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STUDY ON MOLECULAR EPIDEMIOLOGY OF HIV AND HOST FACTOR INFLUENCING DISEASE PROGRESSION IN ASIA

Research Project

Project/Area Number 13376002
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionNATIONAL INSTITUTE OF INFECTIOUS DISEASES

Principal Investigator

TAKEBE Yutaka  NATIONAL INSTITUTE OF INFECTIOUS DISEASES, AIDS RESEARCH CENTER, CHIEF, エイズ研究センター, 室長 (50126116)

Co-Investigator(Kenkyū-buntansha) SHIODA Tatsuo  OSAKA UNIVERSITY, PROFESSOR, 微研免疫・ウイルス感染制御分野, 教授 (00187329)
SHIINO Teiichirou  NATIONAL INSTITUTE OF INFECTIOUS DISEASES, AIDS RESEARCH CENTER, SENIOR RESEARCHER, エイズ研究センター, 主任研究官 (90291129)
SATO Hironori  NATIONAL INSTITUTE OF INFECTIOUS DISEASES, DIVISION OF MOLECULAR GENETICS, SENIOR RESEARCHER, 遺伝子解析室, 主任研究官 (80260272)
YASUTOMI Yasuhiro  MIE UNIVERSITY, ASSOCIATE PROFESSOR, 医学部・生体防御学医学講座, 助教授 (90281724)
TAKIGUCHI Masafumi  KUMAMOTO UNIVERSITY, PROFESSOR, 医学部・エイズ学研究センター, 教授 (00183450)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Fiscal Year 2003: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2002: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2001: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
KeywordsAsia / AIDS / HIV / molecular epidemiology / HIV-1 subtypes / HIV-1 recombinants / genetic polyorphism / host factors / CTLエピトープ / ケモカイン受容体 / 経口ワクチンベクター / CCR2
Research Abstract

(A)Study on Molecular epidemiology of HIV in Asia (Dr. Takebe)
1)Molecular epidemiology of HIV outbreaks in Northern Vietnam:
We investigated the molecular nature of recent HIV outbreaks among injecting drug users (IDUs) in Northern Vietnam. We found that CRF01_AE strains distributed among IDUs in Northern Vietnam was closely related to those found in Pingxiang city in Guangxi Province of China, sharing a unique valine substitution at 12 amino acids downstream of the V3 loop. The data indicated that HIV outbreaks among IDUs in northern Vietnam were caused by the recent introduction of a highly homogeneous CRF01_AE variant (Ev-variant) that shared the origin with those prevailing in nearby Southern China.
2)High prevalence of HIV-1 unique recombinant forms in Myanmar:
We found that 10-30% of HIV-1 strains circulating in Myanmar were diverse forms of HIV-1 intersubtype recombinants, comprised of various combinations of three HIV-1 strains, including HIV-1 subtypes B' (Thailand variant of sub … More type B) and C and CRF01_AE, circulating in Myanmar. The results suggest the presence of highly exposed population and social networks in this particular area in Asia.
3)Geographical hotspot of extensive HIV-1 intersubtype recombination in Yunnan province of China:
Yunnan Province is thought to be an epicenter of explosive HIV-1 epidemic in China. We identified the unique geographical site in western part of Yunnan Province where approximately 2/3 of circulating strains were HIV-1 unique recombinant forms (URFs). We also found new class of HIV-1 recombinants comprised of two previously established circulating recombinant forms in China (CRF07_BC and CRF08_BC). The results suggest that mixing of different HIV-1 strains could quickly generate various forms of recombinants. This may further complicate the development of efficacious vaccine to control the epidemic in this particular area in Asia.
(B)Study on host genetic factors influencing the susceptibility to HIV-1 and disease progression in Thai population (Dr. Shioda):
Cross-section study using discordant couples in Thailand revealed that CCR5 927T mutation is an important genetic predisposition related to resistance to HIV-1 infection in Thai population. The study based on cohort in northern Thailand demonstrated the linkage between 1L4-589T homozygosity and slower disease progression in female population and the patients under HAART.
(C)Immunological study for future vaccine strategies in Asia (Drs. Takiguchi and Yasutomi):
Dr. Takiguchi's group characterized the cytotoxic T-cell recognition of HIV-1 cross-clade and clade-specific epitopes in HIV-1 subtype B and CRF01_AE-infected Thai and Japanese patients. Dr. Yasutomi and his colleagues developed novel orally-available vaccine vehicle based on virus-like particle (VLP) from hepatitis E virus that allow to incorporate DNA vaccine constructs and elicit humoral and cytotoxic T cell responses. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (68 results)

All Other

All Publications (68 results)

  • [Publications] Kato, K., et al.: "Closely related HIV-1 CRF01_AE variants among injecting drug users in northern Vietnam : Evidence of HIV spread across the Vietnam-China border."AIDS Res and Human Retroviruses. 17. 113-123 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uno-Furuta., et al.: "Induction of virus-specific cytotoxic T lymphocytes by in vivo electric administration of peptides."Vaccine. 19. 2190-2196 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusagawa, S., et al.: "Isolation and characterization of full-length molecular DNA clones of Ghanaian HIV-1 intersubtype A/G recombinant (CRF02_AG) which is replication-competent in restricted host-range"AIDS Res and Human Retroviruses. 17(7). 649-655 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sato, H., et al.: "Augmentation of human immunodeficiency virus type 1 subtype E (CRF01 AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase."J.Virol.. 75(12). 5604-5613 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuromatsu, I., et al.: "Induction of effective antitumor immune responses in a mouse bladder tumor model by using DNA of an a antigen from mycobacteria"Cancer Gene Therapy. 8. 483-490 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] The Members of WHO-UNAIDS Vaccine Advisory Committee: "Approaches to the development of broadly protective HIV vaccines : Challenges posed by genetic, biological and antigenic variability of HIV-1"AIDS. 15. W1-W25 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Louisirirotchanakul, S., et al.: "Genetic analysis of HIV-1 discordant couples in Thailand : CCR2 64I homozygosity is associated with HIV-1 negative status"J Acquir Immune Defic Syndr.. 29(3). 314-315 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusagawa, S., et al.: "Isolation and characterization of replication-competent molecular DNA clone of CRF01_AE with different coreceptor usages."AIDS Res and Human Retroviruses. 18(2). 115-122 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhang, C., et al.: "High prevalence of HIV-1 and HCV coinfection among injecting drug users in the southeast region of Yunnan, China."J Acquir Immune Defic Syndr. 29(2). 191-196 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fukuda, K., et al.: "Cytotoxic T cell recognition of HIV-1 cross-clade and clade-specific epitopes in HIV-1-infected Thais and Japanese patients"AIDS. 16. 701-711 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murakami, Y., et al.: "A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck."Antiviral Research. 55. 161-168 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yang, R., et al.: "On-going generation of multiple forms of HIV-1 intersubtype recombinants in Yunnan province of China"AIDS. 16. 1401-1407 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuoka-Aizawa, S., et al.: "Isolation and molecular characterization of a Nelfinavir (NFV)-resistant human immunodeficiency virus type 1 that exhibits NFV-dependent enhancement of replication"J.Virol.. 77(1). 318-327 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yang, R., et al.: "Identification and characterization of new class of HIV-1 recombinants comprised of two circulating recombinant forms, CRF07 BC and CRF08 BC, in China."J.Virol.. 77(1). 685-695 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Motomura, K., et al.: "Different subtype distribution in the two cities in Myanmar : Evidence for independent clusters of HIV-1 transmission."AIDS. 17(4). 14-17 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaizu, M., et al.: "Infection of macaques with an R5-tropic SHIV bearing a chimeric envelope carrying subtype E V3 loop among subtype B framework"Archives of Virology. 148(5). 973-988 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takebe, Y., et al.: "High prevalence of diverse forms of intersubtype recombinants in Central Myanmar : geographical hot spot of extensive recombination."AIDS. 17. 2077-2087 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusagawa, S., et al.: "Identification of HIV-2 subtype B transmission in East Asia."AIDS Res and Human Retroviruses. 19(11). 045-1049 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takamura, S., et al.: "DNA vaccine-encapsulated virus like particles derived from an orally transmissible virus stimulates mucosal and systemic immune responses by oral administration"Gene Ther. 11(7). 628-635 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kato, K., et al.: "Closely related HIV-1 CRF01_AE variants among injecting drug users in northern Vietnam : Evidence of HIV spread across the Vietnam-China border."AIDS Res and Human Retroviruses. 17. 113-123 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uno-Furuta, S., et al.: "Induction of virus-specific cytotoxic T lymphocytes by in vivo electric administration of pepetides."Vaccine. 19. 2190-2196 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusagawa, S., et al.: "Isolation and characterization of full-length molecular DNA clones of Ghanaian HIV-1 intersubtype A/G recombinant (CRF02_AG) which is replication-competent in restricted host-range."AIDS Res and Human Retroviruses. 17(7). 649-655 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sato, H., et al.: "Augmentation of human immunodeficiency virus type 1 subtype B (CRF01_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase."J.Virol.. 75(12). 5604-5613 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuromatsu, I., et al.: "Induction of effective antitumor immune responses in a mouse bladder tumor model by using DNA of an a antigen from mycobacteria."Cancer Gene Therapy. 8. 483-490 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] The Members of WHO-UNAIDS Vaccine Advisory Committee: "Approaches to the development of broadly protective HIV vaccines : Challenges posed by genetic, biological and antigenic variability of HIV-1."AIDS. 15. W1-W25 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Louisirirotchanakul, S., et al.: "Genetic analysis of HIV-1 discordant couples in Thailand : CCR2 641 homozygosity is associated with HIV-1 negative status."J Acquir Immune Defic Syndr.. 29(3). 314-315 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusagawa, S., et al.: "Isolation and characterization of replication-competent molecular DNA clone of CRE01_AE with different coreceptor usages."AIDS Res and Human Retroviruses. 18(2). 115-122 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhang, C., et al.: "High prevalence of HIV-1 and HCV coinfection among injecting drug users in the southeast region of Yunnan, China."J Acquir Immune Defic Syndr.. 29(2). 191-196 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fukuda, K., et al.: "Cytotoxic T cell recognition of HIV-1 cross-clade and clade-specific epitopes in HIV-1-infected Thais and Japanese patients."AIDS. 16. 701-711 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murakami, Y., et al.: "A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck."Antiviral Research. 55. 161-168 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yang, R., et al.: "On-going generation of multiple forms of HIV-1 intersubtype recombinants in Yunnan province of China."AIDS. 16. 1401-1407 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuoka-Aizawa, S., et al.: "Isolation and molecular characterization of a Nelfinavir (NFV)-resistant human immunodeficiency virus type 1 that exhibits NFV-dependent enhancement of replication."J.Virol.. 77(1). 318-327 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yang, R., et al.: "Identification and characterization of new class of HIV-1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China"J.Virol.. 77(1). 685-695 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Motomura, K., et al.: "Different subtype distribution in the two cities in Myanmar : Evidence for independent clusters of HIV-1 transmission."AIDS. 17(4). 14-17 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kaizu, M., et al.: "Infection of macaques with an R5-tropic SHIV bearing a chimeric envelope carrying subtype E V3 loop among subtype B framework."Archives of Virology. 148(5). 973-988 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takebe, Y, et al.: "High prevalence of diverse forms of intersubtype recombinants in Central Myanmar : geographical hot spot of extensive recombination."AIDS. 17. 2077-2087 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusagawa, S., et al.: "Identification of HIV-2 subtype B transmission in East Asia."AIDS Res and Human Retroviruses. 19(11). 1045-1049 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takamura, S., et al.: "DNA vaccine-encapsulated virus like particles derived from an orally transmissible virus stimulates mucosal and systemic immune responses by oral administration."Gene Ther. 11(7). 628-635 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuoka-Aizawa, S., Sato, H., Hachiya, A., Tsuchiya, K., Takebe, Y., Gatanaga, H., Kimura, S., Oka, S.: "Isolation and molecular characterization of a Nelfinavir(NFV)-resistant human immunodeficiency virus type 1 that exhibits NFV-dependent enhancement of replication."J.Virol.. 77(1). 318-327 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yang, R., Kusagawa, S., Zhang, C., Xia, X., Ben, K., Takebe, Y.: "Identification and characterization of new class of HIV-1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China."J.Virol.. 77(1). 685-695 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kaizu, M., Sato, H., Ami, Y., Isumi, Y., Nakasone, T., Tomita, Y., Someya, K., Takebe, Y., Kitamura, K., Tochikubo, O., Honda, M.: "Infection of macaques with an R5-tropic SHIV bearing a chimeric envelope carrying subtype E V3 loop among subtype B framework."Archives of Virology. 148(5). 973-988 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takebe, Y., Motomura, K., Tatsumi, M., Lwin, H.H., Zaw, M, Kusagawa, K.: "High prevalence of diverse forms of intersubtype recombinants in Central Myanmar : geographical hot spot of extensive recombination."AIDS. 17. 2077-2087 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kusagawa, S., Imamura, Y., Yasuoka, A., Hoshino, H., Oka, S., Takebe, Y.: "Identification of HIV-2 subtype B transmission in East Asia."AIDS Res and Human Retroviruses. 19(11). 1045-1049 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakuragi, J., Ueda, S., Iwamoto, A., Shioda, T.: "Relationship between dimerization and packaging of HIV-1 genome RNA ; a possible role of dimerzation in genome packaging."J.Virol.. 77. 77:4060-77:4069 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matano, T., Kano, M., takcda, A., Nakamura, H., Nomura, N., Furuta, Y., Shioda, T., Nagai, Y.: "No significant enhancement of protection by Tat-expressing Sendai viral vector-booster in a macaque AIDS model."AIDS. 17. 17:1392-17:1394 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uno-Furuta, S., Matsuo, K., Tamaki, S., Takamura, S., Kamei, A., Kuromatsu, I., Kaito, M., Matsuura, Y., Miyamura, T., Adachi, Y., Yasutomi, Y.: "Immunization with recombinant bacillus Calmette-Guerin(BCG)-hepatitis C virus(HCV)elicits HCV-specific cytotoxic T lymphocytes in mice."Vaccine. 21. 3149-3156 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hayashi, T., Yasutomi, Y., Hasegawa, K., Sasaki, Y., Onodera, T.: "Interleukin-4-expressing plasmid inhibits reovirus type-2-triggered autoimmune insulitis in DBA/1J suckling mice."Int.J.Exp.Path. 84. 101-106 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishikubo, K, Murata, Y., Tamaki, S., Sugama, K., Imanaka-Yoshida, K., Yuda, N., Kai, M., Takamura, S., Sebald, W., Adachi, Y., Yasutomi, Y.: "A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma."Gene Ther.. 10. 2119-2125 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakayama, E.E., Tanaka, Y., Nagai, Y., Iwamoto, A., Shioda, T.: "A CCR2-V64I polymorphism affects stability of CCR2A isoform."AIDS. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takamura, S., Niikura, M., Li, T.C., Takeda, N., Kusagawa, S., Takebe, Y., Miyamura, T., Yasutomi, Y.: "DNA vaccine-encapsulated virus like particles derived from an orally transmissible virus stimulates mucosal and systemic immune responses by oral administration."Gene Ther.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takebe, Y., Kusagawa, S., Motomura, K.: "Moleucular epidemiology of HIV : Tracking AIDS Pandemie."Pediatric International. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fukuda, K., Wasi, C., Kusagawa, S., Sato, H., Oka, S., Takebe, Y., Takiguchi, M.et al.: "Cytotoxic T cell recognition of HIV-1 cross-clade and clade-specific epitopes in HIV-1-infected Thais and Japanese patients"AIDS. 16. 701-711 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yang, R., Xia, X., Kusagawa, S., Zhang, C., Ben, K., Takebe, Y.: "On-going generation of multiple forms of HIV-1 intersubtype recombinants in Yunnan province of China"AIDS. 16. 1401-1407 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yang, R., Kusagawa, S., Zhang, C., Xia, X., Ben, K., Takebe, Y: "Identification and characterization of new class of HIV-1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China"J. Virol.. 77(1). 685-695 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsuoka-Aizawa, S., Sato, H., Hachiya, A., Tsuchiya, K., Takebe, Y., Kimura, S., Oka, S.: "Isolation and molecular characterization of a nelfinavir (NFV)-resistant human immunodeficiency virus type 1 that exhibits NFV-dependent enhancement of replication"J. Virol.. 77(1). 318-327 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Motomura, K., Kusagawa, S., Lwin, H.H., Thwe, M., Kato, K., Ohishi, K., Yamamoto, N., Zaw, M., Nagatake, T., Takebe, Y.: "Different subtype distribution in the two cities in Myanmar : Evidence for independent clusters of HIV-1 transmission"AIDS. 17(4). 14-17 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kaizu, M., Sato, H., Ami, Y., Isumi, Y., Nakasone, T., Tomita, Y., Someya, K., Takebe, Y., Kitamura, K., Tochikubo, O., Honda, M.: "Infection of macaques with an R5-tropic SHIV bearing a chimeric envelope carrying subtype E V3 loop among subtype B framework. Archives of Virology"Archives of Virology. (accepted).

    • Related Report
      2002 Annual Research Report
  • [Publications] Takebe, Y., Motomura, K., Tatsumi, M., Yang, R., Lwin, H.H., Zaw, M, Kusagawa, K.: "High prevalence of diverse forms of intersubtype recombinants in Central Myanmar : geographical hot spot of extensive recombination"AIDS. (accepted). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kato, K., Kusagawa, S, Motomura, K, Takebe, Y., et al.: "Closely related HIV-1 CRF01_AE variants among injecting drug users in northern Vietnam : Evidence of HIV spread across the Vietnam-China border"AIDS Res. and Hum. Retroviruses. 17. 113-123 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uno-Furuta, S., Tamaki, S., Takebe, Y., Takamura, S., Yasutomi, Y., et al.: "Induction of virus-specific cytotoxic T lymphocytes by in vivo electric administration of pepetides"Vaccine. 19. 2190-2196 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kusagawa, S., Takebe, Y., Yang R., Motomura K., Ampofo, W., Nagai, Y., Ttsumi, M., et al.: "Isolation and characterization on full-length molecular DNA clones of Ghanaian HIV-1intersubtype A/G recombinant(CRFO2-AG)which is replication-competent in restricted host-range"AIDS Res. and Hum. Retroviruses. 17(7). 649-655 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato, H., Tomita, Y., Ebisawa, K., Hachiya, A., Oka, S., Takebe, Y., Nagai, Y., et al.: "Augmentation of human immunodeficiency virus type 1 subtype E(CRF01_AE) multiple-drug resistance by insertion of a foreign II-amino-acid fragment into the reverse transcriptase"J. Virol.. 75(12). 5604-5613 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kuromatsu, I., Matsuo, K., Takamura, S., Kim, J., Takebe, Y., Kawamura, J., Yasutomi Y.: "Augmentation of human immunodeficiency virus type 1 subtype E(CRF01_AE) multiple-drug resistance by insertion of a foreign II-amino-acid fragment into the reverse transcriptase"Cancer Gene Therapy. 8. 483-490 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kusagawa, S., Sato, H., Tomita, Y., Tatsumi, M., Kato, K., Motomura, K., Yang, R., Notomi, K., Takebe, Y.: "Isolation and characterization of replication-competent molecular DNA clone of CRF01_AE with different coreceptor usages"AIDS Res. and Hum. Retroviruses. 18(2). 115-122 (2002)

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      2001 Annual Research Report
  • [Publications] Louisirirotchanakul, S., Liu, H., Roongpisuthipong, A., Takebe, Y., Shioda, T., Wasi, C., et al.: "Genetic analysis of HIV-1 discordant couples in Thailand : CCR2 641 homozygosity is associated with HIV-1 negative status"AIDS. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Zhang, C., Yang, R., Xia, X., Tan, S., Dai, J., Zhang, Z., Peng, Z., Wel, T., Takebe, Y., Ben, K., et al.: "High prevalence of HIV-1 and HCV coinfection among injecting drug users in the southeast region of Yunnan, China"J. Acquir Immune Defic Syndr.. 29(2). 191-196 (2002)

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      2001 Annual Research Report
  • [Publications] Fukuda, K., Tomiyama, H., Wasi, C., Matsuda, T., Kusagawa, S., Sato, H, Oka, S., Takebe Y., Takiguchi, M.: "Cytotoxic T cell recognition of HIV-1 cross-clade and clade-specific epitopes in HIV-1-infected Thais and Japanes"AIDS. (in press). (2002)

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      2001 Annual Research Report
  • [Publications] Yang, R., Xia, X., Kusagawa, S., Zhang, C., Ben, K., Takebe, Y.: "On-going generation of multiple forms of HIV-1 intersubtype recombinants in Yunnan province of China"AIDS. (accepted).

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      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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