| Project/Area Number |
13460089
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
FUJIMOTO Kenshiro TOHOKU UNIVERSITY, GRADUATE SCHOOL OF AGRICULTURAL SCIENCE, PROFESSOR, 大学院・農学研究科, 教授 (00005620)
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| Co-Investigator(Kenkyū-buntansha) |
MIYASHITA Kazuo HOKKAIDO UNIVERSITY, GRADUATE. SCHOOL OF FISHERIES SCIENCE, PROFESSOR, 大学院・水産科学研究科, 教授 (10182015)
ENDO Yasushi OHOKU UNIVERSITY, GRADUATE SCHOOL OF AGRICULTURAL SCIENCE, ASSOCIATE PROFESSOR, 大学院・農学研究科, 助教授 (60194049)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 2002: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥5,900,000 (Direct Cost: ¥5,900,000)
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| Keywords | conjugated highly unsaturated fatty acid / conjugated trienoic acid / Ptilota pectinata / polyenoic acid isomerase / cytotoxicity on cancer cells / oxidative stability / lipid metabolism / hypolipidemic activity |
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| Research Abstract |
Conjugated trienoic fatty acids were fairy unstable in bulk phase, however cathechin was effective as an atioxidant. Dietary conjugated trienoic and highly unsaturated fatty acids did not induce lipid peroxidation in the tissues of rat or hen. Dietary conjugated fatty acids were not accumulated in the tissues but retarded the deposition of fat. Alternatively conjugate linoleic acid was observed in the tissue lipids. Conjugated trienoic acids showed a remakable cytotoxic activity on the cultured cancer cell lines. Dietary conjugated trienoic acids inhibited the azoxymethane-induced colonic aberrant crypt foci in rat. Chemopreventive activity of conjugated trienoic acid was suggested. A polyunsaturated fatty acid isomerase was isolated from a red alga Ptilota pectinata. The isomerase converted eicosapentaenoic acid and arachidonic acid to conjugated trienoic acids which were highly toxic to HepG2 cells.
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