| Project/Area Number |
13460118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Kyushu University |
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Principal Investigator |
FURUSE Mitsuhiro Faculty of Agriculture, Professor, 大学院・農学研究院, 教授 (30209176)
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| Co-Investigator(Kenkyū-buntansha) |
BUNGO Takashi Ehime University, Associate Professor Faculty of Agriculture, 農学部, 助教授 (40325361)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2001: ¥11,500,000 (Direct Cost: ¥11,500,000)
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| Keywords | CRF / GLP-1 / NPY / Ghrelin / L-pipecolic acid / Food intake / Sleep / Chick / CRF / α-MSH / GRF / Ghrelin / Ketone body / AGRP / Catecholamine / Chick |
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| Research Abstract |
Corticotropin-releasing factor (CRF), urocortin and urotensin I share amino acid sequences, and they inhibit food intake in mammals. The effect of these three peptides on food intake in the neonatal chick was compared. The results indicated that the suppressive effect on food intake was strongest for CRF followed by urotensin I, then urocortin. Both CRF and glucagon-like peptide-1 (GLP-1) inhibit food intake of chicks, but they also produce other behaviors. In conclusion, CRF and GLP-1 interact in the chick brain, but the response depends on the behavior being measured. The involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks was examined. Endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks. Neuropeptide Y (NPY) is one of the most potent neuropeptides known to induce feeding in animals, and has been suggested to be a physiological signal for food intake. It was elucidated that NPY receptor agonists, except for neuropeptide Y-(13-36), are potent stimulators of food intake in the neonatal chick. Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue (GHS) receptor. The effect of central injection of different ghrelins including chicken and bullfrog ghrelin, and synthetic GH-releasing peptide (GHRP) on feeding of neonatal chicks was investigated. The results indicate that the chicken GHS receptor is affected by several forms of GHS, and that food intake of neonatal chicks is inhibited by GHS receptor agonists. L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the brain. The results suggest that L-PA has an important role for the regulation of feeding and sleeping behaviors in the neonatal chick.
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