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DEVELOPMENT OF DISINTEGRATION AND CONTROL TECHNIQUE OF MICROCAPSULES INCLUDING A GAS BUBBLE FOR DRUG DELIVERY SYSTEMS USING UNDERWATER SHOCK WAVE

Research Project

Project/Area Number 13450074
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fluid engineering
Research InstitutionKyushu Institute Of Technology (2002-2003)
Kyoto University (2001)

Principal Investigator

TAMAGAWA Masaki  Kyushu Institute Of Technology, Associate Professor, 大学院・生命体工学研究科, 助教授 (80227264)

Co-Investigator(Kenkyū-buntansha) AKAMATSU Teruaki  Seteunan University, 工学部, 教授 (40025896)
川那辺 洋  京都大学, エネルギー科学研究科, 助教授 (60273471)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2003: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2001: ¥6,100,000 (Direct Cost: ¥6,100,000)
KeywordsShock wave / DDS / Micro Capsule / Micro Jet / 気泡 / ドラッグデリバリシステム
Research Abstract

Recently shock waves and shock wave technology are. applied to medical and biotechnological industries, especially extracorporeal shock wave lithotripsy (ESWL), bone reconstruction for orthpaedic, gene therapy with drug. Shock wave is large pressure change wave whose propagating velocity is larger than sound speed, and its features are (1)single and discontinues wave with large rising frequency, (2)duration time is about micro second order, (3) large energy transfer per unit time. Using these features, new technology and technique for medicine and industry are needed, but the fundamental mechanism for cell disintegration has not been, elucidated yeti In this study, our aim is to investigate this mechanism and apply the shock wave technology to disintegrate cell in the bioprocess industry and medical field.
In our research group, the study about the cell disintegration using shock wave and a bubble, and also the new bioprocess and drug delivery systems (DDS) using these have being develo … More ped. In this research project, with cooperation of LSTM (Institute of Fluid Mechanics in German) in the University of Erlangen, Germany, which has been in pride of flow measurements and analysis, the following three topics are investigated, (1) Capsule disintegration by turbulent shear stress (Reynolds shear stress), (2)Capsule disintegration and establishment of mathematical cell deformation process model using shock wave, (3)Disintegration of microcapsules including a bubble using shock-wave for applying Drug Delivery Systems (DDS) And the results for these in this projects are
(1)The threshold of shear stress for cell integration in turbulent shear flow is from 1200 to 1400 Pa, and this result are also applicable to the development of artificial organs, for instance blood pumps, and other medical flow device.
(2)Modifying the mathematical model of spherical shell -water interactions, deformation and damage of a single and two cells in water by ultrasonic and shock wave with changing parameter (thickness of membrane and Young modulus) are investigated.
(3)Deformation process of a capsule including, a bubble by ultrasonic and shock wave is analyzed using arbitrary Lagrangian-Eulerian (ALE) computational method, and it is found that asymmetry of internal bubble and micro jet have largeeffects on he damage of microcapsules.
Using these results, the microcapsule disintegration rate should be controlled by shock wave in future. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] M.Tamagawa, I.Yamanoi: "Deformation process of a gas bubble near curved elastic wall by shock waves for design of DDS"Proc.of the first Asian Pacific Conference on Biomechanics. Vol. 1. 17-18 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa: "Prediction of hemolysis properties and thrombus formation using CFD for blood orifice flow"Proceedings of the Workshop on Biomechanical Engineering and Biomaterials International Symposium on Bio-inspired System. Vol. 2. 97-100 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, I.Yamanoi: "Deformation process of microcapsules and cells using shock waves and gas bubbles for design of drug delivery systems"Proc.of the 8^<th> International Conference on Mechanics in Medicine and Biology. Vol. 1. 141 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, I.Yamanoi: "Fundamental Investigation for Developing Drug Delivery Systems and Bioprocess with Shock Waves and Bubbles"JSME International Journal, C. 44, No. 4. 1031-1040 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, S.Minakawa: "Predictions of Index of Hemolysis in Shear Blood Flow (Effects of exposure time under shear stress on prediction accuracy)"JSME International Journal, Series C. 46-2. 604-613 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 皆川重治, 玉川雅章: "せん断乱流場での数値流体力学を用いた溶血予測とその検証"日本機械学会論文集B編. 67-664. 3119-3126 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tamagawa, M., I Yamanoi: "Fundamental Investigation for Developing Drug Delivery Systems and Bioprocess with Shock Waves and Bubbles"JSME International Journal Series. Vo1.44, No.4, Series C,. 1031-1040 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tamagawa, M., Minakawa, S.: "Predictions of Index of Hemolysis in Shear Blood Flow (Effects of exposure time under shear stress on prediction accuracy)"JSME Intl.J.. Vo1.46, No.2, Series C,. 604-613 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, I.Yamanoi, A.Matsumoto: "Deformation process and disintegration of microcapsules including gas bubbles by shock waves in drug delivery systems"Proc.of 23rd International Symposium on Shock Waves. Vol.1. 253 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa: "Analysis of deformation process of cells and internal bubbles by shock waves"The Journal of the Acoustical Society of America. Vol.110, No.5. 2615 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, I.Yamanoi: "Disintegration and deformation of cells and microcapsules using shock waves and gas bubbles for developing DDS"Proc. of 4th World Congress Biomechanics. 26 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, I.Yamanoi, A.Matsumoto: "Deformation process of a bubble near curved elastic wall"Proc.of 10th International Symposium on Flow Visualization. 264 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M Tamagawa, I. Yamanoi: "Effects of the viscosity of the liquid in the microcapsule on deformation process of a bubble for developing DDS using shock waves"The Journal of the Acoustical Society of America. Vol.112, No.5. 2316 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, I.Yamanoi: "Deformation Process of a bubble in a capsule by shock waves for developing drug delivery systems"World Congress on Medical Physics and Biomedical Engineering. 14.02 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, I.Yamanoi: "Deformation process of a gas bubble near curved elastic wall by shock waves for design of DDS."Proc. of the first Asian Pacific Conference on Biomechanics. Vol.1. 17-18 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa: "Prediction of hemolysis properties and thrombus formation using CFD for blood orifice flow"Proc. of the Workshop on Biomechanical Engineering and Biomaterials International Symposium on Bio-inspired System. Vol.2. 97-100 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa: "Deformation process of microcapsules and cells using shock waves and gas bubbles for design of drug delivery systems"Proc. of the 8th International Conference on Mechanics in Medicine and Biology. Vol.1. 14 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] M.Tamagawa, I.Yamanoi: "Deformation process of a gas bubble near curved elastic wall by shock waves for design of DDS"Proc.of the first Asian Pacific Conference on Biomechanics. Vol.1. 17-18 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Tamagawa: "Prediction of hemolysis properties and thrombus formation using CFD for blood orifice flow"Proceedings of the workshop on Biomechanical Engineering and Biomaterials International Symposium on Bio-inspired System. Vol.2. 97-100 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Tamagawa, I.Yamanoi: "Deformation process of microcapsules and cells using shock waves and gas bubbles for design of drug delivery systems"Proc.of the 8^<th> International Conference on Mechanics in Medicine and Biology. Vol.1. 141 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 蒲池雅樹, 玉川雅章, 山野井一郎: "衝撃波DDS開発のための水中衝撃波とその伝播解析"第16回バイオエンジニアリング講演会講演論文集. 3-38. 407-408 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山野井一郎, 玉川雅章, 蒲池雅樹: "衝撃波DDSにおけるマイクロカプセル内気泡の変形挙動解析"第16回バイオエンジニアリング講演会講演論文集. 3-38. 409-410 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 川島真一, 玉川雅章: "衝撃波DDS開発のためのマイクロカプセルの試作と力学的特性"第16回バイオエンジニアリング講演会講演論文集. 3-38. 23-24 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Tamagawa, I.Yamanoi: "Disintegration and deformation of cells and microcapsules using shock waves and gas bubbles for developing DDS"Proc. of 4^<th> World Congress Biomechanics. 26 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Tamagawa, I.Yamanoi, A.Matsumoto: "Deformation process of a bubble near curved elastic wall"Proc. of 10^<th> International Symposium on Flow Visualization. 1. 264 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M Tamagawa, I.Yamanoi: "Effects of the viscosity of the liquid in the microcapsule on deformation process of a bubble for developing DDS using shock waves"The Journal of the Acoustical Society of America. Vol.112 No.5. 2316 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Tamagawa, S Minakawa: "Predictions of Index of Hemolysis in Shear Blood Flow -Effects of Exposure Time under Shear Stress on Prediction Accuracy-"Japan Society of Mechanical Engineer International Journal, Series C. (To be Published). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 玉川雅章: "バイオプロセスにおける水中衝撃波の気泡内包細胞内伝播シミュレーション"日本機械学会第15回バイオエンジニアリング講演会講演論文集. No.02-35. 413-414 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 山野井一郎, 玉川雅章, 松尾純明: "衝撃波DDS開発のための弾性壁面近傍での気泡変形挙動解析"日本機械学会第15回バイオエンジニアリング講演会講演論文集. No.02-35. 241-242 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 皆川重治: "せん断乱流場での数値流体力学を用いた溶血予測とその検証"日本機械学会論文集 B編. Vol.67 No.664. 3119-3126 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Tamagawa: "Fundamental Investigation for Developing Drug Delivery Systems and Bioprocess with Shock Waves and Bubbles (Numerical Analysis of Deformation of Cell Model and Observation of Bubble Behavior near the Cell-Membrane Model)"JSME International Journal, Series C. Vol.44 No.4. 1031-1040 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Tamagawa: "Analysis of deformation process of cells and internal bubbles by shock waves"The Journal of the Acoustical Society of America. Vol.110, No.5. 2615 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Tamagawa: "Prediction methods for hemolysis in turbulent shear flow using CFD"Proceeding of the 5th International Symposium on Computer Method in Bimechanics and Biomedical Engineering. Vol.1. 53 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Tamagawa: "Deformation process and disintegration of microcapsules including gas bubbles by shock waves in drug delivery systems"Proceeding of the 23rd International Symposium on Shock Waves. 253 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松本淳: "衝撃波バイオプロセスにおける細胞破壊"日本機械学会第12回バイオエンジニアリング学術講演会・秋季セミナ講演論文集. No.1-27. 81 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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