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A basic study on the development of metallic biomaterials

Research Project

Project/Area Number 13450050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionKEIO University

Principal Investigator

KOMOTORI Jun  Keio University, Faculty of Science &Technology, Associate Professor, 理工学部, 助教授 (30225586)

Co-Investigator(Kenkyū-buntansha) YAMADA Taketo  Keio University, Faculty of Science &Technology, Associate Professor, 医学部, 助教授 (60230463)
SUZUKI Tetsuya  Keio University, Faculty of Science &Technology, Associate Professor, 理工学部, 助教授 (10286635)
OKA Kotaro  Keio University, Faculty of Science &Technology, Associate Professor, 理工学部, 助教授 (10276412)
KATAHIRA Kazutoshi  Riken, The Institute of Physical and Chemical Research Materials Fabrication Laboratory, Special Postdoctoral Researcher, 研究員
NISHINO Souichiro  Ibaraki University, Faculty of Engineering, Assistant Professor, 工学部, 講師 (00272112)
木村 綾子  慶應義塾大学, 理工学部, 助手 (30327689)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2002: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥6,700,000 (Direct Cost: ¥6,700,000)
KeywordsMetallic biomaterials / Titanium alloy / Corrosion / Macrophages / SUS316 / 生体材料 / ステンレス鋼 / マクロファージ / 生体適合性 / ELID法
Research Abstract

Metallic biomaterials are required to have high corrosion resisitan-ce, strength, and biocompatibility.The corrosion relates not only to the biocompatibility of the metallic biomaterials but also to the frac-ture.Therefor we must understand corrosion actions in vivo. But it difficult to elucidate the corrosion phenomenon in vivo. The purpose of this study is to investigate the effects of biological factor on corrosion properties in vitro of metallic implants.This study indecated that the biological factor on corrosion was macrophages in vivo. The corrosion damage of 316 stainless steel disk were performed on seven conditions of immersion test ; that are RPMI1640+FBS, RPMI-1640+FBS+U937 cells, RPMI1640+FBS+Ma-crophages, each medium with high-density polyethylene particles, and Ringer solution. We measured corrosion rate (Rp-1) of SUS316 in each condition by AC. Impedance method and compared their rate. We observed the corrosion process. The results are summarized as follows :
1) The surface of SUS316 in medium culturing macrophages at immesion test was incidenced any number of minute protuberances of unevenness. And the average roughness (Ra) and Rp-1 in medium with culturing macrophages increased more than medium without cells, with culturing U937 cells and ringer solution. Therefor these indicated that the existence of macrophages must influence corrosion behavior of bioimplants.
2) In case of performing immersion test in medium with macrophages phagocytosed polyethylene particles, the Ra and Rp-1 increased much higher than them in medium with macrophages without phagocytosing. This suggests that the activating macrophages phagocytosed polyethylene particles were sped up corrosion of metallic materials.
3) This study suggested the corrosion model in vivo, and it shows that the model can explain a series of experimental results.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Masayoshi MIZUTANI: "Effect of ELID Grinding Method on Corrosion resistance and Micro-Hardness of Metallic Biomaterials (Ti-6Al-4V alloy)"Conference proceedings of 5th international conference and general meeting of EUSPEN, Germany, May(2003).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yutaka Kameyama: "Effect of FPB(Fine Particles Bombardment) Treatment on the Friction Coefficient of Ti-6A1-4V Alloy"10^<th> World Conference on Titanium, Hamburg, July(2003).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yusuke Goto: "Effect of Plastic Deformation and Static Stress on Corrosion of Ti-6A1-4V Alloy"10^<th> World Conference on Titanium, Hamburg, July(2003).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazue Murakami: "Biocompatibility of Ti-6A1-4V Alloy Modified by Fine Particle Bombardment (FPB)"10^<th> World Conference on Titanium, Hamburg, July(2003).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yosuke Ohmori: "Corrosive Wear Mechanism of Ti-6A1-4V Alloy in Vitro"International Conference on Erosive and Abrasive Wear (ICEAW II),Cambridge, Sept.(2003).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hitoshi Ohmori: "Improvement of Corrosion Resistanace in Metallic Biomaterials by a New Electrical Grinding Technique"Annuals of CIRP, San Sebastian, Aug.(2002).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizutani Masayoshi: "Effects of ELID Grinding Condition on Corrosion Response of Metallic Biomaterials(Ti-6Al-4V alloy)"6^<th>International Conference on Progress of Machining Technology(ICPMT),Xian, P.R.China, Sept.(2002).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizutani Masayoshi: "Surface Finishing for Biomaterials-Application of The ELID Grinding Method"Third International Conference on AMDP, Daegu, Korea, Oct.(2002).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 片平和俊: "ELID研削による耐食金属材科の表面機能改善"型技術. 17巻8号. 126-127 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 水谷正義: "金属系生体材料(Ti-6Al-4V合金)の腐食特性に及ぼすELID研削の影響"2002年度精密工学会春季大会学術講演会,東京,3月.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 水谷正義: "金属系生体材料(Ti-6Al-4V合金)の表面安定化に及ぼすELID研削条件の影響"2002年度精密工学会秋季大会学術講演会,熊本,10月.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 片平和俊: "ELID研削による表面機能性の改善(ステンレス鋼の腐食特性に及ぼすELID研削の効果)"2001年度精密工学会秋季大会学術講演会,大阪,9月.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masayoshi Mizutani: "Effect of ELID Grinding Method on Corrosion resistance and Micro-Hardness of Metallic Biomaterials (Ti- 6Al-4V alloy)"Conference proceedings of 5th international conference and general meeting of EUSPEN, Germany. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yutaka Kameyama: "Effect of FPB(Fine Particles Bombardment) Treatment on the Friction Coefficient of Ti-6Al-4V Alloy"10^<th> World Conference on Titanium, Hamburg. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yusuke Goto: "Effect of Plastic Deformation and Static Stress on Corrosion of Ti-6Al-4V Alloy"10^<th> World Conference on Titanium,Hamburg. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazue Murakami: "Biocompatibility of Ti-6A1-4V Alloy Modified by Fine Particle Bombardment (FPB)"10^<th> World Conference on Titanium, Hamburg. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yosuke Ohmori: "Corrosive Wear Mechanism of Ti- 6A1-4V Alloy in Vitro"International Conference on Erosive and Abrasive Wear (ICEAW II ), Cambridge. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hitoshi Ohmori: "Improvement of Corrosion Resistance in Metallic Biomaterials by a New Electrical Grinding Technique"Annuals of CIRP, San Sebastian. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizutani Masayoshi: "Effects of ELID Grinding Condition on Corrosion Response of Metallic Biomaterials(Ti- 6Al-4V alloy)"6^<th> International Conference on Progress of Machining Technology(ICPMT), Xian, P.R..China. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizutani Masayoshi: "Surface Finishing for Biomaterials-Application of The ELLD Grinding Method"Third International Conference on AMDP, Daegu, Korea. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masayoshi MIZUTANI: "Effect of ELID Grinding Method on Corrosion resistance and Micro-Hardness of Metallic Biomaterials (Ti-6Al-4V alloy)"Conference proceedings of 5th international conference and general meeting of EUSPEN, Germany, May(2003).

    • Related Report
      2002 Annual Research Report
  • [Publications] Yutaka Kameyama: "Effect of FPB(Fine Particles Bombardment) Treatment on the Friction Coefficient of Ti-6A1-4V Alloy"10^<th> World Conference on Titanium, Hamburg, July(2003).

    • Related Report
      2002 Annual Research Report
  • [Publications] Yusuke Goto: "Effect of Plastic Deformation and Static Stress on Corrosion of Ti-6A1-4V Alloy"10^<th> World Conference on Titanium, Hamburg, July(2003).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kazue Murakami: "Biocompatibility of Ti-6A1-4V Alloy Modified by Fine Particle Bombardment (FPB)"10^<th> World Conference on Titanium, Hamburg, July(2003).

    • Related Report
      2002 Annual Research Report
  • [Publications] Yosuke Ohmori: "Corrosive Wear Mechanism of Ti-6A1-4V Alloy in Vitro"International Conference on Erosive and Abrasive Wear(ICEAWII), Cambridge, Sept.(2003).

    • Related Report
      2002 Annual Research Report
  • [Publications] Hitoshi Ohmori: "Improvement of Corrosion Resistance in Metallic Biomaterials by a New Electrical Grinding Technique"Annuals of CIRP, San Sebastian, Aug.(2002).

    • Related Report
      2002 Annual Research Report
  • [Publications] Mizutani Masayoshi: "Effects of ELID Grinding Condition on Corrosion Response of Metallic Biomaterials(Ti-6A1-4V alloy)"6^<th> International Conference on Progress of Machining Technology(ICPMT), Xian, P.R.China, Sept.(2002).

    • Related Report
      2002 Annual Research Report
  • [Publications] Mizutani Masayoshi: "Surface Finishing for Biomaterials-Application of The ELID Grinding Method"Third International Conference on AMDP, Daegu, Korea, Oct.(2002).

    • Related Report
      2002 Annual Research Report
  • [Publications] 片平和俊: "ELID研削による耐食金属材料の表面機能改善"型技術. 17巻8号. 126-127 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 水谷正義: "金属系生体材料(Ti-6A1-4V合金)の腐食特性に及ぼすELID研削の影響"2002年度精密工学会春季大会学術講演会,東京,3月.

    • Related Report
      2002 Annual Research Report
  • [Publications] 水谷正義: "金属系生体材料(Ti-6A1-4V合金)の表面安定化に及ぼすELID研削条件の影響"2002年度精密工学会秋季大会学術講演会,熊本,10月.

    • Related Report
      2002 Annual Research Report
  • [Publications] 片平和俊: "ELID研削による表面機能性の改善(ステンレス綱の腐食特性に及ぼすELID研削の効果)"2001年度精密工学会秋季大会学術講演会,大阪,9月.

    • Related Report
      2002 Annual Research Report
  • [Publications] 永田仁: "異なる表面性状を有するTi-6Al-4V合金の腐食特性"材料と環境討論会論文集. 187-190 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 水谷正義: "金属系生体材料(Ti-6Al-4V合金)の腐食特性に及ぼすELID研削の影響"精密工学会春季学術講演論文集. (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 片平和俊: "ELID研削による表面機能改善(ステンレス鋼の腐食特性の及ぼすELID研削の効果)"精密工学会秋季大会学術講演論文集. 339 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 前田澄満: "金属系生体材料の腐食挙動に及ぼすマクロファージの影響"日本機械学会2001年度年次大会講演論文集. IV. 65-66 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 前田澄満: "ポリエチレン粒子を添加したマクロファージ培養液中におけるステンレス鋼の腐食"第48回材料と環境討論会講演集. 489-492 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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