori M, Sato T, Miki T, Ikeda K, Nara Y, Mtabaji J: "Prevalence of overweight and hypertension in Tanzania Special emphasis on resting energy expenditure and leptin"Clin Exp Pharmacol Physiol. Oct;29uppl4. S23-S26 (2002)

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  • [Publications] Sasaki Y, Noguchi T, Yamamoto E, Giddings JC, Ikeda K, Yamori Y, Yamamoto J: "Effects of Ginkgo biloba extract (EGb 761) on cerebral thrombosis and blood pressure in stroke-prone spontaneously hypertensive rats"Chin Exp Pharmacol Physiol. Nov;29(11). 963-967 (2002)

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  • [Publications] Kuga S, Njelekela M, Noguchi T, Kanda T, Yamori M, Sato T, Miki T, Ikeda K, Nara Y, Mtabaji J: "Prevalence of overweight and hypertension in emphasis on resting eliergy expenditure and leptin"Clin Exp Pharmacol Physiol Suppl. Oct;(29). S23-6 (2002)

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  • [Publications] Kato N, Kanda T, Sagara M, Bos A, Moriguchi EH, Moriguchi Y, Yamori Y: "Proposition of a feasible protocol to evaluate salt sensitivity in a population-based setting"Hypertens Res. Nov;25(6). 801-809 (2002)

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  • [Publications] Yamori Y, Moriguchi EH, Teramoto T, Miura A, Fukui Y, Honda KI, Fukui M, Nara Y, Taira K, Moriguchi Y: "Soybean isoflavones reduce postimenopausal bone resorption in female Japanese immigrants in Brazil: a ten-week study"J Am Coll Nutr. Dec 2l(6). 560-563 (2002)

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  • [Publications] Ikeda K, Kitamura A, Machida H, Watanabe M, Negishi H, Hiraoka J, Nakano T: "Effect of Undaria pinnatifida (Wakame)on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats"Chin Exp Pharmacol Physiol. Jan-Feb;3O(1-2). 44-48 (2003)

    • Related Report
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  • [Publications] Negishi H, Ikeda K, Nara Y, Yamori Y: "Estimation of hydroxyl radicals based on the salicylate trapping method in hippocampus of stroke-prone spontaneously hypertensve rats (SHRSP) during transient ischemia and recircuilation"Adv Exp Med Biol. 510. 313-317 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamagata K, Tagami M, Takenaga F, Yamori Y, Nara Y, Itoh S: "Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells"Neuroscience. Feb;116(3). 649-656 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kato N, Mashimo T, Nabika T, Cui ZH, Ikeda K, Yamori Y: "Genorne-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony"J Hypertens. Feb;2l(2). 295-303 (2003)

    • Related Report
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  • [Publications] Michihara A, Sawamura M, Yamori Y, Akasaki K, Tsuji H: "Peroxisome Proliferative Drugs Do not Induce and Increase of Rat Mevabonate Pyrophosphate Decarboxylase"Biol Pharm Bull. Jan26;(1). 93-5 (2003)

    • Related Report
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  • [Publications] Yamagata K, Tagami M, Torii Y, Takenaga F, Tsumagari S, Itoh S, Yamori Y, Nara Y: "Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes"Glia. Jan15;41 (2). 199-206 (2003)

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  • [Publications] Noguchi T, Ikeda K.Sasaki Y, et al.: "Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats"Hypertens Res.. 24(6). 735-742 (2001)

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  • [Publications] Yoshida H, Teramoto T, Ikeda K, et al.: "Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells"Biosci Biotechnol Biochem.. 65(5). 1211-1213 (2001)

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  • [Publications] Njelekela M, Negishi H, Nara Y et al.: "Cardiovascular risk factors in Tanzania : a revisit"Acta Trop.. 79(3). 231-239 (2001)

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  • [Publications] Negishi H, Ikeda K, Nara Y et al.: "Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats"Neurosci Lett.. 306(3). 206-208 (2001)

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  • [Publications] Negishi H, Ikeda K, Kuga S et al.: "The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania"J Hypertens.. 19(3pt2). 529-533 (2001)

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  • [Publications] Pan W, Ikeda K, Takebe M, et al.: "Genistein, daidzein and glycitein inhibit grbwth and DNA synthesis of aortic smooth muscle cells"J Nutr.. 131(4). 1154-1158 (2001)

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Published: 2001-04-01   Modified: 2021-12-06  

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